The current study addressed a research gap regarding the influence of risk factors in predicting self-control among immigrant and nonimmigrant adolescents. Three research hypotheses were postulated to test the applicability of self-control theory across generational status groups, and the influence of family and environmental factors on youths’ self-control development. The hypotheses were evaluated through hierarchical multiple regression analyses using a school-based sample of 2,056 U.S. adolescents (4% first-generation immigrants, 13% second-generation immigrants, 83% native-born) from the Second International Self-Reported Delinquency Study Dataset. In partial support of self-control theory, the results demonstrated that nearly the same set of variables including family bonding, parental supervision, neighborhood disorganization, school disorganization, and delinquent peer associations significantly predicted self-control for all three generational status groups, but that school climate significantly predicted self-control for only native-born youth. The results also showed that factors across family, neighborhood, school, and peer contexts significantly contributed to immigrant and native-born youths’ self-control. The findings suggest both family and environmental factors shape youths’ self-control. However, the variation in the contribution of those factors on self-control development for immigrant and nonimmigrant youth may be due to cultural differences promoted by acculturation. Implications for future research and delinquency prevention are discussed.