Purpose: Racial/ethnic minorities have an increased incidence of colorectal cancer (CRC) and tend to present with a more advanced stage of CRC relative to whites. In addition, studies have shown that racial/ethnic minorities are also less likely to undergo CRC screening tests (including fecal occult blood testing [FOBT], flexible sigmoidoscopy [FS], and colonoscopy) than whites. The aim of this study was to identify the proportion of racial/ethnic minorities that are offered and accept CRC screening and to identify barriers to CRC screening among racial/ethnic minorities over the age of 50 years as compared with whites. Methods: Subjects ≥50 years old completed a detailed questionnaire at the time of their scheduled outpatient primary care clinic visit. Data collected included demographics, self-reported race/ethnicity, prior CRC screening (FOBT, FS, and/or colonoscopy), as well as barriers to CRC screening. Results: Of the 688 subjects enrolled, 376 were white (W), 188 were black (B), 92 were Hispanic (H), and 32 identified their race/ethnicity as other (O). W patients were slightly older than B, H, or O racial/ethnic groups (65.0 vs. 62.1 vs. 62.5 vs. 63.7 years; P= 0.002) but had a similar prevalence of male subjects (93.1% vs. 92.0% vs 91.3% vs. 81.3%, P= 0.13). There were no significant differences between W, B, H, and O racial/ethnic groups who were offered FOBT (73.7% vs. 73.9% vs. 69.6% vs. 59.4%; P= 0.31), FS (60.4% vs. 52.1% vs. 51.1% vs. 56.3%; P= 0.18), or screening colonoscopy (73.7% vs. 67.0% vs. 67.4% vs. 68.8%; P= 0.34). However, whites were significantly more likely than racial/ethnic minorities to ever have completed FOBT (71.0% vs. 59.6% vs. 48.9% vs. 28.1%; P < 0.001), FS (60.4% vs. 49.5% vs. 34.8% vs. 28.1%; P < 0.001), and screening colonoscopy (73.1% vs. 49.5% vs. 43.5% vs. 53.1%; P < 0.001). In addition, we found that there were significant differences in the number and type of barriers to CRC screening between whites and racial/ethnic minorities. Conclusion: Racial/ethnic minorities are less likely to undergo CRC screening than whites. The lower rate of CRC screening among racial/ethnic minorities is not due to provider discrimination and is explained by a lower acceptance rate among racial/ethnic minorities as compared with whites. Future studies to attempt to overcome barriers to CRC screening among racial/ethnic minorities are needed.