Schiff Base Research Articles

Schiff Bases and their Pharmaceutical Applications: A review

Schiff Bases and their Pharmaceutical Applications: A review

Hydrophobic and decay-resistant green building wood modified by aromatic aldehydes based on Schiff base

Hydrophobic and decay-resistant green building wood modified by aromatic aldehydes based on Schiff base

New Strategies in the Chemical Control of Fusarium oxysporum Using Synthetic Bioisosteres of Secondary Metabolites: A Review of the Synthetic Methods for Novel Compounds with Potential Antifungal Activity

Abstract: One of the main problems affecting the world is food scarcity which is occasioned by different causes, including difficult climatic conditions, economic and technical limitations, infrastructure and transportation, food safety and insecurity, and diseases caused by microorganisms (phytopathogens) such as Fusarium oxysporum whose damage triggers a series of irreversible effects on several crops, causing economic losses worldwide. Given the complexity that the chemical control of phytopathogens represents, various investigations have been refocused on exploring new biomimetic actions that lead to synthesizing new compounds with potential antifungal activity. In addition, computational chemistry and chemoinformatics tools (molecular docking and molecular dynamics) make it possible to understand and often predict these compounds' mechanisms of action, thereby formulating Quantitative Structure-Activity Relationship (QSAR) models. These strategies have established an important advance in designing new molecules capable of inhibiting pathogens from a rational development of antifungal compounds. This article reviewed the novel synthetic bioisosteres of secondary metabolites biologically active against Fusarium oxysporum, their synthetic protocols, and the strategies implemented for its control. The most innovative examples of this class of active organic compounds are presented, such as N,S-dialkyl dithiocarbamates, Schiff bases, N-alkyl substituted amides, and several heterocyclic systems with potential antifungal activity. Likewise, the use of computational tools is discussed, showing how these results can conduce to the design of new antifungal agents.

In vitro and in vivo studies of a decanuclear Ni(II) complex as a potential anti-breast cancer agent

A non-platinum-metal decanuclear complex [Ni10L4(CH3COO)8 (C2H5OH)8]·8(C2H5OH) (Ni10 complex) has been developed with a tri-dentate 2,3-dihydroxybenzaldehyde-2-aminophenol Schiff base ligand (H3L). Single crystal X-ray analysis reveals that the Ni10 complex displays a sandwich loaf-shaped decanuclear structure and its anticancer activity was evaluated. The cell cytotoxicity results indicating that the Ni10 complex is most effective to human breast cancer cells MDA-MB-231 and its mechanism were further investigated. Flow cytometry analysis showed that the Ni10 complex triggered cell cycle arrest and induced apoptosis of MDA-MB-231 cells. Western blot analysis of the changes of intracellular protein expression showed that Ni10 triggers MDA-MB-231 apoptosis through mitochondrial mediated apoptosis signaling pathways. In vivo experiments showed that the Ni10 complex significantly suppressed breast tumor growth with low toxicity against major organs in a nude mice model. The good treatment effect, low toxicity and pharmacological mechanisms of the decanuclear NiII complex may provide a clue for the research and development of non-platinum multinuclear based chemotherapeutic drugs.

Facile synthesis of Metal-Organic Framework/Chitosan cryogel as a robust Scavenger for Diclofenac sodium

Diclofenac sodium (DS), a commonly detected contaminant in aquatic environments, poses a a significant risk to both the ecological balance and the safety of aquatic products. Therefore, efficient removal of DS from water is ergently needed but remains a major challenge. In this study, an environmentally friendly Fe-based metal–organic framework/chitosan (NH2-MIL-53(Fe)/CS) cryogel was prepared through a Schiff base condensation reaction under mild conditions. Taking advantage of the catalytic role of the MOF in accelerating the reaction between CS and 1,3,5-triformylphloroglucinol, NH2-MIL-53(Fe) powders were incorporated into the polymeric networks within 30 s. Owing to the rich binding sites, the resulting NH2-MIL-53(Fe)/CS cryogel demonstrated remarkable efficacy in eliminating DS from water. The adsorption process reached equilibrium within 120 min with a maximum adsorption capacity of 728.6 mg g−1. A comprehensive mechanistic investigation revealed that the exceptional adsorption capability of the NH2-MIL-53(Fe)/CS cryogel for DS was attributed to the synergistic effect of multiple interactions, including favorable hydrophilicity, electrostatic forces, π-π stacking, hydrogen bonding, and coordination. Thus, this study provides a straightforward and rapid synthesis route for MOF/CS cryogel, offering a promising adsorbent that combines exceptional adsorption performance with ease of separation. The resulting MOF/CS cryogel holds great potential for the treatment of DS-contaminated wastewater.

Structure-based design and synthesis of (E)-l-(s-pheny1)-N-(4-(2,2,4-trimethy1-2,3-dihydro-lH-benzo[b][l,4]diazepin-l-yl)phenyl)methanimine motifs as antimicrobial and anti-tubercular agents

Benzodiazepines' chemistry and synthesis as heterocyclic compounds have recently attracted a lot of attention, due to their extensive biological diversity in drug design and potential for usage in agrochemicals. Eco-friendly and highly efficient method was herein reported for the synthesis of a new series of Schiff base of benzodiazepine derivatives 3a-l using microwave-assisted approach. Firstly, 2,2,4-trimethy1-2,3-dihydro-lH-benzo[b][l,4]diazepine (1) was synthesized by AgNO3-catalyzed reaction of o-phenylenediamine with excess of acetone. Coupling of benzodiazepine 1 with 4-chloroaniline afforded intermediate benzodiazepine 2 which was subsequently reacted with benzaldehyde derivatives via microwave irradiation technique to access twelve final targeted benzodiazepine Schiff bases, 3a-l. The chemical structures of the scaffolds 3a-l were authenticated using analytical and spectroscopic data. Benzodiazepine Schiff bases 3a-l were investigated for their in vitro antimicrobial activities using Agar diffusion technique and screened for their minimum inhibitory concentration (MIC) using microtube dilution technique. Ten pathogenic organisms comprising of seven bacterial and three fungal isolates were utilized for the screening. Ciprofloxacin was the positive control for antibacterial screening while fluconazole was engaged as the positive control for the antifungal screening. The most efficacious antimicrobial agent among the series was (E)-l-(2-Chloropheny1)-N-(4-(2,2,4-trimethyl-2,3-dihydro-lH-benzo[b][l,4] diazepinlyl)phenyl)methanimi ne (3b) with a MIC value of 3.13 µg/mL and MBC of 6.25 µg/mL among all the synthesized compounds synthesized and screening for antimicrobial assessment. Compound 3b also emerged as the best anti-tubercular agent IC50 of 40 µg/mL against Mycobacterium tuberculosis, Mycobacterium bovis and H37Rv

Synthesis of Some Novel 4-bromobenzoic Acid Clubbed Hydrazone Schiff Base Derivatives as Potent α-amylase Inhibitors: In vitro and In silico Studies

Aims: Synthesis of novel 4-bromobenzoic acid-based hydrazone-Schiff base derivatives and to screen them for their α-amylase inhibitory activity. Objective: The biological activities of hydrazone-Schiff base compounds encouraged us to evaluate the synthesized derivatives (4-32) for in-vitro inhibition activity against the α-amylase enzyme. Methods: In current research work twenty-nine Schiff base derivatives (4-32) of 4-bromobenzoic acid were synthesized in worthy yields by treating various replaced aldehydes with 4- bromobenzohydrazide using methanol solvent in catalytic quantity of acetic acid. The products were structurally described through the support of several spectroscopic methods (EI-MS and 1HNMR) and finally evaluated against α-amylase enzyme. Results: All the made derivatives exhibited worthy inhibition potential from IC50 = 0.21 ± 0.01 to 5.50 ± 0.01 μM when equated to the usual acarbose drug having IC50 = 1.34 ± 0.01 μM. Compound 21 (IC50 = 0.21 ± 0.01 μM) was established as the most active inhibitor among the series better than standard. The structure-activity relationship study showed that the alteration in the activity of the produced products might be due to the attached position and nature of the substituents. Furthermore, in-silico study supported the effects of groups attached on the binding interaction with α-amylase enzyme. Conclusion: A series of substituted hydrazone Schiff bases based on 4-bromobenzoic acid were produced, confirmed the structures by EI-MS and 1H-NMR spectroscopic methods and lastly tested for their in-vitro α-amylase inhibitory potential. Among the series, twenty-four products indicated brilliant inhibition potential having IC50 values from 0.21 ± 0.01 to 1.30 ± 0.01 μM. The structure-activity relationship study showed that the alteration in the activity of the synthesized products might be due to the attached position and nature of the substituents. On the other hand, in silico studies advocated that the synthesized Schiff base derivatives have prevalent interactions of binding within the active site of the α-amylase enzyme, and because of their various attached substituent, their conformation is altered in the active site of the enzyme. The current study recognized a number of lead candidates derived from 4-bromobenzoic acid. Additional investigation of the synthesized derivatives for coming research to get novel α-amylase inhibitors.

New chitosan schiff base-modified ferrite: Mechanistic insights and performance enhancement in photocatalysis and antibacterial applications

Harnessing biocompatibility and magnetic separability a Chitosan Schiff base-modified ferrite is an innovative approach for addressing the issue of environmental pollution. This study aims to use a new visible light-activated photocatalyst made of cobalt ferrite (CoFe) anchored with Chitosan Schiff Base (CSB) to examine Rhodamine B (RhB) photodegradation. CSB@CoFe composite was synthesized using hydrothermal and sol-gel methods. This modified CSB composite and oxygen vacancies (OVs) have been proven by X-ray photoelectron spectroscopy, experimental calculations, and radical capture tests. The process of oxidative degradation is facilitated by radicals such as hydroxyl (OH•) and superoxide (O2•−), as evidenced by research utilizing reactive species capture. The CSB@CoFe photocatalyst degraded 94.5 % of Rhodamine B (RhB, 50 mg/L) in 60 min at pH 7 and 1.0 g/L. The CSB@CoFe heterostructure outperformed CSB against Gram-positive and Gram-negative bacteria. The photocatalyst exhibited exceptional stability across the five cycles. This study shows CSB@CoFe's persistent photocatalytic ability to degrade hazardous pollutants and act as an antimicrobial. It employs visible light to solve environmental issues positively.

High-homogeneous recyclable self-cured epoxy resins based on imine

The production of high-performance epoxy resins currently depends on combining rigid epoxy oligomers and non-flexible hardeners. However, the high melting points and incompatibilities of raw materials, along with the inhomogeneous crosslinked networks of thermoset resins, challenge the development of high-performance epoxy resins simultaneously enhancing strength and toughness with excellent processing properties. To address this issue, we propose a self-curing strategy to obtain a novel thermosetting epoxy resin by simply melting the epoxy oligomers containing the Schiff base structure. The mechanism of self-cured was also revealed by density functional theory. Remarkably, this method eliminates the need for curing agents, catalysts, or active hydrogen structures. The resulting self-cured epoxy resin (VEP-SC) simplifies processing steps. In particular, VEP-SC forms a more homogeneous cross-linked network and exhibits superior mechanical properties due to the unique preparation method. Compared to traditional thermosetting epoxy cured with a curing agent, the tensile strength, elongation at break, and flexural strength of VEP-SC were 133.4 %, 168.4 %, and 276.2 % higher than those of VEP-MeHHPA, respectively. Furthermore, the Schiff base structure imparts the vitrimeric behavior of self-cured epoxy resin, achieving recyclability. This approach provides innovative solutions for developing versatile and high-performance epoxy resins.

Computational Studies and Antimicrobial Activity of 1-(benzo[d]oxazol-2- yl)-3,5-diphenylformazan Derivatives.

Due to the biological importance of the benzoxazole derivatives, some 1- (benzo[d]oxazol-2-yl)-3,5-diphenyl-formazans 4a-f were synthesized and screened for in-silico studies and in-vitro antibacterial activity. The benzo[d]oxazole-2-thiol (1) was prepared by reacting with 2-aminophenol and carbon disulfide in the presence of alcoholic potassium hydroxide. Then 2-hydrazinylbenzo[d] oxazole (2) was synthesized from the reaction of compound 1 with hydrazine hydrate in the presence of alcohol. Compound 2 was reacted with aromatic aldehydes to give Schiff base, 2-(2- benzylidene-hydrazinyl)benzo[d]oxazole derivatives 3a-f. The title compounds, formazan derivatives 4a-f, were prepared by a reaction of benzene diazonium chloride. All compounds were confirmed by their physical data, FTIR, 1H-NMR, and 13CNMR spectral data. All the prepared title compounds were screened for in-silico studies and in-vitro antibacterial activity on various microbial strains. Molecular docking against the 4URO receptor demonstrated that molecule 4c showed a maximum dock score of (-) 8.0 kcal/mol. MD simulation data reflected the stable ligand-receptor interaction. As per MM/PBSA analysis, the maximum free binding energy of (-) 58.831 kJ/mol was exhibited by 4c. DFT calculation data confirmed that most of the molecules were soft molecules with electrophilic nature. The synthesized molecules were validated using molecular docking, MD simulation, MMPBSA analysis, and DFT calculation. Among all the molecules, 4c showed maximum activity. The activity profile of the synthesized molecules against tested micro-organisms was found to be 4c>4b>4a>4e>4f>4d.

Synthesis, spectroscopic characterization, density functional theory calculations and biological evaluation of novel Cu(II) and Zn(II) Schiff base complexes as antimicrobial agents

Synthesis, spectroscopic characterization, density functional theory calculations and biological evaluation of novel Cu(II) and Zn(II) Schiff base complexes as antimicrobial agents

Comparative Analysis of Tetravalent Actinide Schiff Base Complexes: Influence of Donor and Ligand Backbone on Molecular Geometry and Metal Binding.

A series of isostructural early actinide AnIV complexes was synthesized in order to investigate the influence of a conjugated framework in the ligand backbone on An bonding. Therefore, the AnIV complexes [An(pyrophen)2] (An = Th, U, Np, and Pu) with the pure N-donor ligand bis(2-pyrrolecarbonylaldehyde)-o-phenylenediamine referred to as pyrophen, were synthesized and characterized. Solid state analysis via single-crystal X-ray diffraction (SC-XRD) reveals two sets of ligands binding in an almost orthogonal arrangement to the actinide center. For the larger actinides Th and U, the coordination sphere allows for additional coordination by a solvent molecule. Nuclear magnetic resonance spectroscopy (NMR) studies show the presence of highly symmetrical complexes in solution in good agreement with the solvent-free solid structures. While SC-XRD suggests mainly ionic binding, an analysis of paramagnetic NMR contributions and quantum chemical bond analysis hint towards significant covalency in the U, Np, and Pu compounds. This series of An complexes allowed for a thorough structural and theoretical comparison of a conjugated system to a closely related N-donor ligand (pyren)[1] as well as to the mixed N,O Schiff base ligands salophen (conjugated) and salen (non-conjugated).

Two New Coordination Polymers: Crystal Structures and Fluorescence Properties.

A new Ni (II) metal-organic frameworks with the formula [Ni2(HL)2(H2O)4]∙3H2O (1) and a novel phenoxo-O bridged rare-earth dinuclear Schiff base complex with the formula [La2(dbm)4L·CH3OH] (2), where the HL2- is the partial deprotonated of the organic ligand H3L, and H2L is a bis-Schiff foundation ligand (H3L = 4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazine-2-carboxylic acid, H2L = N, N'-bis (2-hydroxy-3-methoxybenzylidene) -propane-1,2-diamine, Hdbm = dibenzoylmethane), have been successfully generated under the solvothermal condition. The targeted product sample of 1 and 2 has been fully characterized by single-crystal X-ray data, elemental analysis, FT-IR, powder X-ray diffraction, and thermogravimetric analysis. Furthermore, fluorescence performance testing of the complexes revealed that in complex 1, H3L forms a rigid chain through coordination with Ni2+ ions and further forms a highly rigid three-dimensional framework within the hydrogen bond network, resulting in fluorescence enhancement of up to 13.7-fold, displaying deep blue fluorescence with CIE coordinates of (0.1626, 0.1375). In contrast, complex 2 forms only discrete zero-dimensional molecules and exhibits light blue fluorescence with CIE coordinates of (0.1744, 0.2306). This demonstrates their potential as fluorescent materials.

Design, Synthesis, ssDNA Binding Affinities, and Evaluation of Novel Metal‐Centered Ferrocene as an Effective Antimicrobial and DNA Cleavage Agent

ABSTRACTMetal (Co3+, Ni2+, and Pt2+)–centered and noncentered ferrocene–Schiff bases were prepared. They have been structurally characterized by spectroscopic methods, elemental analysis, conductivity, and magnetic moment. Electron spin resonance was used for the characterization of the Co3+‐centered complex. All synthesized compounds showed antibacterial activity against all tested Gram‐positive and Gram‐negative strains, as well as potent antifungal effect against Candida species. Remarkably, these compounds demonstrated greater efficacy against Gram‐positive bacteria than Gram‐negative. Without an additional oxidant or reductant, the compounds exhibited DNA cleavage capability in the dark. The development of synthesized novel chemical compounds having DNA cleavage and antimicrobial activity plays a profound role in the advancement of medical therapeutics.

Characterization of Schiff base self-healing hydrogels by dynamic speckle pattern analysis.

Self-healing hydrogels are emerging materials capable of restoring functionality after damage, making them highly suitable for biomedical applications, such as tissue engineering, wound healing, and drug delivery. In this study, we synthesize and characterize a novel biodegradable, conductive, and self-healing hydrogel. The synthesis is based on a Schiff base formed between gelatin and hyaluronic acid, and the dynamic reversible Schiff base bond provides the self-healing property. To characterize and assess the self-healing behavior of the hydrogel, dynamic speckle pattern (DSP) analysis is introduced as a non-destructive, non-contact, and easy-to-implement method. Speckle patterns are formed upon scattering of laser light from a diffusive matter and includes a huge overall information about the sample, to be extracted by statistical processing. DSP analysis is employed to monitor the self-healing process of the hydrogel at both macroscopic and microscopic scales. Experimental procedure involve in situ acquisition of speckle patterns over time under controlled environmental conditions, followed by statistical analysis to evaluate the internal dynamics of the healing process. Several statistical parameters are computed for real-time monitoring of the self-healing property of the hydrogel. The findings, on the one hand, underscore the potential of Schiff base hydrogels in advanced biomedical applications where self-healing properties are critical for sustained performance and longevity. On the other hand, the introduced analysis method shows its potential to serve as an effective approach for biomaterial characterization.

Synthesis and evaluation of vanillin Schiff bases as potential antimicrobial agents against ESBL-producing bacteria: towards novel interventions in antimicrobial stewardship.

The escalating challenge of antimicrobial resistance necessitates the development of novel antibacterial agents. In this study, a series of five vanillin Schiff bases (SB-1 to SB-5) were synthesized from vanillin and various aromatic amines. The chemical structures of these compounds were characterized using Thin Layer Chromatography (TLC), Fourier Transform Infrared Spectroscopy (FT-IR), proton nuclear magnetic resonance ( -NMR), carbon-13 NMR ( -NMR), and mass spectrometry techniques. Antibacterial efficacy was evaluated against strains of bacteria producing extended-spectrum beta-lactamases (ESBL), including Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae using the disc diffusion method. Cytotoxic effects were assessed through haemocompatibility and brine shrimp lethality assays. The Schiff bases demonstrated notable antibacterial activities, with SB-1, SB-2, SB-4, and SB-5 exhibiting zones of inhibition up to 16.0, 16.5, 16.6, and 15.5 mm against ESBL E. coli, respectively. SB-3 showed a maximum inhibition zone of 15.0 mm against ESBL K. pneumoniae. In cytotoxicity assays, the compounds exhibited IC values against red blood cells (RBCs) greater than 200 μg/mL and ranging from 45.7 to 50.5 μg/mL for the brine shrimp assay. While demonstrating potent antibacterial properties, the toxicity towards human RBCs suggests that further toxicity evaluations and structural modifications are essential for developing safer therapeutic agents based on vanillin Schiff bases.

Introducing the SNW-1 Covalent Organic Framework to the Polyamide Layer of the TFC-RO Membrane with Enhanced Permeability and Desalination Performance.

This study investigates the synthesis and characterization of Schiff base network-1 (SNW-1) covalent organic framework (COF) nanomaterials and their application in the fabrication of thin-film nanocomposite (TFN) membranes. The embedding of SNW-1 COF in reverse osmosis (RO) membranes with a polysulfone (PSf) substrate was done using the interfacial polymerization method. The result of the study demonstrated that the porous and hydrophilic structure of the COF increased the hydrophilic properties of the produced RO membranes. When the COF was embedded with a concentration of 0.02 wt %, the hydrophilicity of the RO membrane was higher than that of the other membranes, with a contact angle value of 45.2°. Pure water flux, saline solution flux, and humic acid (HA)/sodium chloride (NaCl) foulant solution flux were measured to determine the membrane performance, and it was found that as the COF ratio increased, the fluxes increased up to a certain concentration rate. The RO membrane with a SNW-1 concentration of 0.005 wt % had the highest values of pure water flux and saline solution flux with high salt rejection (34.2 and 32.2 LMH, 97.1%, respectively) and was the most resistant membrane against fouling. This study presents the potential of the SNW-1 COF with precise design capabilities and controlled unique properties as an additive for desalination applications.

A composite film of oxidized levan crosslinked with gelatin: strong hydrophobic and mechanical properties and effective preservation of fresh Mozzarella cheese.

The fructosan levan was synthesized in vitro using a recombinant levansucrase. The levan was oxidized with sodium periodate to prepare oxidized levan (OLevan) with three oxidation degrees. OLevan, gelatin (Gel), and gallic acid (GA) were used to prepare the composite films by the method of plate pouring. The analytical results of FT-IR and XPS indicated that OLevan and gelatin were covalently crosslinked through a Schiff base reaction. The crosslinked films had better properties compared to the non-crosslinked films, especially the Gel/GA/50%OLevan film. The film had the lowest swelling degree (44.4 %), while that of Gel/GA/Levan film was 352.6 %. Gel/GA/50%OLevan film also had the highest tensile strength (25.48 MPa), while that of Gel/GA film was 9.48 MPa. Also, Gel/GA/50%OLevan film was used as a packaging material of Mozzarella cheese. The film effectively slowed down changes in the texture and color of the cheese. On the first day, the coliform in the control and PE groups had already exceeded the maximum acceptable limit of cheese (2.0 Log CFU/g). However, that of Gel/GA/50%OLevan group reached the limit on the fifth day. The results show that the new film prepared by crosslinking and composite of natural edible materials has good potential as a safe food packaging material.

Pyrene Based Schiff Base for Cascade Fluorescent "On-Off" Detection of Aluminium(III) and Fluoride Ions and its Applications in Live Cells Imaging.

An easy-to-prepare pyrene-based Schiff base PNZ was synthesized by condensing equimolar amount of 1-pyrenebutyric hydrazide with 2-hydroxy-naphthaldehyde, and employed as a fluorescent chemosensor for in-situ cascade detection of aluminium (Al3+) and fluoride (F-) ions. In DMSO:H2O (1 : 1, v/v), the weakly emissive PNZ showed a significant fluorescence enhancement at 455 nm selectively upon the addition of Al3+ due to the complexation-induced formation of a pyrene excimer. Schiff base PNZ and Al3+ formed a complex in 2 : 1 binding ratio with the estimated binding constants of K1:1=9826.01 M-1 and K2:1=3188.49 M-1. The sensing mechanism was explored by performing quantum mechanical calculations and 1H-NMR titration of PNZ with Al3+. The in-situ formed PNZ-Al3+ complex species enabled the fluorescent turn-off detection of F-. Using PNZ and PNZ-Al3+, the concentrations of Al3+ and F- ions can be detected down to 2.89×10-7 M and 1.88×10-7 M, respectively. The cytotoxicity of the PNZ and its ability to bioimage Al3+ and F- ions was examined in the human cervical cancer cell line. Finally, the receptor PNZ was applied for the quantification of Al3+ and F- ions in various real samples, such as tap water, river water, rainwater, mouthwash, and toothpaste.

Synthesis of Ferrocene‐Containing Schiff Bases Based on 3‐Aminopropyltriethoxysilane Oligomers for Covalent Modification of Glass Surfaces and Creation of Soft Magnetic Materials

ABSTRACTA ferrocene‐containing oligoorganosiloxane with a number‐average degree of polymerization of 8.8 and a number‐average molecular weight of 3200 is synthesized by hydrolytic condensation of 3‐aminopropyltriethoxysilane followed by chemical modification of the resulting oligomer with acetylferrocene. Its structure is characterized by MALDI‐TOF, NMR and IR spectroscopy. 1H NMR spectroscopy shows the predominance of more thermodynamically stable units containing anti‐configuration Schiff bases. Using IR spectroscopy as well as experimental determination of surface energy and its polar (acid–base) and dispersion components, the covalent immobilization of ferrocene‐containing oligoorganosiloxane on a glass surface after heating at 110°C is shown. The formed coating provides hydrophobization, acid–base indifference of the glass surface and serves as a precursor for the formation of magnetically soft materials after pyrolysis in argon already at 350°C. The main stages of ferrocene‐containing oligoorganosiloxane thermal destruction in an inert atmosphere and the formation of a mixture of iron and silicon oxides during its thermal oxidative destruction are established by combination of TGA/DTA, IR spectroscopy and elemental analysis. The proposed approach opens up new possibilities for functionalizing silicates surfaces, creating magnetic glasses, as well as regulating surface energy and its components.