A major tsunami-like event, locally known as ‘marrobbio’, impacted the southwestern coast of Sicily on 25–26 June 2014. The event was part of a chain of hazardous episodes in the Mediterranean and Black seas during the last week of June 2014 resulting from an anomalous atmospheric system (“tumultuous atmosphere”) propagating eastward over the region. The synoptic patterns and vertical structure of the atmosphere over Sicily at the time of the event indicate that atmospheric wave ducting was responsible for the generation of tsunamigenic air pressure disturbances that produced especially high sea level responses (“meteotsunamis”) at certain sites along the Sicilian coast. The strongest sea level oscillations were observed at Mazara del Vallo, where a 1-m meteotsunami bore, propagating upstream in the Mazaro River, was generated. The combined effects of external resonance (Proudman resonance on the western Sicilian shelf) and internal resonant conditions (bathymetric and topographic characteristics of specific sites) were found to be the key factors that caused the meteotsunami (marrobbio phenomenon) on the coast of Sicily and the meteobore at Mazara del Vallo.