Active Search Research Articles

Ultimate Rationality. Husserl on Critical Position-Taking (Stellungnahme) in the Theoretical and Axiological Spheres

AbstractAs a fervent rationalist, Husserl placed considerable emphasis on the delineation of the different levels of reason. Its highest form, he contends, is position-taking (Stellungnahme) understood as a critical stance towards a positional act P. Specifically, such a Stellungnahme is a three-step procedure: the subject, possibly motivated by a passive discordance, starts by questioning P (active doubt); she then seeks to validate P by returning to its originary fulfillment (active search for evidence); finally, she ratifies such a fulfillment in an act of acknowledgment (active decision), thereby making P a permanent personal conviction. In the literature, the role of position-taking in the formation of persons has been aptly emphasized, but insufficient attention has been paid to its intrinsic structure and concrete functioning; furthermore, the few existing studies on this topic are limited to the theoretical domain. The aim of this paper is to fill this twofold gap by providing a comprehensive account of critical Stellungnahme in both the intellectual and the axiological spheres, drawing especially on the manuscripts from the Studien zur Struktur des Bewusstseins. The first part examines Stellungnahme in the theoretical realm, underscoring its teleological orientation towards justification and the active role played by the subject in it. The second part shows how this procedure can be extended to rationalize value-experiences, by elucidating the nature of affective evidence and approval (Billigung). Finally, the third part demonstrates how a particular value, that of knowledge, can concretely pass the axiological position-taking and thus be recognized as an actual value.

Immunocorrective effects of Tricor fenofibrate in the treatment of the early and intermediate stages of age-related macular degeneration

Age-related macular degeneration (AMD) is the leading cause of irreversible visual impairment, blindness and disability in the elderly. Treatment of end-stage AMD is extremely limited and requires invasive interventions. Currently, there is an active search for remedies aimed at preventing the degenerative process in the retina in the early stages of the disease. AMD is a multifactorial pathology, has common mechanisms with diseases associated with aging, metabolic shifts and hemodynamic disorders. The study of the effects of drugs already used to correct these disorders in the general clinic may also be of interest to ophthalmologists. The aim of the work was to study the dynamics of inflammatory markers of activation of the vascular endothelium and cytokines of the immune response in the tear fluid (TF) of patients with initial and intermediate stages of AMD against the background of the use of Tricor fenofibrate. 65 people were examined, divided into three groups according to the AREDS classification: group I – 20 people with early AMD (AREDS2), group II – 16 patients with intermediate AMD (AREDS3), 29 healthy elderly people without ophthalmopathology entered the age control group (AREDS1 – risk group). Patients of groups I and II received Tricor at a dose of 145 mg once a day for 9 months. Tear fluid (TF) was taken twice: before and immediately after the completion of the course of treatment. The determination of sICAM-1, sVCAM-1, sE-, sP-selectin and MCP-1/CCL2 in CS was performed by flow cytometry using a self-constructed multiplex panel from compatible simplex test kits Human FlowCytomixTM Simplex (Bender MedSystem GmbH, Germany); IL-1β, IL-2 IL-6 TNFα was determined within the framework of the Human Flow CytomixTM 15 Flex system (Bender MedSystem GmbH, Germany). Data processing was performed in the FlowCytomix Pro v 6.0 package (Bender Med Systems GmbH, Germany). According to the results of the study, a significant effect of Tricor fenofibrate was found on the initially high levels of local production of IL-1β, IL-2, IL-6, MCP-1/CCL2 and sICAM-1 in the AREDS2 group, which indicated a direct anti-inflammatory, vasoprotective effect in the treatment of the initial stage of AMD; a similar effect of the drug, but less pronounced, noted in the AREDS3 group. The ophthalmological examination data also indicated stabilization of visual functions and the clinical picture of the fundus, improvement of intraocular blood circulation in patients of the main groups. Thus, the use of Tricor can help prevent the degenerative process in the retina in the early stages of AMD development.

Survey of Reptiles in Nechisar National Park, Southern Ethiopia

Species diversity, composition, relative abundance and evenness of the reptilian communities in Nechisar National Park were studied. The survey was conducted using pitfall traps, active search and cover sheet methods. The study identified 34 reptile species belonging to 3 orders (Squamata, Testudines, and Crocodylia). Squamata was the most diverse containing 30 species belonging to 2 suborders: Sauria which consists of 19 species from 7 families and 10 genera; and Serpentes which consists of 11 species from 5 families and 10 genera. Testudines included 3 species from 2 families and 3 genera. Crocodylia was represented by a single species. Reptile diversity varied among the different habitat types, with the bushland habitat having the highest number of species representing 29.69% of the total species recorded.

Habitat Utilization of Endemic Green Pit Viper (<i>Peltopelor trigonocephalus</i>) in the Wet Zone, Sri Lanka

The endemic arboreal pit viper Peltopelor trigonocephalus is restricted to three climatic zones of Sri Lanka. In this study, the habitat utilization of P. trigonocephalus was investigated by active search and the quadrate method between April 2021 and March 2022. Data on 49 individuals of P. trigonocephalus were collected from riparian, forest, and open habitats. A high encounter rate was recorded in riparian habitats which included areas with thick vegetation. Based on Principal Component Analysis, some habitat variables were key determining factors of microhabitat preference of this species. Ambient temperature, distance to stream, canopy cover and light intensity were significantly affecting the occupied microhabitat structure. Ambushing behavior was more prominent and time-consuming than other behaviors, with 42.59% of recorded sit-and-wait hunting activity. The results of this research indicate that P. trigonocephalus actively selects and utilizes the most suitable macro and microhabitats in wet zones, providing crucial insights for the conservation and management of the species as well as its natural habitat.

BLOOD PRESSURE MONITORING USING TELEMEDICINE TECHNOLOGIES IN PATIENTS WITH HEART FAILURE

An urgent task of modern cardiology is to ensure continuous monitoring of cardiovascular patients' condition indicators. Monitoring of patients with heart failure (HF) is especially important due to the instability of the condition, extremely high prevalence of pathology and life-threatening. Currently, active search and development of optimal devices and programs for medical telemonitoring continues. The review presents the results of Russian and foreign studies on the introduction of invasive and non-invasive technologies for blood pressure (BP) monitoring and demonstrates their clinical significance. The comparison of clinical data of several studies using wireless remote monitoring of pulmonary artery pressure with the help of CardioMEMS sensor was carried out. Mobile applications and telephone monitoring are also considered as an alternative to invasive devices, and information about their effectiveness and impact on the quality of life of patients is given. The article also compares the effectiveness of treatment of hypertension and HF using remote monitoring with standard practice and demonstrates the dependence of the risk of hospitalization for HF and the presence of monitoring of the condition.

Association of FSHR gene polymorphism with fertility of Holstein cows

Relevance. The view of the mechanisms of hormonal regulation of the ovarian cycle of cows has allowed the development of a large number of synchronization programs. An active search is underway for biomarkers related to the fertility of cows, as well as to identify animals with a high ovarian response to the injection of exogenous gonadotropins. The aim of the work is to study the polymorphism of the FSHR gene and its association with reproduction indicators in black-and-white Holstein dairy cows.Results. Based on the results of genotyping cows (n = 128) using the FSHR gene, the frequency of occurrence of the CC genotype was determined at the level of 0.601, the CG genotype — 0.360, GG — 0.031. It was found that for productive insemination, animals with the CG genotype require fewer inseminations. At the same age, the frequency of insemination of heifers with the CG genotype was 1.43, with the CC genotype — 1.60. After the first calving, the animals with the CG genotype responded more actively to hormonal stimulation in the postpartum period. The interval from the first to fruitful insemination in cows with the CG genotype was 34.7 days, in cows with the CC genotype — 57.2 days (p < 0.05). The number of pregnant cows with the CG genotype re-inseminated after natural hunting was 2.1 times higher than the number of cows with the CC genotype (66.7% and 31.2%). It is assumed that exogenous hormone injection has a stimulating effect on the hypothalamus-pituitary-gonad system in cows with the CG genotype.

Method for disrupting the reproductive pheromone bond of the cotton bollworm on sunflower crops

Background: Synthetic analogs of sexual pheromones provide an effective method of biorational control of the number of phytophagous insects based on the directed disruption of reproductive functions in populations of the target pest on the protected crop without affecting the integrity of the agrocenosis. The work aims to determine the biological effectiveness of methods of mass trapping and disorientation of the cotton bollworm (Helicoverpa armigera) to protect sunflower (Helianthus annuus) crops.Methods: The experiments were carried out in 2022-2023 in the Central Zone of the Krasnodar Territory, Russia in the stationary scientific crop rotation at the Federal Research Center for Biological Plant Protection, Krasnodar (2.5 ha) and the Kononenko farm, Novovelichkovskaya village, Dinsky district (10 ha). The biological effectiveness of elimination and disorientation methods was judged by the degree of damage to plants and buds. The disorientation effect was calculated by the number of males captured at the disorientation sites compared to the control sites.Result: The decrease in males’ search activity (disorientation effect) reached 85.3%. The damage to buds by the pest in this variant was 2.0% compared to 10.8% in the control group. In the mass trapping variant, it equaled 1.5-3.0 and 7.5%, respectively, indicating the prospects of including these techniques in the H. armigera biorational control system.Conclusion: Our findings could aid future research on insect chemical communication to develop effective biological control methods.Keywords: Biological plant protection; Sunflower; Cotton bollworm; Synthetic sex pheromones; Elimination; Disorientation; Biological effectiveness

Imported arboviral disease cases and entomological surveillance of Aedes albopictus in Valencian Autonomous Region (Spain) along 2022

Abstract The Laboratory of Entomology and Pest Control (LEPC) of the University of Valencia, hired by the regional government of the Generalitat Valenciana, carried out the entomological surveillance of the Asian tiger mosquito along 2022 in the Valencian Autonomous Region, excepting the city of Valencia for which the surveillance was conducted by a private pest control company. The main purpose of this plan of action was both to continue the detection and monitoring of Aedes albopictus in the Valencian municipalities free of its presence until the end of 2021, and to carry out the entomological surveys related to imported arbovirus cases notified by the Regional Health System. The active search and detection of the mosquito breeding sites in both urban and peri-urban environments throughout the provinces of Alicante, Castellón and Valencia, has revealed the absence of new populations of this allochthonous mosquito in all those municipalities free of this species in December of 2021. Besides, the LEPC has conducted the mosquito surveys in 31 municipalities of the three provinces, in relation to the declaration of 33 cases of arthropod-borne diseases due to Chikungunya, dengue or Zika viruses, which were reported in travellers returning from countries of Latin America, Asia, or West Africa. The methods used to minimise the risk of local transmission of these viruses by Ae. albopictus were focused on detecting the presence of the tiger mosquito and other common native mosquito populations, at both adult and larval stages, in the surroundings of the residence of imported cases to guide the treatments of the detected resting and breeding sites. As result, tiger mosquito populations were recorded in 18 of the 33 municipalities where imported arbovirus cases were reported in 2022.

Internet Search Activity for Intentional Self-Harm Forums After a High-Profile News Publication: Interrupted Time Series Analysis.

Searches for "pro-suicide" websites in the United States peaked during the week a high-profile news story was published and remained elevated for 6 months afterward, highlighting the need to avoid mentioning specific sources of explicit suicide instructions in media publications.

Seasonal and Weekly Patterns of Korean Adolescents' Web Search Activity on Insomnia: Retrospective Study.

Sleep deprivation in adolescents is a common but serious public health issue. Adolescents often have a progressive circadian delay and suffer from insufficient sleep during weekdays due to the school schedule. Temporal patterns in internet search activity data can provide relevant information for understanding the characteristic sleep problems of the adolescent population. We aimed to reveal whether adolescents exhibit distinct temporal seasonal and weekly patterns in internet search activity on insomnia compared to adults. We hypothesized that adolescents exhibit larger variations in the internet search volume for insomnia, particularly in association with the school schedule (e.g., academic vacations and weekends). We extracted the daily search volume for insomnia in South Korean adolescents (13-18 years old), adults (19-59 years old), and young adults (19-24 years old) during the years 2016-2019 using NAVER DataLab, the most popular search engine in South Korea. The daily search volume data for each group were normalized with the annual median of each group. The time series of the search volume was decomposed into slow fluctuation (over a year) and fast fluctuation (within a week) using fast Fourier transform. Next, we compared the normalized search volume across months in a year (slow fluctuation) and days in a week (fast fluctuation). In the annual trend, 2-way ANOVA revealed a significant (group) × (month) interaction (P<.001). Adolescents exhibited much greater seasonal variations across a year than the adult population (coefficient of variation=0.483 for adolescents vs 0.131 for adults). The search volume for insomnia in adolescents was notably higher in January, February, and August, which are academic vacation periods in South Korea (P<.001). In the weekly pattern, 2-way ANOVA revealed a significant (group) × (day) interaction (P<.001). Adolescents showed a considerably increased search volume on Sunday and Monday (P<.001) compared to adults. In contrast, young adults demonstrated seasonal and weekly patterns similar to adults. Adolescents demonstrate distinctive seasonal and weekly patterns in internet searches on insomnia (ie, increased search in vacation months and weekend-weekday transitions), which are closely associated with the school schedule. Adolescents' sleep concerns might be potentially affected by the disrupted daily routine and the delayed sleep phase during vacations and weekends. As we demonstrated, comparing various age groups in infodemiology and infoveillance data might be helpful in identifying distinctive features in vulnerable age groups.

Further description of the phenotypic spectrum of neuronal ceroid lipofuscinosis type 11

PurposeCeroid lipofuscinosis type 11 (CLN11) is a very rare disease, being reported in only 13 unrelated families so far. Further reports are necessary to comprehend the clinical phenotype of this condition. This article aims to report 9 additional cases of CLN11 from 9 unrelated Latin American families presenting with relatively slow disease progression. MethodsThis was a retrospective observational study including patients with CLN11. Patients were identified through an active search for granulin precursor gene (GRN) pathogenic variants across the entire database of next-generation sequencing of a commercial laboratory and by contacting attending physicians to check for clinical and radiologic findings compatible with a neuronal ceroid lipofuscinosis phenotype. ResultsNine CLN11 patients from unrelated families were evaluated. Age of onset varied between 3 to 17 years. The most common findings were visual impairment, cerebellar ataxia, seizures, myoclonus, and cognitive decline. One patient had a previously unreported finding of cervical, perioral, and tongue myoclonus. Most of the patients were able to walk unassisted after an average of 14.2 years (SD 4.76 y) from disease onset. ConclusionWe describe 9 new cases of a very rare type of neuronal ceroid lipofuscinosis (CLN11) from Latin America with a recurrent p.(Gln257ProfsTer27) and a novel p.(Cys83Ter) nonsense variant. Our findings suggest that a slowly progressive neuronal ceroid lipofuscinosis might be a clue for the diagnosis of CLN11.

Surge in Eye Drop Safety Concerns and Interest in Alternative Dry Eye Disease Therapy Following Eye Drop Recalls: A Cross-Sectional Google Trends Analysis.

Beginning in January 2023, numerous eye drops were recalled following reports of contamination. To investigate hesitancy in topical therapies for dry eye disease (DED), we analyzed trends in Internet search traffic for alternative DED therapies and eye drop safety concerns following initial recalls. Google Trends (GT) was used to measure the popularity of specific search terms during a given time period. The main GT output metric for gauging interest in a search term is the Search Volume Index (SVI). We collected worldwide SVI data for terms "dry eye vitamin," "are eye drops safe," "stop eye drops," "lipiflow," "ilux treatment," "dry eye mask," "dry eye warm compress," "omega-3 for dry eyes," "dry eye plugs," "dry eye humidifier," "itear," and "IPL dry eye" from April 24, 2022, to October 29, 2023. Statistical analysis was performed with Microsoft Excel v.16.77.1, and comparisons between groups were performed using paired t tests. A significant increase in SVI was observed for most keywords. When comparing the 40-week period before and after the initial recall, 7/10 alternative DED therapies demonstrated a statistically significant surge in Internet search traffic after recall (P < 0.05). Furthermore, 2/2 keywords pertaining to eye drop safety concerns demonstrated an increase in SVI (P < 0.0001). We identified a significant surge in Internet search activity for eye drop safety and alternative DED therapies following eye drop recalls. Public health agencies and physicians may find this information valuable while attempting to address safety concerns and navigating noncompliance of routine eye drop therapy.

The impact of news media coverage on voluntary disclosure

AbstractThis study investigates whether and how firm‐specific news media coverage affects corporate voluntary disclosure. I predict that media coverage influences managers' disclosure decisions by directing investor attention toward firms and increasing investor demand for firm information. I find that managers are more likely to issue earnings guidance if their recent earnings guidance receives more media coverage. The relation between media coverage and guidance issuance is stronger for news articles that purely disseminate information quickly and are published by news outlets that target institutional investors. Consistent with my hypothesis that media coverage influences investor demand for information, I find evidence that media coverage of guidance positively relates to subsequent institutional information search activity, which in turn positively relates to future guidance issuance. Examining sources of plausibly exogenous variation in media coverage, I find further corroborative evidence of a positive relation between media coverage and earnings guidance. Overall, these analyses indicate that the news media influence managers' provision of voluntary disclosure.

UN Assistance to African countries in building climate-resilient agriculture

Relevance. Africa is the mirror and quintessence of modern international processes. The continent faces a gigantic number of challenges, some of an existential nature. But at the same time, there is an active search for ways to solve them.The purpose is to consider the experience of forming climate-resilient agriculture on the example of individual African countries and the role of the UN in this process.Objectives: to characterize the conditions and reasons for the formation of climate-resilient agriculture in the African region; assess the policies of the governments of Kenya, Tanzania, Ethiopia, and Rwanda on the development of climate-resilient agriculture.Methodology. The comparative research method was used in the study of agricultural development programs in African countries. Chronological and historical methods of studying legal documents, programs of the United Nations, FAO, NEPAD, Kenya, Tanzania, Ethiopia, Rwanda aimed at the formation of climate-resilient agriculture. A statistical research method for operating with data from the statistical databases of Globaleconomy and the World Health Organization.Results. The introduction of new technologies in agriculture is a condition for saving the environment, which is under pressure from two sides: global climate change and unprecedented growth in the population and its needs. One of the most important areas is to increase the productivity of agriculture, the solution of this urgent task will depend on the introduction of new technologies: seeds, fertilizers, irrigation, plant protection, etc.Conclusions. The introduction of programs and technologies for the formation of climate-resilient agriculture in African countries requires significant funding and institutional and legal preparation.

Enabling patients with health-related social needs.

183 Background: Addressing health-related social needs (HRSNs) is essential to help ensure patients surviving cancer achieve optimal outcomes. Socioeconomic and environmental insecurities can make it challenging for patients to successfully complete their treatments. The US Oncology Network (The Network), has partnered with Findhelp, a resource facilitation tool enabling anyone with internet access to connect with community-based organizations providing discounted or free social services to meet resource needs. This alliance enables an enhanced level of assistance for patients in need, supporting optimal outcomes for those disadvantaged by various circumstances, such as HRSNs impacted by social drivers of health (SDoH). Methods: Beginning April 25 th , 2024, patients utilizing Navigating Cancer’s patient portal, across 302 community-based oncology clinics serving nearly 500,000 patients annually, could access information through a Findhelp website unique to practices in The Network. The investigators are collecting engagement data based on click rates to the Findhelp website link via the patient portal, the number of unique visitors to The Network’s Findhelp application, and the county, city, and zip code of users accessing the application. Data from the Findhelp website will be assessed to determine which insecurity categories (i.e. food, housing, goods, transit, health, money, care, education, work, legal) and areas across the nationwide network of practices receive the highest engagement, and if there is variability based on subgroup analyses. The subgroup analyses will be performed based on patient demographics and include age, gender, race, and geographic location. Results: Initial retrospective results from this prospective study reveals the average number of searches by patients prior to go-live was 106/day. Post go-live averages have been 4,369/day, a 4,037% uplift in engagement. Top searched needs have been health (26.5%), food (22.3%), and housing (21.1%). Additional data elements are being derived from aggregated, de-identified patient engagement and search activity by geographic location categorized by resource insecurity. Conclusions: Conclusions are being drawn based on outcome measures and cross walking with search and referral activities. The goal of the collaboration is to increase awareness of technologies and local organizations within communities bridging the resource gap by way of facilitating services through the Findhelp platform; ultimately empowering patients to overcome health-related social needs and barriers to care leading to improved access.

Social Influence, Trust and Future Usage: A study of BIPOC Users of CHATGPT and other AI Chatbots

ABSTRACTIn this paper we examine the determinants (trust and social influence) that influence users' future use intentions of generative artificial intelligence (AI) applications among black, indigenous and other people of color (BIPOC) users of generative AI applications such as ChatGPT and other large language models. An online survey instrument was administered to 119 BIPOC identified individuals residing in the United States. Descriptive and inferential statistics were used to analyze data through SPSS. Results indicate no statistically significant differences among ethnic/ racial groups in social influence and continued use intentions. However, with respect to trust, Hispanic/LatinX users perceive information from AI chatbots as more trustworthy and accurate, and that their search activity was more secure than other BIPOC populations. The study also found that trust and social influence were significant factors driving future use intentions.

Enabling Serendipity During Digital Library Search

ABSTRACTWhen a serendipitous discovery is made while searching within a digital library collection (such as an academic digital library at a university), the searcher has a difficult choice to make: either pursue the serendipitous discovery or set it aside and deal with it later. If they take the first option, this breaks the flow of the primary search activity which may make it difficult to resume. If they take the second option, they may have difficulty re‐finding what they discovered when they are finished with the primary search activity. We have developed a novel search interface that includes topic‐based workspaces and a “read it later” list. Serendipitous discoveries can be easily added to the “read it later” list, allowing the searcher to stay focused on their current search activity knowing that they can easily return to the discovered resource. For each resource saved to the “read it later” list, a textual similarity is calculated against the collection of documents saved in each of the searcher's workspaces. This allows them to easily identify which of their prior search tasks is a best fit for the discovery, as well as an ability to create a new workspace if desired.

Italian Search and Rescue Seaplanes From the 50s to the 70s: A Brave People and Mighty Aircraft Story

Following a previous article that described the early days of Italian air rescue and that reached up to the immediate postwar period (World War II), this article describes the search and rescue activity carried out by the Italian Grumman Albatross HU-16A from the postwar period until the end of the 70s.

Tracking Public Interest Through Google Trends: Comparative Analysis of Global Movements

This paper examined the digital dynamics of three significant social justice movements: Black Lives Matter (2020), South African unrest (2021), and Mahsa Amini protests (2022) through the lens of Google Trends analysis. By tracking search interest patterns during key events, the study explored how each movement gained momentum and sustained visibility online. The analysis revealed distinct public engagement patterns for each movement: The Black Lives Matter movement experienced global peaks in search interest, with sustained attention driven by discussions on police reform and racial justice. The South African unrest saw sharp, localized spikes in search activity, particularly during moments of heightened tension such as the looting incidents and the government’s deployment of the military. The Mahsa Amini protests demonstrated sustained, high-level interest globally, with search trends reflecting the growing international focus on human rights and state repression in Iran. The findings highlighted how search engines like Google played a pivotal role in amplifying these movements, documenting societal reactions, and shaping the global public discourse. This study underscored the power of digital platforms to reflect and influence the trajectory of social movements across different political and cultural contexts.

Detecting pyramid scheme activity with Google trends data

ABSTRACT This article explores the relationship between pyramid scheme participation and internet search activity, using a case study of a shuttered pyramid scheme in the United States. Comparing results against the Bass diffusion model, we estimate the relationship between monthly pyramid scheme uptake at the state level and the search frequency of key terms in that state (e.g. the scheme name). Using monthly data from 2004 to 2013, we find evidence that Google Trends data can be an effective complement to other fraud detection methods at the state level. This tool is especially useful in situations where consumer complaints are rare, and it is difficult to detect or measure the level of scheme activity.