Abstract. Mineral dust significantly influences the Earth's climate system by affecting the radiative balance through the emission, absorption and scattering of solar and terrestrial radiation. Estimating the dust radiative effect remains challenging due to the lack of detailed information on the physical and chemical properties of dust. High-spectral-resolution instruments in the infrared (IR) spectrum, such as the Infrared Atmospheric Sounding Instrument (IASI), have demonstrated the ability to quantify these aerosol properties. A crucial parameter for characterizing mineral dust from space is the complex refractive index (CRI), as it links the dust's physical and chemical properties to its optical properties. This paper examines the impact of six prior laboratory CRI datasets to improve the characterization of dust microphysical properties using IASI. The CRIs include older measurements obtained through the classical pellet method, commonly employed in mineral dust applications, as well as newer datasets that incorporate the latest advancements in laboratory measurement techniques for aerosol generation. These datasets are tested on IASI measurements during a dust storm event over the Gobi Desert in May 2017. We evaluate the sensitivity of IASI to different CRI datasets using the Atmospheric Radiation Algorithm for High-Spectral Resolution Measurements from Infrared Spectrometer (ARAHMIS) radiative transfer algorithm and explore the datasets' impact on retrieving size distribution parameters by mapping their spatial distributions. The results indicate that the laboratory CRI datasets decrease the total error in the covariance matrix by 30 %. In addition, we assess the ability to accurately reconstruct IASI detections and the extent to which we can retrieve the microphysical properties of dust particles. The choice of CRI significantly impacts the accuracy of dust detection and characterization from satellite observations. Notably, datasets that incorporate recent aerosol generation techniques with higher spectral resolution and samples from the case study region show improved compatibility with IASI observations. The outcomes of this research emphasize two key points: the crucial link between chemical composition of dust and its optical properties and the importance of considering the specific composition of the CRI dataset for improved retrieval of the microphysical parameters. Furthermore, this study highlights the critical role of ongoing enhancements in CRI measurement approaches, as well as the potential of high-spectral-resolution infrared sounders for aerosol atmospheric investigation and for understanding the radiative impacts of sounders.