Screening Equipment Research Articles

Design of monitoring system for material vibration screening equipment

In order to effectively reduce the failure rate of vibrating screens, a vibration monitoring system design was proposed based on the structure and working principle. The system should be able to monitor the operating state of the vibrating screen in real time, including vibration amplitude, frequency, axial displacement, etc., and be able to detect abnormal conditions in time and give warning prompts. The key hardware of the monitoring system was designed, including acceleration sensor, power module, signal filtering circuit, etc. The sensitivity of the acceleration sensor was measured using comparative method and accurately completed parameter calibration. The eccentric block was used to simulate different deviation of excitation force for system vibration signal test and calibration. The results show that under normal operating conditions, the amplitude of each frequency of the vibrating screen is less than 0.04 g. Under the condition of excitation force deviation, the amplitude of 16 Hz is obviously lower than that of other frequencies, which means that the vibrating screen is currently experiencing lateral oscillation.

Research on screening effect and time-frequency characteristics of screen surface with additional striking beam

ABSTRACT In this study, a new flexible screen surface structure with an additional striking beam was proposed for improved efficiency and addressing the clogging issue while processing moist coal material. Vibration tests were used to analyze the time-frequency characteristics of the screen surface and the striking beam under no-load and load conditions. The effects of different process parameters on the elastic screening effect of viscous and wet materials were explored. Further, the industrial application of the equipment was preliminarily carried out. The results showed that the load did not affect the main vibration frequency of the elastic screen surface and the striking beam. When the axis distance was adjusted to 7.5 cm, the displacement from the feeding end to the discharge end gradually decreased, promoting the rapid loosening and stratification of the material group. Semi-industrial tests showed that the optimal screening effects had a screening efficiency of 92.16% and a total misplaced content of 5.95% when exciting force was 18 kN, the exciting frequency was 10.8 Hz, the feeding rate was 9.36 t/h, the distance was 7.5 cm, and the moisture content was 8.21%. The GQPSS1848 vibrating screen applied in the industry achieved a screening efficiency of 86.66% at a processing capacity of 85 t/h with a broad commercial prospect. The study aims to provide theoretical and technical support for the research and development of flexible screening equipment and the efficient classification of −3 mm sticky and wet materials.

Comparison of real-time ultrasonography with waveform capnography in verifying endotracheal tube location- An observational study

Immediate post-intubation confirmation of endotracheal tube requires direct observational or secondary gadgets-dependent measures having variable sensitivity and specificity. In this study, dynamic real-time ultrasonography is used for the evaluation of endotracheal tube. The correlation between the gold standard test(Capnography) and the unconventional test(Ultrasonography) is also evaluated.One hundred ASA PS 1, and ASA PS 2 patients were evaluated for endotracheal intubation using real-time ultrasonography. The desired endotracheal intubation was further confirmed by using time capnography. Victorious tracheal intubation was identified using some radiological signs, only one air-mucosa interface with a comet-tail artefact and enhanced posterior acoustic shadowing indicative of endotracheal intubation. Two air-mucosa interfaces with comet-tail artefacts with posterior shadowing were indicative of oesophageal intubation.The mean (SD) ages of the studied patients were 41.25±7.76 Yrs. A total of 87% of patients had endotracheal intubation and 13% had oesophageal intubation based on ultrasonography scan findings. Capnography finding was 91% endotracheal intubations, 9% were true oesophageal. The true positive and true negative rate, positive predictive value and negative predictive values of real-time ultrasonography were 95%, (95% confidence interval (CI) 88% to 98%) 100% (95% CI 62% to 100%), 100% (95% CI 94% to 100%), 69% (95% CI 38% to 89%) respectively. Kappa (k) value was 0.8. Ultrasonography is a portable sensitive screening equipment for ETT position confirmation. There is a strong association between USG findings with time capnography results.

Establishment of a digital electrocardiogram telemonitoring system and remote consultation service.

The use of telemonitoring electrocardiogram (ECG) improves the detection rate of various arrhythmias as it offers an extended recording time and does not impose activity restrictions. However, many community hospitals lack the resources to conduct this test due to a lack of cardiac function specialists and antiquated screening equipment. To establish a digital ECG telemonitoring system and remote consultation service between tertiary hospitals and community medical service stations to improve diagnosis and treatment effectiveness. We used the PI ECG telemonitoring data acquisition system, with a personal digital assistant (PDA) or computer serving as the platform for ECG acquisition, storage, display, printing, and transmission. We introduced this system to standardize the storage and transmission of ECG telemonitoring data, and ensure accurate transmission, reproducibility, and preservation of data. The implementation of the PI ECG telemonitoring data acquisition system enabled the sharing of remote ambulatory electrocardiography data between Beijing Shijitan Hospital and its affiliated community hospitals. This has resulted in reduced waiting times for patients to receive reports (from 0.3 to 1 hour, to 0.1 or less), shortened consultation times (from 2 hours to 0.1 hour), and improved patient satisfaction with consultations (> 20% of the patients reported they were highly satisfied). The system successfully combined the goals of intelligence, real-time synchronization, and efficiency, revolutionizing ECG telemonitoring diagnosis in the network era. Sharing digital telematics information between tertiary and community hospitals enables a tiered approach to diagnosis and treatment and allows for more efficient, accurate, and convenient remote diagnostics.

A Method for Stabilizing the Vibration Amplitude of a Flip-Flow Vibrating Screen Using Piecewise Linear Springs

The flip-flow vibrating screen (FFVS) is a novel multi-body screening equipment that utilizes vibrations to classify bulk materials in the field of screening machinery. The relative amplitude of FFVSs determines the tension and ejection intensity of elastic flip-flow screen panels, which is a critical operating parameter affecting the screening performance. However, FFVSs generally suffer from large variations of relative amplitude caused by the loading of materials and the changes in shear spring stiffness (the temperature changes of the shear springs lead to their stiffness changes), which significantly reduce the screening efficiency and lifespan of FFVSs. To address this problem, this paper proposes a nonlinear stiffness-based method for stabilizing the vibration amplitude of FFVSs using piecewise linear springs. By introducing these springs between the two frames, the sensitivity of the relative amplitude to shear spring stiffness is reduced, thereby achieving the stabilization of the relative amplitude of FFVSs. In this study, the variations of the vibration amplitude of the FFVS due to the loading of materials and the changes in shear spring stiffness were first demonstrated in a reasonable operating frequency range. Then the reasonable operating frequency range and dynamics of the resultant nonlinear flip-flow vibrating screen (NFFVS) with piecewise linear springs were investigated using the harmonic balance method (HBM) and the Runge–Kutta numerical method. The operating frequency region for the NFFVS lies between the critical frequency ωcs and the frequency ωlb corresponding to the saddle-node bifurcation point. Finally, a test rig was designed to validate the theoretical predictions. Theoretical and experimental results demonstrate that piecewise linear springs can effectively stabilize the relative amplitude of the FFVS.

Parameter optimization and spatio-temporal distribution of material for variable trajectory combined equal-thickness screen

Vibrating screen is important screening equipment used extensively in coal separation and utilization at the global scale. Traditional vibrating screen usually adopts a single vibration mode, which leads to poor screening effect. In this study, the equal-thickness screening theory was applied to the combined vibrating screen, and non-uniform frequency operation of the vibrating screen was achieved. The concept of combined excitation parameter was introduced, which presented additional adjustable parameters for the screen. These made it easier for material layer on the screen to achieve equal-thickness. Subsequently, single-factor experiments were conducted for systematic exploration of the impact of various parameters on the screening efficiency. By regulating the excitation force and frequency of the four excitation motors of the variable-trajectory combined screen, the study aims to regulate the motion speed of material groups, the distribution of materials under the screen, and the thickness distribution of the material layer on the screen. The result showed that when D = 2/19, f1&f2 = 15.00 & 11.37 Hz, respectively, k = 1.2, equal-thickness screening was realized, and the screening efficiency η was 96.32%, which is 3.35% higher than those under the optimal conditions with equal amplitude and equal vibration frequency.

Sarcopenia screening of community-dwelling individuals aged 65 and over within the primary care setting

BACKGROUND: The term sarcopenia, referring to declining function with age, has no universally agreed definition. Sarcopenia develops from multifactorial interactions, resulting in health problems such as frailty and increased falls risk; and for which screening may enable timely intervention. As sarcopenia screening equipment recommended by The European Working Group on Sarcopenia in Older People (EWGSOP2) is not always available in primary care, alternate screening strategies are needed. OBJECTIVE: To investigate the efficacy of the SARC-CalF questionnaire for sarcopenia screening in primary care and agreement between SARC-CalF and SARC-F questionnaires, with EWGSOP2 cut-off values. METHODS: Fifty community-dwelling adults aged 65yrs and over completed the SARC-CalF and EWGSOP2 strength and physical performance outcome measures. Calculations for probability of sarcopenia and skeletal muscle mass were completed. Agreement between operational definitions and outcome measures were assessed to establish screening accuracy. RESULTS: Prevalence of probable sarcopenia ranged from 10–48% depending on outcome measure; SARC-CalF increased prevalence by 55% compared to SARC-F. Questionnaires agreed more strongly with probable sarcopenia as measured by leg than grip strength. Gait speed agreed significantly with strength and physical performance measures. CONCLUSIONS: In community-dwelling adults aged 65yrs and over, outcome measure used influenced rates of probable sarcopenia. Within primary care, equations may enable assessment of muscle mass, while formulae may enable assessment of the probability of sarcopenia. Gait speed is recommended for quantification of sarcopenia severity.

Barriers to cervical cancer screening in Africa: a systematic review

IntroductionAfrica has one of the highest burdens of cervical cancer in the world. The unacceptably high incidence and mortality rates could be reduced through implementing a comprehensive approach to its prevention and control that includes screening, which however, is low in most low-and-middle-income countries. Hence, this systematic review aims at exploring factors that prevent women from utilising cervical cancer screening services in the region.MethodsA mixed method systematic review was conducted. A search was performed on PubMed (Medline), EMBASE, CINAHL (EBSCOHOST) and Scopus databases for articles published until May 2019 without time, language or study design limits. Two reviewers critically appraised the included studies independently using the standard quality assessment criteria for evaluating primary research papers. Results of the quantitative and mixed methods studies were transformed into qualitative data and synthesised using thematic analysis.ResultsFrom a potential 2 365 studies, 24 from 11 countries met the eligibility criteria and were selected; eight qualitative, 13 quantitative, and three that used the mixed-method approach. The primary barriers were identified as poor access to screening services, lack of awareness and knowledge on cervical cancer and screening, and socio-cultural influences. Service providers perceived lack of skills, screening equipment and supplies, and staff shortages as the major barriers to the provision of screening services.ConclusionBarriers to cervical cancer screening in Africa are multifaceted and require a holistic approach that will address them concurrently at the health system, individual, interpersonal, community and structural levels. Political will complimented by stakeholder involvement is required in the development and implementation of strategies that will ensure acceptability, availability, accessibility, and affordability of screening to minimise barriers in accessing the service.

Evaluation of the Canadian approved drug screening equipment cut-off levels for tetrahydrocannabinol (THC).

In 2018, Canada introduced roadside oral fluid (OF) screening devices, called Approved Drug Screening Equipment (ADSE), as an investigative tool in impaired driving investigations to detect tetrahydrocannabinol (THC), cocaine and/or methamphetamine in drivers. In this work, we compare the detection and concentration of THC in blood samples collected from suspected impaired drivers that tested positive at the roadside for THC on an ADSE. The two ADSEs that were utilized were the Dräger DrugTest® 5000 (DDT) and the Abbott SoToxa™ (SoToxa), both configured with a THC OF concentration cut-off concentration of 25 ng/mL. Blood samples were screened for cannabinoids using immunoassay and positive results were followed up by confirmation/quantitation of THC by ultra-performance liquid chromatography with tandem mass spectrometry (UPLC-MS-MS). A total of 230 cases were available where a blood sample was collected from a suspected impaired driver subsequent to a positive THC screen result on an ADSE. The blood samples were taken an average of 1.4 hours (range = 9 minutes to 3.2 hours) after the ADSE test. THC was confirmed in 98% of blood samples with concentrations across all samples ranging from not detected (cut = off 0.5 ng/mL) to greater than 20 ng/mL. Further, 90% of the blood samples had a THC concentration of 2.0 ng/mL (the lower per se limit in Canada) or greater. A positive ADSE test of a suspected impaired driver may predict that the driver has a detectable level of THC in their blood, and there is a high likelihood that the THC blood concentration is 2.0 ng/mL or higher. Hence, ADSE may be a useful tool for law enforcement and aid in the development of grounds to believe that a driver is operating a conveyance with a THC concentration exceeding Canadian per se limits.

The relationship between management of facilities and tenants’ satisfaction towards retirement homes: An exploratory study

This paper intends to explore whether there exists any relationship between management of facilities and tenants’ satisfaction towards retirement homes in Malaysia. A set of questionnaire was administered to 400 tenants of retirement homes in Selangor, Kuala Lumpur, Johor, and Kelantan and only 205 complete questionnaires were used for the study. The questionnaire consists of six items on management of facilities with a high reliability value of α = 0.93; and eight items on tenants’ satisfaction with a high reliability value of α = 0.91. The results from Pearson correlation analysis show that there is a strong, positive and significant relationship between management of facilities and tenants’ satisfaction towards retirement homes. The respondents agreed with the items on efficient management of facilities which are collaborations with NGOs in providing transport and medical assistance, creating awareness of these collaborations, availability of food bank supply, an integrated database, effective management of activity space, collaboration with public professional healthcare and skilled social volunteers. As for tenants’ satisfaction, the tenants agreed with the items which include an increase in the number of retirement home tenants, availability of health screening equipment, high quality food and facilities, and skilled caretakers, retirement homes equipped with internet facilities, and happy with activities conducted. Hence, the findings show that the management of facilities in retirement homes has a direct relationship with tenants’ satisfaction towards these retirement homes.

Synchronization and vibration absorption analysis of a dual-body vibrating screen driven by multiple motors with double-frequency actuation

Vibrating screen is the pivotal equipment of solid control in drilling mud purification system. With the continuous upgrading of rapid drilling technology, the conventional single-body vibrating screen with the same-frequency excitation is difficult to satisfy the needs of current drilling operations. Therefore, a newly dual-body vibration absorption system model with double-frequency excitation is proposed to improve the mechanical performance of screening equipment. To grasp the dynamic characteristics of the vibration system, the synchronization mechanism and stability criterion are theoretically studied by modified small parameter average method and Poincare-Lyapunov method. Meanwhile, the vibration absorption ability, coupling torque and synchronization state of the system are numerically discussed. Lastly, the electromechanical coupling model of system is established by Runge-Kutta method to verify the reliability of theoretical analysis and numerical calculation. According to the results of research, the synchronous characteristics are mainly determined by the installation position of motors and the mass ratio of eccentric rotors. Besides, the synchronization ability between identical-frequency motors is stronger than different frequency motors. The present work can provide theoretical direction for designing of new screening equipment.

Pilot Implementation of a Community-based, eHealth-enabled Service Delivery Model for Newborn Hearing Screening and Intervention in the Philippines.

This study explores the potential of the HeLe Service Delivery Model, a community-based newborn hearing screening (NHS) program supported by a web-based referral system, in improving provision of hearing care services. This prospective observational study evaluated the HeLe Service Delivery Model based on records review and user perspectives. We collected system usage logs from July to October 2018 and data on patient outcomes. Semi-structured interviews and review of field reports were conducted to identify implementation challenges and facilitating factors. Descriptive statistics and content analysis were used to analyze quantitative and qualitative data, respectively. Six hundred ninety-two (692) babies were screened: 110 in the RHUs and 582 in the Category A NHS hospital. Mean age at screening was 1.4±1.05 months for those screened in the RHU and 0.46±0.74 month for those in the Category A site. 47.3% of babies screened at the RHU were ≤1 month old in contrast to 86.6% in the Category A hospital. A total of 10 babies (1.4%) received a positive NHS result. Eight of these ten patients were referred via the NHS Appointment and Referral System; seven were confirmed to have bilateral profound hearing loss, while one patient missed his confirmatory testing appointment. The average wait time between screening and confirmatory testing was 17.1±14.5 days. Facilitating factors for NHS implementation include the presence of champions, early technology adopters, legislations, and capacity-building programs. Challenges identified include perceived inconvenience in using information systems, cost concerns for the patients, costly hearing screening equipment, and unstable internet connectivity. The lack of nearby facilities providing NHS diagnostic and intervention services remains a major block in ensuring early diagnosis and management of hearing loss in the community. The eHealth-enabled HeLe Service Delivery Model for NHS is promising. It addresses the challenges and needs of community-based NHS by establishing a healthcare provider network for NHS in the locale, providing a capacity-building program to train NHS screeners, and deploying health information systems that allows for documentation, web-based referral and tracking of NHS patients. The model has the potential to be implemented on a larger scale - a deliberate step towards universal hearing health for all Filipinos.

Screening practices for obstructive sleep apnea in healthy community people: a Chinese community-based study.

Owing to the lack of clear guidelines, the significance of obstructive sleep apnea (OSA) screening in healthy community people is unclear. This study aimed to screen for OSA in a healthy community population and provide a basis for its screening. Permanent residents from five communities in the coastal and mountainous areas of south China were selected. The screening process included demographic and sleep questionnaire surveys, and an OSA screening. To compare the prevalence and risk factors of OSA in different areas, a type IV wearable intelligent sleep monitor (WISM) was used for screening. A total of 3,650 participants completed all studies, with a mean age of 53.81±12.71 years. In addition, 4,318 participants completed the OSA screening within 30 days, and the objective screening speed was 200 people per day. The recovery rate of the screening equipment was 99.37% (4,291/4,318), the screening success rate was 89.63% (3,846/4,291), and the rejection rate was 2.7% (120/4,438). The prevalence of high-risk OSA screened using the Stop-Bang questionnaire was 42.8% (1,563/3,650) and that screened using the device was 30.7% (1,119/3,650). The prevalence of OSA screened using the Stop-Bang questionnaire was higher than that screened using the device (P<0.01). Further analysis of sleep quality and daytime sleepiness showed that 47.6% (1,736/3,650) of the community population had good sleep quality and 6.6% (240/3,650) had daytime sleepiness. Age, sex, body mass index (BMI), neck circumference, and hypertension were risk factors for OSA in the community population. The use of objective type IV sleep detection equipment to screen a large sample population in the community in a short time is feasible. The prevalence of high-risk OSA screened using the Stop-Bang questionnaire was higher than that screened using the objective screening device.

Evaluation of the observation of infection control protocols in dental offices during the COVID-19 pandemic based on Centers for Disease Control and Prevention guidelines in Zahedan in 2020-2021

Coronavirus disease-2019(COVID-19) was identified as a significant threat to health worldwide. During dental procedures, large amounts of aerosols are produced; therefore, dentists, the staff, and patients are exposed to the virus. The present study aimed to evaluate the observation of infection control protocols in dental offices during the COVID-19 pandemic based on the Centers for Disease Control and Prevention(CDC) guidelines in Zahedan, Iran, in 2020-2021. The present descriptive study was carried out with the collaboration of general dental practitioners and specialists in 11 clinics and 133 private dental offices in the public and private sectors in Zahedan, who were active during the COVID-19 pandemic in 2020-2021. The simple sampling method was used, and the data were collected using a checklist prepared based on the guidelines of the CDC. The dentists’ personal protection score was 63%, with 73% for the patients and clients. The mean scores for the personnel’s educational requirements, patients’ and clients’ educational requirements, screening, and personal protection equipment in the dental centers were 76%, 60.5%, 71.8%, and 81%, respectively. The observation of the infection prevention protocols in the dental offices in Zahedan by dentists, staff, and patients was moderate, necessitating further and more appropriate programs to improve it based on the CDC guidelines. Continuous education programs are necessary for dentists, with further information for the general population through the mass media and virtual social networks. periodic studies are necessary to evaluate the efficacy of these programs so that modifications in the policies can be implemented if necessary.

Comparative Study on Chronic Obstructive Pulmonary Disease Screening Tools in Primary Healthcare Institutions in Beijing, China.

Chronic obstructive pulmonary disease (COPD) has a high incidence rate in China, but the diagnosis rate remains insufficient. This study aimed to explore and compare COPD screening tools for primary healthcare institutions in China. Exploring COPD Screening Tools and Their Combined Use for Primary Healthcare Institutions in China. From September 2022 to March 2023, a screening for COPD was conducted among residents aged 35 years and above in primary healthcare institutions in Beijing, China. The screening involved the use of the CAPTURE scale, COPD-SQ scale, and peak expiratory flow rate test. Any positive results from these screening tests were followed by further pulmonary function testing to confirm the diagnosis. Sensitivity, specificity, positive predictive value, negative predictive value, and receiver operating characteristic (ROC) curves were calculated for each screening tool alone and in combination. A total of 986 individuals completed the screening tests. The positive rates for the CAPTURE scale, COPD-SQ scale, and peak flow meter screening were 41.78%, 29.11%, and 52.03%, respectively. Of the participants, 166 (24.09%) underwent pulmonary function tests, with an average age of 61.69±13.68 years. The peak flow meter screening showed the highest sensitivity (83.78%) when used alone, while the COPD-SQ scale exhibited the best specificity (59.69%), positive predictive value (31.58%), and negative predictive value (58.56%). Significant differences (P<0.05) were observed between any two of the three screening tools. Among the combinations, the peak flow meter screening + COPD-SQ scale showed the highest accuracy, with a Youden index of 0.277 and an AUC of 0.638. There is variation in the accuracy of existing screening tools for COPD when used alone. For primary healthcare institutions, the optimal COPD screening tool is the combination of peak flow meter screening and the COPD-SQ questionnaire. If limited by screening equipment conditions, the COPD-SQ questionnaire can be used alone for screening.

Barriers to and facilitators of prostate cancer screening among men in Uganda prisons.

Studies have shown that prostate cancer (PCa) is increasing at a rate of 5.2% per annum in Uganda and as few as 5% of men have ever been screened for PCa in Uganda. The situation may be worse among male prisoners given their 'vulnerable status'. The goal of this study was to examine the perceptions, attitudes and beliefs of men in Ugandan prisons regarding barriers to and facilitators of PCa screening. This would enable the identification of potential interventional strategies to promote PCa screening among men in Ugandan prisons. This study applied the explanatory sequential mixed methods study design. We first conducted 20 focus group discussions and 17 key informant interviews. The qualitative data were analysed to enrich a survey among 2,565 prisoners selected using a simple random sampling technique. Qualitatively, the belief that all cancers have no cure was a barrier against most participants considering screening to be of any value, coupled with the fear of screening positive for PCa and the associated stress. In addition, poor PCa knowledge and lack of PCa screening services in prisons were perceived as barriers to PCa screening in prison settings.The quantitative data from the survey of 2,565 participants with a mean age of 50.2 (9.8), indicated that the main barriers to PCa screening were mainly myths, beliefs, lack of screening facilities and technical capacity. The majority believed that creating PCa awareness, conducting screening outreach in prisons, and providing equipment for PCa screening in prisons health facilities will facilitate PCa screening, as well as working with the Uganda prison service to train the prison health staff to perform PCa screen to facilitate Prison Health Centres capacity to screen for PCa. There is a need to develop interventions to increase awareness among the inmates in the prison health system, while ensuring that the prison health facilities are equipped with the required screening logistics, backed with outreaches from cancer-specialised hospitals/facilities.

A rigid-flexible coupled dynamic model of a flip-flow vibrating screen considering the effects of processed materials

Flip-flow vibrating screens (FFVSs) are the critical screening equipment for classifying and dewatering wet materials in mining processing industry. During the screening process, the FFVSs can be regarded as a complex rigid-flexible coupled multi-body system where the screening operation and the dynamics of two screen frames interact. However, there exists no mechanical model that can describe the dynamics of FFVSs during the screening process. The lack of such a dynamic model causes the amplitudes of the main and the floating screen frames unpredictable after the processed materials are loaded on FFVSs, which affects the screening performance and the service life of FFVSs. To bridge this research gap, the loaded dynamic model of a FFVS is established in this paper. First, dynamic tests are performed to investigate the equivalent stiffness and the equivalent damping of the force along the screen surface which is induced by the processed materials. Then, the proposed model of the FFVS is verified qualitatively by existing experimental results, and the effects of the processed materials on the dynamics of the FFVS are explored by comparing the non-load dynamics of the FFVS. Finally, the sensitivities of the main parameters on the dynamic response are investigated based on Sobol's method of global sensitivity analysis. It is shown that the proposed rigid-flexible coupled multi-body dynamic model of the FFVS can not only effectively reveal the dynamic response of FFVS in the screening process, but can also provide a reference for modelling the dynamics of the screening process of other screening equipment.

Abstract 671: Exploiting macrophage differentiation and plasticity as an immunomodulating strategy

Abstract The infiltration of macrophages into the tumor microenvironment (TME) is a well-known characteristic of tumor progression and therapy resistance. Depending on the signals derived from TME, macrophage plasticity allows them to undergo a variety of polarization states. Two extremes of macrophage polarization are M1 and M2 phenotypes. M1 macrophages provide enhanced anti-tumor inflammatory reaction while M2 macrophages are usually associated with tumor progression due to their immune suppression, angiogenesis and neovascularization promoting capabilities. Modulating the macrophage differentiation or polarization has emerged as a therapeutic strategy to synergize or complement current treatments. At Reaction Biology we have established human macrophage assay pipelines to evaluate the novel macrophage polarization compounds in vitro. Both, monocyte cell lines like THP-1, and and freshly isolated monocytes from donor derived PBMCs, are of great value. Donor derived differences could become an issue during the screening phase compared to the use of cell lines. Yet, after the screening phase, the evaluation across several healthy donors is crucial to assess the impact of a compound on the general population. Monocytes from primary human peripheral blood mononuclear cell (PBMC) are isolated, differentiated into naïve macrophages, and polarized. Effects of compounds modulating the differentiation and polarization of macrophages are analyzed by flow cytometry. Moreover, the functional reprogramming of monocytes and macrophages can be analyzed by measuring the phagocytic or tumor cell killing capacity via flow cytometry or using high content screening equipment. In the addition, a wide range of secreted cytokine can be quantified by MSD ELISA. Our data shows that human primary monocytes grown under M1 polarizing conditions express high levels of CD86 and HLA-DR in contrast to those cultivated under M2 polarizing conditions, with high expression of CD163 and CD206. A pH-sensitive phagocytosis could be shown for M2 macrophages. Modulation of surface markers from polarized macrophages under different treatment conditions could be observed, as well as changes in their functionality, supporting the translational value to evaluate the efficacy of immunomodulating compounds in vitro. Citation Format: Carla Castro, Philipp Metzger, Cynthia Obodozie, Holger Weber. Exploiting macrophage differentiation and plasticity as an immunomodulating strategy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 671.

Study of "Green Manufacturing" on Rural Crystal Coconut Sugar SMEs

Crystal coconut sugar production will produce waste which will have an impact on environmental pollution. Waste generated is liquid waste and solid waste. Waste reduction handling can applied to "green manufacturing" principle. Research aims are: (1) identify waste generated, (2) determine green manufacturing opportunities, (3) green manufacturing opportunities analyze feasibility, and (4) green manufacturing implementation determine priority. Research phase includes: (1) quick scan analysis, (2) material, energy and waste flows identification, (3) alternative green manufacturing opportunities, (4) feasibility analysis (financial, technical and environmental), and (5) determination green manufacturing implementing priority. Results showed that ant sugar production produces waste in excrement on sap form, ashes from combustion, energy loss, crystal nuclei, and spilled sugar. Green manufacturing alternatives that are technically, environmentally and financially feasible are ash into inorganic fertilizers utilization, replacing cooking furnace, modifying drying equipment, replacing process materials, repairing and modifying screening, drying and packaging equipment. Implementing green manufacturing priority alternatives indicates that main alternatives to implemented are repairs and screening, drying and packaging equipment modifications which are considered technical and technological capabilities good in criteria, finance, human resources (HR), and environment. These results indicate that "Green Manufacturing" in rural SMEs crystal coconut sugar to increase global competitiveness "Green Economy".

Securing medical image privacy in cloud using deep learning network

The worldwide usage of Internet of Things (IoT) applications enhanced the utilization of consumer devices, such as smartphones, computers, screening equipment used in hospitals that merely rely on imaging techniques. Numerous images got generated over the cloud platform in a daily basis ad create storage complexity. On the other hand, securing the data stored in the cloud is important. Instead of storing large amount of data into the cloud, lightweight dynamic processing of data suppresses the complex issues in cloud security. Here secure cloud-based image processing architecture is discussed. Privacy preserving medical data communication is considered as the specific research scope. Cryptographic technique used to encode the original data and decode the data at the other end is currently in usage as conventional design. Providing privacy to the medical records through adding noise and denoising the same records is the proposed idea. The proposed work is keenly focused on creating a light weight cloud architecture that communicates the medical data effectively with privacy perseverance using deep learning technique. In the proposed system, the design of an efficient image denoising scheme with a hybrid classification model is created to ensure reliable and secure communication. Deep learning algorithms merged to form a Pseudo-Predictive Deep Denoising Network (PPDD). The proposed system's benefit is ensuring added security in Dark Cloud using a newly structured algorithm. The original data is packed in the Deep cloud using the Gaussian noise act as a key. The complete packing and unpacking of medical data is encapsulated by the transformed images. Over the cloud premise, the data is highly secured and invisible to the malicious users. To reduce the storage complexity, the dynamic data is unpacked and denoise process is applied at the edge devices. During the authorized access period alone, the data is decrypted and accessible at the edge nodes. The maximum process is dynamically happen in the cloud without depending on the storage boundary. The performance of proposed PPDD network model is evaluated through Signal to noise ratio (SNR), Similarity index (SI),Error Rate(ER) and Contrast to noise ratio(CNR). The proposed architecture is comparatively validated with existing state-of-art approach.