Scarring Effects Research Articles

Comparison of healing activity between azadirachta indica and moringa oleifera seed oils on cutaneous wounds in wistar rats

Medicinal plants are natural remedies that bring benefits to the organism. Phytomedicine’s production has increased in the last decades due to the adverse reactions of designer drugs. This research focused on basic principles that rule the scarification of wounds as a natural response to the damages produced with specific functions of tissue restoration and integrity. For this reason the acceleration of the scarring effect with Azadirachta indica seeds oil and Moringa was studied. Nine groups of animals were made: normal, negative and negative control, three Neem groups, three Moringa groups (30, 60.120 µl) respectively. The wound was made after placing the animal under anesthesia using the punch method. For seven days, these groups were observed while they received the treatment. After the test, the animals were euthanized, and scarred skin tissue samples were collected for histopathologic tests. As a result, after the second day, the concentration of Neem tested 4,38 mg/ml showed humity and inflammation of 73% and 76% respectively, which eventually dropped to zero. The presence of crust in the third day was 20% and in the sixth, 100%. On the other hand, concerning to the Moringa oil 4,48 mg/ml, no significant changes could be seen in any of the evaluated parameters. Comparing the percentages of the crust coverage among these groups, it can be said that: natural scarification(B) 10% the third day and 40% at the end of the research. The subjects treated with neem (E) 30% the third day and 100% the sixth, while D, F 80% the same day and 100% the seventh, the same as seen in C (iodine). The groups with Moringa presented 10% in the third day and 60% by the end. In conclusion, the groups with neem showed acceleration in the scarification process within the experimentation period.

Toxicology study of a tissue anchoring paclitaxel prodrug

BackgroundLocal drug presentation made possible by drug-eluting depots provides benefits for a vast array of diseases, including cancer, microbial infection, and wound healing. Drug-eluting depots provide sustained drug release of therapeutics directly at disease sites with tunable kinetics, remove the need for drugs to access disease sites from circulation, and reduce the side effects associated with systemic therapy. Recently, we introduced an entirely novel approach to local drug presentation named Tissue-Reactive Anchoring Pharmaceuticals (TRAPs). TRAPs enables local drug presentation without any material carriers, capitalizing on innate tissue structures to anchor drugs at the site of administration.MethodsIn this report, we comprehensively evaluate the local and systemic toxicological profile of a paclitaxel version of TRAPs in mice by clinical observations, body weight monitoring, histopathological evaluations of injection sites and major organs, as well as blood and urine analyses.ResultsWe find that intradermal administration of TRAP-paclitaxel does not induce substantial toxic effects. Localized inflammatory responses were observed at the injection sites and secondary minimal, non-specific inflammation was observed in the liver. All other organs displayed unremarkable histological findings.ConclusionsThese findings support the potential of TRAP-paclitaxel as a promising candidate for localized cancer treatment, offering high-concentration drug delivery while mitigating scarring and adverse side effects.

The Scarring Effect of a Prolonged School-to-Work Transition on Young People’s Future Careers and the Influence of Family Background

AbstractWithin the EU-27, Italy is one of the countries with the highest levels of inequality and intergenerational transmission of disadvantage. This paper aims to verify the effect that different conditions of vulnerability, such as a low socio-economic family background (SEB) and a prolonged period in the school-work transition, have on individuals’ future careers. The analysis is based on a dataset obtained by matching the EU-SILC data with the administrative archives of the National Institute of Social Security. We measured the determinants of the duration of the waiting time to the first job (STWT). The Cox survival function shows that growing up in a disadvantaged family context strongly increases the probability of longer STWT. We also explore the effects of this duration, combined with the family socio-economic background, on the subsequent ten years of job career. A longer STWT increases the probability of experiencing longer spells of unemployment or inactivity, leading to more precarious working conditions. The relationship is complex and non-linear, with a diminishing negative impact on career stability as STWT duration increases, especially for individuals with high SEB.

Unlucky migrants: Scarring effect of recessions on the assimilation of the foreign born

Unlucky migrants: Scarring effect of recessions on the assimilation of the foreign born

A historical syndemic? The impact of synergistic epidemics of measles and scarlet fever on life expectancy in Victoria, Australia (1860s-1870s).

To explore whether synergistic epidemics of measles and scarlet fever in 1860s-1870s Victoria, Australia could be characterized as syndemics, we apply the methods of Sawchuk, Tripp, and Samakaroon (Social Science & Medicine 2022, 295, 112956) to quantify the impact of each of the two major co-occurring epidemic events (1867, 1875) in terms of life expectancy (LE) changes. Sawchuk et al. posit the presence of a harvesting effect, indicated by a statistically significant increase in LE in the immediate post-epidemic "fallow period", as a criterion for identification of a historical syndemic. We test an alternate hypothesis that the same methods can identify a short-term scarring effect. Using annual age- and cause-specific death statistics and census population data, we constructed abridged period life tables for baseline period, potential syndemic year, and "fallow" year for each of the two periods (1860s and 1870s). We compared LE at birth using Z-tests. We decomposed age-cause-specific mortality according to Arriaga's method to identify age-and cause-specific contributions to LE change. LE was significantly lower than baseline (1864-1865) in 1867 but not in the "fallow" year (1869). LE in 1875 and the 1878 "fallow" year were both significantly below baseline (1871-1873). Age-cause-specific decomposition showed similar patterns for 1867 and 1875 for measles and scarlet fever combined effects. Evidence of a scarring effect following the 1875 measles/scarlet fever combined peak supports the interpretation of this event as a syndemic. We suggest the short-term scarring effect can be a useful additional criterion for identifying historical syndemics.

Minilifting: Short-Scar Rhytidectomy with Thread Lifting.

Facelifting techniques have been developed over time to mask the aging process. However, conventional facelifts cause scarring. Because of patient demands, various noninvasive lifting techniques have been introduced, including absorbable thread lifting. Minilifting is known for its short-scar excision and is used to improve skin laxity and lifting using absorbable threads but the definition and operation techniques are not certain. In this article, we described the definition, development, and operative techniques used in minilifts. Minilifting procedures represent an added option for patients with minimal scarring and adequate lifting effects.

Long-Term Effects of Childhood Exposure to War on Domestic Violence

AbstractThis paper highlights the scarring effects of early life exposure to civil war, by examining the impact of exposure to conflict in childhood on the incidence of domestic violence in adulthood among married women. To estimate these effects, we use a difference-in-differences model which exploits variation in exposure to Nigeria’s 30-month-long civil war by year of birth and ethnicity. Our results, based on the 2008 Nigerian Demographic Health Survey, show that women exposed to the war during childhood are more likely to be victims of domestic violence in adulthood compared to those not exposed to the war, with larger effects observed for those exposed at younger ages. Additionally, we explore the mechanisms through which exposure to civil war might affect domestic violence and find some support for both the normalisation of violence and weakened bargaining power hypotheses. Understanding the root causes of domestic violence is important given the high prevalence in developing countries and the deleterious consequences for women and their children.

How do different forms of early employment instability affect future employment chances? A factorial survey experiment with employers

PurposePeriodic economic instabilities and structural changes in the labour market have given rise to a variety of forms of job insecurity. This article compares the scarring effects of different forms of job insecurity on future employment chances, and how they vary across education groups.Design/methodology/approachUsing a sample of real vacancies and data collected in a vignette experiment with employers in Switzerland, a country with a strongly developed vocational education and training (VET) system, this article investigates how employers evaluate a period of unemployment, job hopping and work experience in deskilling jobs when hiring candidates.FindingsThe findings reveal that work in deskilling jobs is by far more scarring than unemployment or job hopping. The study also demonstrates that applicants with upper secondary vocational education are impacted the greatest by all three forms of job insecurity.Originality/valueThe study makes use of real vacancies. While experiments have the strength of high internal validity, most experimental studies in recruitment research rely on students as respondents. As this study works with real employers hiring for positions it benefits from high external validity.

Scars of the job market “ice-age”

Abstract Existing studies found that entering the labor market during a recession has persistent negative effects—the scarring effects—on employment and earnings for Japanese men. The cohorts who entered the labor market during the prolonged recession between 1993 and 2004 are called “the ice-age cohorts,” and the persistent gap between them and older cohorts who entered the labor market during the bubble economy is often interpreted as the scarring effect of business cycle conditions at entry. However, the existing studies in Japan use data covering cohorts who enter the labor market in the 1990s or earlier. Motivated by the lack of empirical evidence with updated data, this article revisits the scarring effects of a recession at labor market entry on employment and earnings using data covering graduation cohorts 1984–2013. Younger cohorts who enter the labor market during the recovery do not earn more or enjoy more stable employment than the cohorts who enter the bottom of the ice-age, and that the effects of unemployment rate at entry on employment and earnings are no longer statistically significant for cohorts who enter the labor market after the job market ice-age. I also discuss potential factors that may have weakened scarring effects.

“NEET status duration and socio-economic background”

NEET refers to young people who are not in employment, education or training. It can occur in a variety of situations and requires attention, especially if it tends to persist over time. Indeed, individuals who leave education and enter the labor market looking for a job are classified as NEET. While in the majority of cases they tend to move into employment status within a short period of time, in others they remain in this status for longer, with negative consequences for their future career or never enter the labor market. Although the scarring effect of longer spells outside the labor market (for unemployment or inactivity) is well known in the economic literature, empirical evidence on this topic are very limited due to the lack of adequate data needed for this analysis.This article aims to fill this gap in the literature and is finalized to verify the influence exerted by the socio-economic background of individuals on the likelihood of becoming and remaining for a long time NEET, according to different levels of education. The analysis is based on AD-SILC dataset, obtained by matching the EU-SILC data with the administrative archives of the INPS, the National Institute for Social Security. Our results reveal that individuals with the same level of educational attainment, but from a higher socio-economic status, have a significantly shorter duration in the NEET condition and a higher probability of transitioning to employment. Conversely, individuals with the same level of education show no significant effects if they come from a low socio-economic background.

Slow to launch: Young men's parental coresidence and employment outcomes

AbstractObjectiveThe authors investigate the potential early career consequences of parental coresidence for young men and whether they vary by duration of coresidence.BackgroundYoung adult coresidence with parents is becoming more common, particularly since the Great Recession and the recent pandemic. Although many studies have investigated the factors that predict coresidence, few examine the consequences. Some prior research suggests that coresidence may directly reduce career opportunities and indirectly shape employment through its effects on mental health and family formation. Yet, the consequences may be milder if coresidence is short‐term.MethodUsing data from the National Longitudinal Survey of Youth 1997, the authors examine the associations between parental coresidence after the age of 24 and employment status (n = 3915) and occupational standing (n = 3613) for young men in their early 30s in the United States. They explore how this association varies by the duration of coresidence, testing several model specifications and controlling for factors that select young men into parental coresidence.ResultsShort‐term coresidence of about 1 year is marginally associated with an improved likelihood of full‐time employment, but longer‐term parental coresidence of 4 to 6 years is negatively associated with occupational standing.ConclusionParental coresidence may be beneficial for young men in their peak ages of career growth if it is only for a few years. However, just as long‐term unemployment can have a scarring effect on employment outcomes, long‐term parental coresidence might negatively impact career growth.

The costs of job loss and task usage: Do social tasks soften the drop?

AbstractDo different tasks shield differently from the scarring effects of job loss? This study examines how the effects of job loss depend on task usage. We use Finnish linked employer–employee data from 2001 to 2016, representative survey data on task usage, and plant closures to identify individuals who involuntarily lose their jobs. We find that heterogeneity in the cost of job loss is linked to task usage. Workers in more social task-intensive origin jobs have smaller employment and earnings losses, whereas workers in routine jobs face larger wage losses. The probability of being employed is 8.3 pp higher (3.9 pp lower) per one standard deviation higher than mean social (routine) task usage 1 year after the job loss event. We also find that workers with longer tenure face larger losses and that task usage contributes more to their losses. The results show that the costs of job loss depend on task usage in the origin job. Public policy measures should be targeted at employees in routine-intensive jobs, since they face the largest losses.

Separating Scarring Effect and Selection of Early-Life Exposures With Genetic Data

Causal life course research examining consequences of early-life exposures has largely relied on associations between early-life environments and later-life outcomes using exogenous environmental shocks. Nonetheless, even with (quasi-)randomized early-life exposures, these associations may reflect not only causation (“scarring”) but also selection (i.e., which members are included in data assessing later life). Investigating this selection and its impacts on estimated effects of early-life conditions has, however, often been ignored because of a lack of pre-exposure data. This study proposes an approach for assessing and correcting selection, separately from scarring, using genetic measurements. Because genetic measurements are determined at the time of conception, any associations with early-life exposures should be interpreted as selection. Using data from the UK Biobank, we find that in utero exposure to a higher area-level infant mortality rate is associated with genetic predispositions correlated with better educational attainment and health. These findings point to the direction and magnitude of selection from this exposure. Corrections for this selection in examinations of effects of exposure on later educational attainment suggest underestimates of 26–74%; effects on other life course outcomes also vary across selection correction methods.

Severe prenatal shocks and adolescent health: Evidence from the Dutch Hunger Winter

This paper investigates health impacts at the end of adolescence of prenatal exposure to multiple shocks, by exploiting the unique natural experiment of the Dutch Hunger Winter. At the end of World War II, a famine occurred abruptly in the Western Netherlands (November 1944–May 1945), pushing the previously and subsequently well-nourished Dutch population to the brink of starvation. We link high-quality military recruits data with objective health measurements for the cohorts born in the years surrounding WWII with newly digitised historical records on calories and nutrient composition of the war rations, daily temperature, and warfare deaths. Using difference-in-differences and triple differences research designs, we first show that the cohorts exposed to the Dutch Hunger Winter since early gestation have a higher Body Mass Index and an increased probability of being obese at age 18. We then find that this effect is partly moderated by warfare exposure and a reduction in energy-adjusted protein intake. Lastly, we account for selective mortality using a copula-based approach and newly-digitised data on survival rates, and find evidence of both selection and scarring effects. These results emphasise the complexity of the mechanisms at play in studying the consequences of early conditions.

Scarring effects of major economic downturns: The role of fiscal policy and government investment

Long shunned as slow and ill timed, the response to the Covid-19 pandemic initiated a reassessment of fiscal policy as stabilisation tool. At the same time, there is ample evidence that major economic downturns produce lasting effects on real GDP in spite of active fiscal policy interventions. This paper takes a fresh look at economic scarring in 26 OECD countries, including 14 EU member states, since 1970 and examines the role played by fiscal policy. We find that higher current expenditure – the favoured active response - does not mitigate the lasting impact of major economic downturns on real GDP. In contrast, more government investment can help but generally receives little attention. As a result, scarring effects are significant confronting governments with sustainability risks, which in turn weigh on the room for manoeuvre in subsequent downturns. In sum, fiscal policy makers face two difficulties in the event of a major economic downturn: (i) adopt the right type of fiscal expansion, and (ii) find the right time to pivot from short-term stabilisation to fiscal consolidation while protecting investment. Both challenges are fraught with political economy issues.

Skill loss during unemployment and the scarring effects of the COVID-19 pandemic

We integrate the SIR epidemiology model into a search and matching framework with skill loss during unemployment. As infections spread, fewer jobs are created, skills deteriorate and TFP declines. The equilibrium is not efficient due to infection and skill composition externalities. Job creation increases infections due to increased interactions among workers. However, lower job creation decreases TFP due to skill loss. A pandemic causes the unemployment rate to increase by 13.4 percentage points and TFP to decline by 0.61%, i.e. nearly 54% of productivity losses in past recessions. We study the efficient allocation given the trade-off between both externalities and show that quantitatively the skill composition externality is sizable.

Kissing Nevus of Eyelid: A Rare Case Report

Introduction : Kissing nevus, also known as kissing mole, is a rare dermatological condition in the world and characterized by the presence of congenital nevi on both the upper and lower eyelids in symmetrical fashion. Additionally, this report highlights the treatment options available for patients with kissing nevus and discusses the importance of regular monitoring.
 Case Illustration : An 11-year-old female patient came with a complaint of a mole on the upper and lower eyelids since birth. The mole was felt to be getting bigger and starting to bother her. The patient feels insecure with the presence of this mole. The patient underwent nevus excision followed by retroauricular graft placement on the superior and inferior eyelidss. Then a biopsy showed benign nevus. After follow-up, it was found that the graft had grown and there was no necrotic tissue.
 Discussion : Kissing nevus is a rare skin condition that affects babies and young children. It is characterized by two identical birthmarks that appear on either side of the body, such as on the eyelids. Surgery involves removing the birthmarks surgically. Our patient underwent wide excision and palpebral reconstruction.
 Conclusion : Kissing nevuse is a unique skin condition marked by the presence of congenital nevi on both the upper and lower eyelids in a symmetrical pattern. It is worth noting that while treatment may be effective, there is a risk of scarring, infection, and other side effects associated with these procedures.

Mortgaged futures: fractured livelihoods and youth debts during COVID-19

ABSTRACT The social and economic impacts of COVID-19 have been devastating for many, and collectively young people generally fared worse than older adults, with the impact amongst young people also being highly uneven. Most studies on this topic focus on Global North contexts, with experiences in the Global South being less well understood. Focusing on young people in Nepal and Indonesia who were especially exposed to the fallout from the pandemic (in part due to their occupations), this paper analyzes over 1400 weekly diary entries from 100 respondents written across four months in the first half of 2021. Participants recall increasingly precarious individual and family situations due to pandemic-related livelihood upheavals and insufficient access to social protection. Amongst diverse ‘coping strategies’, many turned to debt to smooth fluctuating incomes – leading to both financial and social obligations and forcing sometimes life-altering decisions such as leaving education and moving into risky work. Spiralling indebtedness may have consequences for livelihoods across young people’s life-courses; with futures mortgaged to survive precarity at the peak of the Delta wave of COVID-19. Looking ahead, policy makers should reconfigure disaster responses and social protection with a youth-lens to ensure a robust, fair and sustainable recovery from future crises, mitigating inter-generational scarring effects.

Scenario Analysis of Facing the Covid-19 Scarring Effect: Tourism Sector Labor in Bali

Scenario Analysis of Facing the Covid-19 Scarring Effect: Tourism Sector Labor in Bali

The Scarring Effect of Graduate Underemployment: Evidence from the UK

The Scarring Effect of Graduate Underemployment: Evidence from the UK