Quality of a composite material like sandcrete block is basically a function of the basic properties of the constituent ingredients, mix ratio relationship and its production characteristics. This study, investigate the effects of change in quantities of the constituent ingredient on compressive strength of sandcrete blocks produced at various curing ages in Owerri Metropolis. Field survey was conducted in the area to determine the production characteristics of the blocks marketed in the area. Based on the prevalent nominal mix ratio of the block, mix design on the constituent ingredients of the block based on box-wilson symmetric composite plan B3was adopted. Results of the strength from each experimental set of the design were used to formpolynomial regression models of blocks cured at various ages. Findings show that the average compressive strengths of the 7-day, 14-day, and 28-day old cured blocks are 1.578 N/mm2, 1.604 N/mm2, and 1.975 N/mm2.Mono-factorial analysis shows that at its respective age of curing, cement and water factors have stronger effect on the strength of the block than sand factor. The nature of their influences is positive, and more linear than quadratic and mutual interaction relationships. The relationship of mutual interaction between the cement and water factors is seen only in the models of the 7-day and 28-day curing ages in the study. Since the strength of the block increases with increase in the age of curing, it therefore confirms the standard practice of 28-day curing age for improved quality of sandcrete block in the industry; as well as recommending mono-factorial analyses on the effects of the independent factors of the mix designed blocks cured age 28-day age, towards optimum composition of the sandcrete mix ingredients for the desired quality of the blocks produced in the study area.