Purpose Efficacy of Sapien XT valve has been reported for percutaneous pulmonary valve implantation (PPVI). Implantation is complex given the rigidity and the of the Novaflex® delivery system. Sapien 3 valve is the latest evolution of Edwards valves with a more flexible Commander® delivery system. We report our results of off-label use of Sapien 3 for PPVI. Methods Between September 2016 and April 2017, 16 procedures were performed with the Sapien 3 and compared to 26 procedures performed with the Sapien XT between January 2015 and July 2016. Results Sapien 3 were implanted in 16 patients [26 years old (23–38)]. Conduit were native patched valves (n = 6), bioprosthesis (n = 4), tube (n = 4), homograft (n = 1) and Melody valve (n = 1). All patients had pulmonary prestenting (Andrastent XXL, n = 12; eV3 LDmax, n = 4). Valve implantation was performed during a second procedure in 5 cases. Valve diameters were 23 (n = 3), 26 (n = 4) and 29 mm (n = 9). Valves were successfully implanted in all cases. After procedure, one patient had minor pulmonary valve regurgitation. Peak-to-peak gradient across the valves was ≤ 15 mmHg in 14 cases. Two patients had minor valve mismatch. Nor valve dysfunction nor infective endocarditis was reported during follow-up. Procedure duration, fluoroscopy time, dose-length product and kerma were lower with Sapien 3 compared to Sapien XT procedures (0.002, 0.01, 0.006, and 0.007 respectively). Conclusion Sapien 3 valve implantation in pulmonary position with the Commander delivery system is efficient and faster. However, the lack of valve covering onto the delivery system remains an issue.