Relevance. This article is based on the meanings that reveal the problem of increasing the effectiveness of the mechanism for regulating national interests. The main factors of this plan affecting the functionality of the mechanism are considered. In particular, the relevant conditions are investigated, criteria are named, among which the main attention is paid to achieving the goals of the mechanism under study, overcoming the obstacles that arise in this case, as well as some other ways (methods) of its optimization. Scientific judgments, results and conclusions are supported by an analysis of regulatory legal acts.Purpose. To investigate the factors influencing the effectiveness of the mechanism of realization of national interests: conditions, criteria, requirements and others.Objectives: to study, in particular, the conditions, criteria, goals of the mechanism for the realization of national interests, as well as to identify the circumstances that hinder its effectiveness.Methodology. The methodological basis of the research includes general scientific techniques and methods of scientific cognition, as well as special and private scientific methods - formal legal and interpretative.Results. Based on the analysis of scientific, regulatory and legal sources and legal practice, the factors (including requirements) of the effectiveness of the mechanism for the implementation of national interests have been established and systematized, including: economic and resource feasibility; balance of the legal framework; clarity, utmost simplicity and intelligibility of legal constructions and formulations, ensuring in practice their uniform interpretation and subsequent application by authorized entities; social validity and others.Conclusion. The factors of effectiveness of the legal security mechanism in the sphere of realization of national interests are: creation of necessary conditions, including control over its functioning, identification of shortcomings of legal consolidation, reasons for its inefficiency, updating of the regulatory framework in accordance with changing circumstances and existing public needs, elimination of emerging obstacles to the realization of national interests.