Biotechnology constitutes one of the most challenging, cutting-edge, and rapidly growing fields in science today (U.S. Department of Labor, 2008). Its products influence our daily lives on multiple levels and often improve our quality of life. Both the practical implications and the hands-on nature of this ‘modern science’ make the topic of biotechnology an attractive addition to the high school science curriculum (France, 2007). The interdisciplinary nature of biotechnology also makes it an ideal candidate for future curricular offerings that strive to incorporate the K-12 Framework for Science Education (National Research Council [NRC], 2012) and the Next Generation Science Standards (NGSS; http://www.nextgenscience.org/). Bybee (2011) noted that the shift from inquiry methods to the use of both science and engineering practices will likely be the greatest challenges related to the NGSS, and suggested that these practices should be thought of as both instructional strategies and learning outcomes. Indeed, the NGSS performance expectations place emphasis on combining practice and content in the assessment of student learning (Bybee, 2012). Sneider (2012) suggested the use of existing learning activities as a first step in integrating technology and engineering practice into science teaching. The literature provides both a conceptual base for integrating biotechnology into curricular offerings, as well as practical examples implemented by early adopters. Wells (1994), for example, gathered biotechnology experts to compose a common taxonomic structure to guide the development of high school biotechnology curricula. Twenty panel members identified eight main areas, including topics that span both science (e.g., biochemistry, medicine, environmental science) and engineering (e.g., genetic engineering, food science, environmental safety). Similarly, an early survey of biology teachers captured recommendations for science and engineering content (the structure and function of DNA, understanding the genetic code, genetic engineering, cloning, and the biology of cancer), as well as the recommendation that this content be delivered through labs when possible (Zeller,1994). Harms (2002) noted that providing students with the opportunity to practice biotechnology provides specific examples of applied science that generalize to a differentiated understanding of concepts.