SD Height Research Articles

The Effect of Sportsmetrics Training on Landing Technique in Female Volleyball Players With Dynamic Knee Valgus

Background and Aims The most serious and severe injuries among female volleyball players is the knee injury, especially the anterior cruciate ligament (ACL) tear. Its key risk factors are dynamic knee valgus (DKV) and abnormal alignment during jump landing. One of the successful protocols regarding the prevention of knee injuries in female volleyball players is professional sportsmetrics volleyball training. In the present study, the effect of this protocol on DKV correction and landing error scoring system (LESS) was investigated. Methods The current research is quasi-experimental with a pre-test-post-test design. The statistical sample included 30 female volleyball players (Mean±SD age: 20.83±2.22 years, Mean±SD height: 168.16±6.47 cm, Mean±SD weight: 59.13±7.4 kg, Mean±SD body mass index (BMI): 20.83±1.52 kg/m2, and Mean±SD sports experience: 5.46±1.8 years) who were randomly divided into the training (15 people) and control (15 people) groups. Double leg squat and LESS tests were used to evaluate DKV and landing error. The exercise group participated in the present protocol for 6 weeks, three sessions per week. Each session was approximately 90 minutes, including warm-up exercises, sportsmetrics volleyball training, and cool-down. The analyses of covariance were used to evaluate the data at a significant level of P=0.05. Results The results of covariance analysis showed that performing these exercises significantly reduced (P=0.01) DKV (from 23.13 to 7.86) and landing error (from 17.46 to 7.6). In other words, the training group experienced a 66% decrease in DKV and a 56% decrease in landing error after performing six weeks of sportsmetrics volleyball training. Conclusion Sportsmetrics volleyball training has successfully improved performance and prevented ACL injury in female volleyball players. According to the present study results, performing these exercises leads to correct DKV and improves lower extremity alignment and landing technique. Therefore, performing sportsmetrics volleyball training is strongly recommended for female volleyball players with DKV.

Effect of 8 Weeks Aquatic Exercises on the Center of Gravity Sway in Blind Women

Background and Aims Individuals with vision loss are at an increased risk of falls. Due to postural control impairment in blind people, this study aimed to investigate the effect of 8 weeks of aquatic exercises on the center of pressure sway in blind women. Methods Thirty blind females were selected and randomly assigned into the experimental (Mean±SD age: 28.93±2.25 years, Mean±SD height: 1.56±6.46 m, and Mean±SD weight: 58.06±7.91 kg) and control groups (Mean±SD age: 29.13±2.23 years, Mean±SD height: 1.57±7.48 m and Mean±SD weight 57.93±7.99 kg). The experimental group participated in an aquatic exercise program for 8 weeks, while the control group received no intervention. The participants’ index of the center of gravity sways was evaluated using the RS scan pressure distribution before and after the intervention. In the end, the analysis of covariance was used for data analysis (P≤0.05). Results The results showed a significant decrease in the center of pressure sway scores (ellipse area and traveled distance sway of body center of gravity), both in the posterior-anterior and anterior-posterior perturbations, after conducting the 8 weeks aquatic exercise program in the experimental group (P<0.05) compared to the control group. Conclusion Generally, designing an appropriate exercise protocol can significantly change the center of gravity sway (decrease in the ellipse area and traveled distance sway of body center of gravity). Therefore, it is recommended that aquatic and somatosensory exercises be incorporated into training programs for blind people to reduce the risk of falls in these individuals.

Effect of Adding Neurofeedback to Neuromuscular Training on Brain Waves in Athletes With Chronic Ankle Instability: A Randomized Clinical Trial

Background and Aims This study evaluated the effects of neuromuscular training compared with neurofeedback and neuromuscular training on brain waves, foot and ankle ability, and pain intensity of table tennis players with chronic ankle instability. Methods This clinical trial study was conducted on 29 table tennis players with chronic ankle instability, which were randomly divided into combined neurofeedback+neuromuscular (Mean±SD age: 21.73±2.60 years, hieght: 173.42±5.57 cm, wieght: 77.10±10.42 kg) and neuromuscular groups (Mean±SD age: 22.14±2.53 years, Mean±SD height: 169.26±6.77 cm, Mean±SD weight:77.95±15.70 kg). ProComp Infiniti System and BioGraph Infiniti version 5 software were used to measure brain waves and perform neurofeedback protocol. The foot and ankle disability questionnaire and the visual analog scale were employed to assess foot and ankle ability and pain intensity, respectively. The rehabilitation protocol was performed for eight weeks. The paired t test and 1-way analysis of covariance were used for the data analyses. Results The paired t test results revealed a significant decrease in the amplitude of theta, alpha, and sensorimotor rhythm (SMR) waves in both groups (P<0.05) and an increase in the amplitude of the beta wave only in the combined group (P<0.05). In addition, ankle ability was significantly increased during daily activities and exercise in both groups (P<0.05). On the other hand, the results of a 1-way analysis of covariance indicated a significant difference between the two groups regarding theta and beta amplitudes and degree of ankle disability during exercise, and the improvement was greater in the combined group (P<0.05). Conclusion According to the results, combined exercises (neuromuscular and neurofeedback) can be used as rehabilitation in table tennis players with chronic ankle instability to correct brain waves, improve leg and ankle ability, and reduce pain.

The Effect of 8 Weeks of Otago Exercise on the Selected Walking Factors in Patients With Parkinson Disease

Background and Aims Physical activities play a preventive role in Parkinson disease by maintaining the physical fitness and health of the patients. This study aimed to investigate the effect of 8 weeks of Otago exercise on selected walking factors in patients with Parkinson disease. Methods This quasi-experimental study was performed on the experimental and control groups with a pretest-posttest design. The statistical population of the present study comprised all patients with Parkinson disease (with at least stage three on the Hoehn and Yahr intensity scale) referred to the neurologist offices with an age range of 55-75 years. The subjects were randomly divided into groups of Otago exercises (n=16, with Mean±SD age: 63.0±6.4 years, Mean±SD weight: 65.7±5.2 kg, and mean height 1.74±0.07 m) and control (n=16; with Mean±SD age: 63.4±5.7 years, Mean±SD weight: 64.1±5.9 kg, and Mean±SD height: 1.72±0.09 m). Eight weeks of Otago exercise was performed three times a week for 60 minutes at each session. A motion analysis system consisting of 8 cameras and 2 force plates was used to record selected walking factors, including step length, step width, and knee joint extension changes. The paired t test was used to compare each group in the pretest and posttest, and analysis of covariance (ANCOVA) was used to compare between groups. Results The results showed significant differences in the step length, step width, and knee extension changes in patients with Parkinson disease between the experimental and control groups (P<0.001). Also, the results showed that patients with Parkinson disease had longer step length, shorter step width, and greater knee extension in both legs after Otago exercise. Conclusion Otago exercises can be used as one of the easy and low-cost methods in improving the walking components of patients with Parkinson disease.

OR21-04 Long-term Efficacy And Safety Of Once-weekly Somatrogon In Pediatric Subjects With Growth Hormone Deficiency: Results From Up To 8 Years Of Somatrogon Treatment

Abstract Disclosure: Z. Zadik: None. N. Zelinska: Consulting Fee; Self; Novo Nordisk, Berlin-Chemie, Medtronic, Sanofi-Aventis. Research Investigator; Self; MacroGenics, Novo Nordisk, Pfizer, Inc., Merck, OPKO Health, Ferring Pharmaceuticals, Teva Pharmaceutical Industries Ltd., Parexel, Genexine. Speaker; Self; Medtronic, Berlin-Chemie, ACINO, Novo Nordisk, Pfizer, Inc., Sanofi-Aventis, Johnson &Johnson, Wörwag Pharma. V. Iotova: Grant Recipient; Self; Pfizer, Inc. Speaker; Self; Novo Nordisk, Pfizer, Inc., Swixx, Sandoz, Berlin-Chemie. Y. Skorodok: None. O.A. Malievskiy: None. N. Mauras: Consulting Fee; Self; Agios. Grant Recipient; Self; Novo Nordisk, Abbvie. Research Investigator; Self; OPKO Health, Abbvie, Beta Bionics. S.R. Valluri: Employee; Self; Pfizer, Inc. Stock Owner; Self; Pfizer, Inc. A. Pastrak: Employee; Self; OPKO Health. Stock Owner; Self; OPKO Health. R.G. Rosenfeld: Advisory Board Member; Self; Lumos, DNARx, BioMarin. Consulting Fee; Self; OPKO Health. C.T. Taylor: Employee; Self; Pfizer, Inc. Stock Owner; Self; Pfizer, Inc. M. Nijher: Employee; Self; Pfizer, Inc. Stock Owner; Self; Pfizer, Inc. C. Roland: Employee; Self; Pfizer, Inc. Stock Owner; Self; Pfizer, Inc. R. Wang: Employee; Self; Pfizer, Inc. Stock Owner; Self; Pfizer, Inc. M.P. Wajnrajch: Employee; Self; Pfizer, Inc. Stock Owner; Self; Pfizer, Inc. J.F. Cara: Employee; Self; Pfizer, Inc. Stock Owner; Self; Pfizer, Inc. Introduction: Somatrogon, a long-acting recombinant human growth hormone, is approved in multiple countries as a once-weekly treatment for pediatric growth hormone deficiency (pGHD). This abstract describes results from up to 8 y of study (main study + open label extension [OLE]) evaluating the efficacy and safety of somatrogon in pGHD. Methods: This randomized, open-label, dose-finding Phase 2 study comprised 5 treatment periods. Subjects were randomized 1:1:1:1 to once-weekly somatrogon (titrated up to 0.25, 0.48, or 0.66 mg/kg/wk) or once-daily Genotropin (0.24 mg/kg/wk) for 12 mo of the main study (periods I and II), after which they were eligible to enroll in the OLE (periods III-V). In period III, somatrogon recipients continued at their previous dose; Genotropin recipients were re-randomized to 1 of the 3 somatrogon doses. In period IV (OLE Year (Y)2–4), all subjects switched to somatrogon 0.66mg/kg/wk; in period V (OLE Y5 onward), all subjects switched from single-use somatrogon vials to prefilled pen devices (somatrogon 0.66 mg/kg/wk). Results: Of 53 subjects who completed the main study, 48 entered the OLE. At OLE entry, 66.7% were male, all but 1 were pubertal Tanner stage 1, and mean (SD) age was 7.7 (2.1) y. At OLE Y6 end, there were 30 subjects with a mean±SD height velocity (HV) of 6.47±2.07 cm/y and a mean±SD height SD score (HT SDS) of 0.43±0.94. At OLE Y7 end, 26 subjects had a mean±SD HV of 5.31±1.68 cm/y and a mean HT SDS of 0.44±0.96. Four subjects achieved final height (defined as HV <1 cm/y). Their HVs in the last 6-mo interval and last assessed heights were: subject 1: 0.54 cm/y, 174.5 cm; subject 2: 0.7 cm/y, 173.2 cm; subject 3: 0.56 cm/y, 179.5 cm; and subject 4: 0.19 cm/y, 168.7 cm. Somatrogon efficacy was not affected by positive test results for antidrug antibodies (ADA). HV and cumulative ΔHT SDS (cΔHT SDS) were similar between subjects who tested ADA+ vs ADA-: at OLE Y6 end, 15 who tested ADA+ had HV 6.47±1.69 cm/y and cΔHT SDS 3.09±1.04; and 15 who tested ADA- had HV 6.48±2.46 cm/y and cΔHT SDS 3.62±1.40. At OLE Y7 end, 14 subjects who tested ADA+ had HV 5.22±1.52 cm/y and cΔHT SDS 3.06±0.98; 12 who tested ADA- had HV 5.42±1.91 cm/y and cΔHT SDS 3.75±1.39. In OLE Y7, TEAEs were reported in 35.5% subjects, which was lower than the main study (69.0%) and OLE Y1–6 (range: 41.9–57.5%). No serious TEAEs or TEAEs leading to study drug withdrawal occurred in OLE Y7. Study drug–related TEAEs occurred in 2 subjects: keeled chest acquired and scoliosis in 1 and arthralgia in 1. No deaths were reported throughout the OLE. Conclusion: Following up to 8 y of somatrogon treatment, including 7 y of the OLE, subjects demonstrated continued growth, 4 achieved final height, and somatrogon maintained a favorable safety profile. Testing ADA+ did not appear to affect subject growth. Clinicaltrials.gov: NCT01592500. Acknowledgements: The authors wish to thank all the investigators involved in this study. Presentation: Saturday, June 17, 2023

FRI599 Quality Of Life In Girls With Turner Syndrome Using The Quality Of Life In Short Stature Youth Questionnaire (QoLISSY) - A Cross-sectional Study

Abstract Disclosure: N. Vijayakanthi: None. D.J. Marcus: None. S.P. Fritz: None. Y. Xiang: None. D.O. Fadoju: None. Background: Short Stature is a common finding in girls with Turner syndrome (TS). Its impact on Quality of life (QoL) in adolescents/adults with TS have been studied using generic QoL questionnaires. Short stature specific QoL questionnaires have not been used to study the impact of short stature and GH therapy in TS in previous studies. Methods: In this cross-sectional study, we aimed to evaluate QoL and the association between GH therapy and height on QoL of adolescents using the short stature specific questionnaire -Quality of Life in Short Stature Youth (QoLISSY). QoLISSY was designed specifically to assess QoL in short stature children with scales for both parents and children which assesses 3 core QOL dimensions: physical, social, emotional and 3 predictors of quality of life: Coping, Beliefs and Treatment (GH therapy). It has not been previously used in TS. Results: Of the 41 eligible patients, 37 patients were enrolled in the study. The mean age of our cohort was 16.3 ±1.3 years and the average final adult height was 145.03 ± 7.3 cm. About 70% of the patients received GH therapy and 80% received estrogen therapy. Compared to the reference short stature mean values, our TS cohort had comparable scores in all QoL subscales and total scores in both parent and patient reports apart from the parental report treatment subscale which was significantly lower than their respective reference short stature means [Mean ± SD: 47.43±27.13 vs 58.82±16.75; p=0.03]. Girls with height >-3SD had significantly lower score in the coping subscale, compared to the <-2SD height group [Mean ± SD: 42.14 ± 19.04 vs 62.25 ± 16.60; p= 0.024; multivariate analysis: p=0.012. In the parent report, the social subscale was significantly lower in the > -3SD height group compared to the <-2SD height group [Mean ± SD: 57.59 ± 22.25 vs 80.94 ± 11.26; p=0.022; multivariate analysis: p=0.024]. There was no statistically significant difference in the QOL between the GH vs no GH groups. Conclusion: We conclude that the QoL in girls with TS was comparable to the reference short stature population. GH therapy did not improve the QoL in girls with TS in our cohort. Height does not appear correlate with the overall QoL in girls with TS though they have some coping and social difficulties. We recommend psychological counseling and support for girls with TS especially to address their coping and social difficulties. Presentation: Friday, June 16, 2023

THU181 Evaluation Of Bone Mineral Density In A Cohort Of Children With ACH Participating In The PROPEL 2 Study Of Infigratinib

Abstract Disclosure: R. Savarirayan: Advisory Board Member; Self; Ascendis Pharma, BioMarin, QED Therapeutics, Sanofi, Sanofi. Consulting Fee; Self; BioMarin. Grant Recipient; Self; Ascendis Pharma, BioMarin, QED Therapeutics, Therachon. Research Investigator; Self; Ascendis Pharma, BioMarin, QED Therapeutics, Therachon. J. De Bergua: None. P. Arundel: None. J. Salles: None. A. Leiva-Gea: None. M. Irving: Advisory Board Member; Self; Ascendis Pharma, BioMarin, QED Therapeutics, Sanofi, Therachon/Pfizer. Speaker; Self; BioMarin, QED Therapeutics. V. Saraff: None. H. McDevitt: None. M. Salcedo: None. M.P. Nicolino: None. V. Cormier-Daire: Advisory Board Member; Self; BioMarin. P. Kannu: Advisory Board Member; Self; Novartis, Ipsen. Grant Recipient; Self; CIHR. M. Skae: None. M. Bober: Advisory Board Member; Self; Biomarin. Consulting Fee; Self; Ascendis Pharma, Biomarin, Pfizer, QED Therapeutics. Grant Recipient; Self; Ascendis Pharma, BioMarin, Pfizer, QED Therapeutics. Research Investigator; Self; Ascendis Pharma, BioMarin, Pfizer, QED Therapeutics. J. Phillips III: None. T. Candler: None. P. Harmatz: Consulting Fee; Self; Audentes, Aeglea, Homology, JCR, Denali, Inventiva, Paradigm, Capsida, Chiesi, Avrobio. Grant Recipient; Self; BioMarin, Inventiva. Research Investigator; Self; BioMarin, Shire/Takeda, QED Therapeutics, RegenXbio, Denali, Ascendis, Amicus, Allievex, JCR, Orphazyme, Idorsia, Sangamo. H. Saal: Advisory Board Member; Self; Alexion. Grant Recipient; Self; Alexion, BioMarin, Pfizer, QED Therapeutics. Research Investigator; Self; Alexion, BioMarin, Pfizer, QED Therapeutics. J. Hoover-Fong: Consulting Fee; Self; Pfizer/Therachon, BioMarin, QED Therapeutics, Sanofi, Ascendis Pharma. Grant Recipient; Self; Pfizer/Therachon, BioMarin, Ascendis Pharma. Research Investigator; Self; Pfizer/Therachon, BioMarin, Ascendis Pharma. E. Muslimova: Employee; Self; QED Therapeutics. Stock Owner; Self; QED Therapeutics. T. Cho: Employee; Self; QED Therapeutics. Stock Owner; Self; QED Therapeutics. R. Weng: Employee; Self; QED Therapeutics. Stock Owner; Self; QED Therapeutics. D. Rogoff: Employee; Self; QED Therapeutics. Stock Owner; Self; QED Therapeutics. Background: Achondroplasia (ACH) is the most common form of short-limbed skeletal dysplasias and is caused by an activating pathogenic variant of the fibroblast growth factor receptor 3 (FGFR3) gene. People with ACH are at risk for several significant co-morbidities, including foramen magnum stenosis, obstructive sleep apnea, chronic otitis media with conductive hearing loss, spinal stenosis, and a propensity towards obesity. Decreased bone mass has been observed previously in gain-of-function mutation Fgfr3 mice, and adults with ACH can have a decrease in bone mineral density (BMD). Here we describe baseline BMD of a cohort of children with ACH participating in PROPEL 2, a proof-of-concept study evaluating preliminary efficacy and safety of infigratinib, an oral FGFR-1-3 tyrosine kinase inhibitor in development for ACH. Methods: Dual energy X-ray absorptiometry (DXA) scans of the spine (L1-4) were collected at baseline in children participating in PROPEL 2 using a Hologic or GE Lunar scanner following a pre-specified image acquisition procedure. Images were evaluated by a single reviewer. Results are expressed as z-score for age and sex based on average-height children. Results: 52 children (mean±SD age: 7.97±1.9 years; 29 female; mean±SD height z-score: -5.4±1) were included in this analysis. BMD of the lumbar spine was -0.96±0.9 SDS (min -4.1; max 0.7 SDS). No statistical difference was found between males and females. 85% of children (n=44) had a BMD <0 SDS, from which 21 (40%) had a BMD between -2 and < -1 SDS, 18 (35%) presented a BMD between -1 and 0, and 5 (10%) presented a BMD < -2 SDS. Eight children (15%) had a BMD >0 SDS. No correlations were observed between BMD and age, height z-score or BMI. Conclusion: Our findings show that lumbar spine BMD is lower in children with ACH compared with normative data from children of average height. Low BMD in the context of short stature is difficult to interpret, raising the question of the degree to which low bone status can be attributed to smaller bone size relative to age. Even though our findings do not take into account children’s height, no correlation between BMD and baseline height z-score was identified in this cohort, suggesting that the findings may not be solely attributable to overall height. These findings reinforce the need to better understand how to circumvent this limitation in children with skeletal dysplasias in order to improve DXA interpretation and avoid misdiagnoses. Presentation: Thursday, June 15, 2023

Effect of Home-based Aerobic Exercise on Leukocyte TERT Gene Expression Without Altering DNA Oxidative Damage in Postmenopausal Women

Objectives: In middle-aged women, the postmenopausal period is associated with increased oxidative, inflammatory, and psychological stress. We intend to investigate the effect of home-based aerobic exercise (HAE) on serum levels of 8-hydroxy-2’-deoxyguanosine (8-C) and the expression of telomerase reverse transcriptase (TERT) in leukocytes of postmenopausal women. Methods: A total of 20 sedentary postmenopausal women who had at least 12 months passed since their last menstruation participated in the study voluntarily. Their Mean±SD age, height, weight, and body mass index (BMI) were respectively 52.4±3.8 years, 161.4±3.7 cm, 74.4±6.8 kg, and 28.6±3.4 kg/m2 . They were randomly divided into two groups: Home-based aerobic exercise (HAE, n=10) and inactive control (CON, n=10). HAE group undertook 4 weeks of home-based aerobic exercise (4 d/wk, intensity: 70%-80% maximal heart rate) with online supervision. Participants’ weight and fasting blood samples (12-h fasting state) were measured and taken before and 48 hours after the intervention. TERT expression in blood leukocytes and serum levels of 8-OHDG were assessed by real-time PCR and ELISA methods, respectively. The collected data were analyzed using mixed (2×2) repeated measure ANOVA and independent samples t-test in SPSS software. A significance level of P<0.05 was considered for all tests. Results: The findings showed that 4 weeks of HAE increased TERT expression significantly compared to the CON (ES=0.40, P<0.05). Although 8-OHDG serum level in the HAE group increased following training compared to pre-training (P<0.05), no significant difference was observed between the CON and HAE groups (P>0.05). Also, the interaction effect on 8-OHDG was not significant (ES=0.11, P>0.05). In addition, after 4 weeks of HAE, body weight and BMI significantly decreased in the training group compared to the control (P<0.05). Discussion: According to these findings, HEA effectively reduces telomere erosion and improves weight control in postmenopausal women.

PENDIDIKAN KESEHATAN FAKTOR PENYEBAB STUNTING

Stunting is a short and very short body condition that exceeds the deficit of -2 SD belowthe median length or height. Stunting can be diagnosed through the anthropometricindex of height for age which reflects the linear growth achieved in pre and post deliverywith an indication of long-term malnutrition, resulting from inadequate nutrition.Indonesia is still high and is a health problem that must be addressed. Indonesia is in the5th highest rank with the prevalence of stunting children. After India, China, Nigeria andPakistan. The prevalence of stunting in NTB Province is 37.2%, higher than the nationalaverage of 29.6%. That number also increased when compared with the year. 2016which amounted to 29.9% or an increase of 7.29%. For the highest prevalence of stuntingin Sumbawa Regency, namely 41.9% followed by Central Lombok 39.9%, Dompu 38.3%,Mataram City 37.8%, North Lombok 37.6%, Bima 36.6%, Bima City 36 , 3%, West Lombok36.1% and East Lombok 35.1%. Stunting is a linear growth that fails to reach its geneticpotential as a result of poor diet and infectious diseases. In this service activity themethod used is health education about the causes of stunting. Health educationactivities on the factors causing stunting as an effort to increase knowledge of thefactors causing stunting, which were carried out in Geguntur Village, Sekarbela District,Mataram City on May 30, 2022, were attended by 35 mothers. The results of theparticipants' pretest and posttest showed an increase in knowledge about healtheducation on the factors that cause stunting. After this community service activity, it ishoped that the mother's attitude is also positive regarding the factors that causestunting and can apply it in daily life so that stunting events can be prevented early.

The Effect of Corrective Exercises on the Foot Posture and Balance in Female Karate Athletes With Flat Foot

Background and Aims Karate is one of the most popular martial arts worldwide, and flat foot deformity is one of the most common disorders in people participating in this sport. This disorder can negatively affect the static and dynamic balance in individuals. Therefore, this study aimed to investigate the effect of corrective exercises on foot posture and balance in female karate athletes with flat foot. Methods This research was a quasi-experimental study performed in two phases: pre-test and post-test. Forty female karatekas with flexible flat foot postures entered the study as subjects. They were randomly divided into exercise group (Mean±SD age: Mean±SD 20.00±1.81 y, Mean±SD height: 161.4±6.49 cm, and Mean±SD weight: 55.27±6.56 kg) and control (Mean±SD age: 21.02±2.19 y, Mean±SD height cm: 160.4±4.23, and Mean±SD weight: 55.75±3.90 kg). As one of the inclusion criteria, a navicular drop test was performed for all subjects to assess the condition of the foot posture. Also, the balance error scoring system and Y balance tests were used for all subjects to check the static and dynamic balance. Then, the exercise group performed 6 weeks of corrective exercises, but the control group did not perform any specific exercises during this period. After 6 weeks, the tests were repeated. Statistical analysis was performed in SPSS software version 26. A covariance analysis test was used to evaluate the between-group differences, and paired sample t test was used to evaluate the within-group changes. Results This study’s findings showed that the corrective exercise group in thepost-test had a better performance than the pre-test in the navicular drop test, in all three directions of the Y balance test, and in the balance error scoring system (P=0.0001). But in the control group, no significant difference was observed between the two stages of the test (P>0.05). It was also observed in the comparison between groups that in thepost-test in the variables of the navicular drop test and also in all three directions of the Y balance test and the test of the scoring system, the balance error scoring system of the experimental group achieved better results than the control group (P>0.05). Conclusion This study showed that 6 weeks of corrective exercises has significantly improved foot posture and static and dynamic balance in karate women with flexible flat feet. According to the results obtained in this study, it seems that comprehensive corrective exercises can be used in this group to improve balance and posture.

Growth pattern in children with X-linked hypophosphatemia treated with burosumab and growth hormone

BackgroundX-linked hypophosphatemia (XLH) is characterized by increased serum concentrations of fibroblast growth factor 23 (FGF23), hypophosphatemia and insufficient endogenous synthesis of calcitriol. Beside rickets, odonto- and osteomalacia, disproportionate short stature is seen in most affected individuals. Vitamin D analogs and phosphate supplements, i.e., conventional therapy, can improve growth especially when started early in life. Recombinant human growth hormone (rhGH) therapy in XLH children with short stature has positive effects, although few reports are available. Newly available treatment (burosumab) targeting increased FGF23 signaling leads to minimal improvement of growth in XLH children. So far, we lack data on the growth of XLH children treated with concomitant rhGH and burosumab therapies.ResultsThirty-six patients received burosumab for at least 1 year after switching from conventional therapy. Of these, 23 received burosumab alone, while the others continued rhGH therapy after switching to burosumab. Children treated with burosumab alone showed a minimal change in height SDS after 1 year (mean ± SD 0.0 ± 0.3 prepubertal vs. 0.1 ± 0.3 pubertal participants). In contrast, rhGH clearly improved height during the first year of treatment before initiating burosumab (mean ± SD of height gain 1.0 ± 0.4); patients continued to gain height during the year of combined burosumab and rhGH therapies (mean ± SD height gain 0.2 ± 0.1). As expected, phosphate serum levels normalized upon burosumab therapy. No change in serum calcium levels, urinary calcium excretion, or 25-OHD levels was seen, though 1,25-(OH)2D increased dramatically under burosumab therapy.ConclusionTo our knowledge, this is the first study on growth under concomitant rhGH and burosumab treatments. We did not observe any safety issue in this cohort of patients which is one of the largest in Europe. Our data suggest that continuing treatment with rhGH after switching from conventional therapy to burosumab, if the height prognosis is compromised, might be beneficial for the final height.

Response to growth hormone treatment in patients with sufficient secretion

BackgroundThere are situations of short stature, with a normal stimulus test for GH, but decreased nocturnal secretion in which there could be a benefit with GH treatment. ObjetivesTo assess adult height and height gain in patients with neurosecretory dysfunction diagnosis treated with growth hormone. Material y methodsLongitudinal, retrospective and observational study including 61 patients treated with growth hormone after diagnosis of neurosecretory dysfunction who have already reached adult height. Variables such as adult height gain, growth rate, growth prognosis variation and IGF-I and IGFBP-3 were evaluated. Variables related to a good response in the first year have also been calculated, using the Index of responsiveness (IoR). ResultsGH treatment produces an improvement in growth rate and height, observing an increase in adult height with respect to initial height of 1.15±0.60 SD, height with respect to genetic height of -0.015±0.62 SD and adult height with respect to the initial growth prognosis 0,74±1,13 DE. The IoR in the first year is associated with a greater increase in height in the first year (p=0.000), with a greater adult height (p=0.000) and with a greater gain in adult height compared to its initial height (p=0.039). ConclusionsPatients with growth delay due to neurosecretory dysfunction of GH show a good response to treatment with rhGH, observing a significant height gain in their genetic size and improving their initial growth prognosis.

Evaluation of Inferior Intercavernous Sinus in Patients With Pituitary Microadenoma by Contrast-Enhanced SPACE Imaging.

Inferior intercavernous sinus (iICS) is a venous channel below the pituitary gland. Inferior intercavernous sinus injury is predisposed to cause venous bleeding during dura incision in transsphenoidal surgery for pituitary adenomas. Therefore, this study aimed to perform a radiological assessment of iICS before transsphenoidal surgery for pituitary microadenoma. A retrospective evaluation was performed on 156 patients who underwent magnetic resonance imaging examinations in our hospital before endoscopic transsphenoidal surgery for pituitary microadenoma. Both sagittal reformatted and coronal contrast-enhanced (CE) sampling perfection with application optimized contrast using different flip angle evolutions (SPACE) images were interpreted for the presence, shape, and size of the iICS. In CE SPACE, the iICS was identified in 72 patients (46.15%) with pituitary microadenoma. The iICS was appeared as a filiform-shaped hyperintense structure below the pituitary gland on coronal CE SPACE planes and a crescent-shaped hyperintense structure on sagittal CE SPACE planes. The mean ± SD width, depth, and height of iICS were 11.15 ± 3.47 mm, 5.29 ± 1.24 mm, and 1.41 ± 0.19 mm, respectively. Contrast-enhanced SPACE may serve as a promising technique in evaluating iICS and individualized preoperative planning before transsphenoidal surgery for pituitary microadenoma.

Frequency of Pelvic Inflammatory Disease in Infertile Patients

Aim: Frequency of pelvic inflammatory disease in women presenting with infertility Study design: Cross sectional research Setting: Obstetrics/Gynaecology Deptt., Services Hospital, Lahore from 20-10-2017 to 20-04-2018. Methods: One hundred married females with Infertility (Primary/Secondary) were included in the study. Patients with H/o intrauterine contraceptive devices usage, diabetes, male factor Infertility and H/O pelvic surgery were excluded. All women were taken complete history and detailed physical and gynecological examination and HVS was sent to laboratory for culture. Results: Age was from 20 to 35 years with mean ± SD 29.41±2.35 yrs, mean±SD of weight 70.09±12.66kg, mean±SD height 1.54±0.09 meters, mean ± SD of BMI 29.67±5.09 Kg/m2 and mean±SD duration of Infertility was 2.5±0.97 years. Majority of the patients were from 0-2 parity (92%). Primary infertility was found in 64% women while secondary infertility was 36%. Pelvic Inflammatory Disease was found in 27% patients. Conclusion: Tubal damage before and during the index episode of PID is correlated with infertility. Keywords: Infertility, Pelvic inflammatory disease, Frequency

The Effects of Resistance Training With and Without Electrical Muscle Stimulation on Body Composition of Obese Women

Background and Purpose: Nowadays, total body resistance exercise has been added to instability training and has become popular for improving health and sports performance. Resistance training is a beneficial way to improve body composition and increase muscle strength. This study aims to evaluate the effect of suspension training (total resistance exercises [TRX]) with and without electrical muscle stimulation (EMS) on body composition and muscle strength in obese women. Materials and Methods: This quasi-experimental research is an applied study in terms of research goal. A total of 36 Class 1 obese women (mean±SD age: 30.9±5.3 years, mean±SD body mass: 95.4±9.4 kg, mean±SD height: 168.2±7.8 cm) were randomly selected from qualified volunteers and grouped randomly into three groups (n=12 for each group): EMS, TRX, and TRX-EMS. The TRX group performed 8 weeks of suspension resistance training (3 sessions per week), and the TRX-EMS group performed the TRX exercises wearing a whole-body suit that provided electrical stimulation. EMS intervention includes 3 applications of 90 min/3 days per week for 8 weeks. Data were analyzed by analysis of covariance at a significance level of 0.05 using SPSS software. Results: Findings of this study demonstrate significant differences in body composition measurements among three groups after 8 weeks of interventions (P≤0.05). All three interventions increased muscle strength after 8 weeks. TRX+EMS was the most effective intervention on body composition measures (-4.3% in body mass index [BMI], -7.2% in body fat mass [BFM], and +3.6% in skeletal muscle mass [SMM]) and muscle strength (21.93% in BP-1RM and 27.4% in LP-1RM). Also, these findings may indicate that EMS was the least effective intervention on body composition and muscle strength compared with the TRX and TRX-EMS. Conclusion: According to these results, it is suggested that obese women use EMS with suspension training to lose weight and improve body composition and strength.

Evaluating the sensitivity and specificity of the UK and Dutch growth referral criteria in predicting the diagnosis of pathological short stature

ObjectiveThe aim of this observational study was to evaluate the UK and Dutch referral criteria for short stature to determine their sensitivity and specificity in predicting pathological short stature. Adherence...

Emerging Risk Factors for Impaired Lung Function in Chemical Industry Workers of Faisalabad

Objective: To determine the impact, obesity and age on the lung functions determined by PEFR of healthy workers of chemical industries.
 Methodology: This was a cross sectional study performed at private medical college of Faisalabad. Three days medical camp was arranged during 2nd to 4th September 2020 after taking approval from institutional ethical committee. All relevant information including age, residence and history about chemical exposure were recorded in a structured proforma. Obesity was determined on basis of BMI grading. BMI was calculated from estimated Height and weight PEFR of each participant was determined using Wright’s Peak flow meter. Data was analyzed by SPSS21.
 Results: Mean± SD age, height and weight of the studied population was 38.85 ± 12.1, 170.07 ±12.0 and 78.12 ±12.7. lowest PEFR value was found in subjects with age range 61 to 70 years as compred to youger subjects . The mean PEFR value were significantly different with respect to various age catagoeies with p value= 0.000 Highest mean PEFR values were found in taller subjects having height ≥ 180 cm and lowest values were found in subjects with height 150-159 cm, the difference in means was statisticaly significant with p value= 0.05.
 Morbid obese subjects showing comparatively lower PEFR values in morbid obese with significant p value =0.002.
 . PEFR was found to be negatively associated with age ( p- value= 0.000*) and BMI( p value =0.001*). Our results also showed weak positive association of PEFR with height, however this relation was not found to be statistically significant (p value= 0.081).
 Conclusion: Peak expiratory flow rate is negatively associated with increasing BMI and age, reflecting that elderly and obese subjects are more prone to have affected lung function due to exposure to chemicals

Respuesta al tratamiento con hormona del crecimiento en pacientes con secreción suficiente

BackgroundThere are situations of short stature, with a normal stimulus test for GH, but decreased nocturnal secretion in which there could be a benefit with GH treatment. ObjetivesTo assess adult height and height gain in patients with neurosecretory dysfunction diagnosis treated with growth hormone. Material y methodsLongitudinal, retrospective and observational study including 61 patients treated with growth hormone after diagnosis of neurosecretory dysfunction who have already reached adult height. Variables such as adult height gain, growth rate, growth prognosis variation and IGF-1 and IGFBP-3 were evaluated. Variables related to a good response in the first year have also been calculated, using the index of responsiveness. ResultsGH treatment produces an improvement in growth rate and height, observing an increase in adult height with respect to initial height of 1.15±0.60 SD, height with respect to genetic height of −0.015±0.62 SD and adult height with respect to the initial growth prognosis 0,74±1,13 DE. The index of responsiveness in the first year is associated with a greater increase in height in the first year (P<0.001), with a greater adult height (P<0.001) and with a greater gain in adult height compared to its initial height (P=0.039). ConclusionsPatients with growth delay due to neurosecretory dysfunction of GH show a good response to treatment with rhGH, observing a significant height gain in their genetic size and improving their initial growth prognosis.

Половой диморфизм как индикатор микроэволюционной динамики соматического статуса (на модели детей грудного возраста)

Introduction. The level of sexual dimorphism, SD, is treated as independent population quantitative indice – marker of the quality of the surrounding, the level of ecological stress, the indicator of temporal fluctuations of economic and social factors. Materials and methods. Secular dynamics of SD of body dimensions is analyzed at intergroup and intragroup levels. Meta analysis embraces the data of 112 samples of urban children of 12-months-age, examined during 1930-2010 years. The main source of information – books on physical development of children and adolescents of Russia and former USSR. The second part of the work describes the monthly patterns of secular dynamics of SD of body dimensions through the age interval from 0 to 12 months based on data of Moscow children only, also from 1930s till now. The quantitative estimation of the level on SD is realized using Kullback divergence. Results. According to the results of meta analysis, secular dynamics of SD height, weight, chest and head girths of 12-months-old children is not significant (p= 0,13–0,97). Analysis of secular variability of SD of somatic dimensions of Moscow children only showed the existence of common, over temporal and over population, mechanisms of growth, in particular, increase of SD of all somatic traits under discussion through the first trimester. Intergroup differentiation of SD of anthropometric traits is minimal at the start of postnatal ontogenesis. Secular variability of age dynamics of SD of somatic traits through the infancy has nonlinear curve. SD of height and weight of the sample of 1957 for the most age points exceeds SD of both earlier samples of 1930 and 1950 and later samples of 1971 and 2008, which is connected with height rates of acceleration of post-war children. Conclusion. SD of somatic traits is an informative and autonomic indicator of microevolution and age dynamics during infancy as well as during subsequent periods of ascending ontogenesis and definite age. Nonlinear dynamics of SD levels of analyzed body dimensions through the first year of life is fixed. The most significant quantitative indicators of secular trends, fixed for several data series of Moscow infants, is SD of height.

Association between unilateral functional ankle instability, limited ankle dorsiflexion range of motion and low back pain

There is growing evidence that supports the correlation between incidence of ankle dysfunction and low back pain (LPB). Although the spine and ankle seem like distant regions of the body, they are functionally connected by the lower extremity kinematic chain. The aim of the current study was to investigate the association between functional ankle instability (FAI), limited ankle dorsiflexion (DF) range of motion (ROM) and (LPB). One hundred two subjects with chronic ankle sprain pain participated in this study. The mean ± SD age, weight, height, and BMI of the study group were 43.5 ± 12.96 years, 85.27 ± 14.22 kg, 172.9 ± 8.45 cm, and 28.59 ± 4.72 kg/m². LPB was measured by Visual Analogue Scale (VAS), FAI was measured by the anterior drawer test and DF ROM was measured by the lunge test. All statistical analyses were performed using the Statistical Package for Social Studies (SPSS) version 25 for Windows. There was no statistically significant association between pain and age, pain and BMI, pain, and sex (p &gt; 0.05). There was a statistically significant association between pain and drawer test (odd ratio 5.68, p = 0.02) and a statistically significant association between pain and DF ROM (odd ratio 1.16, p = 0.01). The current study supported previous studies recommending FAI and limited ankle DF ROM as a factor in LPB. The authors suggest conducting similar studies with a larger number of participants and include functional measures scales or questionnaires to increase the validity and generalizability of the results.