The petrophysical properties of sediment drill core samples recovered from the Sardinian margin and the abyssal plain of the Southern Tyrrhenian Basin were used to estimate the downhole change in porosity and rates of deposition and mass accumulation. We calculated how the deposited material has changed its thickness as a function of depth, and corrected the thickness for the compaction. The corresponding porosity variation with depth for terrigenous and pelagic sediments and evaporites was modelled according to an exponential law. The mass accumulation rate for the Plio-Quaternary is on average 4.8� 10 4 kg m )2 my )1 on the Sardinian margin and for the Pliocene in the abyssal plain. In the latter area, the Quaternary attains its greatest thickness and a mass accumulation rate of 11– 40� 10 4 kg m )2 my )1 . The basement response to sediment loading was calculated with Airy-type backstripping. On the lower part of the Sardinian margin, the basement subsidence rate due to sediment loading has decreased from a value of 300 m my )1 in the Tortonian and during the Messinian salinity crisis (7.0–5.33 Ma) to about 5 m my )1 in the Plio-Quaternary. In contrast, on the abyssal plain this rate has changed from 8–50 m my )1 during the period 3.6–0.46 Ma, to 95–130 m my )1 since 0.46 Ma, with the largest values in the Marsili Basin. The correlation between age and the depth to the basement corrected for the loading of the sediment in the ocean domain of the Tyrrhenian Basin argues for a young age of basin formation.