We introduce an experimental procedure for the detection of quantum entanglement of an unknown quantum state with a small number of measurements. The method requires neither apriori knowledge of the state nor a shared reference frame between the observers and can thus be regarded as a perfectly state-independent entanglement witness. The scheme starts with local measurements, possibly supplemented with suitable filtering, which essentially establishes the Schmidt decomposition for pure states. Alternatively we develop a decision tree that reveals entanglement within few steps. These methods are illustrated and verified experimentally for various entangled states of two and three qubits.
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