Disgusting deposits (e.g., scale and crude oil) in daily life and industrial production are always serious problems, posing great threats to the safety and economic development. However, most of developed coatings can only conquer one part of these deposits such as superhydrophobic coatings possess anti-scaling capacity but would adhere crude oil. To integrate scale resistance with oil repellence, we herein report a robust superamphiphobic (SAB) coating simultaneously reducing pollution of scale and oil for extended period of time (two weeks with over 98% reduction). Compared with single role of superhydrophobic and amphiphilic surfaces, the SAB coating can not only inhibit interfacial nucleation of scale but also reduce the adhesion of formed scale and polluted oil. The durability of the SAB coating is evaluated via mechanical tests (sandpaper abrasion, tape stripping and sand falling) and chemical corrosion (corrosive liquid immersing), revealed by sustainable high contact angles and low contact angle hysteresis of water and oil. The universality of this strategy can be further confirmed by adding different particles like kaolin, Al2O3, and SiO2, resisting multiple types of scale (i.e., CaSO4, BaSO4 and MgCO3) and oil (i.e., glycerol, glycol, and mineral oil). Therefore, this study provides an ideal avenue for resisting scale and oil, which may be used for conquering the complexity of application environments (e.g., oil production and transportation).