Inorganic scale (salt) deposition in the oil and gas industry is a serious and widespread problem that requires timely measures for effective control and management. The process of formation and deposition of mineral salts depends on a large number of changing factors, which creates additional difficulties for predicting and controlling scale formation processes. The fields of Eastern Siberia, the formation waters of which belong to the category of brines with a mineralization of 250 g/l and more (in some cases more than 600 g/l), are characterized by the scale formation of complex composition (sulfate, carbonate and chloride salts). Scale deposits can occur in the near-wellbore zone of the formation, which can lead to a significant decrease in the productivity of production wells. Many fields in Eastern Siberia have a number of features that complicate their operation. Among them are low reservoir temperature (10–14 °C), reservoir pressure close to the saturation pressure and salinity (halitization) of the reservoir. In the practice of the global oil and gas industry, it has been repeatedly proven that the implementation of technologies to prevent scale deposits is much more technologically and economically efficient than removing already formed sediments. In this regard, the use of scale inhibitors (SI) is one of the key methods to combat the formation of salts. When scale deposits lead to disruption of the operation of submersible well equipment, technologies for continuous or periodic dosing of SI into the annulus of the well can be effective. To protect the bottomhole zone of the formation from scale deposits, the priority technology should be the injection of scale inhibitors or squeeze treatment into the formation under pressure.In this work, based on a set of laboratory filtration experiments, a module has been developed that allows calculating the volumes of scale inhibitor and process fluids required for SI squeeze into the reservoir. The successful results of two operations of SI squeeze into the formation of horizontal wells for protection against deposits of sulfate salts are shown.