The relevance of the stated topic is determined by the social significance of the successful functioning of the system of medical care for citizens to preserve and restore their health. The experience of departmental medical institutions in the previous periods of national history makes it possible to use it rationally in modern conditions along with the services of state and commercial medicine. In scientific terms, the history of the medical and sanitary service of railway transport has not yet been properly developed, as a result of which the study of the declared topic can contribute to the concretization of knowledge about the evolution and problems of the development of domestic healthcare.The purpose of the study is to reveal the features of the post–war restoration of the activities of medical and sanitary institutions of the South-Eastern Railway on the basis of archival documents and periodical press materials.Objectives: to characterize the dynamics of the development of the network of medical and sanitary institutions on the South-Eastern Railway in 1945-1950; to identify the main activities of railway medicine in the period under study; to consider the current problems of the functioning of the industry and ways to solve them.Methodology. The research was based on the principles of objectivity and historicism. To solve the tasks set by the author, the methods of historical-genetic, historical-systemic, historical-comparative, typological, retrospective were used.Results. The study of the main activities of medical and sanitary institutions on railway transport made it possible to present in historical retrospect the features of providing medical care by means of the sectoral healthcare system, which had a certain autonomy and mobility in servicing the entrusted contingent of employees and their family members.Conclusions. During the five post-war years, the transport healthcare system that operated on the South-Eastern Railway restored full efficiency, having managed to improve the material and technical equipment of medical institutions in difficult conditions and strengthen their personnel potential, which positively affected the quality of medical care.