Article1 November 1957THE SIGNIFICANCE OF BACTERIAL HYPERSENSITIVITY IN HUMAN BRUCELLOSIS: STUDIES ON INFECTION DUE TO STRAIN 19 BRUCELLA ABORTUSWESLEY W. SPINK, M.D., F.A.C.P.WESLEY W. SPINK, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-47-5-861 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough the host-parasite relationship in many infectious diseases has been intensively studied in man, it is surprising how little is known about the fundamental mechanisms that are responsible for the resultant human illness. In conjunction with studies on the host-parasite factors in brucellosis, my associates and I have sought an answer to the question, What basic features contribute to the illness of a patient with this disease?The purpose of this report is to point out the significance of bacterial hypersensitivity in the genesis of the illness caused by brucella organisms. Such a thesis has been proposed by others, not...Bibliography1. Gilman HL: Undulant fever caused by Brucella abortus, strain 19, Cornell Vet. 34: 193, 1944. Google Scholar2. SpinkThompson WWH: Human brucellosis caused by Brucella abortus, strain 19, J. A. M. A. 153: 1162, 1953. CrossrefMedlineGoogle Scholar3. Bardenwerper HW: Human sickness caused by Brucella abortus, strain 19, J. A. M. A. 155: 970, 1954. CrossrefMedlineGoogle Scholar4. SaduskBrowneBorn JFASJL: Human brucellosis resulting from Brucella abortus strain 19 vaccine, J. A. M. A. 164: 1325, 1957. CrossrefMedlineGoogle Scholar5. 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HalbergSpinkBittner FWWJJ: Protection by aldosterone and 11,17-oxycorticoids against effects of Brucella somatic antigen in adrenalectomized mice, Endocrinology 59: 380, 1956. CrossrefMedlineGoogle Scholar17. AbernathyHalbergSpink RSFWW: Studies on the mechanism of chlorpromazine protection against Brucella endotoxin in mice, J. Lab. and Clin. Med. 49: 708, 1957. MedlineGoogle Scholar18. SpinkHall WWWH: The influence of cortisone and adrenocorticotrophic hormone on brucellosis. II. Adrenocorticotrophic hormone (ACTH) in acute and chronic human brucellosis, J. Clin. Investigation 31: 958, 1952. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, Minnesota*Presented at the Thirty-eighth Annual Session of The American College of Physicians, Boston, Massachusetts, April 11, 1957.From the Department of Medicine, University of Minnesota Hospitals and Medical School.Requests for reprints should be addressed to Wesley W. Spink, M.D., Department of Medicine, University of Minnesota Medical School, Minneapolis 14, Minnesota. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVeterinary PharmaceuticalsNeedlestick Injuries in Agriculture Workers and Prevention ProgramsBrucellosisBrucellosisAdverse events in humans associated with accidental exposure to the livestock brucellosis vaccine RB51BrucellosisBrucellosisBrucelosis y derrame pleural: Revisión de la literaturaBrucellosisAllergyBRUCELLOSIS AS A HUMAN HEALTH HAZARD IN AUSTRALIAKrankheiten durch BrucellenKrankheiten durch BrucellenHOST-PARASITE RELATIONSHIP IN BRUCELLOSISSection E. Diseases of dairy cattleADRENOCORTICAL STEROIDS IN THE MANAGEMENT OF SELECTED PATIENTS WITH INFECTIOUS DISEASES*WESLEY W. SPINK, M.D., F.A.C.P. 1 November 1957Volume 47, Issue 5Page: 861-874KeywordsAntigensBrucellaBrucellosisHospital medicineHypersensitivityInfectious diseases Issue Published: 1 November 1957 PDF downloadLoading ...
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