Recent welcome news from the Joint United Nations Programme on HIV/AIDS reported a 33% reduction in new human immunodeficiency virus (HIV) infections in adults and children globally in 2012 compared with the number of incident infections in 2001.1 The evidence of progress in preventing expansion of HIV is an impressive tribute to the efforts of many clinicians and researchers, but it is silhouetted against abackdropofanestimated35.3millionpersonsworldwidehaving HIV infection.1 In the United States, the number of cases of new HIV infections, estimated at approximately 50 000 each year,2,3 remains concerning, and despite evidence in support of preexposurechemoprophylaxis forHIVprevention, implementation issues may impede these interventions in fulfilling their promise.4 In terms of treatment,much progress has occurred with the development of effective therapies,5 but questions of resistance and tolerability remain. As in previous years, in July 2014 JAMA will publish a theme issue dedicated to HIV/AIDS research, which will coincide with the 20th International AIDS Conference to be held in Melbourne, Australia.6 Authors are invited to submit evidence-based manuscripts on topics of HIV-related prevention and treatment for consideration for publication in this issue. Original research, especially randomized clinical trials of HIV treatment, will receive the highest priority for publication. Rigorous studies on the epidemiology and management of HIV/hepatitis C coinfection and HIV/ tuberculosis coinfection also are of major interest. Reports of investigations on HIV basic science and its clinical application, behavioral and preventive intervention approaches, and issues related to HIV in international settings also are welcome. Systematic reviews and scholarly Viewpoints on these topics, as well as on topics relevant to clinical, educational, policy, and financial aspects of HIV/AIDS also would be of interest. All submittedmanuscripts will undergo editorial evaluation and if suitable, will then be assessed via the peer review process. High-quality manuscripts not accepted for publication in JAMAmay (with the authors’ permission) be referred for further consideration by one of the JAMA Network journals. Authors should consult the JAMA Instructions for Authors7 regarding the preparation and submission ofmanuscriptsandshouldpleasecontactuswithanyquestions.Manuscripts receivedbyFebruary 14, 2014,will have thebest chance for consideration for the 2014 HIV/AIDS issue. Achieving theestimablegoalof an“AIDS-freegeneration”8 will require building on successes as well as discovering new approaches to remaining issuesofoptimalHIVpreventionand treatment. With this in mind, we will look forward to receiving your manuscripts for the 2014 HIV/AIDS theme issue.