SASTRA University Research Articles

First person – Krittika Sudhakar

ABSTRACTFirst Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Krittika Sudhakar is first author on ‘Alterations in lifespan and sleep:wake duration under selective monochromes of visible light in Drosophila melanogaster’, published in BiO. Krittika conducted the research described in this article while a PhD student (DST-INSPIRE-senior research fellow) in Dr. Pankaj Yadav's lab at SASTRA University, Tirumalaisamudram, India. She is now a Postdoctoral Fellow in the lab of Dr. Adelheid Lempradl at the Van Andel Institute, Michigan, USA, investigating Deciphering the short and long-term effects of nutrition influences Drosophila physiology, aging and metabolism.

Adaptability of Smart Water Systems in Urban Belt-A Case Study at Sastra University, Thanjavur

Adaptability of Smart Water Systems in Urban Belt-A Case Study at Sastra University, Thanjavur

International Conference on Civil Engineering and Infrastructural Issues in Emerging Economies (ICCIEE 2017)

Preface/Introduction:The phenomenal rise in urbanization and industrialization has created a greater need for infrastructure development. In a developing economy, resource utilization and management is the need of the hour. This creates a need for innovation in materials, methods and management with greater emphasis on limited economic solutions. This has opened avenues for experimenting and implementing novel approaches with economic viability. There is also a need for harmony between rapid development and ecological balance to ensure sustainable development. This conference jointly organized by the School of Civil Engineering, SASTRA University, Thanjavur and IGS, Thanjavur Chapter aims to provide a platform for academicians, researchers and the industry to explore the possibilities of the use of nonconventional materials and their economic viability as alternative to conventional construction material, design and construction alternatives for economic and ergonomic structures, water management, sustainable development issues in environmental, geotechnical and transportation engineering and application of geomatics in hazard prediction and management.

INDIAN TRADITIONAL MEDICINE - A CONGLOMERATION OF ANCIENT KNOWLEDGE AND MODERN SCIENCE (21-22 July 2016: Phytocongress | Sastra University)

PHYTOCONGRESS – 2016 The International Conference Phytocongress – 2016 on the theme “Indian Traditional Medicine - A Conglomeration of Ancient Knowledge and Modern Science” was organized by Centre for Advanced Research in Indian System of Medicine (CARISM), SASTRA University, Thanjavur on 21 & 22 July 2016. This conference was focused on the vast, enviable traditional wealth of India, practices and usage of plant drugs, metals, minerals and animals by traditional medical practitioners during ancient times and the current status of traditional and synthetic drugs. This programme analyzed the requirements of modern times and how the same could be benefited through ancient wisdom. Sessions in the seminar covered a wide range of topics emphasizing the scientific merits involved in Ayurveda and Siddha medicines. These sessions highlighted the significance and importance of evidence based studies on traditional medicines and finding new experimental methodologies for their characterization using various sophisticated analytical techniques and their applications. The modern tools of chemistry and biology, in particular allow scientists to detail the exact nature of the biological effects of natural compounds on the human body, as well as to uncover possible synergies, which holds much promise for the discovery of new therapies against many devastating diseases. With the technology at hand today, we can validate the science behind this ancient knowledge and unravel the mysteries behind why and how traditional medicine works. The challenge today is to integrate the best of the different healing traditions to meet the healthcare needs of contemporary society. This International conference brought together leading academic scientists, researchers and research scholars to exchange and share their experiences and wisdom on all aspects of medicinal plants and natural products. It also provided an interdisciplinary platform for researchers, practitioners and educators to present and discuss the most recent innovations, trends, and concerns as well as practical challenges encountered and solutions to be adopted in the fields of medicinal plants and natural products. This conference was inaugurated by Prof. Bhushan Patvarthan, University of Pune, and this Conference was convened by Prof. P. Brindha, Associate Dean and Co-ordinator, CARISM, SATRA University. Invited international speakers from USA, Australia and Malaysia and national speakers gave scintillating lectures covering various aspects on the theme of the conference. Altogether nearly 200 Scientists, Siddha and Ayurveda Researchers, Practitioners and Industrialists participated from various parts of India.

Empirical Performance Analysis of Parallel Programs on Wired and Wireless Local Area Networks Using Beowulf Clusters

DOI: 10.9734/BJMCS/2016/21744 Editor(s): (1) Dariusz Jacek Jakobczak, Chair of Computer Science and Management in this department, Technical University of Koszalin, Poland. Reviewers: (1) Ahmet Sayar, Kocaeli University, Turkey. (2) Anand Nayyar, KCL Institute of Management and Technology, India. (3) Xinwei Niu, SASTRA University, Thanjavur, India. Complete Peer review History: http://sciencedomain.org/review-history/12383

Dual drug combination: an effective coating for drug eluting stent in the treatment of obstructive coronary artery disease

Event Abstract Back to Event Dual drug combination: an effective coating for drug eluting stent in the treatment of obstructive coronary artery disease Purandhi Roopmani1, Swaminathan Sethuraman1 and Uma Maheswari Krishnan1 1 SASTRA University, Centre for Nanotechnology & Advanced Biomaterials, India Introduction: Being minimally invasive biomaterial in vascular space, drug eluting stents face several complications such as stent thrombosis, late stent restenosis and incomplete endothelization due to presence of an anti-proliferative agent [1]. For such complications, a single therapeutic drug is insufficient; therefore approaches to use multiple drug combinations have been made [2]. The current study reports a combination of dual drug loaded poly(L-lactide-co-caprolactone) system for its hemocompatibility and anti-proliferative nature. Materials/Methods: Whole blood assay and platelet adhesion assay: To determine hemocompatibility of dual drug loaded polymer films whole blood assay and platelet adhesion assay were performed. The films were incubated in freshly collected rat blood and isolated platelet rich plasma (PRP). After 2 h, films were washed and fixed with 2.5% glutaraldehyde followed by serial dilution with ethanol. Films were then imaged using scanning electon microscopy (SEM). Cell migration assay: To evaluate an anti-proliferative nature of dual drug loaded polymer films a cell migration assay was conducted using smooth muscle cells (SMC). Films were inbcuated with cells until it formed a monolayer, after which it was scratched to create a wound. Migration of cells was checked for 48 h using phase contrast microscope. Results and Discussion: Dual drug loaded films showed significant reduction in red blood cell adhesion and clot formation as compared to polymer film and controls. In case of platelet adhesion and aggregation, dual drug loaded films display a concentration dependent decrease in platelet aggregation (Figure 1). Cell migration assay shows delay in wound closure on combination films as compare to a tissue culture plate. Conclusion: Dual drug loaded polymer films reported in this study possess anti-thrombogenic and anti-proliferative nature. This system may be explored further for stent applications. Department of Science & Technology under the FIST programme (SR/FST/LSI-453/2010); SASTRA University (TA fund)

HEAL Project Aims to Regenerate Human Limbs by 2030

Recently, the Institute for Regenerative Engineering (IRE) at the University of Connecticut (UConn) Health announced the launch of the Hartford EngineeringA Limb (HEAL) initiative, which aims to “regenerate a new human joint in 7 years and regenerate an entire limb in 15 years.” About 25 UConn researchers will be involved in this HEAL project, including Professors Cato Laurencin, Lakshmi Nair, and Yusuf Khan. Also, scientists and clinicians from around the world will participate in the HEAL project, including research teams at UC Irvine, Harvard University, Columbia University, and SASTRA University in India. The researchers will combine cutting-edge technologies across tissue engineering, bioengineering, and regenerative medicine, which will be the first international collaboration for the knee and the limb regenerative engineering. For leading this new interdisciplinary research program of regenerative engineering, Dr. Cato Laurencin has won a National Institutes of Health (NIH) Pioneer Award, which according to the NIH is for “scientists of exceptional creativity who propose pioneering and possibly transforming approaches to addressing major biomedical or behavioral challenges that have the potential to produce an unusually high impact on a broad area of biomedical or behavioral research.” The HEAL project and IRE are also supported by the grant award from the National Science Foundation for Emerging Frontiers in Research and Innovation, funding from the Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences at UConn Health, and the State of Connecticut. Over the past 20 years, Dr. Laurencin and his colleagues have developed innovative technologies to create component tissues, such as bone, cartilage, ligaments, tendon, skin, nerve, and blood vessels, which have been successfully implanted in human clinical trials. Dr. Laurencin’s strategy for regenerative engineering focuses on the engineering biomimetic tissues that can grow after being integrated into patients rather than making robotic limbs. Now, inspired from salamanders and newts which can regenerate their limbs within few weeks after amputation, they challenge to engineer a complex musculoskeletal system to help patients who have lost limbs or damaged nerve due to cancers, diabetes, infections, trauma accidents, and congenital defects. By utilizing regenerative engineering technology, the team will develop integrated graft systems, such as osteochondral, osteoligamentous, muscle/tendon, and vascularized tissues. Also, peripheral nerves will be integrated into the tissues to generate additional tissues. The team will apply biological, electrical, and biomechanical cues from developmental biology for the regeneration and integration of complex tissues and limb. The HEAL project aims to revolutionize the treatment of musculoskeletal tissues and will generate knowledge that can extend into regeneration of other tissue systems.

A New Definition of Limit of Periodic Function and Periodic g-Contractive Mapping at Infinity

DOI: 10.9734/BJMCS/2015/18768 Editor(s): (1) Sergio Serrano , Department of Applied Mathematics, University of Zaragoza, Spain. Reviewers: (1) Choonkil Park, Department of Mathematics, Hanyang University, Republic of Korea. (2) J. A. Tenreiro Machhado, Dept. of Electrical Engineering, Institute of Engineering (ISEP), Polytechnic of Porto, Portugal. (3) Anonymous, Sastra University, India. (4) Leonardo Simal Moreira, Centro Universitario de Volta Redonda, Brazil. (5) Anonymous, HITEC University Taxila, Pakistan. Complete Peer review History: http://www.sciencedomain.org/review-history.php?iid=1146&id=6&aid=9663

Comparative Analysis of Post University Matriculation Examination in Nigerian Universities Using Fuzzy Logic

DOI: 10.9734/BJMCS/2015/20165 Editor(s): (1) Zhenyou Huang, Department of Mathematics, Nanjing University of Science and Technology, Jiangsu, P. R. China. (2) Dragos Patru Covei, Department of Mathematics, University “Constantin Brâncusi” of Târgu-Jiu, România. (3) Tian-Xiao He, Department of Mathematics and Computer Science, Illinois Wesleyan University, USA. Reviewers: (1) Anonymous, Sastra University, Kumbakonam, India. (2) Harish Garg, Thapar University Patiala, India. Complete Peer review History: http://sciencedomain.org/review-history/11419

Improving Adequacy in a Rule-Based English-to-Igala Automatic Translation System through Word Sense Disambiguation

DOI: 10.9734/BJMCS/2015/19994 Editor(s): (1) Dariusz Jacek Jakobczak, Chair of Computer Science and Management in this department, Technical University of Koszalin, Poland. Reviewers: (1) Anonymous, SASTRA University, India. (2) Milam Aiken, University of Mississippi, USA. (3) Ibrahim El-Zraigat, University of Jordan, Jordan. Complete Peer review History: http://sciencedomain.org/review-history/10648

Editorial [Hot topic: Crucial Role of Redox Signaling in the Regulation of Heart Health (Guest Editor: Dipak K. Das)

Editorial [Hot topic: Crucial Role of Redox Signaling in the Regulation of Heart Health (Guest Editor: Dipak K. Das)

Road Accidents Prevention and Detection

To realize the value of one second, ask the person who has survived an accident.” Transportation plays a key role in development of a country. Travel, mainly road travel is inevitable to any individual. With at least 13 people dying every hour on Indian roads, India had topped the global list of deaths in road accidents (global status report, WHO). Roads are the key access to many places. Places situated over the mountain ranges are sometimes accessible only by roads. Thus ghat roads play a important role in the road transport system. In Ghat roads, the major accident prone zones are Uturns where the approach of vehicles in opposite direction is almost invisible which results in fatal accidents. Besides prevention, the acknowledgement of accidents is a major problem due to poor communication facilities. India doesn’t have a scientific traffic engineering which forms the basis of road safety improvement. Though many conventional methods were implemented, they proved largely unsuccessful. We propose a scientific approach to this problem. Our proposal to prevent this phenomenon is to detect the vehicles approaching the turn by using sensors and to warn the vehicles in opposite direction. To detect the occurred accidents in time, we use electronic toll systems. K. Surya Teja AV hostel345, ECE-III year Sastra University, Tanjore Tamilnadu-613402, India The full text of the article is not available in the cache. Kindly refer the IJCA digital library at www.ijcaonline.org for the complete article. In case, you face problems while downloading the full-text, please send a mail to editor at editor@ijcaonline.org