Searching for two targets produces a dual-target cost compared with single-target search, with reduced attentional guidance toward targets (Stroud, Menneer, Cave, & Donnelly, 2012). We explore the effect of holding a color in working memory (WM) on guidance in single-target search. In Experiments 1 and 2, participants searched for a T of a specific color while holding one of the following in WM: a color patch, a letter, a dot pattern, or an oriented bar. Only when holding a color in WM was guidance in single-target search affected as strongly as it is in dual-target search. In Experiment 3, the target changed color from trial to trial. A color in WM reduced guidance, but not to the extent of dual-target search. However, search and WM error rates were high, suggesting interference and incomplete engagement with the combined task. We conclude that the guidance cost in dual-target search is not solely due to attentional capture by the WM-color, because the WM-color can be effectively separated from search color, with little confusion between the two. However, WM load does cause substantial interference in guidance when both tasks involve color. These results illustrate the complex interactions between WM and attentional guidance. (PsycINFO Database Record (c) 2019 APA, all rights reserved).