Purpose: The general objective of this study was to explore the epistemological implications of radical skepticism. Methodology: The study adopted a desktop research methodology. Desk research refers to secondary data or that which can be collected without fieldwork. Desk research is basically involved in collecting data from existing resources hence it is often considered a low cost technique as compared to field research, as the main cost is involved in executive’s time, telephone charges and directories. Thus, the study relied on already published studies, reports and statistics. This secondary data was easily accessed through the online journals and library. Findings: The findings reveal that there exists a contextual and methodological gap relating to epistemological implications of radical skepticism. Preliminary empirical review revealed that the pervasive influence of skepticism on individuals' perceptions and decision-making processes, leading to feelings of anxiety and uncertainty but also empowerment and critical thinking skills. The findings emphasized the importance of promoting transparency, accountability, and public engagement in scientific discourse, as well as the need for supportive learning environments and cultural sensitivity in addressing epistemological uncertainty. Overall, the study highlighted the complex nature of skepticism and underscored the importance of interdisciplinary collaboration and ethical decision-making in navigating epistemological challenges. Unique Contribution to Theory, Practice and Policy: The Constructivism theory, Social Constructionism theory and the Pragmatism theory may be used to anchor future studies on radical skepticism. The research contributed theoretical insights into knowledge formation and psychological responses to skepticism, offering practical recommendations for educators, policymakers, and practitioners. Policy recommendations emphasized the importance of promoting transparency and accountability in governance, while practical suggestions focused on fostering critical thinking skills and media literacy among the public. The study also identified avenues for future research, encouraging interdisciplinary collaborations and comparative studies across cultural contexts. Overall, the study offered a comprehensive examination of skepticism's impact and potential strategies for mitigating its effects. Keywords: Epistemological, Implications, Radical Skepticism, Education, Media Literacy, Governance, Psychological Responses, Interdisciplinary, Comparative Studies, Transparency, Accountability
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