Introduction: Combined popliteal sciatic nerve and adductor canal block under ultrasound guidance has been described as a safe and effective mean of regional anesthesia for foot and ankle surgery. Limited studies have shown its effectiveness while performed by surgeons. This study aims to assess the effectiveness and safety for this mode of regional anesthesia while carried out by orthopedic surgeons. Method: Patients presented to our unit with trimalleolar fracture of ankle who underwent operation under surgeon-administered ultrasound-guided combined popliteal sciatic nerve and adductor canal block were evaluated in this study. A total of 13 patients with mean age of 57.8 were included. Data regarding the diagnosis, pattern of injuries, comorbidities in American Society of Anesthesiologists Classification, duration of operation, blood loss, intraoperative pain control in visual analog scale (VAS), degree of motor blockage, postoperative pain control and hospital length of stay were collected and evaluated. Result: All patients experienced complete anesthesia with VAS 0 and complete motor blockage throughout the operation. Average operative time was 179 min. Postoperative pain control was satisfactory. There was no regional anesthesia related complication arise. Conclusion: Surgeon-administered ultrasound-guided combined popliteal sciatic nerve and adductor canal block is a safe and effective mean to provide anesthesia for trimalleolar fracture fixation according to our experience.