Abstract The research was conducted on students’ low scientific literacy skills in Indonesia based on PISA, PUSMENDIK data and the lack of science, technology, engineering, and mathematics (STEM)-based teaching materials that measure students’ scientific literacy. Researcher develop teaching material in the form of interactive E-book that can be used on all devices with feasible based on scientific literacy skills on human digestive system material. The research method used is research and development (R&D) with the analysis, design, development, implementation, and evaluation (ADDIE) from Branch. Subjects in this study was 4 experts (1 expert in media, learning design, material, and linguist). The instruments used are tests that experts and non-tests have validated. Test instruments assessment was given to 4 experts (1 expert in media, learning design, material, and linguist). The results showed that resulting validation from a media expert with x̄ = 98.3%, a material expert with x̄ = 83.3%, a learning design expert with x̄ = 95.3%, and a linguist expert with x̄ = 85%, and practically x̄ = 97, then an STEM-based E-book was declared feasible, and practically.