Scientific Exploration Research Articles

Mediation models of the interaction between Internet gaming disorder and psychological pain and symptoms of anxiety, depression, and borderline personality disorder

Introduction: The prevalence of Internet gaming disorder (IGD) ranges from approximately 2% to 27.5% in the world population and 5.5% in the Polish population. Research findings indicate that IGD may be associated with depression, ADHD, anxiety, autism spectrum, and aggressive behaviours. However, there is a lack of research on the relationship between IGD and borderline personality disorder and psychological pain (psychache). The aim of this study is to examine the relationships between IGD and symptoms of anxiety, depression, psychological pain, borderline personality disorder and determining the role of psychological pain as a mediator of the above-mentioned links.; Methods: A sample of Polish gamers (n=201) was assessed using clinical scales (HADS, IGD-20, BPD Checklist) to evaluate the severity of depression, anxiety, IGD, and borderline personality symptoms. Additionally, the psychological pain scale was administered to assess relationship with IGD via mediation models. Results: Regression analysis in a mediation model revealed that IGD significantly predicted anxiety and depression, while borderline personality disorder was a significant predictor of IGD. Moreover, a bidirectional relationship between IGD and psychological pain had been demonstrated–IGD was a significant predictor of psychological pain and vice versa. Psychological pain also mediated the relationship between IGD and anxiety and depression, as well as the relationship between borderline personality symptoms and IGD. Conclusions: In the diagnostic and therapeutic process of people suffering from IGD, the co-occurrence of IGD with psychological pain, depression, anxiety and borderline personality disorder should be considered. Further scientific exploration is required to assess the associations between IGD and clinical variables and psychological pain.

Balanced approach to correcting distal bite in children: the role of chewing-mimic therapy

Annotation. This scientific research focuses on analyzing a balanced approach to correcting distal bite in children and determining the significance of chewing-mimic therapy in this context. The article thoroughly examines key aspects related to distal bite issues and proposes effective correction strategies to achieve optimal results. The authors emphasize the importance of a comprehensive treatment approach, with chewing-mimic therapy playing a pivotal role. The research results illustrate the success of employing this method in improving the condition of patients with a distal bite, underscoring the relevance of implementing such an approach in the clinical practice of dentists and orthodontists. This not only enhances treatment outcomes but also ensures the optimal development of the dental and jaw system in children, particularly crucial in the early stages of growth and development. The analysis conducted in this article not only unveils key aspects of a balanced approach to correcting distal bite in children and the role of chewing-mimic therapy but also has the potential to chart new paths for the development of modern treatment methods in dentistry and orthodontics. The obtained results are valuable for professionals in the field, aiding them in a deeper understanding of the mechanisms involved in treating distal bite and optimizing outcomes. The coverage of this topic in the literature indicates the relevance and importance of studying this aspect in pediatric dentistry, as accurately identified and effectively applied methods can have a far-reaching impact on the oral health of children. Further scientific research and exploration of this topic in the literature can contribute to refining treatment methodologies by incorporating new knowledge and innovations. It is crucial to note that this work can serve as a foundation for future scientific research and articles, expanding our understanding of effective methods for correcting distal bite and their influence on the dental and jaw system’s health in childhood.

Beyond 4 × 4: Paramotoring a novel approach to accelerate plant exploration in challenging environments

Societal Impact StatementAddressing the burning environmental crisis, we explore how the ‘extreme sport’ of paramotoring can enhance and accelerate scientific exploration with minimal environmental impact compared to off‐road vehicles. Our study demonstrates the scientific potential of paramotoring to access fragile desert ecosystems and investigate unrecorded habitats and species. Comparisons with 4 × 4s showed significant reductions in CO2‐eq emissions for longer missions and ninefold faster travel times. Unlike off‐road vehicles, which can damage the equivalent of over one football pitch in area per linear kilometre driven, paramotors cause minimal damage. Integrating extreme sports and science can accelerate data and specimen collection for more effective habitat conservation. This has the potential to spark discoveries and engagement across diverse communities.Summary In the face of an urgent climate and environmental crisis, we explore the potential of paramotoring to expand scientific reach and collection capability without the environmental harm associated with off‐road vehicles. In Peru's fog oasis desert, we brought together paramotor experts and scientists to conduct missions involving monitoring, plant sampling, surveying, sensor placement and transportation. We compared the environmental impact and time taken by paramotoring with surveys conducted using off‐road vehicles and walking. Shorter paramotor missions showed small differences in CO2 equivalents and time efficiency compared to off‐road vehicles. However, longer missions (28 km from base camp) revealed up to nine times faster travel and two thirds less CO2 equivalent emissions. Notably, off‐road vehicles left a substantial environmental footprint (700 to 8000 m2 per km), whilst paramotors had a minimal impact, with a tiny surface ‘footprint’ of just a few square metres, representing orders of magnitude (1000 to 10,000) less environmental impact. With basic training in identification and sampling, paramotorists collected plant specimens that are invaluable for ongoing and future scientific study. Whilst logistical and safety challenges in transporting scientists via paramotors need further investigation, the benefits, especially compared to surface travel, are evident. Integrating extreme sports into scientific endeavour promises wider and more comprehensive exploration, new discoveries and increased engagement across diverse communities—and in summary—offers significant potential to address urgent environmental challenges.

Monitoring JUICE deployment operations with high-accuracy accelerometer data

The Jupiter Icy Moons Explorer (JUICE) mission is a cornerstone of ESA's Cosmic Vision 2015–2025 program devoted to the scientific exploration of Jupiter and its icy moons. Launched on April 14, 2023, from French Guiana, JUICE will perform multiple gravity assists, including an unprecedented lunar-Earth double gravity assist, in order to shape its trajectory to Jupiter, where it will arrive in July 2031. Thanks to a suite of 10 scientific instruments, JUICE will carry out a comprehensive investigation of the jovian system, with special focus on Ganymede. Among these experiments is the Gravity and Geophysics of Jupiter and the Galilean Moons (3GM) radio science and planetary geodesy experiment, supported by the onboard High Accuracy Accelerometer (HAA). The HAA, a three-axis spring mass accelerometer, measures the non-gravitational perturbations acting on the spacecraft, that need to be measured in order to fully exploit the highly accurate range and range rate measurements of 3GM. This paper analyzes the HAA data collected in the very early phase of the mission, to monitor the initial deployment of the spacecraft's moving appendages. The vibration modes of the magnetometer boom and solar arrays were clearly detected during the appendages' deployment, as well as the latching of the Langmuir probe hinges. The detected resonance frequencies of the first and second magnetometer boom bending modes are equal to 0.44 and 0.46 Hz, respectively. The HAA data contributed to identifying the root-cause of the anomalous Radar for Icy Moon Exploration (RIME) antenna deployment. The strong external perturbations due to the actuators' activation have been used to characterize the spacecraft tranquillization time. Despite the significant increase in the spacecraft noise floor during deployment events, the full sensitivity of the instrument was regained within 10 min. This information can be used to plan the spacecraft operations during the scientific phase of the mission.

A thermophysical mechanism exploration of the brain: Motor cortex modeling with canonical ensemble theory

The brain, recognized as one of the most intricate systems globally, has been a focal point for scientific exploration. Researchers have made efforts to construct models of the brain based on neural dynamics and complex networks to gain insights into its workings. It is crucial to investigate the brain's working principles from various perspectives. This study presents a novel thermophysical model of the motor cortex and examines its potential thermodynamic properties. Utilizing canonical ensemble theory, we constructed the thermophysical model using spike and local field potential (LFP) signals obtained from intracortical brain-machine-interfaces (iBMIs) in two monkeys. The parameters derived from this model—namely internal energy, free energy, and entropy—were employed to assess the thermodynamic properties and observe alterations in these properties during reaching and grasping movements. Furthermore, this proposed model was applied to movement pattern decoding, highlighting its potential in neural decoding tasks. In both LFP- and spike-based thermodynamic models, there was an increase in internal energy and free energy, coupled with a decrease in entropy when the motor cortex was activated across various movement tasks. This suggests that the neural system adheres to the principles of a thermophysical system. Notably, the thermodynamic features demonstrated superior performance in decoding movement intentions compared to traditional LFP and spike features. This study represents the first construction of a comprehensive thermodynamic model of the motor cortex based on LFP and spike signals. The model exhibits remarkable stationarity and holds promise for long-term and stable evaluations of motor cortex functions.

Research constituent, intellectual structure and current trends in environmental sustainability-an analytical retrospective

Climate change is a paramount problem for humanity, representing a substantial danger to all living organisms. Industrialization, a vital factor for economic progress, has resulted in global warming, posing a threat to the long-term viability of our ecosystem. Currently, a wide range of techniques and technologies are being used to guarantee the preservation of the environment for future generations. This study employed data from the Scopus database to do topic modeling. Authors used latent Dirichlet allocation to extract research themes related to environmental sustainability from a corpus of 4023 research articles published between 1976 and 2022. By utilizing clustering methodologies to analyze the collection of words, Authors successfully forecasted two, five, and ten study subjects, emphasizing specific domains that necessitate additional investigation by scholars. Based on coherence ratings, five subjects have been identified as prospective study areas requiring further scientific exploration. The results of our research emphasize the significance of incorporating environmentally-friendly technologies in different industries to promote a long-lasting and eco-friendly ecosystem. In addition, authors recommend prioritizing implementing sustainable and environmentally friendly technologies, improving the management of ecosystems, encouraging water conservation, promoting agricultural advancements, and advancing renewable energy resources as crucial strategies for protecting the environment and enhancing ecological conditions. This analysis illuminates current research trends in environmental sustainability and potential pathways for future investigation and intervention.

Interstellar computation their challenges and approaches in interplanetary cloud systems and data transmission

With the advancement of human civilisation beyond the confines of Earth's atmosphere, there has been an increasing need for efficient data processing and transmission in extraterrestrial environments. The article explores innovative strategies for resolving intricate computational challenges encountered in the context of interplanetary distances. The purpose of this study is to investigate the impact of issues such as latency, data corruption, and power consumption on classical computing paradigms in space. We examine the concept of "interplanetary cloud systems", which use distributed computation and data storage to tackle these issues. The article also covers advanced techniques for sending data, including communication systems using quantum entanglement and deep space networks. The article integrates the disciplines of astronomy, computer science, and space exploration to provide a holistic perspective on the issue. It is crucial to emphasise that the implementation of fault-tolerant systems, adaptive algorithms, and robust networking protocols is essential for the success of extrasolar computing programs. The article thoroughly explores the potential and risks that arise when space travel, astronomy, and computer science intersect. We explore the potential future of interplanetary data processing and communication technologies via the examination of fault tolerance, adaptive algorithms, and resilient networking. The importance of resolving computational issues in space increases as humanity extends its presence in the cosmos. The study results have significant ramifications for the development of forthcoming technology enabling interplanetary data transfer, hence facilitating human colonisation and scientific exploration beyond Earth.

Unlocking the hidden dimension: power of chirality in scientific exploration.

In the boundless landscape of scientific exploration, there exists a hidden, yet easily accessible, dimension that has often not only intrigued and puzzled researchers but also provided the key. This dimension is chirality, the property that describes the handedness of objects. The influence of chirality extends across diverse fields of study from the parity violation in electroweak interactions to the extremely large macroscopic systems such as galaxies. In this opinion piece, we will delve into the power of chirality in scientific exploration by examining some examples that, at different scales, demonstrate its role as a key to a better understanding of our world. Our goal is to incite researchers from all fields to seek, implement and utilize chirality in their research. Going this extra mile might be more rewarding than it seems at first glance, in particular with regard to the increasing demand for new functional materials in response to the contemporary scientific and technological challenges we are facing. This article is part of the theme issue 'Celebrating the 15th anniversary of the Royal Society Newton International Fellowship'.

Sex steroid hormone residues in milk and their potential risks for breast and prostate cancer.

Milk was a source of important nutrients for humans and was especially important for children and adolescents. The modern dairy animal production pattern had contributed to residual sex steroid hormones in milk. When this milk was consumed by humans, these hormones entered the body leading to hormonal disruptions and potentially increasing the risk of various types of cancers. This article reviewed the presence of residual sex steroid hormones in milk, their potential risks on human health, and their possible association with the incidence of breast and prostate cancer. The potential linkage between dairy consumption and these cancers were described in detail. The hormones present in dairy products could affect the development and progression of these types of cancer. Sex steroid hormones could interact with different signaling pathways, influencing carcinogenic cascades that could eventually lead to tumorigenesis. Given these potential health risks, the article suggested appropriate consumption of dairy products. This included being mindful not just of the amount of dairy consumed, but also the types of dairy products selected. More scientific exploration was needed, but this review provided valuable insights for health-conscious consumers and contributed to the ongoing discussion on dietary guidelines and human health.

Scientific exploration and hypotheses concerning the meridian system in traditional Chinese medicine

The meridian theory is an important component of traditional Chinese medicine, playing a crucial role in disease diagnosis, treatment, and health preservation. Serving as the media for the effects of acupuncture, moxibustion, herbal medicine, and acupressure massage, meridians exert undeniable impact on the human body. However, the essence of meridians remains a topic of debate. Recent research has primarily focused on their anatomical structures, leading to numerous hypotheses. Simultaneously, other researchers have approached this subject from an energetic perspective, discovering information interactions within the meridian system. These findings suggest that meridians possess both physical and information dimensions, indicating that a singular approach to their study is insufficient. To bridge this gap, a shift from purely structural research toward an exploration of the information aspects of meridians is necessary. By integrating this information approach with traditional meridian theory, it may be possible to develop a new, modernized meridian theory that is aligned with contemporary concepts, making it more accessible and applicable in clinical settings.

Extraction and characterization of novel alternative cellulosic fiber for sustainable textiles from Aloe barbadensis Miller stems (agricultural waste)

Novel research has been conducted on Aloe vera, focusing on stems fiber (agricultural waste), for the extraction of cellulosic fiber, an area lacking prior scientific exploration. This fiber is being reported for the first time in the scientific community. Aloe barbadensis Miller variety was subjected to various cultivation methods, including the application of inorganic and organic fertilizers, along with the removal of lower leaves to promote stem growth. Stem fibers were extracted using the water retting method and subsequently analyzed. The moisture content was 55.35 % and 6.99 % ash content in the fibers. The bacteriostatic analysis of Aloe vera fibers was assessed against four bacterial strains, with both ethanol and water extracts showing varying degrees of inhibition zones. The UV–Visible spectrum exhibited a distinct λmax at 247 nm in ethanol, while FT-IR analysis provided characteristic peaks at 3759, 1590, 1750, 1663, 1250, 564, SEM images displayed the smooth surface morphology of the fibers, and X-ray diffraction analysis indicated a high degree of crystallinity (78.67 %), suggesting a well-structured and crystalline nature. Energy dispersive X-ray (EDX) analysis was conducted to determine the elemental composition of the fibers, revealing the presence of carbon, oxygen, calcium, and copper, with carbon being the predominant element in cellulose. These results showed promising properties suggesting potential applications in textile industry as an alternative sustainable natural cellulosic fiber.

Laser wireless power transfer system design for lunar rover

In order to address the future power generation needs for scientific exploration of the lunar permanently shadowed regions, this paper proposes a laser wireless power transfer (LWPT) system from a power source at the illuminated rim of the crater to a photovoltaic laser receiver on a rover exploring inside the permanently shadowed region. To fill a gap between the conceptual design and an operational system, the required conditions were analyzed regarding the effects of beam alignment and shaping, wavelength-dependent conversion efficiency on the system level efficiency, and a ground-based prototype system was established. Electric–electric efficiency of 11.55% was measured at a ground transmission distance of 10 m. The study is complemented by discussing optimization analysis for subsequent research, can be more effective and employed in the future.

Nanotechnology-Enabled PCR with Tunable Energy Dynamics.

This Perspective elucidates the transformative impacts of advanced nanotechnology and dynamic energy systems on the polymer chain reaction (PCR), a cornerstone technique in biomedical research and diagnostic applications. Since its invention, the optimization of PCR-specifically its efficiency, specificity, cycling rate, and detection sensitivity-has been a focal point of scientific exploration. Our analysis spans the modulation of PCR from both material and energetic perspectives, emphasizing the intricate interplay between PCR components and externally added entities such as molecules, nanoparticles (NPs), and optical microcavities. We begin with a foundational overview of PCR, detailing the basic principles of PCR modulation through molecular additives to highlight material-level interactions. Then, we delve into how NPs, with their diverse material and surface properties, influence PCR through interface interactions and hydrothermal conduction, drawing parallels to molecular behaviors. Additionally, this Perspective ventures into the energetic regulation of PCR, examining the roles of electromagnetic radiation and optical resonators. We underscore the advanced capabilities of optical technologies in PCR regulation, characterized by their ultrafast, residue-free, and noninvasive nature, alongside label-free detection methods. Notably, optical resonators present a pioneering approach to control PCR processes even in the absence of light, targeting the often-overlooked water component in PCR. By integrating discussions on photocaging and vibrational strong coupling, this review presents innovative methods for the precise regulation of PCR processes, envisioning a new era of PCR technology that enhances both research and clinical diagnostics. The synergy between nanotechnological enhancements and energy dynamics not only enriches our understanding of PCR but also opens new avenues for developing rapid, accurate, and efficient PCR systems. We hope that this Perspective will inspire further innovations in PCR technology and guide the development of next-generation clinical detection instruments.

An appraisal of the Zulu antidiabetic medicinal plants

Diabetes mellitus is a chronic metabolic disorder that affects millions of people worldwide. Its conventional management involves diet modification, exercise, and majorly the use of synthetic drugs, which may be ineffective, have adverse effects, and of relatively expensive costs. To mitigate the downsides of the available treatments, alternative therapies from medicinal plants are commonly sought by different ethnic groups including the Zulus. This paper appraised the antidiabetic plants used by the Zulus, their local and botanical names, the parts commonly used, isolated bioactive principles and their reported mechanisms of action. 38 plants covering 20 families were identified with Asteraceae accounting for 31.57 % and the leaves was the most used plant part (50 %). Out of the 38 plants identified, 28 have been scientifically validated using in vitro/in vivo models but identifying the plant with the most potent hypoglycemic activity remains challenging due to variations in biological activities. Important antidiabetic agents such as quercetin, squalene, kaempferol, isomukaadial acetate, phytol, sitosterol, apigenin, catechin and their derivates have been isolated and characterized from the verified plants though, more scientific exploration is required to develop these principles into valuable antidiabetic medications with establish mechanism of action. Scientists therefore needs to beam their searchlight and dedicate resources to the rich botanicals of the Zulu land with the view to providing indigenous solutions that can be incorporated into modern medicine for diabetes management.

Snapshot on 3D printing with alternative binders and materials: Earth, geopolymers, gypsum and low carbon concrete

The rapid development of 3D concrete printing now offers mechanical efficiency and freedom to push the limits of construction design. The digital manufacturing process holds potential for reducing carbon footprints through design optimization. Printable concrete, which is a mix of cement (based on ordinary Portland cement), aggregates, and admixtures, is attractive due to widespread and cost-effective constituents. However, many common formulations omit gravel, requiring higher cement paste volumes and inducing significant embodied carbon. Assessing the potential of low-carbon cements like Limestone Calcined Clay Cement (LC3), calcium aluminate cement (CAC), or magnesium-based cement for 3D printing is a current challenge that can address this issue. Tailoring these construction materials to printing applications and environmental needs now drives scientific exploration. This paper comprehensively reviews alternative materials and binders such as earthen materials, geopolymers, low carbon binders or gypsum-based materials, addressing fresh and hardened properties, developed digital processes, targeted applications, and discussing advantages and drawbacks of each alternative.

Decoding China's urban agglomerations policies: A scientific evaluation and exploration of economic benefits

Urban agglomerations planning policies are a critical driver for sustainable urban development. The Chinese central and local governments have implemented a series of policies to guide the development of urban agglomerations. However, the scientific soundness of these policies and their impact on promoting high-quality urban economic development have received limited attention. This study addresses this research gap by examining the scientific rationale of China's urban agglomerations policy formulation through the policy modeling consistency (PMC) index model. Then, it empirically assesses the economic effects of policy implementation using a difference-in-differences (DID) model based on statistical data from 182 cities spanning 2000 to 2021. The results show that: (1)while the overall level of urban agglomerations policies is excellent, there are areas for improvement, such as policy objectives, implementation, and financial support; (2) Urban agglomerations policies contribute to a 1.8% increase in high-quality economic development; (3) Mechanisms underlying policy effect include the scale effect of industrial agglomerations, the radiation effect of infrastructure construction, and the spillover benefits of advanced industrial structure. Moreover, the effects of policy vary across urban agglomerations of different scales, with larger urban agglomerations demonstrating more substantial benefits. The research outcomes provide valuable insights for policymakers in formulating scientifically and economically beneficial urban agglomerations policies.

HPTLC quantification of garcinol in three endemic Garcinia species of Assam, estimation of secondary metabolites and evaluation of in vitro antioxidant activity

AbstractGarcinol, the main polyisoprenylated benzophenone present in Garcinia species. A simple, rapid, reliable high-performance thin-layer chromatography (HPTLC) technique has been developed for simultaneous detection and quantification of garcinol in three endemic Garcinia sp. of Assam, India. While G. mangostana and G. indica have garnered extensive recognition, these lesser-known species have not received proportionate level of scientific exploration, therefore has served as the subject of investigation. Chromatographic separation was achieved using pre-coated silica gel 60 F254 plates. The optimized mobile phase (Toluene-Ethyl acetate-Formic acid, 5:4:1V/V) at 276 nm produced well-defined and sharp peaks of garcinol, maintaining a constant RF value of 0.75. The regression equation demonstrated a linear relationship with a correlation coefficient of 0.9955. The method was validated in accordance with International Conference of Harmonization guidelines (ICH), encompassing assessments for precision, accuracy, repeatability and robustness, all of which yielded low percentage of relative standard deviation values, attesting to its excellent performance. The content of garcinol found in the extracts were in the range of 0.58–0.98% w/w. In secondary metabolite analysis, significant amount of phenols (26.06 ± 1.65–57.51 ± 2.62 gallic acid equivalent mg g−1), flavonoids (11.27 ± 1.06–21.09 ± 1.34 quercetin equivalent mg g−1) and ascorbic acid (3.56 ± 0.12–3.65 ± 0.11 mg/10 g) contents were detected in the extracts. Further, the extracts exhibited good anti-radical activity, which may be attributed to the presence of important secondary metabolites. Therefore, this research establishes the three endemic Garcinia sp. as promising source of garcinol. Additionally, the developed method can be applied for routine quality control analysis of herbal formulations containing garcinol.

Botany, Traditional Use, Phytochemistry, Pharmacology and Quality Control of Taraxaci herba: Comprehensive Review.

Taraxaci herba, as a traditional Chinese medicine, is the name of the Taraxacum genus in the Asteraceae family. Documented in the Tang Herbal Medicine (Tang Dynasty, AD 657-659), its medicinal properties cover a wide range of applications such as acute mastitis, lung abscess, conjunctival congestion, sore throat, damp-heat jaundice, and vision improvement. In the Chinese Pharmacopoeia (Edition 2020), more than 40 kinds of China-patented drugs containing Taraxaci herba were recorded. This review explores the evolving scientific understanding of Taraxaci herba, covering facets of ethnopharmacology, botany, phytochemistry, pharmacology, artificial cultivation, and quality control. In particular, the chemical constituents and pharmacological research are reviewed. Taraxaci herba has been certified as a traditional medicine plant, and its flavonoids, phenolic acids, and terpenoids have been identified and separated, which include Chicoric acid, taraxasterol, Taraxasteryl acetate, Chlorogenic acid, isorhamnetin, and luteolin; they are responsible for anti-inflammatory, antioxidant, antibacterial, anti-tumor, and anti-cancer activities. These findings validate the traditional uses of Taraxaci herba and lay the groundwork for further scientific exploration. The sources used in this study include Web of Science, Pubmed, the CNKI site, classic monographs, the Chinese Pharmacopoeia, the Chinese Medicine Dictionary, and doctoral and master's theses.

Radio U-Net: a convolutional neural network to detect diffuse radio sources in galaxy clusters and beyond

ABSTRACT The forthcoming generation of radio telescope arrays promises significant advancements in sensitivity and resolution, enabling the identification and characterization of many new faint and diffuse radio sources. Conventional manual cataloguing methodologies are anticipated to be insufficient to exploit the capabilities of new radio surveys. Radio interferometric images of diffuse sources present a challenge for image segmentation tasks due to noise, artifacts, and embedded radio sources. In response to these challenges, we introduce Radio U-Net, a fully convolutional neural network based on the U-Net architecture. Radio U-Net is designed to detect faint and extended sources in radio surveys, such as radio haloes, relics, and cosmic web filaments. Radio U-Net was trained on synthetic radio observations built upon cosmological simulations and then tested on a sample of galaxy clusters, where the detection of cluster diffuse radio sources relied on customized data reduction and visual inspection of Low-Frequency Array Two metre Sky Survey (LoTSS) data. The 83 per cent of clusters exhibiting diffuse radio emission were accurately identified, and the segmentation successfully recovered the morphology of the sources even in low-quality images. In a test sample comprising 246 galaxy clusters, we achieved a 73 per cent accuracy rate in distinguishing between clusters with and without diffuse radio emission. Our results establish the applicability of Radio U-Net to extensive radio survey data sets, probing its efficiency on cutting-edge high-performance computing systems. This approach represents an advancement in optimizing the exploitation of forthcoming large radio surveys for scientific exploration.

East meets west: integrating Yin-Yang theory with immunology teaching.

This perspective article delves into a novel integration of Yin-Yang theory-an ancient Chinese philosophical cornerstone-with the sophisticated realm of immunology. Given the intricate concepts inherent in immunology, many students find it challenging to comprehend the delicate mechanisms governing immune equilibrium and regulation. Given the deep-rooted understanding of Yin-Yang theory among Chinese students, we advocate for an educational strategy that contextualizes the concept of immune equilibrium within the framework of Yin-Yang, thereby offering a more intuitive and engaging learning experience. This method not only capitalizes on the cultural significance of Yin-Yang, but also corresponds to its principles of equilibrium and harmony, thus mirroring the homeostatic essence of immune responses. This article critically assesses this technique's capacity to bolster immune comprehension amongst Chinese students, while also considering its limitations. Despite these limitations, the fusion of these seemingly divergent fields holds substantial promise for augmenting immunology education, promoting critical thinking, and advancing cross-cultural academic discourse. The amalgamation of age-old philosophical insights with modern scientific exploration prompts a reassessment of educational methodologies within immunology, underscoring a novel pedagogical approach that bridges traditional wisdom with contemporary scientific education.