Objective To explore the experience of nurse-physician collaboration construction and its clinical practice effects. Methods From June 2013 to December 2015, based on the SBAR communication model, nurse-physician collaboration was constructed in oncology and surgery wards of Affiliated Cancer Hospital of Zhengzhou University, He'nan Cancer Hospital. The situation of nurse-physician collaboration, satisfaction of doctors, nurses, patients to nursing work were evaluated using the convenience sampling method and questionnaire survey method, before and after the implementation of nurse-physician collaboration mode. Results After the application, the score of Nurse-Physician Collaboration Scale (NPCS) was (114.89±14.56) , which was higher than before (94.37±16.21) , and the difference was statistically significant (t=-8.75, P<0.01) . The satisfaction degrees about nursing work of physicians, nurses and patients were (93.57±6.43) , (95.50±7.89) and (94.80±6.72) , which were all higher than before, and the differences were statistically significant (t=-2.07, -5.81, -7.02; P<0.05) . Conclusions Based on the SBAR communication mode, the establishment of nurse-physician collaboration mode could effectively promote the degree of cooperation between physicians and nurses, improve the satisfaction of physicians, nurses and patients, and improve the hospital care quality. Key words: Nurses; SBAR communication mode; Nurse-physician collaboration; Collaboration; Satisfaction