Search Items Research Articles

Biomarkers for the diagnosis of Alzheimer’s disease, dementia Lewy body, frontotemporal dementia and vascular dementia

BackgroundDementia is a chronic brain disorder classified by four distinct diseases that impact cognition and mental degeneration. Each subgroup exhibits similar brain deficiencies and mutations. This review will focus on...

A review of online platforms in training and surgical education

The use of technology in surgical education has rapidly evolved. Blended learning refers to provision of online instruction platforms by international technology companies, prompting a combination of face-to-face teaching with computer-mediated tuition. This nonsystematic literature review focuses on online teaching platforms with applications for potential use in future surgical education. A literature search was performed using PubMed, Embase, OVID, and Google Scholar. To identify studies on online platforms in surgical education, the following search terms were used: “online platform,” “online learning,” “surgical education and online learning,” and “surgical education and blended learning.” The search was limited to citations in English from 1998 to 2018. The first author performed the detailed literature search. The final list of the articles was included by consensus between authors. Search items were studied from the nature of the articles, country of origin, date of publication, and aims and findings in relation to use of online platforms surgical education. Altogether 279 relevant citations were reviewed, of which 22 articles met the inclusion criteria: 19 papers (ten original research, two review items, seven Internet articles) and three books were found to be relevant for this study. Their analysis comprised models of platforms along with their applications in surgical education. Data on the advantages and disadvantages of online platforms as well as authors’ personal experience of this instruction manner in surgical education were extracted. Problems with determining, analyzing, and integrating reading matters in a nonsystematic literature review comprising different teaching methods combined with the use of online platforms in surgical education were discussed and resolved. Online platforms were introduced by international technology companies to encourage paperless blended learning in schools. We envisaged the use of online classrooms in surgical education because of its simple format, easy access, low costs, and interaction-inspiring nature between teachers and students in professional surgical education.

You’re looking for what? Comparing search for familiar, nameable objects to search for unfamiliar, novel objects

ABSTRACTSearching for items in one’s environment often includes considerable reliance on semantic knowledge. The present study examines the importance of semantic information in visual and memory search, especially with respect to whether the items reside in long-term or working memory. In Experiment 1, participants engaged in hybrid visual memory search for items that were either highly familiar or novel. Importantly, the relatively large number of targets in this hybrid search task necessitated that targets be stored in some form of long-term memory. We found that search for familiar objects was more efficient than search for novel objects. In Experiment 2, we investigated search for familiar versus novel objects when the number of targets was low enough to be stored in working memory. We also manipulated how often participants in Experiment 2 were required to update their target (every trial vs. every block) in order to control for target templates that were stored in long-term memory as a result of repeated exposure over trials. We found no differences in search efficiency for familiar versus novel objects when templates were stored in working memory. Our results suggest that while semantic information may provide additional individuating features that are useful for object recognition in hybrid search, this information could be irrelevant or even distracting when searching for targets stored in working memory.

Stress Induced Type 2 Diabetes Mellitus among Industrial Workers-A Review

Objectives: To give a condensed summary of research findings on the health complications of industrial workers due to stress particularly on Type 2 Diabetes Mellitus (T2DM). Method: Abstracts of previous publications related to stress induced T2DM were collected from research database using T2DM, stress, trauma, life events and work stress as search items. Results: The outcomes of many previous studies have revealed that stress induced T2DM were found to be prevalent among industrial workers. The conclusions of many longitudinal studies have revealed that emotional stresses, anxiety, sleeping disorder, anger hostility are the factors that accelerate the development of T2DM. Conflicting results are also found regarding childhood neglect, life events and stress that accelerate the development of T2DM. Such stress induced T2DM will lead to many complications associated with T2DM. Conclusion: As of date as per WHO statistics 422 million people are living with DM and work related stress is said to play a part in this. Complications like CVD, vascular disease, nephritis, retinopathy and neuropathy are prevalent among Industrial workers due to work related stress. This review article highlights the outcome of many prospective studies done on the health implications of Industrial workers. More studies are required in this field to identify the mechanisms linking various forms of stress to T2DM.

Various Scoring Systems for Predicting Revascularization of Chronic Coronary Total Occlusion by Percutaneous Coronary Intervention

Successful revascularization of chronic total occlusion (CTO) by percutaneous coronary intervention (PCI) is associated with reduced major adverse cardiovascular events (MACEs) compared with CTO PCI failure. The developments of new strategies and new devices have improved the success rate of CTO PCI. However, the complexity of CTO lesions, clinical characteristics of patients and operator experience highly determine the successful revascularization. Using search items, “chronic total occluion”, “percutaneous coronary intervention”, “scoring systems”, “predictablity”. We searched Pubmed, ScienceDirect, Web of Science, Cochrane Library, and CNKI. We found six clinically used scoring systems from 2011 to 2018. They included J-CTO score, CT-RECTOR score, CL score, PROGRESS CTO score, ORA score, and Ellis score. All parameters of each scoring systems have been systematically reviewed. The patients with higher score have found to have adecreased probability of CTO recanalization. Ellis score that mainly focused on ambiguous proximal cap and hybrid approach seems to provide better predictability in deciding procedure strategy.

Treatment of oral lichen planus: a narrative review

Event Abstract Back to Event Treatment of oral lichen planus: a narrative review Luca Oberti1*, Federica Gabrione1, Alberta Lucchese2, Dario Di Stasio2, Francesco Carinci3 and Dorina Lauritano1 1 University of Milano-Bicocca, Department of Medicine and Surgery, Italy 2 Second University of Naples, Multidisciplinary Department of Medical-Surgical and Dental Specialties, Italy 3 University of Ferrara, Department of Morphology, Experimental Medicine and Surgery, Italy Aim. The aim of this study was to perform a narrative review of treatment of oral lichen planus. Materials and Methods. We examined the main publications related to OLP management, identified by searching the PubMed electronic database. We used the following search items: oral lichen planus, oral lichen planus management, oral lichen planus treatment, oral lichen planus therapy, randomized trial oral lichen planus, oral lichen planus placebo, oral lichen planus steroids, oral lichen planus laser, oral lichen planus photo-dynamic therapy, oral lichen planus calcineurin inhibitors, and oral lichen planus curcumin. A total of 216 citations were considered, but only randomized controlled trials, comparing an active treatment with placebo, or between different active treatments, were included in this systematic review. We examined 25 RCTs controlled trials: 22 of these were parallel group studies, 1 was a cross-sectional study and 2 were split-mouth design studies. Furthermore, 4 were single-blind studies and 9 were double-blind studies. Only patients with symptomatic OLP were included and interventions of all types were considered (topical treatment, systemic drugs, non-pharmacological intervention). Results. The examined studies confirm that the most efficient and effective therapy in patients with symptomatic OLP is topical treatment with corticosteroids, which, nowadays, remains the first-line therapy for this type of lesion. The use of intralesional steroids, although fairly uncommon, can represent a valid alternative in cases that only partially respond to topical steroid therapy, while the use of systemic corticosteroids is only indicated in patients whose condition is unresponsive to topical first- and second-line therapies, or with a relevant involvement of oral mucosa. The use of photodynamic therapy and lasertherapy appear to be very effective in reducing the size of injuries and pain. Even the use of calcineurin inhibitors (tacrolimus and pimecrolimus) has also produced excellent results with fewer relapses. Finally, many other therapies, which have proved to be effective, have been proposed but they must be further investigated (curcuma derivatives, retinol, tocopherol and other natural substances, often used as an addition to conventional steroid therapy). Discussion. Topical steroids remain the first-line treatment for symptomatic OLP, however, many different pharmacological and non-pharmacological therapies would represent a valid alternative for its management, but, nowadays they require further investigations.

Food Preference of Cavia magna (Rodentia: Caviidae) on a Subtropical Island in Southern Brazil

Abstract This study aimed to link the plants consumed by Cavia magna and their availability in the environment, (Ilha dos Marinheiros) determining its food preference. In the environment, 96 species were recorded. Twenty-four plant species were identified in the fecal samples. There wasn’t significant difference in the composition of plant species among seasons, although the variation was significant between the island’s northern and southern areas concerning the fecal samples. Mantel test’s results supported that the availability of vegetation has significant influence on the species consumed. Being that the most consumed species (present on the feces) were distant to their distribution areas, we propose that C. magna of Ilha dos Marinheiros actively search and select items to eat, showing food preference for some species.

Medical Treatment: An Emerging Standard in Acute Appendicitis?

Appendicectomy has been accepted as the gold standard for the management of appendicitis over the years, but there has been an increasing evidence and trend toward the conservative approach to the management of appendicitis. The aim of this review is to search existing literature and to evaluate and compare the conservative and operative approaches to the management of appendicitis. An electronic search of published literature was conducted through Pubmed, Google Scholar, Embase, and Medline using a variety of search items to find relevant observational studies, randomized clinical trials, systematic reviews, and meta-analyses. Bibliographies of selected articles were also analyzed for publications of interest relevant to the scope of the topic. The articles that reported primary outcomes after the management of appendicitis, complications, economic implications, and duration of follow-up were reviewed in detail. The major primary outcomes show a high recurrence rate and failed treatment associated with the conservative management of appendicitis. The other outcomes obtained show that there is an increased incidence of complications associated with operative management. Economic implications and cost-effectiveness analysis show that conservative treatment may be preferred. The length of hospital stay was significantly higher in conservative approach to management; however, shorter time off activities was observed. In general, the conservative management of appendicitis is still regarded as safe, effective, and efficacious, and further research with well-constructed study design, and larger sample size is required.

Image Enhancement via Indented Frame Over Fusion

In this era of artificial intelligence (AI), the Internet of things (IoT) with the capability of connecting a great number of heterogeneous terminals and the popularity of mobile devices, which makes more devices available as another pair of eyes for people, such as video surveillance and smart navigation. As image enhancement is assisting people to better work together and helping people live a smarter life, it is therefore becoming increasingly important. Nevertheless, many vision systems are sensitive to factors like the scattering of light or motion which may cause blur. This paper promotes an image enhancement method and is dedicated to reduce the adverse effects of blurred images on vision systems. We first researched the theory of indented frame over fusion (IFOF) and presented an automatic screening function. Then subtly combined color reversal, registration and transformation. Lastly, we tested two examples with this method and gained good results. Image processed by this method, facing strong scattering of light environment, has improved its quality and visual effects. With the development of this kind of technology, there will be more practical and intelligent applications in our lives, such as license plate numbers recognition in bad weather and important items search on fire scenes.

Exploring the experiences of people vlogging about severe mental illness on YouTube: An interpretative phenomenological analysis.

Evidence suggests that, compared to the general population, individuals with severe mental illness (SMI) are more likely to engage in online social networking and share personal experiences through blogging. However, little is known about the impact of creating and publicly sharing mental health videos (vlogging) on individuals with self-identified SMIs. The present study aims to investigate the experiences of individuals with self-identified SMIs who vlog about their SMI on YouTube. YouTube was systematically searched using four key search items ("schizophrenia", "bipolar disorder", "major depressive disorder" and "schizoaffective disorder"). After manually screening approximately 50 channels, a set of 30 videos by individuals with self-identified SMIs discussing their experience of vlogging was selected and transcribed verbatim. An interpretative phenomenological analysis (IPA) was employed for the analysis of the data. The analysis produced three global themes: Minimising Isolation; Vlogging as Therapy; and Fighting stigma. The data collected was limited as regards depth of content by the inability to ask follow-up questions. The findings suggest that engaging in the act of vlogging about mental illness may benefit and encourage recovery in individuals with SMIs by providing them with peer support, enhancing self-efficacy, and reducing self-stigma. Future research should employ interviews to produce more robust data for analysis.

Diagnostic and Therapeutic Long-term Management of Eosinophilic Esophagitis- Current Concepts and Perspectives for Steroid Use.

Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus, which requires short- and long-term treatment. In addition, patients under long-term treatment for any chronic condition should have a structured follow-up. The mainstays in EoE treatment are drugs (such as swallowed topical corticosteroids [STC] and proton pump inhibitors), dietary exclusions, and endoscopic dilations. STC are the most widely used treatment and have proven efficacy in inducing clinical, endoscopic and histological remission in active EoE. However, data regarding maintaining disease remission and long-term management are limited. Ongoing disease activity and relapses despite STC treatment are frequently observed. This sheds light on the urgent need for adequate maintenance strategies, which have not been well defined. In terms of follow-up concepts, to date neither guidelines nor consensus recommendations have been published. To summarize the current knowledge on long-term diagnostic and therapeutic STC management of EoE, we conducted a literature search using PubMed and Embase applying the following key search items: Eosinophilic esophagitis, eosinophils, esophagus, swallowed topical corticosteroids, fluticasone, budesonide, long-term, treatment, therapy, and follow-up. In addition, we present empirically developed long-term management concepts applied at two large EoE centers, with a special focus on STC treatments. Finally, we highlight areas of future research and perspectives regarding the long-term management of EoE.

Feature synchrony-asynchrony and rate of change in visual search

ABSTRACTAttention is known to be sensitive to the temporal structure of scenes. We initially tested whether feature synchrony, an attribute with potential special status because of its association with objecthood, is something which draws attention. Search items were surrounded by colours which periodically changed either in synchrony or out-of synchrony with periodic changes in their shape. Search for a target was notably faster when the target location contained a unique synchronous feature change amongst asynchronous changes. However, the reverse situation produced no search advantage. A second experiment showed that this effect of unique synchrony was actually a consequence of the lower rate of perceived flicker in the synchronous compared to the asynchronous items, not the synchrony itself. In our displays it seems that attention is drawn towards a location which has a relatively low rate of change. Overall, the pattern of results suggested the attentional bias we find is for relative temporal stability. Results stand in contrast to other work which has found high and low flicker rates to both draw attention equally [Cass, J., Van der Burg, E., & Alais, D. (2011). Finding flicker: Critical differences in temporal frequency capture attention. Frontiers in Psychology, 2, 320]. Further work needs to determine the exact conditions under which this bias is and is not found when searching in complex dynamically-changing displays.

Modulation of parafoveal word processing by cognitive load during modified visual search tasks

During visual search for simple items, the amount of information that can be processed in parafoveal vision depends on the cognitive resources that are available. However, whether this applies to the semantic processing of words remains controversial. This work was designed to manipulate simultaneously two sources of cognitive load to study their impact on the depth of parafoveal word processing during a modified visual search task. The participants had to search for target words among parafoveally presented semantic, orthographic or target-unrelated distractor words while their electroencephalogram was recorded. The task-related load was manipulated by either giving target words in advance (literal task) or giving only a semantic clue to define them (categorical task). The foveal load was manipulated by displaying either a word or hash symbols at the centre of the screen. Parafoveal orthographic and semantic distractors had an impact on the early event-related potential component P2a only in the literal task and when hash symbols were displayed at the fovea, i.e., when both the task-related and foveal loads were low. The data show that all sources of cognitive load must be considered to understand how parafoveal words are processed in visual search contexts.

Bistable Perception Is Biased by Search Items but Not by Search Priming.

During visual search, selecting a target facilitates search for similar targets in the future, known as search priming. During bistable perception, in turn, perceiving one interpretation facilitates perception of the same interpretation in the future, a form of sensory memory. Previously, we investigated the relation between these history effects by asking: can visual search influence perception of a subsequent ambiguous display and can perception of an ambiguous display influence subsequent visual search? We found no evidence for such influences, however. Here, we investigated one potential factor that might have prevented such influences from arising: lack of retinal overlap between the ambiguous stimulus and the search array items. In the present work, we therefore interleaved presentations of an ambiguous stimulus with search trials in which the target or distractor occupied the same retinal location as the ambiguous stimulus. Nevertheless, we again found no evidence for influences of visual search on bistable perception, thus demonstrating no close relation between search priming and sensory memory. We did, however, find that visual search items primed perception of a subsequent ambiguous stimulus at the same retinal location, regardless of whether they were a target or a distractor item: a form of perceptual priming. Interestingly, the strengths of search priming and this perceptual priming were correlated on a trial-to-trial basis, suggesting that a common underlying factor influences both.

PO-256 Influences of Exercise on Circulating Irisin in Overweight or Obese Individuals: a system review

Objective Irisin is a newly identified myokine, which is mainly secreted by skeleton muscle, adipose and cerebellar. It is shown to be related to some physiology process. The aim of this study is to evaluate the influence of exercise on circulating irisin concentrations in overweight or obese individuals
 Methods Searches were performed on nine online electronic databases including PubMed, EMbase, The Cochrane Library, web of science, Ebsco, CNKI, VIP, CBM and Wan-Fang Data databases. The search items were irisin, fibronectin type Ⅲ domain-containing protein 5, FNDC5, exercise, training, physical activity, obesity, overweight, obese, body mass index, BMI, adiposity and fat. Randomized controlled trials (RCT) or clinical controlled trials about the effect of exercise on circulating irisin concentrations in overweight or obese individuals in English or Chinese were eligible for the study. The trials compare exercise intervention with no intervention, or combined interventions of exercise and other with other intervention(s), and the exercise intervention is not one acute time. Besides, the trial objects belong to overweight or obese regardless of the judgement’s indicator. According to the criteria, the data extracted by two research independently. If there was disagreement, discussion between all the authors were used to settle. The risk of bias among the included studies was assessed by the Cochrane Collaboration Risk-of-Bias tool, which consists of seven domains and each one was judged to ‘unclear risk’ ‘low risk’, or ‘high risk’ following the recommendations detailed of the Cochrane handbook. Lastly an analysis about the final studies was done. 
 Results The search identified a total of 855 possible articles. Of those, 364 were removed as duplicates, and the remaining 491 were screened for the titles and abstracts. The full-texts of 56 trials were retrieved to assess for eligibility. After the evaluation, four articles of RCTs were retained for the final system review from the year of 2015 to 2017, producing 6 study estimates. The assessments class of methods quantality of them are A. All the research subjects are more than 18 years old, and in one study subjects are men, men and women in two, women in three. The types of exercise intervention are dissimilar, such as strengthen or endurance exercise (including high intensity interval training, HIIT). In the duration of exercise, three studies are 8 weeks, and two for 12 weeks, one for 24 weeks. In circulating irisin, the detection methods of all is enzyme-linked immunosorbent assay, and three are in plasm, three in serum. Furthermore, the concentration unit in five studies is ng/ml, and one is µg/ml. Bonefate suggests that aerobic exercise with the frequency of 3 times per week for 24 week maintains plasma FNDC5/irisin of middle-age obese men, same as 8 weeks aerobic exercise for overweight/obese adults by Kim, but three is an opposite result from Wu, which proved that aerobic exercise of twelve weeks ascends serum irisin of young obese women. HIIT of eight or twelve weeks ascends serum irisin in sedentary obese women or young obese women according to Tofighi or Wu suggestion. Moreover, resistance exercise of 8 weeks significantly increases plasma irisin of overweight/obese adults From Kim’s study.
 Conclusions The study about effect of exercise on circulating irisin levels in overweight or obese individuals is not sufficient to come to a positive result, although the quality assessments of current evidences are high. Basing on the available literatures, exercise can maintain or improve circulating irisin levels in overweight or obese individuals. The effect needs to be illustrated by further RCTs with large sample size.

Tick-borne zoonoses in the Order Rickettsiales and Legionellales in Iran: A systematic review.

BackgroundTick-borne zoonoses in the Order Rickettsiales and Legionellales cause infections that often manifest as undifferentiated fevers that are not easy to distinguish from other causes of acute febrile illnesses clinically. This is partly attributed to difficulty in laboratory confirmation since convalescent sera, specific diagnostic reagents, and the required expertise may not be readily available. As a result, a number of tick-borne zoonoses are underappreciated resulting in unnecessary morbidity, mortality and huge economic loses. In Iran, a significant proportion of human infectious diseases are tick-borne, with anecdotal evidence suggesting that tick-borne zoonoses are widespread but underreported in the country. Epidemiological review is therefore necessary to aid in the effective control and prevention of tick-borne zonooses in Iran. The aim of this review is to provide an in-depth and comprehensive overview of anaplasmosis, ehrlichiosis, spotted fever group rickettsioses and coxiellosis in Iran.MethodsUsing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, all relevant publications on tick-borne zoonoses in the Order Rickettsiales and Legionellales in Iran were searched using a number of search terms. The search was confined to authentic resources from repositories of popular data bases among them PubMed, Web of Science, Google Scholar, Science Direct, SpringerLink and SCOPUS. The search items included peer reviewed journals, books and book chapters published between 1996 and 2017.ResultsA total of 1 205 scientific publications and reports were sourced, of which 63 met the search criteria and were reviewed. Of the 63 articles reviewed, 36 (57.1%) reported on coxiellosis, 15 (23.8%) on anaplasmosis, 11 (17.5%) on ehrlichiosis and 1(1.6%) on spotted fever group rickettsiae in a large scale study involving four countries, among them Iran. The existence of tick-borne pathogens in the Order Rickettsiales and Legionellales was confirmed by molecular, serological and microscopic techniques conducted on samples obtained from sheep, cattle, goats, camels, poultry, animal products (milk and eggs), dogs, ticks and even human subjects in different parts of the country; pointing to a countrywide distribution.DiscussionBased on the review, coxiellosis, anaplasmosis, ehrlichiosis, and SFG rickettsiae can be categorized as emerging tick-borne zoonotic diseases in Iran given the presence of their causiative agents (C. burnetii, A. phagocytophilum, A. marginale, A. bovis, A. ovis, A. central, E. canis, E. ewingii, E. chaffeensis and R. conorii) collectively reported in a variety of domestic animals, animal products, arthropods and human beings drawn from 22 provinces in Iran.ConclusionGiven the asymptomatic nature of some of these zoonoses, there is a high likelihood of silent transmission to humans in many parts of the country, which should be considered a public health concern. Presently, information on the transmission intensity of tick-borne zoonoses caused by pathogens in the Order Rickettsiales and Legionellales to humans and its public health impact in Iran is scanty.

Sales Transaction Data Analysis using Apriori Algorithm to Determine the Layout of the Goods

In a shop, usually apply a sales strategy in order. The sales strategy can be in the form of determining the layout of goods so that they are close to one another. Determining the layout of items can be based on items that are often purchased simultaneously. Searching for items that are often purchased together can be done using data mining techniques, which is processing data to become more useful information. Sales transaction data processing can be done using apriori algorithm. Apriori algorithm is the most famous algorithm for finding high-frequency patterns and generating association rules. From the results of the discussion and data analysis, there were 3 (three) association rules formed, namely "If you buy Milo Active 18 grm, then buy ABC Kopi Susu 31G" with support 0.36% and 75% confidence, "If you buy Dancow 1 + Honey 200 grm, then buy Ice Cream Corneto" wit H Support 0.36% and confidence 60%, "If you buy SIIP Roasted 6.5 grm, then buy Davos Strong 10 grm" with support 0.36% and 75% confidence. From the association's rules can be used as decision making to determine the layout of goods that are likely to be purchased simultaneously by the buyer

When visual search target is rare: overweighting or under weighting the probability?

The prevalence of items in visual search may have substantial performance consequences. In laboratory visual search tasks in which the target is rare, viewers are likely to miss the target. A dual-threshold model proposed by Wolfe and Van Wert (2010) assumes that in the low prevalence condition, viewers shift their criteria resulting in more miss errors. However, from the prospective of prospect theory (Kahneman & Tversky, 1979), decision makers tend to overweight small probability. To explore how viewers subjectively weight the probability in the low prevalence visual search task, we compared viewers’ criteria with the optimal criteria by presenting different probability descriptions for a fixed prevalence rate. The data from this experiment indicated that target presence had an effect on viewers’ accuracy and response times but not probability descriptions. Viewers’ criteria under different probability descriptions were higher than optimal. These results are in accordance with the dual-threshold model assumption that viewers respond “target absent” more frequently than optimal, leading to more miss errors in the low prevalence condition.

Multiobjective e-commerce recommendations based on hypergraph ranking

Recommender systems are emerging in e-commerce as important promotion tools to assist customers to discover potentially interesting items. Currently, most of these are single-objective and search for items that fit the overall preference of a particular user. In real applications, such as restaurant recommendations, however, users often have multiple objectives such as group preferences and restaurant ambiance. This paper highlights the need for multi-objective recommendations and provides a solution using hypergraph ranking. A general User–Item–Attribute–Context data model is proposed to summarize different information resources and high-order relationships for the construction of a multipartite hypergraph. This study develops an improved balanced hypergraph ranking method to rank different types of objects in hypergraph data. An overall framework is then proposed as a guideline for the implementation of multi-objective recommender systems. Empirical experiments are conducted with the dataset from a review site Yelp.com, and the outcomes demonstrate that the proposed model performs very well for multi-objective recommendations. The experiments also demonstrate that this framework is still compatible for traditional single-objective recommendations and can improve accuracy significantly. In conclusion, the proposed multi-objective recommendation framework is able to handle complex and changing demands for e-commerce customers.

Negative cues lead to more inefficient search than positive cues even at later stages of visual search

Observers can focus their attention on task-relevant items in visual search when they have prior knowledge about the target's properties (i.e., positive cues). However, little is known about how negative cues, which specify the features of task-irrelevant items, can be used to guide attention away from distractors and how their effects differ from those of positive cues. It has been proposed that when a distractor color is cued, people would first select the to-be-ignored items early in search and then inhibit them later. The present study investigated how the effects of positive and negative cues differ throughout the visual search process. The results showed that positive cues sped up the early stage of visual search and that negative cues led to initial selection for inhibition. We further found that visual search with negative cues was more inefficient than that with positive cues even at later stages, suggesting that sustained inhibition is needed throughout the visual search process. Taken together, the results indicate that positive and negative cues have different functions: prior knowledge about target features can weight task-relevant information at early stages of visual search, and negative cues are used more inefficiently even at later stages of visual search.