ABSTRACTTo identifying whether biotechnological teaching learning with Science Technology Society approach Ergonomics-Based (STMBE) could improve the learning outcome and the students’ learning achievement. Methods: This is a randomized pre-and post-test control group design and involved 16 samples from the control group and another 16 samples from the experiment group. All data obtained was then statistically analyzed by employing t group test and Mann-Whitney at 5% significant levels. Results: The results showed that the biotechnological teaching learning using STMBE approach applied to the experimental group could increase the learning outcome viewed from the facts that the musculoskeletal complaint went down by 43.68% (p<0.05), that the exhaustion decreased by 34.90% (p<0.05), that boredom dropped by 22.64% (p<0.05), and that the learning activity went up by 42.72% (p<0.05), and that the students’ achievement rose by 43.56% (p<0.05). Conclusion: It could be concluded that the biotechnological teaching learning using STMBE approach could increase the learning outcome and the students’ learning achievement.