Scientific Advisory Research Articles

Professor Sir Peter Gluckman appointed Chief Science Adviser to Prime Minister

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Science advice for international governance – An evidence-based perspective on the role of SCAR in the Antarctic Treaty System

Knowledge brokers are essential for science-based international governance. Recently, the objectivity of the Antarctic Treaty System’s (ATS) primary knowledge broker, the Scientific Committee on Antarctic Research (SCAR), has been questioned, both in discussions at ATS meetings and now in a recent published perspective. Much of the concern is based on a misunderstanding of SCAR’s history, structure and internal operations, and of its interactions with the ATS, in particular at Antarctic Treaty Consultative Meetings (ATCMs). Articulation of these concerns provides a useful basis for an examination of science-based advice in an international governance system founded on peace and science. Therefore, this study provides an evidence-based assessment of SCAR’s operations and history with respect to its interactions with the Antarctic Treaty Consultative Parties (ATCPs). It shows that the dangers of lack of objectivity by SCAR, or its politicization by one or more of its Members have long been recognised by SCAR, and that SCAR has policies and procedures that are specifically designed to preclude this happening, as might be expected from a reliable international knowledge broker. Evidence-based clarification of SCAR’s interactions with the ATCPs demonstrate that no evidence exists of bias to SCAR’s advice to ATCMs throughout its history. This study therefore shows that concerns about lack of objectivity do not reflect any systematic problems within SCAR. Rather, the study shows they reflect insufficient appreciation of the way in which SCAR acts as a reliable knowledge broker in the ATS. The assessment provides a useful overview of best practice in science-based advice for international governance.

Emerging issues in fisheries science by fisheries scientists.

The current epoch in fisheries science has been driven by continual advances in laboratory techniques and increasingly sophisticated approaches to analysing datasets. We now have the scientific knowledge and tools to proactively identify obstaclesto the sustainable management of marine resources. However, in addition to technological advances, there are predicted global environmentalchanges, each with inherent implications for fisheries. The 2023 symposium of the Fisheries Society of the British Isles called for "open and constructive knowledge exchange between scientists, stakeholders, managers and policymakers" (https://fsbi.org.uk/symposium-2023/), a nexus of collaborative groups best placed to identify issues and solutions. Arguably, the Centre of Environment, Aquaculture and Fisheries Science (Cefas) and their Scientific Advice for Fisheries Management (SAFM) Team sit at the centre of such a network. SAFM regularly engages with managers and stakeholders, undertakes scientific research, provides fisheries advice to the UK government, and are leading experts within the International Council for the Exploration of the Sea (ICES). As such, this paper is an opinion piece, linked to individual authors specialisms,that aims to highlight emergingissues affecting fisheries and suggest where research efforts could be focused that contribute to sustainable fisheries.

Emerging infodemic management strategies focus on technology: They can't forget trust.

Public health authorities around the world are planning to manage infodemics as part of their next public health emergency. But the experience of managing communications for Ontario's COVID-19 Science Advisory Table suggests that emerging infodemic management (IM) strategies should include three key principles, which appear to be missing from much of the existing literature: (1) emerging IM strategies should incorporate leadership from epidemiologists who can align infodemic response with underlying disease; (2) they should embrace journalists who mediate trust in crises; and (3) they should acknowledge the unique opportunity for public health leaders to build public trust rapidly in the first days of a crisis-a foundation for all subsequent IM. Standardizing infodemic response may help accelerate interventions during a public health emergency, especially when paired with technology. But over-standardizing the human work of building trust risks losing the infodemic fight before it starts.

CD19-directed T cell-engaging antibodies for the treatment of autoimmune disease.

Jennifer S. Michaelson, Chief Scientific Officer at Cullinan Oncology, and Patrick A. Baeuerle, scientific advisor to Cullinan Oncology and honorary professor in immunology at Ludwig Maximilians University Munich, discuss the use of CD19-specific T cell-engaging antibody therapies (TCEs) as therapeutics for autoimmune diseases.

Research on proton displacement damage effects in charge-domain accumulation type TDI CMOS image sensors

TDI CMOS image sensors are the most widely used photodetectors in space earth observation and multispectral imaging. The displacement damage caused by high-energy proton irradiation in the space environment leads to the continuous degradation of TDI CMOS image sensor parameters, seriously affecting its performance, reliability, and service life. This paper focuses on a space-based TDI CMOS image sensor chip and carries out 3 MeV proton irradiation tests and post-irradiation annealing tests to obtain the change rules of optical and electrical parameters. The degradation mechanism of sensitive parameters of TDI CMOS image sensors caused by proton irradiation is analyzed, and the sensitive region of proton displacement damage are discussed. The study demonstrates that after proton irradiation, the parameters especially full well capacity and temporal dark noise of the device degrade less, with small sensitivity to proton irradiation. However, the dark current, CTE, and pixel column FPN significantly degrade, and the degree of degradation is linearly related to the proton irradiation dose. In addition, the test also obtained the short-term and long-term annealing changes of sensitive parameters after proton irradiation of TDI CMOS image sensors, providing scientific advice for TDI CMOS image sensors space proton radiation effect tests and evaluations. The research results of this paper provide important references for the evaluation of radiation effects, on-orbit performance estimation, and radiation resistance reinforcement of space-based TDI CMOS image sensors.

Differences in perceived sources of uncertainty in natural hazards science advice: lessons for cross-disciplinary communication

IntroductionWe conducted mental model interviews in Aotearoa NZ to understand perspectives of uncertainty associated with natural hazards science. Such science contains many layers of interacting uncertainties, and varied understandings about what these are and where they come from creates communication challenges, impacting the trust in, and use of, science. To improve effective communication, it is thus crucial to understand the many diverse perspectives of scientific uncertainty.MethodsParticipants included hazard scientists (n = 11, e.g., geophysical, social, and other sciences), professionals with some scientific training (n = 10, e.g., planners, policy analysts, emergency managers), and lay public participants with no advanced training in science (n = 10, e.g., journalism, history, administration, art, or other domains). We present a comparative analysis of the mental model maps produced by participants, considering individuals’ levels of training and expertise in, and experience of, science.ResultsA qualitative comparison identified increasing map organization with science literacy, suggesting greater science training in, experience with, or expertise in, science results in a more organized and structured mental model of uncertainty. There were also language differences, with lay public participants focused more on perceptions of control and safety, while scientists focused on formal models of risk and likelihood.DiscussionThese findings are presented to enhance hazard, risk, and science communication. It is important to also identify ways to understand the tacit knowledge individuals already hold which may influence their interpretation of a message. The interview methodology we present here could also be adapted to understand different perspectives in participatory and co-development research.

PFAS Contamination in Europe: Generating Knowledge and Mapping Known and Likely Contamination with "Expert-Reviewed" Journalism.

While the extent of environmental contamination by per- and polyfluoroalkyl substances (PFAS) has mobilized considerable efforts around the globe in recent years, publicly available data on PFAS in Europe were very limited. In an unprecedented experiment of "expert-reviewed journalism" involving 29 journalists and seven scientific advisers, a cross-border collaborative project, the "Forever Pollution Project" (FPP), drew on both scientific methods and investigative journalism techniques such as open-source intelligence (OSINT) and freedom of information (FOI) requests to map contamination across Europe, making public data that previously had existed as "unseen science". The FPP identified 22,934 known contamination sites, including 20 PFAS manufacturing facilities, and 21,426 "presumptive contamination sites", including 13,745 sites presumably contaminated with fluorinated aqueous film-forming foam (AFFF) discharge, 2911 industrial facilities, and 4752 sites related to PFAS-containing waste. Additionally, the FPP identified 231 "known PFAS users", a new category for sites with an intermediate level of evidence of PFAS use and considered likely to be contamination sources. However, the true extent of contamination in Europe remains significantly underestimated due to a lack of comprehensive geolocation, sampling, and publicly available data. This model of knowledge production and dissemination offers lessons for researchers, policymakers, and journalists about cross-field collaborations and data transparency.

Inteligencia Artificial - Chatgpt: un estudio bibliométrico y su aplicación en el caso de Gases de Efecto Invernadero

La aparición de la Inteligencia Artificial (IA) ha potenciado la interacción del ser humano con los sistemas informáticos, que van desde lo cotidiano hasta la investigación aplicada. ChatGPT utiliza el modelo de lenguaje Generative Pre-trained Transformer (GPT) de OpenAI, que permite realizar tareas específicas y responder preguntas. En la actualidad se viene explorando la aplicación de este modelo de lenguaje en distintas áreas de investigación tales como educación, salud, etc. Este estudio busca caracterizar la bibliometría de “ChatGPT” y analizar su posible aplicación en la revisión de literatura sobre gases de efecto invernadero. Hasta el 17 de enero de 2024, se han registrado 4 288 documentos científicos que mencionan a la IA, siendo Estados Unidos, el país con mayor aporte de documentos. Al consultar sobre ¿Cuáles son las principales aplicaciones en que ChatGPT revolucionará la búsqueda sobre gases de efecto invernadero en el mundo? Las respuestas fueron: acceso a información actualizada, análisis y modelado, divulgación científica, asesoramiento y recomendaciones; y educación y concientización. ChatGPT proporciona respuestas útiles y relevantes, sin embargo, no fundamenta sus respuestas. Por esta razón, la sustentación técnica y científica sigue siendo responsabilidad del investigador, dado que esta Inteligencia Artificial complementa el juicio humano, no la reemplaza.

Confidence in Covid-19 models

Epidemiological models of the transmission of SARS-CoV-2 played an important role in guiding the decisions of policy-makers during the pandemic. Such models provide output projections, in the form of time -series of infections, hospitalisations, and deaths, under various different parameter and scenario assumptions. In this paper I caution against handling these outputs uncritically: raw model-outputs should not be presented as direct projections in contexts where modelling results are required to support policy -decisions. I argue that model uncertainty should be handled and communicated transparently. Drawing on methods used by climate scientists in the fifth IPCC report I suggest that this can be done by: attaching confidence judgements to projections based on model results; being transparent about how multi-model ensembles are supposed to deal with such uncertainty; and using expert judgement to ‘translate’ model-outputs into projections about the actual world. In a slogan: tell me what you think (and why), not (just) what your models say. I then diffuse the worry that this approach infects model-based policy advice with some undesirably subjective elements, and explore how my discussion fares if one thinks the role of a scientific advisor is to prompt action, rather than communicate information.

Fostering scientific integrity and research ethics in a science-for-policy research organisation

The Joint Research Centre (JRC) is the European Commission’s in-house science and knowledge service, employing a substantial staff of scientists devoted to conducting research to provide independent scientific advice for EU policy. Focussed on various research areas aligned with EU priorities, the JRC excels in delivering scientific evidence for policymaking and has published numerous science-for-policy reports and scientific articles. Drawing on a scientific integrity statement, surveys among JRC’s research staff, and thematic discussions with JRC’s research leaders, the JRC has developed a comprehensive Scientific Integrity and Research Ethics (SIRE) framework, including instruments, procedures, and guidelines to ensure high standards and independence in its research. Key components of the SIRE framework include a Scientific Integrity Officer, an Editorial Review Board, a Research Ethics Board, and guidelines for responsible conduct of research. This article provides an overview of the JRC’s SIRE framework and how it was developed, emphasising the importance of maintaining independence, integrity, and ethics in scientific research that supports EU policy. The article also discusses potential gaps in the framework and where additional efforts may be needed, comparing with the recent U.S. National Science and Technology Council report on Protecting the Integrity of Government Science.

Advancing Wearable Biosensors for Congenital Heart Disease: Patient and Clinician Perspectives: A Science Advisory From the American Heart Association.

Wearable biosensors (wearables) enable continual, noninvasive physiologic and behavioral monitoring at home for those with pediatric or congenital heart disease. Wearables allow patients to access their personal data and monitor their health. Despite substantial technologic advances in recent years, issues with hardware design, data analysis, and integration into the clinical workflow prevent wearables from reaching their potential in high-risk congenital heart disease populations. This science advisory reviews the use of wearables in patients with congenital heart disease, how to improve these technologies for clinicians and patients, and ethical and regulatory considerations. Challenges related to the use of wearables are common to every clinical setting, but specific topics for consideration in congenital heart disease are highlighted.

Innovative research methodologies in the EU regulatory framework: an analysis of EMA qualification procedures from a pediatric perspective.

The European Medicines Agency (EMA) offers scientific advice to support the qualification procedure of novel methodologies, such as preclinical and in vitro models, biomarkers, and pharmacometric methods, thereby endorsing their acceptability in medicine research and development (R&D). This aspect is particularly relevant to overcome the scarcity of data and the lack of validated endpoints and biomarkers in research fields characterized by small samples, such as pediatrics. This study aimed to analyze the potential pediatric interest in methodologies qualified as "novel methodologies for medicine development" by the EMA. The positive qualification opinions of novel methodologies for medicine development published on the EMA website between 2008 and 2023 were identified. Multi-level analyses were conducted to investigate data with a hierarchical structure and the effects of cluster-level variables and cluster-level variances and to evaluate their potential pediatric interest, defined as the possibility of using the novel methodology in pediatric R&D and the availability of pediatric data. The duration of the procedure, the type of methodology, the specific disease or disease area addressed, the type of applicant, and the availability of pediatric data at the time of the opinion release were also investigated. Most of the 27 qualifications for novel methodologies issued by the EMA (70%) were potentially of interest to pediatric patients, but only six of them reported pediatric data. The overall duration of qualification procedures with pediatric interest was longer than that of procedures without any pediatric interest (median time: 7 months vs. 3.5 months, respectively; p = 0.082). In parallel, qualification procedures that included pediatric data lasted for a longer period (median time: 8 months vs. 6 months, respectively; p = 0.150). Nephrology and neurology represented the main disease areas (21% and 16%, respectively), while endpoints, biomarkers, and registries represented the main types of innovative methodologies (32%, 26%, and 16%, respectively). Our results underscore the importance of implementing innovative methodologies in regulatory-compliant pediatric research activities. Pediatric-dedicated research infrastructures providing regulatory support and strategic advice during research activities could be crucial to the design of ad hoc pediatric methodologies or to extend and validate them for pediatrics.

Stability versus flexibility in projectified science–policy context: what is the role of science advisors?

Abstract Science–policy interaction is frequently organized through projects, lauded as flexible and focused administrative solutions for policy learning. However, there is a risk of stifling projects with overly rigid interfaces or, controversially, losing project results amidst the cracks of inter- and intra-organizational cleavages when interfaces are excessively flexible. This article examines how science advisors in Estonian ministries contributed to resolving this controversy through an in-depth case study of an agenda-setting bioeconomy project. The results suggest that the potential of science advisors to provide necessary flexibility is contingent on their position relative to bureaucratic hierarchies and boundary objects.

Patient and public involvement at the German Center for Mental Health: achievements and challenges

Patient and public involvement (PPI) describes the participation of patients and relatives, i.e., experts by experience (EE), in the research process. The PPI has not been widely adopted in the fields of medicine and clinical psychology in Germany and there is anotable absence of institutional support. The German Center for Mental Health (DZPG), which has been under construction since May 2023, aims to achieve nationwide and cross-center implementation of PPI, constituting one of its primary objectives. Participation of EE is to be implemented in the DZPG at all levels of decision-making. The article describes the origins, development and challenges associated with the implementation of participation structures and projects in the DZPG. The central political PPI committee in the DZPG, the Trilogue Center Council (TZR), developed acomprehensive PPI strategy for the DZPG in almost 3 years of work, before the beginning of the financial support of the DZPG. Among various measures, the strategy entails establishing afar-reaching representation for EE in all decision-making bodies of the DZPG, to involve EE as reviewers in evaluating research proposals, to integrate participatory elements into all studies of the DZGG and to foster user-initiated research endeavors. The implementation of the strategy is ensured by across-center PPI infrastructure, the Center for PPI, and scientific PPI consultants. The Center for PPI's tasks include supporting the voice of the EE and developing instruments and guidelines for participatory research, bringing together EE and researchers for joint DZPG projects as well as the documentation and quality assurance for participatory research. One of the particular challenges for the successful implementation of the PPI strategy is the limited experience with PPI in Germany in the field of mental health research and the widespread lack of structural implementation. Currently developed solution strategies include training for researchers and EE to communicate the benefits and pathways in the realization of PPI and thus enable shared decision-making and research. In addition, extensive access to knowledge and resources for EE will be created and uniform remuneration regulations for EE will be developed. APPI strategy at the DZPG has been successfully developed and is currently being implemented by the cross-center infrastructure Center for PPI.

An Inclusive Civil Society Dialogue for Successful Implementation of the EU HTA Regulation: Call to Action to Ensure Appropriate Involvement of Stakeholders and Collaborators.

Stakeholder involvement has long been considered a success factor for a joint European health technology assessment (HTA) process, and its relevance is now anchored in the EU HTA Regulation's (EU HTAR) legislative wording. Therefore, we aimed to explore the roles, challenges, and most important activities to increase the level of involvement per stakeholder group. At the 2022 Fall Convention of the European Access Academy (EAA), working groups addressed the involvement of patients, clinicians, regulators, health technology developers (HTD), and national HTA bodies and payers within the EU HTA process. Each working group revisited the pre-convention survey results, determined key role characteristics for each stakeholder, and agreed on the most important activities to fulfill the role profile. Finally, the activities suggested per group were prioritized by plenary group. The prioritized actions for patients included training and capacity building, the establishment of a patient involvement committee, and the establishment of a patient unit at the EC secretariat. For clinicians, it included alignment on evidence assessment from a clinical vs. HTA point of view, capacity building, and standardization of processes. The most important actions for regulators are to develop joint regulatory-HTA guidance documents, align processes and interfaces under the regulation, and share discussions on post-licensing evidence generation. HTDs prioritized scientific advice capacity and the review of the scoping process, and further development of the scope of the assessment report fact checks. The top three actions for national HTA bodies and payers included clarification on the early HTD dialogue process, political support and commitment, and clarification on financial support. Addressing the activities identified as the most important for stakeholders/collaborators in the EU HTA process (e.g., in the implementation of the EU HTA Stakeholder Network and of the guidance documents developed by the EUnetHTA 21 consortium) will be key to starting an "inclusive civil society dialogue", as suggested by the European Commission's Pharmaceutical Strategy.

Crisis Leadership in the Time of Covid: Effects of Personality Traits on Response Speed

Abstract Why were some countries faster than others at introducing COVID-19 mitigation policies? Existing research shows that leaders are central to defining and making sense of crises, which then shapes their governments’ crisis response. I argue that crisis-sense-making depends on leaders’ personality traits pertaining to how they perceive their power status, collect and process information, and interact with their environment, subsequently influencing their governments’ crisis response speed. I test this argument in the context of the European experience with COVID-19, combining an original Leadership Traits Analysis dataset of thirty-two leaders with the Oxford COVID-19 Government Response Tracker data. I show that leaders who were highly self-confident or exhibited a tendency to challenge constraints were significantly slower at introducing pandemic mitigation policies. Leaders who were open to information were significantly faster to do so. I also show that policy emulation between countries over time dissipated the slowing effects of the leaders’ need for power and conceptual complexity on response speed. The results present new and systematic evidence on how leader personality shaped pandemic policy-making, contributing to the literature on crisis policy-making and political leadership. They also offer science advisors food for thought on how to communicate with leaders.

"Follow the Science" in COVID-19 Policy: A Scoping Review.

"Follow the science" was commonly repeated during debates on COVID-19-related policy. The phrase "follow the science" raises questions that are central to our theories of knowledge and the application of scientific knowledge to maximize the wellbeing of our society. The purpose of this study was to (1) perform a scoping review of literature discussing "follow the science" and COVID-19, and (2) consider "follow the science" in the context of pediatric health. A comprehensive search of 14 databases was performed on May 23, 2023. Articles were included if they used terms such as "follow the science", "follow the scientists", "listen to science" or "listen to scientists", and discussed COVID-19. There were 24 articles included in the final review. Existing literature on "follow the science" (1) differentiates between scientific knowledge and policy decisions; (2) emphasizes the importance of social sciences in policy making; (3) calls for more transparency in the knowledge synthesis and policy generating process; and (4) finds that scientific advisors see their role as advising on science rather than policy decision making. There was no definitional, epistemological, or philosophical intellectual defense of "follow the science" in the peer reviewed literature. Policy requires (1) reliable data and (2) agreement on what to do considering those empirical facts by appealing to values, ethics, morality, and law. A review of school shutdowns is used as an example of the inadequacy of "follow the science" as a guiding principle for public policy.

Science Advisory to Governments and Regional/Sub-Regional Organizations in West and Central Africa

Science advice to governments and regional and sub-regional organizations in West and Central Africa has been reviewed. The objectives were to analyze its evolution and characterize the sources of advice. During the colonial period, it was by the colonial administrations and for their needs. At independence, in general, the new nations (particularly French speaking) entered into agreements with the former colonial powers to develop science, technology and innovation capacity for sustainable development. English speaking nations sought more partners outside the colonial experience. Colonial research institutes were increasingly transformed into national research institutes/institutions with national development mandates. Governments increasingly turned to science advice from consultants, inter- ministerial committees, advisory bodies, ad hoc experts’ groups, or a combination of these. Regional/sub-regional organizations sought advice from consultants, ad hoc technical experts’ groups, advisory bodies or a combination of these. Increasingly, science advice is delivered by Africans. Science advice by science academies is most rigorous. The arrival of more science academies, with varying links with governments, indicates that evidence-based science advice is growing in the region.

Benefits and barriers for researcher-practitioner collaboration on marine and coastal management issues

The complex management problems facing marine and coastal systems require diverse, multidisciplinary perspectives to inform more holistic, sustainable management. Collaboration between researchers and practitioners is needed to maximise the utility of research to management and ensure management is informed by the best available scientific advice. However, collaboration across the research-policy interface is notoriously difficult. Here, using results from two online surveys, we explore the benefits and barriers for UK-based researchers and practitioners when collaborating with each other. We found complimentary motivations for collaboration: researchers were most often motivated to collaborate in order to have impact and for their research to be used, while practitioners wanted to gain access to expertise and deliver on evidence needs. For both groups the most common barrier to collaboration was time constraints. For researchers these time constraints were compounded by a lack of recognition for practitioner-focused research activity, while practitioners faced compounding issues around poor delivery or low utility of research outputs. There was also recognition of the differing agendas between the groups and how this can impede collaboration. With the exception of early-career researchers, both groups relied heavily on existing contacts when initiating collaborations and results highlight the importance of ongoing investment by both groups in relationship development, knowledge exchange and networking opportunities. Alongside that, we argue a major perception shift is needed with academia, such that (applied) science in the direct service of society has the same prestige as (blue-sky) science in the service of curiosity.