Population Sample Research Articles

National health examination surveys; a source of critical data.

The aim of this paper is to contribute technical arguments to the debate about the importance of health examination surveys and their continued use during the post-pandemic health financing crisis, and in the context of a technological innovation boom that offers new ways of collecting and analysing individual health data (e.g. artificial intelligence). Technical considerations demonstrate that health examination surveys make an irreplaceable contribution to the local availability of primary health data that can be used in a range of further studies (e.g. normative, burden-of-disease, care cascade, cost and policy impact studies) essential for informing several phases of the health planning cycle (e.g. surveillance, prioritization, resource mobilization and policy development). Examples of the use of health examination survey data in the World Health Organization (WHO) European Region (i.e. Finland, Italy, Malta and the United Kingdom of Great Britain and Northern Ireland) and the WHO Region of the Americas (i.e. Chile, Mexico, Peru and the United States of America) are presented, and reasons why health provider-led data cannot replace health examination survey data are discussed (e.g. underestimation of morbidity and susceptibility to bias). In addition, the importance of having nationally representative random samples of the general population is highlighted and we argue that health examination surveys make a critical contribution to external quality control for a country's health system by increasing the transparency and accountability of health spending. Finally, we consider future technological advances that can improve survey fieldwork and suggest ways of ensuring health examination surveys are sustainable in low-resource settings.

Association of the oral microbiome with cognitive function among older adults: NHANES 2011–2012

BackgroundAn association between the gut microbiome and cognitive function has been demonstrated in prior studies. However, whether the oral microbiome, the second largest microbial habitant in humans, has a role in cognition remains unclear. Design, setting, participantsUsing weighted data from the 2011 to 2012 National Health and Nutrition Examination Survey, we examined the association between oral microbial composition and cognitive function in older adults. The oral microbiome was characterized by 16S ribosomal RNA gene sequencing. Cognitive status was assessed using the Consortium to Establish a Registry for Alzheimer’s Disease immediate recall and delayed recall, Animal Fluency Test, and Digit Symbol Substitution Test (DSST). Subjective memory changes over 12 months were also assessed. Linear and logistic regression models were conducted to quantify the association of α-diversity with different cognitive measurements controlling for potential confounding variables. Differences in β-diversity were analyzed using permutational analysis of variance. ResultsA total of 605 participants aged 60–69 years were included in the analysis. Oral microbial α-diversity was significantly and positively correlated with DSST (β, 2.92; 95% CI, 1.01–4.84). Participants with higher oral microbial α-diversity were more likely to have better cognitive performance status based on DSST (adjusted odds ratio, 2.35; 95% CI, 1.28–4.30) and were less likely to experience subjective memory changes (adjusted odds ratio, 0.43; 95% CI, 0.25–0.74). In addition, β-diversity was statistically significant for the cognitive performance status based on DSST (P = 0.031) and subjective memory changes (P = 0.023). ConclusionsOral microbial composition was associated with executive function and subjective memory changes among older adults among older U.S. adults in a nationally representative population sample. Oral dysbiosis is a potential biomarker or therapeutic target for cognitive decline. Further work is needed to elucidate the mechanisms underpinning the association between the oral microbiome and cognitive function.

Premenstrual syndrome among medical versus non-medical workers and its association with work-related quality of life

BackgroundPremenstrual syndrome (PMS) is a commonly underestimated disorder that negatively impacts a woman’s life. Medical workers, who live a more stressful life, may report an increased rate of PMS. Studies on the relationship between PMS and work-related quality of life for medical professionals are scarce, particularly in the Arab world. This study aimed to compare the frequency of PMS among medical versus non-medical workers at Zagazig University and to assess the association between PMS and their work-related quality of life.MethodsA comparative cross-sectional study was conducted. The sample population consisted of 48 medical and 48 non-medical female workers aged 18–45 years from Zagazig University. The two groups filled out a questionnaire with 3 parts: sociodemographic and occupational data, the Premenstrual Symptoms Screening Tool (PSST), and the Work-Related Quality of Life Scale (WRQL).ResultsSevere PMS was reported in 45.8% of medical workers versus 20.8% of non-medical workers with a statistically significant difference between both groups (p = 0.009). Binary logistic regression showed that being a medical worker, clinical specialty, ≥ 8 years of work, ≥ 24 working hours per week, and having a non-set hourly schedule were predictors for severe PMS. PMS was found to be a statistically significant predictor of poor WRQL (p < 0.001). There was a highly significant negative correlation between the PMS score and the WRQL score (r = − 0.302, p < 0.001).ConclusionAmong medical workers, PMS is more common and more severe, and WRQL is worse and negatively correlated with PMS. We suggest further studies with larger samples to prove this association and planning for public health programs to screen for and manage PMS among medical workers in our community.

Lietuviškosios Viešojo kalbėjimo nerimo skalės faktorių struktūra ir patikimumas

Social Anxiety Disorder (SAD) is especially prevalent among young individuals aged 18–25 and significantly affects daily social activities and interpersonal relationships. Public Speaking Anxiety (PSA), a subtype of SAD, is a widespread concern that affects one in five individuals. The study focuses on the Public Speaking Anxiety Scale (PSAS), with the aim of assessing the factor structure and reliability of the Lithuanian version (PSAS-LT). The PSAS-LT, administered to 227 participants aged 18–25, comprises 17 Likert-scaled items, evaluating cognitive, behavioral, and physiological aspects of PSA. Three models were tested: a single-factor model, a three-factor model and a single factor model with positive and negative item wording factors model. Results indicate less than desirable fit for the single, and three-factor models, suggesting the need for alternative structures. The model that included a single factor as well as positive and negative item wording factors demonstrated a reasonably good fit. The diagnostic validity confirmed that the PSAS-LT effectively differentiated between participants with and without history of anxiety disorders. The total score of the PSAS-LT had excellent internal consistency. Despite limitations, including convenience sampling and nonrepresentative sample, the study contributes valuable insights into refining the understanding of PSA assessment features, emphasizing the importance of considering response patterns. Future research should validate these findings with larger and more diverse samples of the Lithuanian population.

Specific antitumor activity of anti-CA125 CAR-T lymphocytes against CA125-positive and CA125-negative cells

Aim. To evaluate the antitumor efficacy of our developed drug based on cytotoxic T lymphocytes genetically modified with a chimeric antigen receptor (CAR) specific to the CA125 antigen in relation to both CA125-positive and CA125negative cell cultures.Materials and methods. We performed an in vitro study on CA125-positive human ovarian cancer cells (OVCAR-3, OVKATE) and CA125 negative cells (breast cancer MCF 7, embryonic kidney HEK293). Cytotoxic effects on tumor cells were evaluated after 0, 4, 8 and 24 hours using the 3’-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and Lactate Dehydrogenase (LDH) tests. We also studied the changes in the number of cells “in real time” when exposed to transfected lymphocytes using the RTCA iCELLIgence device (ACEA Biosciences, USA). Lymphokineactivated killer (LAK) cells were used as a specificity control.Results. The study demonstrated that anti-CA125 CAR-T lymphocytes exhibited a pronounced cytotoxic effect on OVCAR-3 and OVKATE cell cultures, exceeding the effect of LAK by 1.3 times. The cell population in the experimental samples decreased by 70 ± 4%, which exceeded the LAK effect by 9 ± 8.2%. With regard to the MCF-7 cell line, the cytotoxic effect of anti-CA125 CAR-T lymphocytes was minimal as evidenced by a 25.8% decrease in the relative number of live cells in comparison to the LAK cytotoxicity of 68%. Real-time monitoring of cell proliferation and viability proved a high specific cytotoxic effect of anti-CA125 CAR-T lymphocytes against tumor cultures expressing CA-125, while inferior to LAK in cultures not expressing CA125 (MCF-7, HEK293).Conclusions. The use of anti-CA125 CAR-T lymphocytes against CA125-positive tumor cell lines OVCAR-3 and OVKATE demonstrated a pronounced specific cytotoxic effect exceeding the cytotoxic effect of LAK, which was not achieved against CA125-negative MCF-7 and HEK293 cells.

Can provincial-pooling of urban and rural resident basic medical insurance improve the health performance of migrant population?

Enhancing the pooling level of medical insurance is an inevitable requirement to strengthen the mutual assistance capability of funds and achieving national health. In China, with the continuous expansion of the migrant population seeking medical treatment in other regions, the role of provincial-pooling of basic medical insurance is becoming increasingly prominent. While there is limited research on the impact and mechanism of provincial-pooling of basic medical insurance on the health of migrant population. Therefore, this study aims to explore the impact of provincial-pooling of basic medical insurance on the health performance of migrant population and analyze the mediating role of social integration. Using data of three waves (2014, 2016 and 2018) of the China Labor force Dynamics Survey, this study focuses on a sample of migrant population enrolled in Urban and Rural Resident Basic Medical Insurance and employs the estimation methods of time-varying difference-in-difference and mediating effect model. The results of time-varying difference-in-difference show that provincial-pooling of basic medical insurance improves the health performance of migrant population by 9.6% (p < 0.05), and the event study method and placebo test all indicate that the research results are robust. The mediating effect analysis demonstrates that the provincial-pooling of basic medical insurance enhances health performance by fostering the subjective and objective social integration, and neighbourhood assistance, social equity, life happiness and trust in the majority are specific intermediary channels. The results of heterogeneity analysis indicates that provincial-pooling of basic medical insurance is more effective in improving the health performance of high-income (β = −0.090; P < 0.05), new-generation (β = −0.116; P < 0.1) and highly-educated (β = 0.130; p < 0.05) migrant population. Our results call for accelerating the promotion of provincial-pooling of basic medical insurance to improve health performance of migrant population.

The Brief Symptom Inventory-9 (BSI-9): Development and validation in a German general population sample

BackgroundThe Brief Symptom Inventory-18 (BSI-18) is a self-report questionnaire with three subscales, somatisation, anxiety, and depression, based on longer measures of distress. The present study proposes a shorter, nine-item version (BSI-9) of the BSI-18 as a brief screening tool for distress.MethodsConfirmatory factor analyses and reliability and validity analyses were carried out using a representative sample of the German general population. Confirmatory factor analysis demonstrates a good model fit for the three-dimensional BSI-9.ResultsThe total scale was found to have strong internal consistency (αCronbach = 0.87 for the global severity index). The internal consistency coefficients of the three-item subscales reflect the brevity of these scales (somatisation αCronbach = 0.72, depression α Cronbach = 0.79, anxiety αCronbach = 0.68). The subscales were found to be significantly related with subscales of the Patient Health Questionnaire-4 and Hopkins Symptom Checklist-25.LimitationsThe present study used a limited number of distress measures, and a more recent dataset would be useful to provide a more current picture of the general population’s distress levels.ConclusionsThe BSI-9 provides a short, valid, and reliable screener for distress in the general population. Future work should examine its utility in clinical settings and different cultural contexts.

Attentiveness and mental health in adolescents with moderate-to-severe atopic dermatitis without ADHD

Patients with moderate-to-severe atopic dermatitis (AD) experience intense chronic itch and impaired sleep. Reports from parents and teachers suggest that AD patients may also have attention problems. However, attention has not yet been directly assessed in AD patients. We utilized an objective, computer-based continuous performance test (CPT) validated for use in attention-deficit/hyperactivity disorder (ADHD) diagnosis to formally evaluate attention in adolescent AD subjects. This was a single-visit, cross-sectional, non-interventional study of moderate-to-severe (Investigator’s Global Assessment [IGA] ≥ 3) AD subjects aged 12–17 years without clinician-diagnosed ADHD. Attention was evaluated using two performance-based measures: Conners, CPT-3 and the Stroop Color and Word Test. The primary parameter was CPT-3 detectability (d’) measure. Lesional severity measures included Eczema Area and Severity Index (EASI) and body surface area (BSA) involvement. Subjects completed self-report rating scales assessing sensory responsiveness patterns (Adult/Adolescent Sensory Profile [AASP]), itch (Peak Pruritus Numerical Rating Scale [PP-NRS]), skin pain, quality of life, sleep, anxiety, and depressive symptoms. A total of 44 subjects were included in the study (61.4% female; mean age 15.0 [SD 1.78] years; mean EASI 20.4 [SD 7.8]; mean PP-NRS 7.0 [SD 1.8]). Results indicated substantial disease impact on sleep, quality of life, and comorbid anxiety and depressive symptoms. The mean (SD) Conners, CPT-3 dʹ T-score was 48.7 (SD 10.7), similar to the expected mean from a randomly selected age/gender-matched sample of the general population (50 [SD 10], by definition). Overall, 13.6% of subjects exhibited a dʹ T-score ≥ 60 (clinically significant poor performance), which was not greater than the expected general population value (15.9%). Subject-level data review by two psychologists determined that only 2 subjects demonstrated an overall response pattern that clearly indicated attention deficit. Many subjects had atypical sensory responsiveness profiles: sensory hypersensitivity (38.6%), sensory avoidance (50%), and low registration (hypo-sensitivity, 36.4%). Adolescents with moderate-to-severe AD without existing ADHD diagnosis did not demonstrate greater attention problems on performance-based measures than would be expected in age/gender-matched peers.Trial registration NCT05203380.

New insights on the chromosomal inversion thermal adaptation in insects: American populations of Drosophila subobscura

AbstractDrosophila subobscura is an excellent model species for testing genetic variation in thermal adaptation due to its rich inversion chromosomal polymorphism. In Palearctic populations, the inversions of this species can be classified as “cold”, “warm” or “nonthermal” adapted. Based on this classification the Chromosomal Thermal Index (CTI) was developed, which allows measuring the thermal adaptation of populations and monitoring changes over time. Here, we aim to use this index in American colonizing populations of D. subobscura for the first time to obtain new information on the species thermal adaptation. Thus, thermal adapted inversions (“cold” and “warm”) were defined for the American continent and CTI was computed in South American (1981 and 1999 samples) and North American (1985 and 2004 samples) populations of D. subobscura. In general, both American populations showed an inverse relationship between CTI values and latitude, with CTI values decreasing when latitude increases. When comparing populations sampled in different years, an increase in CTI values was detected in four out of six temporal comparisons (only one was significant) of South America (1981 and 1999) and in six out of seven populations of North America (1985 and 2004). A global analysis using a one‐way repeated measures anova of CTI values in both American hemispheres showed a trend of increase for “warm” adapted inversions in Chile and North America, but this increase was only significant for the latter. Overall, these results are in agreement with global warming expectations, although natural selection acted differently in the colonized hemispheres.

Restrictive Spirometric Pattern and Preserved Ratio Impaired Spirometry in a Population 50-64 Years.

Knowledge regarding prevalence and shared and unique characteristics of Restrictive spirometric pattern (RSP) and Preserved ratio impaired spirometry (PRISm) is lacking for a general population investigated with post-bronchodilator spirometry and computed tomography of the lungs. To investigate shared and unique features for RSP and PRISm. In the Swedish CArdioPulmonary bioImage Study (SCAPIS), a general population sample of 28,555 people aged 50 - 64 years (including 14,558 never-smokers) was assessed. The participants answered a questionnaire and underwent computed tomography of the lungs, post-bronchodilator spirometry, and coronary artery calcification score (CACS). Odds ratios (OR) with 95% confidence intervals (CI) were calculated using adjusted logistic regression. RSP was defined as FEV1/FVC≥0.70 and FVC<80%. PRISm was defined as FEV1/FVC≥0.70 and FEV1<80%. A local reference equation was applied. The prevalence of RSP and PRISm were 5.1% (95% CI 4.9 - 5.4) and 5.1% (95% CI 4.8 - 5.3), respectively, with similar values seen in never-smokers. For RSP and PRISm, shared features were current smoking, dyspnea, chronic bronchitis, rheumatic disease, diabetes, ischemic heart disease (IHD), bronchial wall thickening, interstitial lung abnormalities (ILA), and bronchiectasis. Emphysema was uniquely linked to PRISm (OR 1.69, 1.36-2.10) vs 1.10 (0.84-1.43) for RSP. CACS≥300 was related to PRISm, but not among among never-smokers. PRISm and RSP have respiratory, cardiovascular, and metabolic conditions as shared features. Emphysema is only associated with PRISm. Coronary atherosclerosis may be associated with PRISm. Our results indicate that RSP and PRISm may share more features than not.

Sustainability Business and Its Impact on Project Performance In the mining Industry in Kenya: A case of Tata Chemicals Magadi, Kenya

Sustainability business is a self-regulating business model that helps a company to be socially accountable to itself, its stakeholders and public. The general objective of the study is to establish the impact of sustainability business on project performance in the mining industry in Kenya. Different theories and literature relating to the study were reviewed and the emerging knowledge gap identified. The research was conducted in the mining industry specifically within Tata Chemicals Magadi Limited (TCML). The target population was 300 respondents from different departments including marketing and supply chain (internally) and externally the population included women and young people. The researcher used stratified random sampling. From the possible 300 target population, stratified random sampling was employed to select a total of 72 sample population. This is 24% of the total population. The method used for data collection was quantitative design where a structured questionnaire was used to get the views. Both qualitative and quantitative process was used to analyze the data that was collected and compute the information using Statistical Package for Social Sciences (SPSS). The findings were presented to the panelists by use of power point presentation. The study recommends that companies should focus on maintaining health and safety of employees as this would minimize the cost of the business that is associated with work place injuries and also enhance productivity. The study also recommends the necessity of equitable treatment of employees. By applying principles of equity, this will enable the mining company create workforces that are accessible to all irrespective of physical ability, cognitive difference or social economic background. It also endorses that a similar study to be conducted on the influence of CSR initiatives on project performance on other industries.

Complete Spectrum of Physical Comorbidities with Autism Spectrum Disorder in a Nationwide Cohort.

The associations between autism spectrum disorder (ASD) and physical diseases (PD) based on ICD-8 and ICD-10 diagnoses were studied, comparing with the risks of the general population. All individuals diagnosed before 30th April 2018 with ASD (n = 12,063) and a 5% random sample of the general population (n = 41,251) were drawn from Danish registers of the birth cohorts 1984-1995. For each of the entire spectrum of 13 PD categories, participants were followed from birth to first diagnosis, death, emigration, or 31st December 2017, whichever came first. Time from inclusion at birth to time of first physical diagnosis, accounting for censoring, was studied by use of time-stratified Cox models. When compared to the control sample, the individuals with ASD had a substantial added immediate risk in infancy and in childhood for 12 of the 13 categories. Particularly prominent were estimated associations for nervous system diseases at ages 0-9, and diseases of the eye and adnexa at ages 0-11. The associations were observed for both sexes, but were stronger among females than males, especially for genitourinary system diseases. On the cumulative scale, individuals with ASD were at pronounced greater risk through follow-up for 8 categories, with the greatest cumulative risk of respiratory system diseases, which at ages 5 and 30 was 24.9% and 41.5% for the ASD cohort while for the control sample it was 16.3% and 34.5% at the same ages. Especially in infancy and childhood, the present study found increased risks for a multitude of physical diseases.

Proposal for a grading system to determine the clinical status and sequence of permanent teeth eruption: A pilot study

ObjectivesThe objective of the study was to propose and test a new grading system to quantify the clinical eruption of teeth into the oral cavity. In addition, the study also aimed to apply the grading system to a sample population to determine the chronology and sequence of permanent tooth eruptions, comparing the results with an existing standard table. MethodsA cross-sectional study was designed, and 1220 children aged 5–18 years were selected from five schools in Chennai. The clinical status of permanent tooth eruption was graded using the newly proposed system. The sequence and chronology of permanent tooth eruptions were determined using Probit analysis and compared with those established by Logan and Kronfeld. The difference in stages of eruption between the sexes was analyzed using the ANOVA test. ResultsThe study sample included 515 boys and 705 girls. A total of 23,218 permanent maxillary and mandibular teeth were examined and graded. Of the 11,085 maxillary teeth, 367 were classified as grade 1, 660 as grade 2, and 10,058 as grade 3. Similarly, of the 12,133 mandibular teeth, 497 were grade 1, 793 were grade 2, and 10,843 were grade 3. The eruption of the maxillary canines, second molars, and mandibular second premolars was observed to have occurred earlier than in the traditional table of tooth eruption. The most significant differences in the stages of eruption between the sexes were observed in the 9–12 age group. ConclusionsThe newly proposed grading system was found to be simple, objective, less confusing, and more robust, compared with the existing systems in determining the clinical status of tooth eruptions. The ages of eruption of maxillary canines, second molars, and mandibular second premolars were earlier.

Depression during the COVID pandemic in La Manouba Governorate, Tunisia: A community survey.

It is difficult to quantify the impact of the COVID-19 pandemic on mental health as many community surveys have limited quality, rely on screening tests to measure mental health conditions and distress, and often use convenience samples. Moreover, robust surveys come mainly from high-income countries. To measure the prevalence of depressive disorders with onset during the pandemic in a community of a Lower-Middle-income country (LMIC)-Tunisia. Clinical semi-structured face-to-face interviews were carried out during the pandemic (September-December 2021) by medical doctors among a representative sample of the general population in the governorate of La Manouba, Tunisia. Psychiatric diagnoses were established according to DSM-IV. The prevalence of Major Depressive Disorder (MDD) started or recurred after the pandemic was 5.66%. The factors associated with MDD were loss of job and considerably diminished income due to the pandemic (OR = 2.1, 95% CI [1.5, 2.9]) and the perception of having the family's financial situation below the Tunisian average (OR = 2.3, 95% CI [1.7, 3.2]). Female sex, marital status as separated/divorced, and having a COVID-19 infection were associated with MDD only in the overall sample and urban areas, but not in rural areas. Age and having loved ones who passed away due to COVID-19 were not associated with MDD. In Tunisia, the pandemic seems to have increased the risk of depression in people experiencing a precarious financial situation, also due to the pre-existing economic crisis. Specific local level factors, such as not establishing a rigid lockdown for an extended period, may have protected young people and allowed for better mourning in families suffering the loss of a loved one.

Can ChatGPT read who you are?

The interplay between artificial intelligence (AI) and psychology, particularly in personality assessment, represents an important emerging area of research. Accurate personality trait estimation is crucial not only for enhancing personalization in human-computer interaction but also for a wide variety of applications ranging from mental health to education. This paper analyzes the capability of a generic chatbot, ChatGPT, to effectively infer personality traits from short texts. We report the results of a comprehensive user study featuring texts written in Czech by a representative population sample of 155 participants. Their self-assessments based on the Big Five Inventory (BFI) questionnaire serve as the ground truth. We compare the personality trait estimations made by ChatGPT against those by human raters and report ChatGPT's competitive performance in inferring personality traits from text. We also uncover a ‘positivity bias’ in ChatGPT's assessments across all personality dimensions and explore the impact of prompt composition on accuracy. This work contributes to the understanding of AI capabilities in psychological assessment, highlighting both the potential and limitations of using large language models for personality inference. Our research underscores the importance of responsible AI development, considering ethical implications such as privacy, consent, autonomy, and bias in AI applications.

Ontogenetic biomechanics of tufted (Sapajus) and untufted (Cebus) capuchin mandibles.

Cortical bone geometry is commonly used to investigate biomechanical properties of primate mandibles. However, the ontogeny of these properties is less understood. Here we investigate changes in cortical bone cross-sectional properties throughout capuchin ontogeny and compare captive versus wild, semi-provisioned groups. Tufted capuchins (Sapajus spp.) are known to consume relatively hard/tough foods, while untufted capuchins (Cebus spp.) exploit less mechanically challenging foods. Previous research indicates dietary differences are present early in development and adult Sapajus mandibles can resist higher bending/shear/torsional loads. This study utilized microCT scans of 22 Cebus and 45 Sapajus from early infancy to adulthood from three sample populations: one captive Cebus, one captive Sapajus, and one semi-provisioned, free-ranging Sapajus. Mandibular cross-sectional properties were calculated at the symphysis, P3, and M1. If the tooth had not erupted, its position within the crypt was used. A series of one-way ANOVAs were performed to assess differences between and within the sample populations. Mandible robusticity increases across ontogeny for all three sample populations. Sapajus were better able to withstand bending and torsional loading even early in ontogeny, but no difference in shear resistance was found. Semi-provisioned, free-ranging Sapajus tend to show increased abilities to resist bending and torsional loading but not shear loading compared to captive Sapajus. This study helps advance our understanding of the primate masticatory system development and opens the door for further studies into adaptive plasticity in shaping the masticatory apparatus of capuchins and differences in captive versus free-ranging sample populations.

Characterization of Cochlear Implant Artifact and Removal Based on Multi-Channel Wiener Filter in Unilateral Child Patients

Cochlear implants (CI) allow deaf patients to improve language perception and improving their emotional valence assessment. Electroencephalographic (EEG) measures were employed so far to improve CI programming reliability and to evaluate listening effort in auditory tasks, which are particularly useful in conditions when subjective evaluations are scarcely appliable or reliable. Unfortunately, the presence of CI on the scalp introduces an electrical artifact coupled to EEG signals that masks physiological features recorded by electrodes close to the site of implant. Currently, methods for CI artifact removal have been developed for very specific EEG montages or protocols, while others require many scalp electrodes. In this study, we propose a method based on the Multi-channel Wiener filter (MWF) to overcome those shortcomings. Nine children with unilateral CI and nine age-matched normal hearing children (control) participated in the study. EEG data were acquired on a relatively low number of electrodes (n = 16) during resting condition and during an auditory task. The obtained results obtained allowed to characterize CI artifact on the affected electrode and to significantly reduce, if not remove it through MWF filtering. Moreover, the results indicate, by comparing the two sample populations, that the EEG data loss is minimal in CI users after filtering, and that data maintain EEG physiological characteristics.

Use of lure sticks for non‐invasive genetic sampling of European wildcat populations: lessons learnt and hints for future insights

Abstract Non‐invasive genetic sampling is an increasingly common approach in wildlife research. It allows the gathering of first‐hand data on wild mammalian populations without capturing or handling individuals. For this reason, it has proved to be particularly useful when applied to elusive species living at low population densities and/or hard to identify in the field. The European wildcat represents an interesting case study in this respect. Several papers have been produced in the last decades, in which non‐invasive genetic sampling has been applied. Nevertheless, evidence from different case studies presents a complex scenario, where the efficiency of the method can vary considerably. This paper aimed to analyse possible interpretations of such differences and to identify potential drivers and barriers. 20 papers on the subject have been reviewed and compared, although differences in several details reported in the examined papers limited an in‐depth comparison. The review showed that the overlap of the study period with the reproductive season does not affect the final results of lure stick hair sampling research on the European wildcat. Moreover, valerian lure sticks generally provided positive results in the Continental ecoregion, whereas, in the Mediterranean and Atlantic regions, outcomes were absent or very scarce. Most of the other working hypotheses remain still plausible, despite not yet being definitely provable. Setting up future wildcat monitoring schemes based on effective non‐invasive genetic sampling in different biogeographical regions of Europe is certainly a scope to be pursued. Some suggestions are provided in this respect (e.g. the set of parameters needed to allow further comparisons; the need to test other types of attractants, to make the application of the method possible where the use of valerian was proven to be inefficient or scarcely efficient, in order to allow a better comparison of future results).

Estimating the Health-Related Quality of Life Benefit of Prophylactic Treatment for COVID-19 in Immunocompromised People: A Multimethod Valuation Study.

Background: Pre-exposure prophylaxis (PrEP) for COVID-19 provides additional protection, beyond vaccines alone, for individuals who are immunocompromised (IC). This may reduce the need for preventative behavioral modification, such as shielding-a behavioral restriction limiting an IC individual to minimize face-to-face interactions and/or crowded places. Therefore, PrEP may improve psychosocial well-being and health-related quality of life (HRQoL) for individuals with IC conditions. Objective: To estimate the potential HRQoL and utility benefit of PrEP for prevention of COVID-19 in individuals with IC conditions who may not have an adequate response of full vaccination (and therefore are at "highest risk" of severe COVID-19) that can be used in future economic evaluations of preventative therapies against COVID-19. Methods: Vignettes describing HRQoL associated with 2 pre-PrEP states (shielding and semi-shielding behavioral restrictions) and a post-PrEP state were developed from a literature review and tested through interviews with clinicians (n = 4) and individuals with IC conditions (n = 10). Vignettes were valued by a general population sample (N = 100) using a visual analog scale (VAS), time trade-off (TTO), and EQ-5D-5L. A sample of individuals with IC conditions (n = 48) valued their current HRQoL and a post-PrEP vignette using VAS and EQ-5D-5L. Results: Individuals with IC conditions reported a mean current EQ-5D-5L score of 0.574, and 0.656 for post-PrEP based on the vignette. PrEP would lead to behavior changes for 75% (30/40) of individuals with IC conditions and an emotional benefit for 93% (37/40) of individuals with IC conditions. Mean values from the general population valuation based on EQ-5D-5L ranged from 0.606 ("shielding") to 0.932 ("post-PrEP"). Conclusion: This study quantified the expected health state utility benefit of reduced psychosocial burden and behavioral restriction. PrEP would potentially result in a utility gain between 0.082 and 0.326, dependent on valuation approach and expected change in behavioral restrictions, leading to improvements in daily activities and emotional well-being.

How adverse childhood experiences impact the professional quality of life of residential care workers: resilience as a mediator for burnout, secondary traumatic stress, and compassion satisfaction

IntroductionThe well-being of trauma-affected children and youth in residential care settings is contingent upon the well-being of the workers who care for them, who are increasingly expected to provide care in a trauma-informed manner. The well-being of residential care workers (RCWs) may be impacted by their own histories of adversity, their capacity individually and collectively to navigate to resources that sustain their well-being (resilience), and current perceptions of their professional quality of life.ObjectiveThis study aimed to fill a research gap by canvassing the perspectives of RCWs to determine what and how they need to be supported in their work. We sought to better understand what personal (adverse childhood experiences, resilience) and professional (compassion satisfaction, burnout, secondary traumatic stress) experiences and capacities they bring into their work that might impact the quality of care they provide to children and youth.MethodA sample of 226 residential care workers from four residential care organizations across three Canadian provinces completed a self-report questionnaire to provide a portrait of their history of adverse childhood experiences as measured by the ACE questionnaire, which included two additional questions reflecting the more nuanced and expanded understanding of potential adversity in childhood in the Canadian context; their resilience, as measured by the Adult Resilience Measure; and compassion satisfaction, burnout, and secondary traumatic stress, as measured by the Professional Quality of Life Measure. Mediation was conducted to examine whether and how resilience mediated the relationship between ACEs and professional quality of life indicators.Results(1) RCWs reported experiencing ACEs at rates much higher than general population and norm samples, especially regarding the experience of 4–5+ ACEs, known to be a threshold for increased severity in negative outcomes; (2) RCWs experienced levels of resilience and indicators of professional quality of life similar to those in other human services professions serving trauma-impacted individuals; and (3) RCW resilience significantly mediated the relationship between ACEs and compassion satisfaction, burnout, and secondary traumatic stress, and had a significant total effect for the relationship between ACEs and secondary traumatic stress. These results suggest the importance of enhancing RCW resilience in multiple ways, mainly in their professional contexts. Recommendations for resilience enhancement and suggestions for future research are provided.