Scoping Review Of Literature Research Articles

Visualization Analysis of Tau Protein in the Brain of Alzheimer's Disease: A Scoping Literature Review.

This study analyzed the current status, hotspots, and development trends of tau protein research in Alzheimer's disease (AD) and to provide a reference for future research in this field. CiteSpace software was used to scientifically measure and visualize the relevant articles in the field of tau protein in AD brain from the Web of Science Core Collection database from 1991 to 2022. A total of 568 articles were included, with an exponential growth in the number of articles published from 1991 to 2022, with an average of 17.8 articles per year. The United States is the most productive country in this field, accounting for 46.83% of the total literature. The New York State Institute for Basic Research is the most productive organization, followed by MRC Laboratory Molecular Biology in the UK. The most influential are Kings College London, University of California, San Francisco, and others. Iqbal K is the most productive author. The most productive journal is the Journal of Biological Chemistry, and the journal with the highest impact factor is Acta Neuropathologica. The journal with the highest cumulative impact factor is Nature. The research hotspots mainly focus on the formation and degradation mechanisms of tau protein paired helical filaments and abnormal phosphorylation, AD neurofibrillary tangles and degenerative changes, and model research, mainly involving tau protein abnormal phosphorylation, phosphorylation sites, dephosphorylation, aggregate helical filaments, neurofibrillary tangles mouse models. The research frontier trends mainly focus on the study of pathological changes in tau protein, intervention mechanisms, and the development and practice of clinical therapeutic drugs.

Economic Evaluations of Health Service Interventions Targeting Patients with Multimorbidities: A Scoping Literature Review.

Multimorbid patients have been growing, leading to an exponential increase in healthcare costs and patterns of resource utilization. Despite the heightened interest toward integrated care programs as a response to the complex need of multimorbid patients, economic evaluations of these programs remain scarce. This work investigated the economic evaluations of service interventions targeting multimorbid patients, to identify the characteristics of these programs and the methods applied to their evaluation. We conducted a scoping review of papers published between 2010 and 2021 on PubMed, Science Direct, EconLit and Web Of Science. The search strategy was built around three keyword blocks: service interventions, multimorbidity, economic evaluations. We selected economic evaluations of service interventions delivered through multiple care settings and targeting patients with 2+ chronic conditions. Twenty-five articles were included. Interventions were categorized as organizational-type versus patient-oriented. The selected studies often targeted patients with one chronic disease, associated with a mental disorder, like depression or anxiety. Included studies were mostly cost-utility analyses conducted with the healthcare perspective. This work confirmed that economic evaluations of service interventions for multimorbid patients are limited in number. This could suggest that decision-making regarding the delivery of healthcare services for multimorbid patients may not always be based on a solid evidence base. More economic analyses are needed to inform evidence-based coverage decision-making.

How have interventions targeting pregnant women from refugee, migrant and culturally and linguistically diverse backgrounds living in high-income countries been developed or tailored to meet community needs? A systematic scoping review of stillbirth-related literature

BackgroundPeople from migrant, refugee and culturally and linguistically diverse backgrounds experience significant disparities in pregnancy outcomes compared to the general population, including a higher risk of stillbirth. This study aimed to identify stillbirth-related programs or interventions for pregnant women from culturally and linguistically diverse backgrounds and explore how these interventions have been developed and/or tailored for culturally and linguistically diverse women.MethodsWe searched MEDLINE, CINAHL, Embase, and Scopus for articles published from inception to 12 Jan 2023. We included studies that report on the development and/or evaluation of a program or intervention to reduce the risk of stillbirth which has been specifically developed or tailored for pregnant women from culturally and linguistically diverse backgrounds living in high-income countries. Two independent reviewers conducted screening of the articles, data extraction, and quality appraisal. We first summarized the descriptive information of eligible studies using text and tables and then thematically grouped interventions based on approaches to meet community needs and synthesized data qualitatively.ResultsWe identified 1999 studies from the database search. After removing duplicates and screening for eligibility, 9 studies met our inclusion criteria and were included in the review. Studies were conducted in Australia, the UK, US and Denmark between 1986 and 2021, with multi-ethnic populations (n = 6) or specific cultural and language groups (n = 3) (e.g. Pakistani and Indian women; African American and Hispanic population groups). Approaches to tailoring included the use of interpreters and translated materials, linking women to existing community resources and networks and community outreach delivered to women outside of hospital settings. Training of staff in cultural competence and multi-component, multiagency interventions addressing the wider social determinants of health and system-based approaches to facilitate access to language services were also identified.ConclusionWhile there are currently few targeted interventions for pregnant women from migrant, refugee and culturally and linguistically diverse backgrounds, approaches to cultural tailoring identified in this review can be used as a starting point for effectiveness testing and wider application. Ongoing work is needed to continue to address significant disparities in pregnancy outcomes for minoritised community groups. Protocol registrationThe protocol for this review was registered in PROSPERO (CRD42021289321).

P-425. A Scoping Review of Data Systems for HPV Vaccination and HPV-Related Outcomes in China

Abstract Background Human papillomavirus (HPV) is a major cause of cervical cancer, the sixth most common cancer among women in China. In 2023, China launched a new government plan to facilitate the elimination of cervical, requiring reliable data systems for monitoring and evaluating progress. This study aimed to identify, understand, and summarize data systems that record HPV vaccination, cervical cancer screening, HPV infection, HPV-related cervical and non-cervical diseases, as well as sexual and life behaviors in China. Methods A scoping review of literature from PubMed and the China National Knowledge Infrastructure databases was conducted, covering publications from 2012 to 2023. Two reviewers independently reviewed articles in two rounds, and all disagreements were resolved by a third reviewer. Results From 234 studies, 146 data sources were identified, covering topics including HPV vaccination (n=2), HPV-related cervical and non-cervical diseases (n=121), cervical cancer screening and HPV infection (n=11), HPV-related knowledge, attitude, and belief (n=1), and sexual and life behaviors (n=7). The main source for HPV vaccination data is the National Immunization Program Information Management System, while HPV-related cancer data primarily come from the National Central Cancer Registry of China. Cervical screening and HPV infection data are recorded in clinical or laboratory databases, including KingMed Diagnostics Laboratory and the national “Two Cancer” Screening database. HPV knowledge, attitude and sexual behaviors are mainly collected from surveys of individuals registered in epidemiology registries. Notably, several cities, including Yinzhou, Chengdu, Suzhou, and Lecheng, have recently established population-level data systems linking vaccination, screening to cervical/other HPV outcomes; however, a national system linking HPV vaccination and cervical screening with HPV-related disease outcomes, health beliefs, and risk behaviors is lacking. Conclusion There is a clear need for comprehensive and integrated data systems in China to effectively monitor and evaluate the impact and progress of public health intervention for cervical cancer elimination. Disclosures Wei Wang, PhD, Merck: Stocks/Bonds (Public Company) Ruixuan Wang, MPP, Merck: Co-Op Ya-Ting Chen, PhD, Merck & Co., Inc: Stocks/Bonds (Private Company)

Constructing masculinity through ulwaluko : a scoping literature review

Constructing masculinity through <i>ulwaluko</i> : a scoping literature review

Synthesizing the Evidence Base to Enhance Coordination between Humanitarian Mine Action and Emergency Care for Casualties of Explosive Ordnance and Explosive Weapons: A Scoping Review.

Humanitarian mine action (HMA) stakeholders have an organized presence with well-resourced medical capability in many conflict and post-conflict settings. Humanitarian mine action has the potential to positively augment local trauma care capacity for civilian casualties of explosive ordnance (EO) and explosive weapons (EWs). Yet at present, few strategies exist for coordinated engagement between HMA and the health sector to support emergency care system strengthening to improve outcomes among EO/EW casualties. A scoping literature review was conducted to identify records that described trauma care interventions pertinent to civilian casualties of EO/EW in resource-constrained settings using structured searches of indexed databases and grey literature. A 2017 World Health Organization (WHO) review on trauma systems components in low- and middle-income countries (LMICs) was updated with additional eligible reports describing trauma care interventions in LMICs or among civilian casualties of EO/EWs after 2001. A total of 14,195 non-duplicative records were retrieved, of which 48 reports met eligibility criteria. Seventy-four reports from the 2017 WHO review and 16 reports identified from reference lists yielded 138 reports describing interventions in 47 countries. Intervention efficacy was assessed using heterogenous measures ranging from trainee satisfaction to patient outcomes; only 39 reported mortality differences. Interventions that could feasibly be supported by HMA stakeholders were synthesized into a bundle of opportunities for HMA engagement designated links in a Civilian Casualty Care Chain (C-CCC). This review identified trauma care interventions with the potential to reduce mortality and disability among civilian EO/EW casualties that could be feasibly supported by HMA stakeholders. In partnership with local and multi-lateral health authorities, HMA can leverage their medical capabilities and expertise to strengthen emergency care capacity to improve trauma outcomes in settings affected by EO/EWs.

Internet of Things Ontologies for Well-Being, Aging and Health: A Scoping Literature Review

Internet of Things Ontologies for Well-Being, Aging and Health: A Scoping Literature Review

Protective and Risk Factors for Campus Dating and Sexual Violence at Non-Traditional Academic Institutions: A Scoping Literature Review.

Despite a plethora of research examining campus dating and sexual violence (DSV) risk and protective factors, little of this research has been conducted at non-traditional institutions such as minority-serving institutions (MSIs), community colleges, or non-predominantly white institutions. A review of research on statistically significant protective and risk factors for campus perpetration or victimization at non-traditional institutions resulted in 12 articles. The inclusion criteria for the study were that the article was in English, in a peer-reviewed journal, and published between 2010 and 2021. Keyword searches identified 1,160 articles on campus DSV, which were then screened to ensure the quantitative research was conducted at a non-traditional institution. Significant perpetration and victimization factors, characteristics of the samples and institutions of these studies, and the research design were extracted. Few studies included in the review investigated DSV at MSIs, commuter campuses, or community colleges. Also, studies more commonly examined victimization, risk factors, and sexual violence, as opposed to perpetration, protective factors, or dating violence. Cross-cutting factors for both dating and sexual violence included alcohol and drug use, demographics, and prior abuse. Cross-cutting factors for both victimization and perpetration included personality characteristics, alcohol and drug use, demographics, and history of abuse. Future research should investigate DSV at non-traditional institutions to increase our understanding of risk and protective factors at these rarely studied institutions.

Pervasive Games for Sexual Health Promotion: Scoping Literature Review.

Serious games play a fundamental role in promoting safe sexual behaviors. This medium has great potential for promoting healthy behaviors that prevent potential risk factors, such as sexually transmitted infections, and promote adherence to sexual health treatments, such as antiretroviral therapy. The ubiquity of mobile devices enhances access to such tools, increasing the effectiveness of video games as agents of change. In this scoping review, we aimed to (1) identify the extent to which pervasive games have been used in the field of sexual health, (2) determine the theories used in the design and evaluation of pervasive games for sexual health, (3) identify the methods used to evaluate pervasive games for sexual health, and (4) explore the reported benefits of using pervasive games for sexual health. Following the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) methodology, we conducted a comprehensive literature search in the Web of Science, Scopus, IEEE Xplore, and ACM databases for articles published between January 1, 2000, and August 4, 2024. Included articles were published in English between 2000 and 2024 and involved the design, implementation, or evaluation of a ubiquitous video game focused on promoting safe sexual behaviors, with qualitative and/or quantitative results based on theory-based techniques and ubiquitous technologies. Review articles, conference papers, or books without available data or quantitative or qualitative results were excluded. We screened 521 of 612 articles (85.1%) after removing duplicates. After the title and abstract review, 51 (9.8%) articles were assessed for eligibility, and 30 (5.8%) articles meeting the criteria were studied and evaluated in depth. The results suggested that the use of pervasive video games has a positive impact on promoting safe sexual behaviors. This is enhanced by the effectiveness of theory-based techniques and the use of mobile technologies as developmental factors that drive the gaming experience. The results indicated that this domain is a growing field that should not be ignored. The literature showed that pervasive video games have been effective in promoting safe sexual behaviors. Substantial growth has been seen in scientific community interest in researching this domain; nevertheless, there is still much to work on. In this context, we advocate for the standardization of design, implementation, and experimentation as essential phases in creating video game experiences. These 3 fundamental aspects are critical in the development of video game-based studies to ensure the reproducibility of experiments.

Considering Sex/Gender-Based Violence as a Form of Hate: The Invisibility of Sex and Gender.

Globally, there is no shortage of examples demonstrating lethal and non-lethal violence motivated, at least in part, by a hatred of women and girls because of their sex or gender. Such violence is not a new phenomenon. Despite this, there remains little consideration of sex/gender-based violence (S/GBV) motivated by hatred in the hate/bias crime literature, including a recent comprehensive review published in this journal. Drawing from a comprehensive scoping review of international literature, this article discusses why this might be the case, identifying both the benefits and challenges of treating sex/gender-motivated violence as a form of hate. The review examined primarily legal- and case-based analyses, grey literature, and some empirically based research articles, both qualitative and quantitative, the latter of which largely had only a peripheral focus on the question posed-the consideration or recognition of sex/gender-motivated hate that leads to violence. Themes surrounding benefits and challenges of doing so were identified. Among the findings was that, while there are valid arguments for and against the inclusion of, or emphasis on, S/GBV as a form of hate, what is largely absent from the body of literature is systematic, empirically based evidence examining the validity of the arguments identified, particularly in recent years. The article concludes by highlighting four broad research and policy priorities which can further (or arguably begin) the conversation about the role of hate in S/GBV.

Decoding Monogenic Hypertension: A Review of Rare Hypertension Disorders.

Hypertension is a growing concern worldwide, with increasing prevalence rates in both children and adults. Most cases of hypertension are multifactorial, with various genetic, environmental, socioeconomic, and lifestyle influences. However, monogenic hypertension, a blanket term for a group of rare of hypertensive disorders, is caused by single-gene mutations that are typically inherited in an autosomal dominant fashion, and ultimately disrupt normal blood pressure regulation in the kidney or adrenal gland. Being able to recognize and understand the pathophysiology of these rare disorders is critical for properly diagnosing hypertension, particularly in children and young adults, as treating each form of monogenic hypertension requires specific and targeted treatment approaches. A scoping literature review was conducted on the available knowledge regarding each of the disorders currently categorized as forms of monogenic hypertension. This narrative review serves to highlight the epidemiology, pathophysiology, clinical presentation, recent case reports, and most current methods of evaluation and treatment for familial hyperaldosteronism types I-IV, Gordon Syndrome. Liddle Syndrome, syndrome of apparent mineralocorticoid excess, congenital adrenal hyperplasia, Geller syndrome, and brachydactyly type E. Recent and future advances in genetic analysis techniques will further enhance the diagnosis and early management of these disorders, preventing the consequences of uncontrolled hypertension.

The current landscape of personalised preventive approaches for non-communicable diseases: A scoping review.

Personalised prevention offers a promising tool to reduce the impact of non-communicable diseases, which represent a growing health burden worldwide. However, to support the adoption of this innovation it is needed to clarify the current state of available evidence in this area. This work aims to provide an overview of recent publications on personalised prevention for chronic conditions. A scoping review of scientific literature from Medline, Scopus, Web of Science and grey literature was conducted. Eligible articles included prospective primary studies and clinical practice directives on personalised preventive approaches for chronic diseases published between January 2017 to December 2023. The review followed Arksey-O'Malley guidelines and PRISMA-ScR checklist. We identified 121 publications including 60 primary cohort studies and 61 clinical practice directives. We extracted 249 personalised preventive approaches, 27% in primary prevention, 27% in secondary prevention, and 46% in tertiary prevention. In primary prevention, 50% of the 67 approaches were from cohort studies, mainly targeting cardiovascular diseases, and 50% from directives primarily focused on cancer. Secondary prevention included 66 approaches, 73% from directives mainly concerning breast cancer. Tertiary prevention included 116 approaches, evenly distributed among the two publication types and focusing mostly on cancer and cardiovascular diseases. Lastly, tertiary prevention is the most represented level of prevention both in primary research studies and directives (54% and 41% respectively). Our study highlights a significant focus on personalised prevention in oncology in the past few years, with numerous recently issued clinical practice directives. We identified substantial original research in personalised primary prevention of cardiovascular diseases, indicating growing interest in the field. However, the distribution of primary studies and directives across the three preventive levels anticipate challenges in generating evidence of clinical utility in primary and secondary prevention, with most approaches falling under tertiary prevention.

How Are You Doing… Really? A Review of Whole Person Health Assessments.

Frustration with the burden of proliferating measures in health care focused on diseases and care processes has added to the growing desire to measure what matters to people, including understanding how people are doing in terms of their whole health. There is no consensus in the literature on an ideal whole person health instrument for use in practice. To provide a foundation for assessing whole person health and support further instrument development, this review summarizes past work on assessing person-reported whole health, articulates conceptual domains encompassing whole health, and identifies lessons from existing instruments, including considerations for administration. A scoping literature review and instrument review were conducted. Concepts from the literature and instruments were thematically coded using a grounded theory approach. We identified four overarching categories of whole person health, consisting of nine domains: body and mind (physical well-being, mental/emotional well-being, meaning and purpose [spiritual well-being], sexual well-being), relationships (social well-being), living environment and finances (financial well-being, environmental well-being), and engagement in daily life (autonomy and functioning, activities). A tenth domain of global well-being was used for instruments that assessed well-being as a whole. In total, 281 instruments were examined; most were specific to a single domain or subdomain. Fifty instruments assessed at least three domains; only five assessed all domains identified. Two key tensions must be navigated in the development of a whole person health instrument: comprehensiveness versus brevity, and standardization versus flexibility. The array of whole person health domains identified in this review and lack of consensus on how best to measure health present an opportunity to develop a new instrument to support a shift to whole health care. In addition to better tools for assessment, a shift to whole health care will require broader system transformation in payment, care delivery, and the ecology of measurement.

Gestão do Conhecimento e o Contexto Arquivístico

Knowledge Management is a strategy for promoting the sharing of knowledge among employees in an organization. As such, archivists, as professionals in archival units or archives, as management spaces, can use it to improve their activities. This article analyzes the relationship between knowledge management and the archival context, based on scientific production in the Web of Science database. Methodologically, it is theoretical in nature, based on a scoping literature review and the PRISMA-ScR 2020 protocol, using the bibliographic survey technique in the selected database. The research is characterized as exploratory and descriptive, with a quantitative and qualitative approach, predominantly qualitative. As a result, we can infer that the study highlights the breadth of knowledge management in various contexts, demonstrating its importance in organizations and the community, especially when combined with Archivology. Despite the high scientific production of Knowledge Management in recent years, there is a low scientific production in the relationship between the areas analyzed. This study is essential to advance the understanding of this relationship between knowledge management, archives and archivists, in other words, the archival context, in terms of the benefits and implications of this management approach.

Factors influencing recurrence in clubfoot treatment with the Ponseti method in children under 5 years of age: a scoping review.

Clubfoot (CF) is one of the most common musculoskeletal congenital abnormalities. Despite having optimal methods for its treatment, factors associated with the recurrence of CF treatment continue to be a topic of interest. The aim of this study was to perform a scoping review of the existing literature on factors associated with the recurrence of CF following treatment with the Ponseti method in children under 5 years of age. A scoping literature review was conducted in March 2024 using PubMed and Embase databases, and a structured research strategy. Screening of articles was performed by independent reviewers to ensure the inclusion of all pertinent studies. Considering inclusion and exclusion criteria, a final of 18 articles were included which encompassed factors associated with the recurrence of CF after treatment with the Ponseti method. The Ponseti method has demonstrated a high success rate in achieving CF correction. Various factors come into play regarding favorable outcomes and recurrence cases. The identified factors were initial severity scores for CF, age at the beginning of treatment, correct identification of idiopathic CF and complex CF, neuromuscular imbalance, poor nutritional status, noncompliance for the brace use, and the availability of a specialized attention center that ensured proper Ponseti method application and treatment adherence. Our findings highlight the importance of identifying different factors associated with the recurrence of CF following treatment with the Ponseti method, where timely intervention could minimize the risk of recurrence and achieve favorable outcomes.

Runnability: A Scoping Review.

Running outdoors is an increasingly popular form of physical activity and has been proven to substantially reduce the risk of major chronic illnesses such as cardiovascular disease. The topic of runnability has received considerable attention but with conflicting conclusions and remaining gaps. The physical environment and its features impact running experiences. Detecting features facilitating and deterring runners is crucial to promoting this physical activity and, therefore, overall health. A scoping review of current literature was conducted to identify environmental factors conducive to running. Online databases were used to identify all articles on runnability to date; a total of one hundred and two (n = 102) papers were selected as they identified environmental correlates preferred by runners. Findings include a preference for green spaces and connecting with nature, perceptions of higher safety away from traffic congestion and pollution, and routes with wide, smooth surfaces and high connectivity. Essentially, natural surroundings are substantially more desirable than urban settings. Studies have shown that even when a running route is within an urban environment, it is usually connected to or between green spaces.

Therapeutic Management in Elderly Male Breast Cancer Patients: A Scoping Review.

Male breast cancer (MBC) is a rare entity which often arises in elderly people. Aim of this review is to evaluate the principal issues related to MBC in elderly, because the therapeutic management of disease is not only related to the biological behavior of the tumor, but also to the comorbidities and frailty of older population. A scoping literature review was performed on Pubmed and Cochrane Database using the following keywords: therapeutic management/ male/ breast cancer/ elderly patients. Papers published before 2000, not edited in English or French language, or not related to the main topic, were excluded. Only articles related to therapeutic issues in MBC and including more than 10 elderly (≥ 65 years) patients were selected for the qualitative outcome analysis. 36 papers regarding surgery, radiotherapy, systemic therapy, racial disparities and therapeutic management in retrospective series of MBC in elderly were examined in details. MBC has a different biological behavior and a poorer prognosis than female, especially in cases with positive nodes at diagnosis. ElderlyMBC patientshave often larger tumors in more advanced stages at the time of diagnosis compared with youngerpatients. In spite of the advanced tumors at presentation, older patients present often cancers with more favorable biological characteristics, but they receive less guideline-concordant curative treatments (as adequate lymph node staging or adjuvant radiation therapy) compared to women. Moreover, racial differences in treatment of older MBC were observed. Therapeutic management of MBC in elderly patients is a subject rarely addressed in literature. Our review highlighted differences in the treatment and in guidelines-concordance for elderly MBC patients. Adequate geriatric assessment and use of therapeutic schemes adapted to age and comorbidities can avoid under/overtreatment, contributing to a better standard of care in this frail population.

Pain Catastrophizing and Substance Misuse: A Scoping Review of the Literature.

Pain catastrophizing, or the interpretation of pain as unbearable or intolerable, can increase pain-related anxiety and severity. High levels of pain catastrophizing have also been linked to substance use, particularly for substances with analgesic properties. Importantly, behavioral treatments can reduce pain catastrophizing, making them promising interventions for mitigating pain-related substance use. The aim of this scoping review is to summarize literature investigating the relationship between pain catastrophizing and substance use in adults. We performed a scoping review of peer-reviewed literature. Included articles had both a measurement of pain catastrophizing and substance use, and reported analyses characterizing the relationship between the two. Of the 341 abstracts identified, 47 articles met eligibility criteria. Most studies focused on people with chronic pain. Some studies also considered samples with substance use disorders (with and without chronic pain) or acute pain, and general population samples. There was generally a positive association between pain catastrophizing and substance misuse; this association was consistent across multiple samples and substances. Most studies were cross-sectional, although associations were also detected in longitudinal studies. The magnitude of associations tended to be stronger for higher severity substance use and more proximal tests of association. More longitudinal and experimental studies are needed, however, to better delineate these effects. Findings indicate a consistent positive association between pain catastrophizing and substance use, highlighting the potential for interventions targeting pain catastrophizing to reduce negative substance-related consequences.

Exploring peripheral fluid biomarkers for early detection of Alzheimer's disease in Down syndrome: A literature review.

People with Down Syndrome (DS) are at high risk of developing Alzheimer's disease dementia (AD) and cerebral amyloid angiopathy, which is a critical factor contributing to dementia in sporadic AD. Predicting and monitoring the decline and onset of dementia is a diagnostic challenge and of essence in daily care and support for people with DS. In this literature scoping review, we first summarize the different blood-based biomarkers for AD in DS. Next, we describe urine-based biomarkers for AD in DS and finally, we explore various blood-based biomarkers in the general AD population. Apart from the classic amyloid beta and Tau biomarkers, we also discuss more out-of-the-box biomarkers such as neurofilament light chain, Dual-specificity tyrosine-regulated kinase 1A, and monoaminergic biomarkers. These potential biomarkers could be a valuable addition to the established panel of fluid biomarkers.

A scoping literature review on influencing factors in live-streaming spectatorship experience

Live-streaming is a popular phenomenon. It attracts both content creators and spectators, visible in new live-streaming platforms appearing and existing social platforms adding live-streaming features. The relevant body of games and human–computer interaction oriented literature has grown considerably. However, the research is highly diverse and multidisciplinary, and reviews on live-streaming research are missing. In this article, we explore the current research on influencing factors in live-streaming, to identify the state of the field and inform future research. A scoping review was conducted to map the currently researched topics and factors, to find emerging or understudied topics, and to analyze the state of multidisciplinary and multicultural cooperation. Two iterations of a literature search and a citation-based literature mapping were used to collect 348 peer-reviewed entries. Identified and classified themes were analyzed along with visualizations of the local citation network, concept co-occurrence, and an inter-country citation graph. As a result, the main actors, genres, and issues in live-streaming, the frequency with which they are researched, and their trends over time were identified and described. Games and esports dominate research; topics recently gaining interest are e-commerce, mental health, collaboration and teaching using streams, and promoting tourism using streams. The body of literature is well connected; scientific disciplines and research groups seem to be aware of each other. For future research, we recommend exploring non-gaming genres and hybrid events and pursuing interdisciplinary collaboration.