The objective of the present study was to compare the physical and psychological health of three groups of African Americans (N = 310): acute sulfuric acid exposed, nonacute exposed, and unexposed controls. Instruments included a health questionnaire, a Toxic Symptom Checklist, the Profile of Mood States (POMS), the Post-Traumatic Stress and the Neurotoxic Anxiety scales of the MMPI-2, the Impact of Event Scale, the Symptom Check List 90-Revised (SCL 90-R), and several brief mood and personality scales. Blood pressure and pulse rates were also taken. Matching produced 51 three-way pairs. MANOVA results indicate significant effects for exposure. Significant univariate Fs (p < .05) were foundfor all the scales across the exposed groups exceptfor the Toxic Symptom category of memory/concentration, POMS depression, and 5 of the 9 SCL 90-R subscales. The t-test results using adjusted a = .0167 indicate both exposed groups had more mood and health symptoms than the controls. The acute were the most symptomatic, and both exposed groups had more respiratory problems, skin rashes, and allergies; results that are consistent with chemical exposure. Results also indicate all three groups had higher than average blood pressure, and the SCL 90-R scores for all three groups were higher than reported in the manual.