The Antarctic ozone hole exerts a substantial impact on the climate of the Southern Hemisphere, yet research exploring its potential influence on the Northern Hemisphere climate is limited. This study unveils a significant positive relationship between interannual variations of Antarctic total column ozone (TCO) during September–October and East Asian precipitation in the subsequent boreal winter. Specifically, ~10% of the East Asian winter precipitation variability is attributed to Antarctic TCO during September–October. Both observational data and model results indicate that the increased Antarctic TCO during September–October triggers a simultaneous meridional southern Indian Ocean tripole sea surface temperature anomalies (SSTA) through the negative phase of the Southern Annular Mode. This SSTA pattern persists from September–November through the boreal winter, subsequently weakening the local-scale zonal-vertical circulation anomalies in the Indian Ocean. The process leads to positive outgoing longwave radiation (OLR) anomalies over the southern Marine Continent. As a result, the linear response of wind anomalies at 850 hPa over East Asia to the OLR-induced diabatic heating anomalies exhibits southwesterlies, as demonstrated by a linear baroclinic model. These anomalous winds facilitate the transport of abundant moisture from the tropics to East Asia, favoring the formation of winter precipitation. We employ the Specified-Chemistry version of the Whole Atmosphere Community Climate Model to validate that the increase of September–October Antarctic ozone substantially enhances East Asian precipitation during boreal winter. Importantly, the relationship between Antarctic ozone and East Asian winter precipitation is found to be independent of El Niño-Southern Oscillation and the Indian Ocean Dipole Mode. Our findings provide a fresh insight into the prediction of the East Asian winter precipitation.