Composite Scale Research Articles

Search potential of the high energy-large hadron collider for spin-1/2 excited quarks in di-jet final state

Composite models, which suggest a possible substructure of fundamental particles, can be directly proven by the discovery of the excited quark. Higher energy and higher-luminosity particle colliders are needed to discover the composite structure predicted in the proposed models. The High Energy Large Hadron Collider (HE-LHC) has the potential to be a possible discovery machine for composite models. In this collider, with a center-of-mass energy of 27 TeV and integrated luminosity between 750 and 15000 fb\textsuperscript{-1}, we calculated the exclusion, observation, and discovery limits for the mass of spin-1/2 excited quark in the \textit{di-jet} final state, as well as the attainable compositeness scale values. In addition to these calculations, we scanned free parameters from 0.06 to 1 to determine the HE-LHC potential to reveal spin-1/2 excited quark.

Addition of a metoclopramide constant rate infusion to prevent ptyalism, regurgitation and vomiting in brachycephalic dogs undergoing spinal surgery

ObjectiveTo assess whether adding metoclopramide to a protocol of maropitant and pantoprazole would reduce incidence of ptyalism, vomiting and regurgitation in brachycephalic dogs undergoing thoracolumbar spinal surgery. Study designRandomized blinded controlled trial. AnimalsA total of 43 brachycephalic dogs undergoing thoracolumbar spinal surgery. MethodsIn addition to a standardized anaesthetic regimen, dogs were randomized to be administered either a 2 mg kg–1 day–1 metoclopramide constant rate infusion (CRI) or a saline solution at an equivalent infusion rate, started after anaesthetic induction and discontinued 5 hours after tracheal extubation. The presence of vomiting, regurgitation and pytalism, and short form of the Glasgow Composite Pain Scale pain scores were assessed by a blinded observer hourly for 4 hours, starting 1 hour postextubation. ResultsRegurgitation occurred in six dogs postoperatively; three dogs were in the placebo group and three in the metoclopramide group. The odds ratio (OR) of regurgitation after surgery did not differ between groups [OR: 0.76, 95% confidence interval (CI): 0.13–4.3, p = 0.76]. The odds of observing ptyalism at 3 and 4 hours was approximately 15 times less than 1 hour postoperatively (both OR: 15.4, 95% CI: 1.8–130.7, p = 0.012) and did not differ based on the addition of metoclopramide (OR: 0.73, 95% CI: 0.07–8.0, p = 0.79). The odds of observing pain did not change over time and did not differ based on the addition of metoclopramide (OR: 0.71, 95% CI: 0.12–4.2, p = 0.71). Vomiting did not occur during the study (0.0%, 95% CI: 0.0–8.2%). No adverse effects were observed during the study period in either group. Conclusions and clinical relevanceThe addition of a metoclopramide CRI to maropitant and pantoprazole did not result in a significant reduction in ptyalism or regurgitation in brachycephalic dogs undergoing thoracolumbar spinal surgery.

A real-time performance improvement method for composite time scale

Abstract The composite time scale (CTS) provides a stable, accurate, and reliable time scale for modern society. The improvement of CTS’s real-time performance will improve its stability, which strengths related applications’ performance. Aiming at this goal, a method achieved by determining the optimal calculation interval and accelerating adjustment stage is proposed in this paper. The determinants of the CTS’s calculation interval (characteristics of the clock ensemble, the measurement noise, the time and frequency synchronization system’s noise and the auxiliary output generator noise floor) are studied and the optimal calculation interval is obtained. We also investigate the effect of ensemble algorithm’s initial parameters on the CTS’s adjustment stage. A strategy to get the reasonable initial parameters of ensemble algorithm is designed. The results show that the adjustment stage can be finished rapidly or even can be shorten to zero with reasonable initial parameters. On this basis, we experimentally generate a distributed CTS with a calculation interval of 500 s and its stability outperforms those of the member clocks when the averaging time is longer than ∼1700 s. The experimental result proves that the CTS’s real-time performance is significantly improved.

Clinical effects of perineural dexmedetomidine or magnesium sulphate as adjuvants to ropivacaine in dogs undergoing tibial plateau leveling osteotomy

The study aimed to compare the quality of perioperative analgesia, the motor block duration, and the effects on main cardiovascular parameters of dexmedetomidine (1 μg/kg/nerve block) or magnesium sulphate (2 mg/kg/nerve block) as adjuvants to 0.3% ropivacaine for sciatic and saphenous nerves block in dogs undergoing tibial plateau leveling osteotomy (TPLO). Dogs randomly received perineural dexmedetomidine-ropivacaine (D group), magnesium sulphate-ropivacaine (M group), or ropivacaine (C group). Fentanyl was administered in case of intraoperative nociception. Postoperative pain was assessed using the Short Form-Glasgow Composite Measure Pain Scale (SF-GCMPS) and VAS scale. The duration of motor blockade and intra- and postoperative cardiovascular parameters were also recorded. Group M required significantly more fentanyl than D group (p = 0.04). Group M had a significantly higher SF-GCMPS score than group C at 4 (p = 0.002) and 5 h after extubation (p = 0.01), and a significantly higher VAS score than group D at 3 h after extubation (p = 0.03), and at 4 h if compared to group C (p = 0.009). No significant differences regarding the duration of motor blockade were detected between groups (p = 0.07). The heart rate was significantly lower in group D than in M and C groups intraoperatively and during the first 1.5 h post extubation. The addition of dexmedetomidine or magnesium sulphate as adjuvants to perineural ropivacaine did not improve the quality of perioperative analgesia and did not prolong the motor blockade in dogs undergoing sciatic and saphenous nerves block for TPLO surgery.

Study on ballistic impact performance of bionic fish scale protective armor

Composite bulletproof armor used in modern battlefield environments is mostly composed of ceramic/ultra-high molecular weight polyethylene (UHMWPE). In order to further improve its bulletproof performance, this study draws on the superposition of fish scales. The upper layer of the flexible protective armor consists of composite scale layers stacked on top of each other, and the lower layer consists of UHMWPE plates with grooved structures at the corresponding locations of the scales, where a single composite scale consists of an upper SiC ceramic layer and a lower UHMWPE layer. Finite element simulation is used to analyze the protective performance of the protective armor. The effects of back plate thickness, scale tilt angle, and impact location on the protection performance are investigated. The results show that the 8 mm thick back plate can effectively resist the impact of Type 53 7.62 mm armor-piercing incendiary ammunition, and the protective effect is best when the scale tilt angle is 30°. The maximum depression depth of the backplane is 12.4 mm, and the deformation of the backplane is reduced by 3 mm when the bullet hits the overlapping area of the scale compared with the central area of the target scale, accounting for 32.67% of the total deformation. The research work has guided the development of new bionic flexible protective armor.

Strain-hardening magnesium-silicate-hydrate composites (SHMSHC) utilizing reactive magnesia cement (MgO) and calcined clay (metakaolin)

This study demonstrated the feasibility of utilizing calcined clay (metakaolin) as a silica source for the development of polyethylene (PE) fiber-reinforced strain-hardening magnesium-silicate-hydrate composite (SHMSHC). The study also discussed the effects of variation in the Mg/Si ratio of the mixture when pure silica source (silica fume with SiO2 content >90 %) is replaced with metakaolin (SiO2 content ⁓ 51 %) on the mechanical performance of SHMSHC. A comprehensive mechanical characterization of SHMSHC at composite scale and fiber-matrix interaction effects was conducted. The damage characterization was carried out using residual crack width and spacing analysis. The chemical characterization of the MSH matrix (SHMSHC without fibers) was performed using XRD, TGA, and FTIR, and the microstructural investigation was done using FE-SEM. The MgO-metakaolin paste based SHMSHC showed compressive strength of 51.9 MPa, tensile strength of 5.0 MPa, and tensile strain capacity of 4.7 %, demonstrating the feasibility of calcined clay utilization in SHMSHC. The tensile strain capacity was reduced after the addition of aggregates in SHMSHC. The study demonstrated that the variation in the Mg/Si ratio significantly affects the toughness of the MSH matrix and fiber-matrix interaction characteristics, influencing the strain-hardening potential of SHMSHC.

Screen Time and its Relation to Toddlers’ Development

Abstract Background Screen-time or digital-screen exposure is the duration of time spent by the individual in using electronic/digital media like television (TV), smartphone, tablet or computer. Even background television exposure has been shown to impact development by reducing the amount and quality of interactions between parents and children. Studies showed that while babies do not absorb content from TV, it can catch and hold their attention. Aim of the Work The aim of the current study was to determine the effect of screen time on different developmental aspects of toddlers. Patients and Methods This was a cross sectional observational study that was conducted in the outpatients’ and Neurodevelopment Clinics, Children’s Hospital, Faculty of Medicine, Ain Shams University on 83 toddlers aged from 1 year to 3 years old who were exposed to screens for a longer duration than the recommended according to the American Academy of Paediatrics (AAP) guidelines. Of 13 months’ time frame, total duration of screen exposure was calculated in minutes/day and was correlated to the composite scores of Bayley scales of infants’ and toddlers’ development third edition. Results A significant negative correlations were found between duration of screen time exposure and all Bayley scales (cognitive, language and motor) composite scores and language scale is more affected. Conclusion The results of this study supported the directional association between screen time and child development. Parents and all the society should be educated about the hazards of screen time exposure on infants and toddlers’ development.

Synthesis and Performance Evaluation of Modified Polyaspartic-Acid-Based Scale Inhibitor

This paper focuses on the selection and application of scale inhibitor by studying the problem of pipeline scaling in geothermal well development. Adding scale inhibitor can effectively reduce the treatment cost and achieve a good scale resistance effect, but the commonly used polyaspartic acid scale inhibitor has problems such as poor scale inhibition effect and large use limitations. Therefore, a new modified polyaspartic acid scale inhibitor (His-Tyr-SA-PASP) was prepared using polysuccinimide (PSI) as the raw material and histidine (His), tyrosine (Tyr), and sulfonic acid (SA) as the modification reagent. When the dosage of His-Tyr-SA-PASP was 8 mg/L, the scale inhibition rate of CaCO3 was 94.40%. In addition, the scale inhibition effect of His-Tyr-SA-PASP on CaCO3 was better than that of PASP. At the same time, under the condition of a static experiment at 75 °C, according to the ion concentration of water samples in different scale zones, this paper also identified the ratio of four composite scale inhibitors. When the dosage of compound scale inhibitor was 100 mg/L, Sodium of Polyaspartic Acid–Diethylene Triamine Penta (Methylene Phosphonic Acid)–2-Phosphonobutane-1,2,4-Tricarboxylic Acid–Amino Trimethylene Phosphonic Acid–Copolymer of Maleic and Acrylic Acid = (10:10:5:1:9), (15:10:5:2.5:2.5), (12.5:5:10:1:6.5), and (15:5:10:4:1) and the scale inhibition rate was more than 95%. Under the condition of a dynamic experiment, the optimized composite scale inhibitor still showed a scale inhibition rate of more than 90%. It provides a useful reference for the practical application of water treatment in geothermal wells and has the prospect of industrial application.

Energy absorption of composite 3D-printed fish scale inspired protective structures subjected to low-velocity impact

This paper reports the performance of protective structure inspired by elasmoid fish scales, employing a combination of experimental and numerical techniques. The composite scale-tissue structures were fabricated using a 3D printer with a dual-material extruder. Each structure was subjected to low-velocity impact using a drop-weight tower system. Investigation of the progressive failure mechanisms relied on finite element analysis and high-speed photography. Geometrical parameters of fish scales, including scale volume fraction, scale overlapping angle, and radius of curved scales were studied for their influence on impact resistance. Further, using Taguchi's method for the design of experiments, it was determined that enhancing impact resistance was achievable through an increase in scale volume fraction (by 15.1 %) and a larger scale overlapping ratio (by 39.4 %). The outcomes suggest that using a composite scale-tissue structure can contribute to developing more effective protective structures.

Repetitive transcranial magnetic stimulation impacts the executive function of patients with vascular cognitive impairment: a systematic review and meta-analysis.

Executive dysfunction is a core symptom of vascular cognitive impairment (VCI), which seriously affects patients' prognosis. This paper aims to investigate the effectiveness of rTMS on executive function in VCI. The databases selected for this study included Pubmed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang, China Science and Technology Journal Database (VIP), and China Biology Medicine Disc (CBM). The screening times were conducted from the time of library construction until August 23, 2023. The inclusion criteria for this meta-analysis were randomized controlled trials (RCTs) on rTMS for VCI, which include executive function scores. The primary metrics were executive subscale scores of the Cognitive Comprehensive Scale and total scores of the Executive Specificity Scale. The secondary metrics were subscale scores of the Executive Specificity Scale. The quality of each eligible study was assessed using the Cochrane Risk of Bias tool. Meta-analysis and bias analysis were performed using Stata (version 16.0) and RevMan (version 5.3). A total of 20 high-quality clinical RCTs with 1,049 samples were included in this paper. The findings from the primary outcomes revealed that within the rTMS group, there were significantly higher scores observed for the executive sub-item on the cognitive composite scale (SMD = 0.93, 95% CI = 0.77-1.08, p < 0.00001, I 2 = 14%) and the total score on the executive specific scale (SMD = 0.69, 95% CI = 0.44-0.94, p < 0.00001, I 2 = 0%) compared to the control group. As for the secondary outcome measures, as shown by the Trail Making Test-A (time) (MD = -35.75, 95% CI = -68.37 to -3.12, p = 0.03, I 2 = 55%), the Stroop-C card (time) (SMD = -0.46, 95% CI = -0.86 to -0.06, p = 0.02, I 2 = 0%) and the Stroop-C card (correct number) (SMD = 0.49, 95% CI = 0.04-0.94, p = 0.03, I 2 = 0%), the experimental group shorts time and enhances accuracy of executive task in comparison to the control group. Subgroup analysis of the main outcome demonstrated that intermittent theta burst stimulation (iTBS), higher frequency, lower intensity, longer duration, and combined comprehensive therapy exhibited superior efficacy. rTMS is effective in the treatment of the executive function of VCI. The present study has some limitations, so multi-center, large-sample, objective indicators and parameters are needed to further explore in the future.Systematic review registration:https://www.crd.york.ac.uk/prospero/, CRD42023459669.

Psychometric Evaluation of the Insomnia Severity Index in Nurses

ABSTRACT Objectives Examine psychometric properties of the Insomnia Severity Index (ISI) in a sample of nurses. Method In a sample of day shift nurses (N = 289), a confirmatory factor analysis (CFA), convergent and discriminant validity analyses, and a test–retest reliability analysis were performed. Results CFA showed that a two-factor model provided the best fit. The ISI had moderate to poor convergent validity with sleep diary parameters, and moderate convergent validity with the Sleep Condition Indicator (r = -.66), Pittsburgh Sleep Quality Index (r = .66), and PROMIS Sleep-Related Impairment measure (r = .67). The ISI demonstrated good discriminant validity with the measures Composite Scale of Morningness (r = −.27), Nightmares Disorder Index (r = .25), PTSD Checklist for DSM-5 (sleep items removed; r = .32), and Perceived Stress Scale (r = .43). The ISI had weaker discriminant validity with the PHQ-9 (r = .69) and Generalized Anxiety Disorder Screener (r = .51). The ISI demonstrated a good test–retest reliability (ICCs = .74–.88). Conclusions The ISI is a psychometrically strong measure for the assessment of insomnia severity in day shift nurses. Overlap with psychological symptoms, primarily anxiety and depression, suggests caution while interpreting these constructs.

Dynamic Color Regulation of the Lycaenid Butterfly Wing Scales

Butterfly coloration originates from the finely structured scales grown on the underlying wing cuticle. Most researchers who study butterfly scales are focused on the static optic properties of cover scales, with few works referring to dynamic optical properties of the scales. Here, the dynamic coloration effect of the multiple scales was studied based on the measurements of varying-angle reflection and the characterization of scale flexibility in two species of Lycaenid, Plebejus argyrognomon with violet wings and Polyommatus erotides with blue wings. We explored the angle-dependent color changeability and the color-mediating efficiency of wing scales. It was found that the three main kinds of flexible scales (cover, ground and androconia scales) were asynchronously bent during wing rotation, which caused the discoloration effect. The three layers of composite scales broaden the light signal when compared to the single scale, which may be of great significance to the recognition of insects. Specifically, the androconia scales were shown to strongly contribute to the overall wing coloration. The cover scale coloration was ascribed to the coherence scattering resulted from the short-range order at intermediate spatial frequencies from the 2D Fourier power spectra. Our findings are expected to deepen the understanding of the complex characteristics of biological coloration and to provide new inspirations for the fabrication of biomimetic flexible discoloration materials.

Molecular dynamics simulations of 2D-layered graphene sheets with tandem repeat proteins

Composites with well-ordered and precisely designed molecular structures have the potential to showcase extraordinary physical properties. A high degree of order in the composite's molecular structure can lead to remarkable properties, such as high strength, stiffness, and toughness. Two-dimensional (2D) materials with atomic thickness are used in composites, but their random distribution within the matrix makes it hard to create highly ordered materials. We studied the mechanical properties of newly developed 2D nanosheets of graphene oxide fillers combined with recombinant squid-inspired tandem repeat proteins. Our results showed that these proteins enable precise molecular length and structure control, resulting in consistent mechanical properties that align with the experimental studies. As a result, the mechanical properties of the composite scale linearly based on the number of repeat units in the tandem proteins. This innovation pushes the boundaries of materials engineering and opens up a future where we can engineer the physical properties of composites to achieve the desired levels of mechanical strength and flexibility.

Comparison of preoperative retrobulbar bupivacaine and postoperative subcutaneous liposome-encapsulated bupivacaine on postoperative analgesia in dogs undergoing enucleation.

To compare the effectiveness of preoperative bupivacaine inferotemporal retrobulbar blocks to postoperative liposome-encapsulated bupivacaine (Nocita) line blocks for analgesia following enucleation. 39 client-owned dogs (40 eyes) presenting to the Ophthalmology Service for enucleation. Dogs were randomly assigned to receive either a preoperative inferotemporal retrobulbar block with 0.5% bupivacaine or a peri-incisional line block with liposome-encapsulated bupivacaine (Nocita) at closure. Patients underwent unilateral enucleation and were hospitalized for 24 hours after surgery. Pain scores were performed by a masked observer with the Glasgow Composite Measure Pain Scale and the University of Wisconsin Ocular Pain Scale at 0.25, 0.5, 1, 2, 4, 6, 8, and 24 hours following surgery. Intraoperative use of blood pressure and anesthetic support mediations as well as need for rescue pain control were recorded and compared between groups. There was no significant difference in rescue rates between treatment groups. When comparing the use of medical intraoperative heart rate, blood pressure, or anesthetic plane support, there were no significant differences in use between groups. Use of preoperative bupivacaine retrobulbar blocks and postoperative Nocita line blocks were equally effective at postoperative pain control with similarly low complication rates.

Usability and feasibility of the open-source GeRI platform for remote assessments in older adults with prostate cancer.

e13664 Background: The Geriatric Remote Initiative (GeRI) is an open-source tool to collect patient-generated health data for older adults with cancer. It comprises a WiFi-enabled Raspberry Pi tablet, a Bangle.js 2 wrist accelerometer, and Mi Body Composition Scale 2 for data collection. Following the initial phase where feedback from older cancer survivors and caregivers refined a demonstration GeRI platform, this study deployed a live version of GeRI in advanced prostate cancer patients to evaluate its feasibility and usability. Methods: In this single-arm pilot feasibility and usability study, we evaluated GeRI among ten advanced prostate cancer patients aged ≥65 years undergoing androgen deprivation (ADT) across varied frailty risk categories. Participants interacted with GeRI for ≥12 weeks. Data collection comprised demographics, clinical information, and vulnerability assessment (Cancer and Aging Research Group [CARG] score) from in-clinic surveys. Biometric (wearable/scale) and electronic patient-reported outcomes data from the tablet were securely transmitted to the institution’s HIPAA-compliant cloud. Usability was evaluated using the System Usability Scale (SUS), aiming for an average score of 68 or higher. Feasibility was achieved if ≥6 participants completed at least 50% of all prompted interactions with the system components (surveys, wearable, and weight/bioimpedance) throughout a 12-week study period. Results: Ten men with metastatic hormone-sensitive prostate cancer [median age: 73 years; 40% minority; median of 3 months of ADT exposure (IQR: 2-4.5); 80% had intensified ADT with 60% getting concurrent prostate-directed radiation] engaged with GeRI for a median of 104 days (IQR: 93-131). 40% were vulnerable with a CARG&gt;5. System usability, evaluated by SUS, yielded a mean score of 84 (SD: 12.5). All participants met the feasibility criterion. Deficiencies in obtaining complete 48-hour accelerometry data from 7 participants were noted with only 1 being due to persistent non-wear of the wearable and the remainder due to transmission failure. Conclusions: The GeRI platform exhibited exceptional usability and met all feasibility benchmarks in a geriatric oncology setting, highlighting its potential despite technical hurdles in accelerometry data collection. Further deployment of GeRI is underway [or planned] through an expanded program focusing on other cancer types, including head and neck, and more robust biometric data collection.

Objective assessment of chronic pain in donkeys using the Donkey Chronic Pain Scale

ObjectiveTo clinically evaluate previously developed pain scales [Donkey Chronic Pain Composite Pain Scale (DCP-CPS), Donkey Chronic Pain Facial Assessment of Pain (DCP-FAP) and combined Donkey Chronic Pain Scale (DCPS)], including behavioural and facial expression–based variables, for the assessment of chronic pain in donkeys. Study designProspective, blinded clinical study. AnimalA group of 77 donkeys (34 patients and 43 healthy control animals). MethodsAnimals were assessed by two observers that were blinded to the condition of the animals. ResultsBoth DCP-CPS and DCP-FAP, and resulting combined DCPS scores, showed good interobserver reliability [intraclass correlation coefficient (ICC) = 0.91, 95% confidence interval (CI) = 0.86–0.95, p < 0.001; ICC = 0.71, CI = 0.50–0.83, p < 0.001 and ICC = 0.84, CI = 0.72–0.91, p < 0.001, respectively]. All scores (DCP-CPS, DCP-FAP and the resulting combined DCPS) were significantly higher for patients than for controls at all time points (p < 0.001 for all three scales). Sensitivity and specificity for identification of pain (cut-off value >3) was 73.0% and 65.1% for DCP-CPS, and 60.9% and 83.3% for DCP-FAP, respectively. For the combined DCPS, sensitivity was 87.0% and specificity 90.9% (cut-off value >6). Conclusions and clinical relevanceBased on behavioural and facial expression–based variables, DCPS proved a promising and reproducible tool to assess different types of chronic pain in donkeys. The combination of behavioural and facial expression–based variables showed the best discriminatory characteristics in the current study. Further studies are needed for refinement of these tools.

"It's a Valuable Service but a Hard Place to Be:" Women's Views About Violence Against Women Shelters.

This mixed-methods secondary analysis examined VAW shelter use by 662 Canadian women abused by partners (50.5% Indigenous, 43.4% White, and 6.1% visible minority). Women who had never resided in shelters (n = 242) had less Severe Combined and Total IPV on the Composite Abuse Scale and fewer PTSD symptoms. More nonresidents worked full time and had higher incomes and no children. The 420 women residents mentioned strengths (70.4%) such as supportive staff and safety, and concerns (29.6%) about unsupportive staff and the shelter rules or facility. Some Indigenous women reported racist attitudes by shelter staff and child apprehensions. Practice implications are presented.

The impact of morningness-eveningness on depression through a serial mediation model of resilience and anxiety.

Resilience has been recently considered one of the possible mechanisms for the association between morningness-eveningness and depression. Meanwhile, anxiety is closely associated with mood disorder, but its association with morningness-eveningness is unclear. Therefore, this study aimed to explore the mediating effects of resilience and anxiety on morningness-eveningness and depression as the possible mechanisms. This study included patient group and nonpatient group. Patient group consists of 743 patients with mood disorders [Major Depressive Disorder (MDD), 233; Bipolar Disorder I (BDI), 113; Bipolar Disorder II (BDII), 397] whereas nonpatient group consists of 818 individuals without mood disorder. The Composite Scale of Morningness, Connor-Davidson Resilience Scale, Self-Rating Depression Scale, and Beck Anxiety Inventory were used to evaluate morningness-eveningness, resilience, anxiety, and depression, respectively. Our model provided a good fit for the data. The association between morningness-eveningness and depression symptoms was partially serially mediated by resilience and anxiety in both the patient and nonpatient groups. The patient group exhibited significantly stronger morningness-eveningness toward resilience and anxiety than the nonpatient group. In the indirect effect of morningness-eveningness on depression, group differences exist only through each mediation of resilience and anxiety, not through serial mediation. Our results expand on the mechanism underlying the association between morningness-eveningness and depression. They highlight the importance of morningness-eveningness modification to increase resilience and the need to consider anxiety jointly in this process.

Development and Validation of a Composite Skin Quality Scale.

The increasing demand for skin quality interventions in aesthetic medicine underscores the necessity for objective, evidence-based assessment tools that may be used to evaluate novel interventions or devices. To develop and validate a 5-point photonumeric rating scale for assessing overall skin quality, including radiance, color evenness, and smoothness. The IBSA (Institut Biochimique SA) Composite Skin Quality Scale was developed and underwent live validation with 88 real-world patients, chosen to encompass a broad spectrum of skin qualities and Fitzpatrick skin types. Scale validation was performed by board-certified plastic surgeons and dermatologists over 2 rounds, 2 weeks apart. Reliability was assessed through intrarater and interrater agreements, utilizing weighted kappa statistics and intraclass correlation coefficient (ICC). The scale's ability to discern a clinically relevant 1-grade difference was evaluated with 72 photo pairs. Combined intrarater reliability results showed weighted kappa values of 0.812 (right side) and 0.815 (left side) and an ICC of 0.903 for both sides, indicating an almost perfect agreement. Interrater reliability ranged from substantial to almost perfect, with kappa coefficients between 0.654 and 0.853 and ICCs between 0.657 and 0.855 across all rater pairs in both rounds. The ability to detect a clinically relevant 1-point difference using the scale was established. Integrating various key aspects of skin quality, the IBSA Composite Skin Quality Scale is a clinically relevant and highly reliable tool, suitable for skin assessment in clinical studies of new aesthetic technologies and products.

Optimizing fouling mitigation in membrane distillation by controlled microbubble size and concentration

Fouling control strategies play a crucial role in membrane distillation (MD) process, primarily due to the significant limitation of fouling during the scaling-up process. The utilization of microbubbles (MBs) aeration has exhibited promising potential in mitigating membrane fouling when treating high salinity wastewater. Aeration can introduce gas-liquid two-phase flow on the membrane surface, thereby increasing the membrane surface shear force. The mechanism of aeration technology for controlling fouling includes the following points: introduction of gas-liquid two-phase flow; physical substitution of concentration polarization layer; pressure pulses caused by bubbles flowing through the membrane surface and increasement of the cross flow velocity. This research aims to optimizing the effect of air MBs with different concentrations and sizes introduced in the feed side on membrane fouling control, we creatively used the method of releasing pressure gradiently to achieve size regulation of MBs within a certain range for the first time, firstly regulated the generation of MBs by manipulating gas flow rate and release pressure. Under the optimal condition of 40 mL/min and 0.6 MPa, it will yield concentration of 1.58 × 104/mL and D50 Sauter size of 64.69 μm MBs with pure water permeance flux of 12.32 kg/(m2·h). It was observed that higher gas flow rates primarily increased MBs concentration, while lower pressures predominantly reduced MBs size through the method of inline imaging. Experimental results indicated that introduction of MBs can slightly improve the temperature polarization coefficient and mass transfer coefficient under different operating modes. Consequently, further investigations focused on the influence of MBs characteristics on different fouling control. All conditions reach 99 % rejection for inorganic salt and HA. This study provided empirical evidence that higher concentration and larger size of MBs intensify the gas-liquid two-phase flow disruption and exhibit a better shear effect on scaling phenomena, which yield advantageous outcomes in terms of augmenting permeance flux and water vapor production, with permeance flux increased from 40.12 % to 55.42 % for inorganic fouling and increased from 68.35 % to 80.15 % for inorganic and HA fouling. These results were confirmed via membrane surface using scanning electron microscopy and energy dispersive spectroscopy. In summary, this research aided in identifying appropriate operating conditions for mitigating inorganic and composite scaling by implementing air-infused MBs in direct contact membrane distillation (DCMD), which provides scientific and technical guidance for controlling fouling in MD in practical applications.