Abstract Background Surgeons and providers in aesthetic medicine seek non-invasive devices that can be utilized for safe, efficient and effective body contouring. Patient demand has propelled the development of novel devices that can simultaneously improve skin laxity, adipolysis along with stimulation of muscle hypertrophy. Objectives To determine the efficacy of body contouring after three treatments using the non-invasive Transform (InMode, Lake Forest, CA) device. Methods A prospective, multi-center study was performed. Outcomes evaluated include: standardized caliper and ultrasound measurements of abdominal skin/soft tissue thickness, waist circumference, histologic evaluation, patient comfort and satisfaction assessments. Results Forty-four patients were successfully enrolled in the study and completed the series of three treatments which involved combined electrical muscle stimulation (EMS) and non-invasive bipolar radiofrequency (RF). Abdominal ultrasound measurements reveal a decrease in soft-tissue thickness (average 3.1mm; p=0.001), there was a significant decrease in caliper measurements of peri-umbilical skin thickness (p<0.003) and the average reduction of abdominal circumference was 1.9cm (p<0.0001) three months after the treatment series. Histology confirmed subcutaneous adipolysis without damaging the dermal layer. Patients reported a high degree of satisfaction with the overall result (p=0.003) and that each of the three treatments were progressively more comfortable (p<0.005). Conclusions This study demonstrates that a series of simultaneous non-invasive RF with EMS treatments to the abdomen decreases subcutaneous soft tissue thickness of the treated area. These comfortable treatments ultimately result in a high degree of patient satisfaction at three months.