This paper investigates the issue of event-triggered adaptive saturated fault-tolerant control (ESFC) for uncertain nonlinear systems with time-varying full state constraints (TFSCs), actuator saturation and faults as well as unknown control direction. A bounded function with an auxiliary variable is constructed by utilizing a novel dynamics of the auxiliary system, which contributes to reducing the adverse impact of actuator saturation. Different from the previous backstepping-based event-triggered control methods such specifications by either using fuzzy approximation or by employing neural approximation techniques, this paper skillfully addresses the unknown nonlinearities, actuator saturation and faults without involving any approximation structures, and thus, we proposes the ESFC on the basis of low-complexity design framework as contributing to communication and computational resource reduction. A rigorous theoretical analysis shows that the proposed control method is an effective way to handle with the problems of actuator saturation and faults, full state constraints, and unknown system uncertainties, while simultaneously simplifying the backstepping design and avoiding the issue of explosion of complexity. The asymptotic stability of the closed-loop system is guaranteed and the Zeno behavior can be effectively removed. We present an application example of a linear motor scenario to illustrate the effectiveness of the method. <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Note to Practitioners</i> —Since state constraints, actuator saturation and faults, unknown mechanism model, and limited bandwidths exist extensively in practical engineering systems, which constantly degrade the operation performance of the plant. To handle these disadvantages, this paper is focus on providing simple but effective ESFC methods to ensure the asymptotic stability and enhance reliability. Compared to existing results, the presented method only uses the state signals of system without using system dynamic functions under mild conditions, which provides a theoretical basis, and has the advantages of low-complexity design, and easy implementation in practical engineering. Preliminary physical experimental comparisons demonstrate that this method is applicable to practical liner-motor platform, and achieves satisfactory control performance.