Sarcoma Of Heart Research Articles

Therapy Insight: malignant primary cardiac tumors

Benign cardiac tumors are resected with a high degree of success with modern cardiac surgical techniques. Malignant cardiac tumors, however, continue to pose a therapeutic challenge to cardiac surgeons and oncologists because of the technical difficulty involved in extensive cardiac resections and the aggressive biological nature of the tumors. The majority of malignant cardiac tumors are sarcomas and can be categorized as right heart sarcoma, left heart sarcoma or pulmonary artery sarcoma. Right heart sarcomas are generally angiosarcomas, which infiltrate widely and metastasize early. A combination of chemotherapy and surgical resection is the preferred therapy. Left heart sarcomas, although large, are often less infiltrative and metastasize later than right heart sarcomas, but a similar approach to treatment is usually employed. Surgical resection is more-frequently necessary for left heart sarcomas because of intracardiac blood flow obstruction and congestive heart failure, although the anatomic position and relation of these tumors to cardiac structures can complicate surgery. We have developed and employed the technique of cardiac autotransplantation, which involves cardiac excision, ex vivo tumor resection with cardiac reconstruction, and cardiac reimplantation, to lessen these technical difficulties. Pulmonary artery sarcomas can be treated by radiotherapy, as well as by the other therapies, because the myocardium can be avoided by the radiation fields. Surgical resection of this sarcoma type often requires pneumonectomy and can require pulmonary root replacement.

Tumors of the heart and stomach induced in European hamsters by intravenous administration of N-methyl-N-nitrosourea.

One hundred twenty captured European hamsters (Cricetus cricetus L.) were inoculated iv with 1/5, 1/10, or 1/20 the median lethal dose of N-methyl-N-nitrosourea (MNU) once weekly for 18 weeks. MNU induced mainly sarcomas in the heart and squamous cell carcinomas and sarcomas in the stomach. The highest incidence of such tumors was demonstrated by the lowest-dosage group. They were more frequent in males than in females. The effect of MNU was also localized at the site of administration and resulted in squamous cell carcinomas of the oral cavity. The possible fibroblastic or neurogenic origin of the sarcomas was explored.

A case of primary heart sarcoma with acute cardiac tamponade.

In the present case, tumors originated from endocardium just under the ulmonary valve orifice. They were polypoid and extended along the pulmonary trunk to the right and left pulmonary arteries, and metastasized to the left ventricle and left adrenal. Histologically, they consisted of fibromyxoma, fibromyxosarcoma, and liposarcoma. Finally, the patient died from acute cardiac tamponade caused by the bleeding from the left ventricular metastatic lesion.

A case of primary sarcoma of heart with vertebral metastases

A case of primary sarcoma of heart with vertebral metastases

Sarcoma of the Heart in a Child

Sarcoma of the Heart in a Child

PRIMARY NEOPLASMS OF THE HEART

Primary rhabdomyosarcoma of heart in an adult has not yet been reported in literature. It is our purpose in this paper to report such a case and to discuss briefly primary of heart. The literature of this subject has been reviewed by Perlstein,1Goldstein,2Beck and Thatcher,3Nowicki4and Morris,5who gives comprehensive references to literature of secondary growths in heart. Goldstein in his opening paragraph states that tumors of heart are uncommon; primary growths are rare; primary sarcoma of heart is a very rare finding. According to Perlstein heart is least frequent site of primary neoplastic change, while Adami6remarks that the heart above all organs is constantly in a state of great efficiency, well nourished, well innervated and functionally always active, so that it is less likely to take on aberrant growth.

Neoplasm in an Indian Rhinoceros (Sarcoma of Heart and Lungs)

Neoplasm in an Indian Rhinoceros (Sarcoma of Heart and Lungs)