Background and Objectives: Depression is one of the most prevalent mental disorders among students associated with a major decline in academic and social performance. This study was carried out to determine the prevalence of depression in Iran's nursing students. Methods: the research was conducted as a systematic review and meta analysis, all published scientific articles related to the prevalence of depression in nursing students were searched in 5 databases (Web of Science, Scopus, PubMed, SID, Magiran) and Google Scholar search engine and then their quality was evaluated. The heterogeneity of the studies was investigated using the I2 index and meta-regression model to evaluate heterogeneity-prone variables at a significance level of 0.05. Ultimately, 9 articles met the criteria for inclusion in this study and were analyzed using Comprehensive Meta-Analysis (CMA) software. Results: Based on the random model, the prevalence of depression in Iranian nursing students was equal to 3.2% (2.1 – 4.5; 95% confidence level). Results showed that the highest prevalence of depression in nursing students was 6.2% (5.3-7.1; 95% confidence limit) in Sistan and Balochestan province in 2004, while the lowest prevalence was 0.8% (0.5-1.2; confidence limit 95%) in Esfahan and Qom provinces in 2016. Also, there was a significant relationship between the calendar year, sample size, average age, and prevalence of depression in Iranian nursing students (P<0.05). Conclusion: The results showed that the prevalence of depression in nursing students was 3.2%, which decreased with the increase of the calendar year and average age. Nevertheless, policymakers and managers must take measures to reduce depression.
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