Abstract. With ongoing climate change, there is a pressing need to better understand how much water is stored as ground ice in areas with extensive permafrost occurrence, as well as how the regional water balance may alter in response to the potential generation of meltwater from permafrost degradation. However, field-based data on permafrost in remote and mountainous areas such as the South American Andes are scarce. Most current ground ice estimates are based on broadly generalized assumptions such as volume–area scaling and mean ground ice content estimates of rock glaciers. In addition, ground ice contents in permafrost areas outside of rock glaciers are usually not considered, resulting in a significant uncertainty regarding the volume of ground ice in the Andes and its hydrological role. In Part 1 of this contribution, Hilbich et al. (2022a) present an extensive geophysical data set based on electrical resistivity tomography and refraction seismic tomography surveys to detect and quantify ground ice of different landforms and surface types in several study regions in the semi-arid Andes of Chile and Argentina with the aim to contribute to the reduction of this data scarcity. In Part 2 we focus on the development of a strategy for the upscaling of geophysics-based ground ice quantification to an entire catchment to estimate the total ground ice volume (and its approximate water equivalent) in the study areas. In addition to the geophysical data, the upscaling approach is based on a permafrost distribution model and classifications of surface and landform types. In this paper, we introduce our upscaling strategy, and we demonstrate that the estimation of large-scale ground ice volumes can be improved by including (i) non-rock-glacier permafrost occurrences and (ii) field evidence through a large number of geophysical surveys and ground truthing information. The results of our study indicate that (i) conventional ground ice estimates for rock-glacier-dominated catchments without in situ data may significantly overestimate ground ice contents and (ii) substantial volumes of ground ice may also be present in catchments where rock glaciers are lacking.