Screen Studies Research Articles

Hospital at home: A systematic review of how medication management is conceptualised, described and implemented in practice-A study protocol.

Hospital at Home (H@H) is a method of healthcare delivery, where hospital level interventions are conducted in the patient's usual place of residence, offering an alternative to hospital admission. This often includes the ability to perform point of care diagnostics and treat conditions using a range of treatments traditionally associated with hospital admission, including intravenous medicines and oxygen. H@H services have been established worldwide but there is a wide variation in definition and delivery models and currently no documented evidence supporting the delivery of medicines and medicines management within the H@H model. Therefore, this study aims to 1) describe how medication management in H@H is conceptulised, 2) describe and identify key components of medication management in H@H and 3) describe and identify variability in the implementation of medication management services within H@H models. We will search a range of databases (PubMed, Medline, Embase, CINAHL), publicly accessible documents and expert recommendations. Studies, reports and policy documents published between 1st January 2000 and 31st January 2022 will be included. Two independent reviewers will 1) screen and select studies based on a priori inclusion/exclusion, 2) conduct quality assessment using the Mixed Methods Appraisal Tool on included studies and 3) extract data. Inductive thematic analysis (objectives 1 and 2), the SEIPS 2.0 model (objective 2) and the Consolidated Framework for Implementation Research (objective 3) will be used to synthesise data. This systematic review will use secondary data sources from published documents, and as such research ethical approval was not required. We will disseminate the findings of this study in a peer-reviewed journal and national/international conference(s). PROSPERO registration number: CRD42022300691. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022300691.

Queer screens with Chinese characteristics?: Reimagining queer Chinese screen studies in the twenty-first century

This introductory essay briefly reviews existing academic understandings and sociocultural imbrications of queer representations of and research on contemporary Chinese-language media and culture. We propose to conceptualize ‘queer Chinese screen studies’ as a critical field of inquiry to interrogate the limitations of identity-politics-based and media-text-focused Chinese cinema studies and queer cinema studies. We emphasize the proliferated forms and intersections of queerness, Chineseness, and screen cultures situated in specific historical, social, cultural, and industrial contexts in the twenty-first century. The seven articles included in this special issue uncover the multiple forms of presence, interconnection, and significance concerning identity-norm-contesting practices, performances, embodiments, and desires, made possible through the production, distribution, regulation, adaptation, mediation, and convergence of queer Chinese screens in the new millennium. These articles make a strong case for a queer Chinese screen studies that acknowledges the complexities and ambivalences of contemporary Chinese screen cultures as constantly oscillating between and negotiating with both queerness and normativities.

Neurocinematics and Beyond: Imagery of Contemporary Screen Culture

Th e paper focuses on the features of emotional perception of screen-displayed videos and images, when the neural response of the viewer is included into the subject fi eld of neuroaesthetics—an interdisciplinary sphere of knowledge at the intersection of art studies, philosophy, psychology of perception, and neuroscience. Th e study describes innovative methods of neuroscientifi c research for studying the reception of a “screen product.” One of such methods is determining the algorithm of evoking certain impressions in the mind of the viewer— “consumer” of the screen culture. Further ways of development of dialectical ties between neuroscience and screen studies are formulated as a research hypothesis. Practical signifi cance of the study is determining the parameters of regulatory/manipulative infl uence of the audiovisual stimuli on the viewer’s behavior in the contemporary situation when objective and subjective realities are gradually substituted by the virtual reality.

Where is Australia’s GLAAD? A case for establishing an Australian LGBTIQA+ Media Institute to improve diversity in screen media representation

As screen studies scholars have noted over the past two decades, media representation is critical in being able to see oneself as important to society. In 2016, Screen Australia released the “Seeing Ourselves: Reflections on Diversity in TV Drama” report on the diversity in Australian TV drama. “Seeing Ourselves” paints a critical picture of the lack of inclusive storytelling on Australian scripted TV, suggesting that lesbian, gay, bisexual, transgender, intersex, queer, asexual and other sexuality- and gender-diverse (LGBTIQA+) people were in fact not seeing themselves—that the representation was lacking diversity, inclusivity, authenticity and complexity. This article presents a case study of the GLAAD Media Institute and similar international organisations and imagines how a similar advisory and advocacy organisation could be established to support Australian screen practitioners and students in being more inclusive of LGBTIQA+ people in their screen stories. It highlights the necessity for, and benefit of, creating an independent organisation that could replicate GLAAD’s three pillars of training, consultation and research to improve the current lack of diversity—the ultimate goal of this organisation being to advocate for real and sustained impact, not just in Australian screen media, but in our local communities and society at large.

Co-creative practice reconciling theory and practice in tertiary student documentary production

ABSTRACT Accommodating theory and practice is a significant pedagogical challenge for screen programmes in higher education. Integrating theory and practice within the pedagogy of documentary screen production raises specific issues related to its ethical obligations and social change remit. Designing screen studies programmes that effectively support students to become critically aware and reflexive practitioners requires historical and theoretical knowledge to underpin and inform production skillsets [Wayne 2003. “Reflections on Pedagogy.” Journal of Media Practice 4 (1): 55–61; de Jong 2006. “From ‘Doing’ to ‘Knowing What You are Doing’: Kolb's Learning Theory in Teaching Documentary Practice.” Journal of Media Practice 7 (2): 151–158]. Prompted by the reaccreditation of our degree, this article critically reflects on the suite of practice and theory-based units that collectively strengthen student understanding and skillsets in factual screen storytelling. Mezirow’ three forms of reflection are framed within Kreber and Cranton’s scholarship of teaching model, to guide reflection on curriculum, pedagogy and three student documentaries as exemplars of aspirational learning outcomes. Our reflections identify how co-creative processes embedded in a spiral curriculum course structure supports opportunities for students to innovate fundamentals of praxis within a community of practice.

Neurocinematics and Beyond: Imagery of Contemporary Screen Culture

The paper focuses on the features of emotional perception ofscreen-displayed videos and images, when the neural response of the viewer is included into the subject field of neuroaesthetics—an interdisciplinary sphere of knowledge at the intersection of art studies, philosophy, psychology of perception, and neuroscience. The study describes innovative methods of neuroscientific research for studying the reception of a “screen product.” One ofsuch methods is determining the algorithm of evoking certain impressions in the mind of the viewer— “consumer” of the screen culture. Further ways of development of dialectical ties between neuroscience and screen studies are formulated as a research hypothesis. Practical significance of the study is determining the parameters of regulatory/manipulative influence of the audiovisual stimuli on the viewer’s behavior in the contemporary situation when objective and subjective realities are gradually substituted by the virtual reality

The Experiences of Intensive Care Nurses in Caring for COVID-19 Patients: A review of the literature

Objective: Intensive care nurses have a critical role in fighting COVID-19. They have been on the front lines to provide high-quality and safe patient care in these facilities. However, the covid-19 pandemic has made their work more challenging. As a result, healthcare workers' physical and mental well-being has affected their ability to offer quality care. Based on these arguments, there is a shortage of empirical research, especially in intensive care nurses’ experiences caring for COVID-19 patients. However, further investigation is needed better to understand these concerns from the nurses’ perspective. Objective: To comprehensively review, describe, and explore the experiences and perceptions of nurses working in an ICU during the COVID-19 global pandemic and their assessments of how these experiences have impacted their personal and professional lives. Material and Methods: The following seven electronic databases were searched systematically to gain relevant studies: CINAHL, EMBASE, PsycINFO, MEDLINE, PubMed, the Cochrane Library and Web of Science. The literature review was the methodology guide for this study. This review used the PICOS (population, intervention, outcomes, and study design) model to formulate research questions and a PRISMA flow diagram to screen and select relevant studies. Eligible studies are written in the English language and are peer-reviewed. The methodological quality was assessed using the Joanna Briggs Institute (JBI) critical appraisal checklist for qualitative studies, while the Mixed Methods Appraisal Tool (MMAT) was used to evaluate mixed methods designs. The narrative synthesis techniques were used to present the findings. Results: A total of 693 records have been screened, and only eight studies were finally included: six studies used qualitative approaches while two used mixed methods design approach. The eight studies were undertaken in SEVEN different geographic areas (Hong Kong, Iraqi Kurdistan, Singapore, Qatar, Australia, USA, Sweden). The eight studies recruited 420 registered nurses, of whom 67% were male (281) and 33% were female (139) aged between 20 to 60 years, and the mean of their experience was eight years. The review had four different themes from the analysis. The finding of the eight included studies related to the RN's experiences, which include psychological distress (depression, anxiety, post-traumatic stress disorder); stressful work environment.; experiences with personal protective equipment (PPE); moral resilience, sense of pride, and commitment. Conclusion: ICU nurses may be considered a particularly vulnerable group of people. They reported increasing workloads in stressful and precarious situations and a challenge in their ability to make decisions independently. There is a need to explore additional aspects of their encounters further when caring for patients during the pandemic by going deeper into areas of their lives relevant to their experiences to understand the aspects that may not be addressed through quantitative methods.

Early interventions for post-traumatic stress following musculoskeletal trauma: protocol for a systematic review and meta-analysis

IntroductionPost-traumatic stress symptoms (PTSS) can be triggered following exposure to a traumatic event, such as violence, disasters, serious accidents and injury. Little is known about which interventions provide the greatest...

Menin inhibitors as targeted therapeutics in KMT2a rearranged infant leukemia and the identification of effective treatment combinations.

10024 Background: KMT2a rearrangements are a hallmark of infant (less than 1 year of age) leukemia and are associated with poor prognosis. Menin is a ubiquitous protein that binds to the N-terminal of the KMT2a-fusion protein to mediate the oncogenic activity of KMT2a-rearranged leukemia cells. In this study, we evaluated the effect of multiple menin inhibitors and effective drug combinations for the treatment of KMT2A-rearranged infant leukemia. Methods: FISH analysis and immunoblotting confirmed the presence of KMT2a-fusion in the primary patient samples and cell lines studied. Lymphocytes from healthy donors were used as controls. Cells were treated with various concentration of multiple menin inhibitors for 72 hours and growth inhibition was measured using alamar blue assay. Infant leukemia cells were treated with a panel of FDA-approved agents (n = 221) to identify potential synergy, additive- and antagonistic-effects with specific menin inhibitors. Therapeutic drug interaction properties were established by calculating combination indices (CI) using the Chou-Talalay method. Mode of cell death and cellular target modulations were determined by western blot analysis. The effect of targeting menin in the context of the leukemogenic bone marrow microenvironment was determined through stromal cell co-cultures. Results: A comprehensive analysis of menin inhibitors on infant leukemia cell lines and primary patient cells exhibited significant and quantitatively diverse responses in cells with distinct molecular properties. Within the panel of menin inhibitors, infant B-ALL cells were found to be more sensitive to MI-463, MI-503 and MI-136 with a mean IC50 of 5.9µM, 6.1µM and 10.2µM, respectively. On the other hand, MI-3 exhibited an IC50 of 35.6µM. The cytotoxic effect of menin inhibitors on normal lymphocytes was minimal, suggesting a favourable therapeutic window (p < 0.0001). High-throughput screening with a library of > 200 FDA-approved drugs revealed significant sensitivity of distinct infant leukemia cells to proteasome, HDAC and CDK9 inhibitors. Among these, substantial drug synergy was observed between menin and proteasome inhibitors. For example, carfilzomib synergised with menin inhibitors over a broad range of concentrations with a CI value of 0.7. Conclusions: In this study, we present and discuss the initial proof-of-concept preclinical data for the effective anti-leukemic activity of menin inhibition against KMT2A-rearranged infant leukemia cells. Furthermore, the comprehensive drug screen and drug combination studies identified a spectrum of mechanistically-validated synergies, providing usable data for the formulation of multi-agent clinical studies for this currently unmet need in pediatric oncology.

A nine‐step pathway to conduct an umbrella review of literature

A nine‐step pathway to conduct an umbrella review of literature

Effects of exercise/physical activity on fear of movement in people with spine-related pain: protocol for a systematic review and meta-analysis

IntroductionLow back pain and neck pain are leading causes of disability. Although several studies have examined the effect of exercise on fear of movement in people with spine-related pain, the...

Scotch Missed: Play for Today and Scotland

This article explores Scotland's relationship with and contribution to the Play for Today series. In order to quantify these, it proposes a working definition of ‘Scottishness’ based on representational content. This generates a body of 21 Scottish Plays for Today, which the article further breaks down into two sub-sets: seven plays produced outside Scotland and fourteen within. Noting that the externally produced plays are far better remembered and much more easily accessible than their locally produced peers, the article asks: do the external plays alone offer a reliable synecdoche for the terms of Scotland's contribution to Play for Today and the images and understandings of Scotland that Play for Today created and/or confirmed? Through extended comparative textual analysis of two externally produced plays – Just Another Saturday and The Elephants’ Graveyard – and two locally produced ones – Degree of Uncertainty and The Good Time Girls – the article demonstrates that the answer to this question is in the negative. The analyses presented here highlight the extent to which the 1970s work of writer Peter McDougall is far more formally and tonally complex than its contemporary popular and critical reputations might suggest. They also highlight the existence of an extended engagement with feminist gender politics and identities within Scottish screen fiction from an earlier date than conventionally identified within the established scholarly consensus. In these ways, the article addresses multiple aspects of Scottish screen and cultural studies’ long-term neglect of television's position and significance within modern Scottish culture and cultural history.

Advertising and the Transformation of Screen Cultures

Advertising and the Transformation of Screen Cultures

Genome-Wide Approaches to Unravel the Host Factors Involved in Chikungunya Virus Replication.

Chikungunya virus (CHIKV), the causative agent of Chikungunya fever (CHIKVF) that is often characterized by fever, headache, rash, and arthralgia, is transmitted to humans by Aedes mosquito bites. Although the mortality rate associated with CHIKV infection is not very high, CHIKVF has been confirmed in more than 40 countries, not only in tropical but also in temperate areas. Therefore, CHIKV is a growing major threat to the public health of the world. However, a specific drug is not available for CHIKV infection. As demonstrated by many studies, the processes completing the replication of CHIKV are assisted by many host factors, whereas it has become clear that the host cell possesses some factors limiting the virus replication. This evidence will provide us with an important clue for the development of pharmacological treatment against CHIKVF. In this review, we briefly summarize cellular molecules participating in the CHIKV infection, particularly focusing on introducing recent genome-wide screen studies that enabled illuminating the virus-host interactions.

Combined inhibition of HMGCoA reductase and mitochondrial complex I induces tumor regression of BRAF inhibitor-resistant melanomas

BackgroundPrimary and posttreatment resistance to BRAFV600 mutation–targeting inhibitors leads to disease relapse in a majority of melanoma patients. In many instances, this resistance is promoted by upregulation of mitochondrial oxidative phosphorylation (OxPhos) in melanoma cells. We recently showed that a novel electron transport chain (ETC) complex I inhibitor, IACS-010759 (IACS), abolished OxPhos and significantly inhibited tumor growth of high-OxPhos, BRAF inhibitor (BRAFi)–resistant human melanomas. However, the inhibition was not uniform across different high OxPhos melanomas, and combination with BRAFi did not improve efficacy.MethodsWe performed a high-throughput unbiased combinatorial drug screen of clinically relevant small molecules to identify the most potent combination agent with IACS for inhibiting the growth of high-OxPhos, BRAFi-resistant melanomas. We performed bioenergetics and carbon-13 metabolite tracing to delineate the metabolic basis of sensitization of melanomas to the combination treatment. We performed xenograft tumor growth studies and Reverse-Phase Protein Array (RPPA)–based functional proteomics analysis of tumors from mice fed with regular or high-fat diet to evaluate in vivo molecular basis of sensitization to the combination treatment.ResultsA combinatorial drug screen and subsequent validation studies identified Atorvastatin (STN), a hydroxymethylglutaryl-coenzyme A reductase inhibitor (HMGCRi), as the most potent treatment combination with IACS to inhibit in vitro cell growth and induce tumor regression or stasis of some BRAFi-resistant melanomas. Bioenergetics analysis revealed a dependence on fatty acid metabolism in melanomas that responded to the combination treatment. RPPA analysis and carbon-13 tracing analysis in these melanoma cells showed that IACS treatment decreased metabolic fuel utilization for fatty acid metabolism, but increased substrate availability for activation of the mevalonate pathway by HMGCR, creating a dependence on this pathway. Functional proteomic analysis showed that IACS treatment inhibited MAPK but activated AKT pathway. Combination treatment with STN counteracted AKT activation.ConclusionsSTN and other clinically approved HMGCRi could be promising combinatorial agents for improving the efficacy of ETC inhibitors like IACS in BRAFi-resistant melanomas.

Memory and Affective Discourses in Pepe Mujica, Lessons from the Flowerbed (Heidi Specogna, 2015) and El Pepe: A Supreme Life (Emir Kusturica, 2018)

ABSTRACT José “Pepe” Mujica has become a charismatic figure not only in Latin American politics but across the world. This article analyzes the representation of memory and affect in two recent transnational documentaries that portray Mujica’s personal and political life: Pepe Mujica, Lessons from the Flowerbed (Heidi Specogna, 2015) and El Pepe: A Supreme Life (Emir Kusturica, 2018). It explores how the films represent Mujica’s memories and past, focusing specifically on his political militance as a member of the Movimiento de Liberación Nacional-Tupamaros (MLN-Tupamaros) during the 1960s and 1970s, and his experiences as political prisoner of the military dictatorship. Drawing from memory and screen studies, this work investigates the narrative devices and cinematic strategies used to create meaning out of the past. Finally, this article outlines how Mujica’s discourses are embedded in these films to establish an affective and ethical connection between past and present that elicits a powerful emotional response.

Mitochondrial aconitase 1 regulates age-related memory impairment via autophagy/mitophagy-mediated neural plasticity in middle-aged flies.

Age‐related memory impairment (AMI) occurs in many species, including humans. The underlying mechanisms are not fully understood. In wild‐type Drosophila (w1118 ), AMI appears in the form of a decrease in learning (3‐min memory) from middle age (30 days after eclosion [DAE]). We performed in vivo, DNA microarray, and behavioral screen studies to identify genes controlling both lifespan and AMI and selected mitochondrial Acon1 (mAcon1). mAcon1 expression in the head of w1118 decreased with age. Neuronal overexpression of mAcon1 extended its lifespan and improved AMI. Neuronal or mushroom body expression of mAcon1 regulated the learning of young (10 DAE) and middle‐aged flies. Interestingly, acetyl‐CoA and citrate levels increased in the heads of middle‐aged and neuronal mAcon1 knockdown flies. Acetyl‐CoA, as a cellular energy sensor, is related to autophagy. Autophagy activity and efficacy determined by the positive and negative changes in the expression levels of Atg8a‐II and p62 were proportional to the expression level of mAcon1. Levels of the presynaptic active zone scaffold protein Bruchpilot were inversely proportional to neuronal mAcon1 levels in the whole brain. Furthermore, mAcon1 overexpression in Kenyon cells induced mitophagy labeled with mt‐Keima and improved learning ability. Both processes were blocked by pink1 knockdown. Taken together, our results imply that the regulation of learning and AMI by mAcon1 occurs via autophagy/mitophagy‐mediated neural plasticity.

“To Believe in an Image (Again)”

Abstract In screen studies and photography studies, the name of the acclaimed film theorist and critic André Bazin is frequently invoked by scholars seeking to defend the import of analogue media on ontological grounds by citing photography's privileged connection to the real. This article seeks to unsettle Bazin's reputation as the patron saint of analogue recording by exploring the ontological implications of the concept of sense in Bazin's writings on neorealism. Placing Bazin's writings into dialogue with a selection of critiques that find the digital image to be lacking in historicity, negativity, and presence, and flag its potentially authoritarian impulses, this essay seeks to reframe Bazin's ontological project as a question of cinema's sense (rather than its essence) to mobilize a different set of conclusions that may in fact prove to restore faith in the digital image and its rapport with the real. By maintaining that what is often treated as a purely technological problem also harbors aesthetics implications, this article confronts the manifest skepticism that has pervaded the discourse around the digital since the 1990s, seeking an alternative outlook in Jean-Luc Nancy's work on sense, an ontological concept that evidences the political potentials (or potential politics) of Bazin's predilection for images, which are said to ameliorate our love for reality by transmitting the excessive sense of the world in its ambiguity, creativity, and unpredictability.

Society for Cinema and Media Studies 2021 Virtual Conference

Meeting Report| September 01 2021 Society for Cinema and Media Studies 2021 Virtual Conference Society for Cinema and Media Studies 2021 Virtual Conference: March 4–6 and 17–21, 2021. Rachel Schaff Rachel Schaff Rachel Schaff is the Postdoctoral Teaching Fellow in Screen Studies at Ithaca College. Her research interests include East Central European cinema, transnational melodrama, and holocaust and genocide studies. Search for other works by this author on: This Site PubMed Google Scholar Afterimage (2021) 48 (3): 4–8. https://doi.org/10.1525/aft.2021.48.3.4 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Rachel Schaff; Society for Cinema and Media Studies 2021 Virtual Conference. Afterimage 1 September 2021; 48 (3): 4–8. doi: https://doi.org/10.1525/aft.2021.48.3.4 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAfterimage Search In mid-March 2020, as the first wave of the COVID-19 pandemic swept across the United States, the Society for Cinema and Media Studies (SCMS) informed its members that its annual conference in Denver, Colorado, was cancelled. As the uncertainties of the global pandemic continued into July, the organizing committee of the conference made the difficult decision to hold the 2021 SCMS Conference fully online. It did so, on the one hand, in response to ongoing concerns about health and safety, as well as international travel restrictions, stay-at-home orders, university spending freezes, and other constraints. On the other hand, 2021 marked the first-ever SCMS Virtual Conference, and should be viewed as a significant milestone, especially given that the Society had long resisted requests to add an online component. The following, then, is not a nostalgic lament for the embodied conferences of a pre-COVID era, or a utopian celebration of the possibilities... You do not currently have access to this content.

Identification of the functional food ingredients with antithrombotic properties via virtual screen and experimental studies

Thrombin is a key therapeutic target protein of thrombosis. To date, massive studies have focused on the exploration of antithrombotic compounds. Here we capitalize on molecular docking, molecular simulations and spectroscopic experiments for virtually screening natural products that can inhibit thrombin and elucidating their interaction mechanism. Six compounds are screened from a natural product database by a cross-analysis based on two semi-flexible molecular docking methods. We show that four compounds can effectively inhibit thrombin and Calceolarioside B is the most competitive one based on enzyme inhibition experiments. Moreover, the binding free energies of these compounds with thrombin exhibit a consistent rank trend with their enzyme inhibition assay results. In addition, the Van der Waals is the main force to drive the interaction between the ligands and the receptor, which can be deduced from the fluorescence spectral results. This work provides a new insight into the development of antithrombotic natural compounds.