South Purulia Shear Zone in India is an important zone that hosts uranium mineralization. Since detailed geophysical studies have not been carried out in this region, an integrated geophysical study using self-potential, resistivity, very low frequency electromagnetic and radiometric methods was performed to identify the subsurface structures that could host the hydrothermally altered uranium deposits in the area. The study reveals the wide and large magnitude of negative self-potential anomaly across the South Purulia Shear Zone. The peak negative self-potential anomalies are correlated with the low gravity and low resistivity anomalies measured along various profiles. The low self-potential, gravity and low resistivity anomaly zones are also correlated with conducting zones inferred from very low frequency electromagnetic measurements. Interpretation of self-potential data reveals multiple thick sheet-type vertical and/or inclined structures which might be associated with uranium mineralization. Schlumberger resistivity sounding data reveals an increasing trend of apparent resistivity with current electrode separations/depth. Apparent conductance measured simultaneously with resistivity measurement reveals an increase in current flow of current as depth increases. This exhibits the presence of thin conducting layers at these depths, which is not reflected in resistivity sounding data due to suppression problem. Also this conducting layer is consistent in various soundings and is connected from Raghunathpur to the South Purulia Shear Zone. Correlation of very low frequency and self-potential data shows that the structures are comparable and a radiometric profile also advocate that the conducting structure is associated with radioactive minerals. These structures are likely to be mineralized zones as hydro-uranium anomaly has also been reported from various locations in the area. Moreover, drilling results at a specific mine near the study area also confirms the presence of uranium mineralization. The hydrothermal activity associated with uranium mineralization seems to be still active in the area. Such combined geophysical studies are essential to understand this highly complex shear zone for the economic exploitation of its natural resources.