Microsphere Samples Research Articles

Sensing of Pb (II) ion by micro and nanocarbon materials- influence of functionality and pi-electron density

In the aspect of pollution due to heavy metal ions, especially Pb (II) ions, there is an urgent need for simple, effective materials and processes for sensing the ions. The present study approaches the sensing of Pb (II) ions by non-metal (O, N and S) doped micro and nanoscale Carbon materials. The unique emission (Fluorescence) properties of the as-prepared doped samples of graphene oxides and Carbon Microspheres were tapped in the selective sensing process of nanomolar to the micromolar concentration of Pb (II) ions. The role-play of Carbon dimensionality, functionality and sp2 Carbon density (pi electron density) in the sensing mechanism was evaluated. The study provided an overview of fundamental aspects of heavy metal ion sensing by Carbon-based nanomaterials (CBNs).

Fabrication of microspheres and characterization of antimicrobial and anti-inflammatory activity isolated fraction from total alcoholic extract of Cassia Fistula (Linn.) in carrageenan-Type-IV induced inflammatory rats

The Cassia fistula Linn is known as the golden shower tree. It’s also referred to as a "disease killer" in Ayurvedic medicine. The current study investigates the effect and estimate of antimicrobial and Anti-inflammatory activity guided fraction isolated from alcoholic extract of Cassia fistula (Linn.) root on carrageenan-Type IV induced Inflammatory rats for using Column fraction of alcoholic extract of root of Cassia fistula (Linn.) An in vivo carrageenan-induced paw edoema model was used to confirm further the anti-inflammatory effect of the fraction aloe-emodin and physcion-loaded microspheres. This study was designed first time for the isolation of alcoholic fraction of aloe emodin and Physcion by root extract and screening of pharmacological activities of Cassia fistula. Aloe-emodin and Physcion fraction demonstrated antibacterial and antifungal effectiveness against the studied pathogens in a dose-dependent manner, according to anti-microbial activity. 50 mg/ml concentration of Physcion-containing microspheres and aloe emodin's antibacterial efficacy against tested pathogens. The anti-inflammatory activity of Aloe emodin and Physcion was found in an equal manner. Both Microsphere samples were found capable of controlling the inflammation till 6 hours. According to the findings of this research, the chosen plant extracts have an immediate anti-inflammatory effect. There are three stages during which carrageenan-induced inflammation mediators are released.

Ce substituted NiCo[formula omitted] microspheres and nanoflakes: Comparison on magnetic features

NiCo2−xCexO4 (0.0 ≤ x ≤ 0.08) microspheres (MCs) and nanoflakes (NFs) were synthesized hydrothermally. X-ray diffraction analysis confirmed the cubic microstructure of all the samples. The microsphere and nanoflake morphologies of the samples have been confirmed by SEM, along with EDX, TEM and HR-TEM. The magnetic properties of the NiCo2−xCexO4 (0.0 ≤ x ≤ 0.08) MCs and NFs were investigated via magnetization measurements using a vibrating sample magnetometer. Room-temperature magnetization measurements revealed weak ferromagnetic behavior for both MC and NF samples. Low temperature magnetization measurements showed strong ferromagnetic behavior for the different samples. The magnetic parameters for both samples were found to differ substantially at a given temperature, which is accredited to the differences in the morphology of the MC-like and NF-like samples. Room-temperature magnetization measurements revealed antiferromagnetic or paramagnetic behavior for MC samples and weak ferromagnetic character for NF samples. It was also found that the magnetization magnitude decreased with increasing cerium dopant level, when compared to the host product. The changes in magnetization are linked to the effect of introduced cerium ions and their magnetic states, which could generate structural/morphological changes, changes in the size and surface lattice, redistribution of cations among the crystal lattices, changes in magnetic moment, etc.

Investigating structural attributes of drug encapsulated microspheres with quantitative X-ray imaging.

The intra-sphere and inter-sphere structural attributes of controlled release microsphere drug products can greatly impact their release profile and clinical performance. In developing a robust and efficient method to characterize the structure of microsphere drug products, this paper proposes X-ray microscopy (XRM) combined with artificial intelligence (AI)-based image analytics. Eight minocycline loaded poly(lactic-co-glycolic acid) (PLGA) microsphere batches were produced with controlled variations in manufacturing parameters, leading to differences in their underlying microstructures and their final release performances. A representative number of microspheres samples from each batch were imaged using high resolution, non-invasive XRM. Reconstructed images and AI-assisted segmentation were used to determine the size distribution, XRM signal intensity, and intensity variation of thousands of microspheres per sample. The signal intensity within the eight batches was nearly constant over the range of microsphere diameters, indicating high structural similarity of spheres within the same batch. Observed differences in the variation of signal intensity between different batches suggests inter-batch non-uniformity arising from differences in the underlying microstructures associated with different manufacturing parameters. These intensity variations were correlated with the structures observed from higher resolution focused ion beam scanning electron microscopy (FIB-SEM) and the in vitro release performance for the batches. The potential for this method for rapid at-line and offline product quality assessment, quality control, and quality assurance is discussed.

Using microfluidic technology to prepare octogen high-energy microspheres containing copper–aluminum composite particles with enhanced combustion performance

Aluminized explosives are widely used in military applications. However, the easy agglomeration of aluminum (Al) powder and its high ignition temperature greatly hinder the reaction of nano aluminum (n-Al) in the process of explosion, thus affecting the combustion and explosion of aluminum-containing explosives. In the present study, copper (Cu) coated n-Al composite particles were introduced into aluminized explosives, and Cu coated n-Al composite particles and ball-milled octogen (HMX) energetic microspheres were prepared via droplet microfluidic technology using binder. The morphology, crystal form, thermal properties, combustion, and mechanical sensitivity of the microspheres were studied using a variety of techniques. The prepared microspheres had regular spherical morphology and uniform particle size, with an even distribution of particles. Using microfluidic technology will not destroy the crystal form of each particle. The introduction of Cu promoted the thermal decomposition of HMX. The mechanical sensitivity of the prepared Cu/Al microspheres was lower than that of the microspheres only containing n-Al. The Cu/Al microsphere samples exhibited excellent and stable combustion performance, and that the addition of Cu increased the combustion speed compared to the microspheres only containing n-Al. This technology represents an inexpensive and simple way to improve on existing aluminized explosives.

Facile preparation of hierarchical mesoporous silica microspheres with tunable porous structure and particle sizes

This work reports that, by supplementing classical ternary template system (TEOS/P123/HCl(aq.)) with poly (vinyl alcohol) (PVA) as additive, hierarchical mesoporous silica (HMS) microspheres can be prepared with tunable particle sizes and porous structures based on the partitioned cooperative self-assembly (PCSA) process. The particle sizes and hierarchical mesoporous (HM) structures of HMS microspheres are found to dependent on the experimental parameters, such as PVA dosages, synthesis/hydrothermal treatment temperatures and partitioning conditions, etc. The BET surface area, pore volume and particle size of typical HMS microsphere sample of 6-4h-4@40P15 reach 792 m2g-1, 1.74 cm3g-1 and 3.51 μm, respectively. The 1st and 2nd mode mesopore sizes are 10.5 nm and 20.5 nm, respectively. Large synthesis domains for HMS microspheres defined by different synthesis parameters were also obtained, enabling their easy and controllable preparation. The scaled-up preparation of HMS microspheres up to five times was also demonstrated with comparable particle morphology and sizes. PVA was newly found to play multiple roles in the preparation of HMS microspheres in (1) improving the dispersibility and spherical morphology, (2) shaping the HM structures and (3) broadening the synthesis domain. The facile and controllable HMS microspheres might further promote their application in different areas.

Preparation of uniform-sized GeXIVA[1,2]-loaded PLGA microspheres as long-effective release system with high encapsulation efficiency

The purpose of this study was to prepare GeXIVA[1,2] PLGA microspheres by W/O/W re-emulsification-solvent evaporation technology and to develop sustained-release formulations to meet the clinical treatment needs of chronic neuropathic pain. Through prescription optimization, the uniformity of particle size and the encapsulation efficiency is improved, so as to achieve the quality standard of the microspheres. The mechanism of trehalose improving the stability of GeXIVA[1,2] was studied and verified by molecular simulation. The results showed that when adding trehalose to W1, using the PLGA model of 75:25, PLGA concentration of 30%, PVA concentration of 1.5%, adding 1% NaCl to PVA and adding 1% NaCl to solidification water, the prepared microspheres are smooth, the particle size is about 25 μm, and the encapsulation rate reaches 90%. The results of in vitro release experiments showed that the microspheres could be released steadily for about 30 days. The microsphere samples were characterized and analyzed by molecular simulation and powder X-ray diffractometer, and the protective mechanism of trehalose on GeXIVA[1,2] was discussed. The results showed that the hydrogen bond formed between trehalose and GeXIVA[1,2] acted as a hydration film and played a certain protective role on GeXIVA[1,2]. In addition, high-viscosity trehalose can form a glass state and wrap around GeXIVA[1,2], reducing the free movement of molecules. In the microsphere system, trehalose can also avoid the influence of PLGA material on the secondary structure of GeXIVA[1,2]. In conclusion, this study is expected to provide a new therapeutic strategy for the treatment of chronic neuropathic pain.

Which is the photocatalytic efficiency better the g-C3N4 on surface or carbon microspheres on surface in carbon microspheres/g-C3N4?

Generally, surface property has an important effect on photocatalytic performance. For a composite photocatalyst g-C3N4/carbon microspheres (CN/CS), which photocatalytic efficiency is better the g-C3N4 on surface or carbon microspheres on surface? Herein, the sample of carbon microspheres on surface (CN/CS-Sur) and the sample of g-C3N4 loaded on the surface (CN/CS-In) were synthesized via thermal decomposition-hydrothermal method or hydrothermal-thermal decomposition, respectively. The photocatalytic rate of the CN/CS-Sur was 5 times that of the CN/CS-In, suggesting that the surface property played important role. The abound surface hydroxyl groups (–OH), which are were origin from the CS, improved the hydrophilicity and dispersibility of the CN/CS-Sur, and caused higher electrostatic adsorption to methylene blue (MB). Furthermore, the high electrical conductivity of CS accelerated the rate of charge transfer and suppressed the recombination of photocarriers. Our results suggest the assemble position evidently affect the surface property and the photocatalytic performance.

Preparation and performance of hydroxyapatite-graphene oxide composite microspheres

Drug-loaded microspheres have been widely studied and applied in biomedical materials, but there are still some open problems such as low drug loading and sudden release. In order to solve such problems, hydroxyapatite-graphene oxide (HA-GO) composite microspheres were prepared by using hydroxyapatite (HA) and graphene oxide (GO). Firstly, spherical calcium carbonate-graphene oxide (CaCO₃-GO) composites were synthesized by hard template method. Then, spherical hollow HA-GO composite microspheres were successfully prepared by a method of hydrothermal-assisted ion exchange. The effect of different synthesis conditions on the prepared HA-GO composites was studied. Through a series of measurements, such as X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Raman infrared spectroscopy, field emission scanning electron microscope (FESEM), ultraviolet visible spectrophotometer (UV-VIS), etc., the prepared samples were analyzed and characterized. The drug-loading performance of the microspheres was tested by using curcumin as the drug-loading model, and the drug-loading performance was evaluated by two indicators of encapsulation efficiency and drug-loading capacity. At the same time, the cytotoxicity test of the microsphere sample materials was also performed. The research results show that the reactant concentration of the system and the hydrothermal reaction time greatly affect the forming effect of the composite microspheres. When the initial reactant concentration is 0.3 mol/L and the hydrothermal reaction time is 6 h, hollow HA-GO composite microspheres with good morphology can be prepared, with a particle size from 5.1 μm to 7.7 μm and a pore size of about 40 nm. At the same time, it was found that the spherical structure can improve the drug loading, the drug encapsulation efficiency was (20.90 ± 0.31)%, and the drug loading was (2.95 ± 0.19)%. This shows that HA-GO composite microspheres have good medical application value.

PHOTOCATALYTIC ACTIVITY OF MESOPOROUS TiO2 (ANATAS) IN THE REACTION OF HYDROGEN RELEASE FROM AQUEOUS-ETHANOLIC MIXTURE

Samples of mesoporous nanocrystalline titanium dioxide (anatase with a crystallite size of about 10 nm) were obtained by a modified sol-gel method in the presence of a template of dibenzo-18-crown-6 and small additives of surfactant (dodecylmethylethylammonium bromide) or ions of lanthanum (III) in butyl alcohol in combination with hydrothermal treatment at 175 °C for 24 hours followed by calcination in air at 500 °C for 4 hours. The photocatalytic activity of the obtained TiO2 samples was investigated in a model reaction of the photocatalytic release of H2 from an aqueous-ethanol mixture. It was found that in all cases the use of hydrothermal treatment significantly increases the photoactivity of the obtained sample, which in some cases is more than 3-4 times higher than the corresponding characteristic for commercial photocatalyst Evonik P25. The key effect of hydrothermal treatment on the increase of photoactivity of the samples is probably the consequence of a drastic increase in the treated samples of pore volume and diameter, as well as a decrease in the size of anatase crystallites. These changes (along with a significant increase in the specific surface area) are greater for samples obtained in the presence of La3+ ions. It is shown that samples of TiO2 microspheres obtained at the same concentrations of reagents in the reaction mixture show slightly higher photocatalytic activity than the corresponding lanthanum-stabilized samples of mesoporous TiO2 powders (micrometer-scale particles are not formed in the presence of lanthanum (III) ions). However, with an increasing concentration of reagents in the reaction mixture, the photocatalytic activity has the sample containing lanthanum. Probably, this can be explained by the high textural characteristics of the TiO2 sample in combination with the peculiarities of its morphology - the formation of secondary nanoparticles of agglomerated formations and the influence of La3+ ions. It is worth noting that the photocatalytic activity of TiO2 samples prepared in the presence of La3+ ions reduces as their specific surface area decreases.

Preparation of high sphericity monodisperse aluminum microspheres by pulsated orifice ejection method

Aluminum microspheres with high sphericity are widely used and urgent demanded in additive manufacturing. However, the current primary atomization method is insufficient in sphericity and particle size distribution. Herein, the monodisperse aluminum microspheres with high sphericity and narrow particle size distribution are successfully prepared by the pulsated orifice ejection method (POEM). The particle size distributions of the prepared aluminum microsphere samples with the average diameter of 325.2 µm are ranged from 315 µm to 332 µm, in which the sphericity of 50% microspheres reached 0.966, and that of 99.59% microspheres reached 0.9. The crucible pressure and interface reaction of aluminum melt with crucible are investigated to explore the influence of technological conditions on aluminum particles. Additionally, the effect of cooling rate on particle size is also studied and the results demonstrate that the sphericity of aluminum microspheres can be improved by decreasing the cooling rate during droplet solidification.

Surfactant-mediated synthesis of monodisperse Poly(benzyl methacrylate)-based copolymer microspheres

Polymeric microspheres (MSs) have broad applications. Poly(benzyl methacrylate) (PBzMA) have various important applications, such as optical materials, electrochromatography, and photoresists. However, previous studies on PBzMA were on fabricating bulk polymers or nano-sized (<500 nm) spheres. In this study, by introducing a cationic surfactant, cetyltrimethylammonium bromide (CTAB), into the processing, we were the first to successfully synthesize PBzMA-based (pristine and co-polymer) highly monodisperse microspheres. In the synthesis, poly(vinyl pyrrolidone) (PVP) is used as the stabilizer to prevent particle aggregation, and cetyltrimethylammonium bromide (CTAB) is used to assist dispersion polymerization. The sizes of PBzMA-based MSs can be tuned between 1.0 and 10.0 µm with a high monodispersity by controlling the CTAB and monomer concentrations. The morphology, molecular structure, molecular weight distribution, thermal stability, and glass transition behavior of the MS samples are determined. Particularly, the glass transition temperature can be tuned continuously and smoothly between 59 °C–120 °C by adjusting the monomer ratio in the synthesis of the copolymer MSs. This study provides insights into a controlled synthesis of size- and property-tunable polymeric and copolymer MSs for broad applications.

Polymer quantification using the Rock-Eval® device for identification of plastics in sediments

In this work, artificial thermal degradation experiments using the Rock-Eval® device were performed on selected polymer microsphere samples (PE, PP, PE100, PA6, PA11, PFA and PET). The main idea of this work is first to create a database of different polymer standard responses using the specific Rock-Eval® FID/IR peak signals. Several specific Rock-Eval® parameters are now defined to characterize each polymer family. For instance, each polymer is characterized by specific quantified parameters like Total HCpolymer, Total COpolymer, TotalCO2polymer, Tpeakpolymer, among others. This study attempts to demonstrate if this quick thermal degradation method can be also used to characterize the plastic contents (detection, type, and quantity) in sedimentary samples. Results indicate that each investigated polymer shows specific Rock-Eval® parameters that can be considered as useful characteristics of polymer families (mainly Tpeakpolymer, TOCpolymer, PCpolymer, RCpolymer, total HCpolymer, total COpolymer and total CO2polymer parameters). Samples containing different mineral matrices (e.g. sand, shale, marl and carbonate) were also mixed with polymers at different concentrations varying between 0.2 and 4.2 wt%. These composite samples were also analyzed in order to evaluate their thermal degradation comparing their specific Rock-Eval® FID/IR signatures. For example, most composite samples show an excellent linear correlation between TOC, PC, RC, total HC, CO and CO2 parameters versus the amount polymer at different concentrations. Although more work is still needed, a methodology is here proposed to distinguish and quantify the presence of plastics in the environment applying the proposed polymer Rock-Eval® database.

Research on the Preparation and Performances of a New Type of Hollow Glass Microspheres

Hollow glass microsphere is a cross-functional frontier material that can be added to a variety of substrate materials to improve their performances and environmental benefits. In this paper, the characteristics, application fields and development status of hollow glass microspheres were summarized, and the basic formula, preparation process, performance testing equipments and methods of a new type of hollow glass microspheres were expounded. By testing and analyzing the main performances such as micro morphology, chemical composition, particle size, floating rate, bulk density, true density, compressive strength and other indicators of the microsphere samples, the properties and application potential of the hollow glass microspheres that we prepared are comprehensively characterized. The experimental results show that the microspheres have regular morphology and uniform particle size, the floating rate of them is higher than 97%, the bulk density is 0.1∼0.4g/cm3, the true density is 0.20∼0.65g/cm3 and fluctuates in a reasonable range; besides, the compressive strength is so good that microspheres are barely broken. What’s more, the development prospect of glass microsphere industry is prospected at the end.

Eco-friendly zeolite/alginate microspheres for Ni ions removal from aqueous solution: Kinetic and isotherm study

Initial Preparation of eco-friendly, reusable, and highly adsorptive materials for heavy metals consider a great challenge in the field of wastewater treatment. Therefore, in this study, we use ecofriendly materials such as zeolite and natural polymer (Alginate) to prepare a special nanocomposite in the form of microspheres to use as sorbent material for nickel Ions Ni (II). Using different analytical methods, we investigated the morphological, molecular structure, and crystalline structure of the prepared nanocomposites samples. Batch experiments for the adsorption of Ni(II) onto prepared microspheres samples were carried out and the effect of adsorption parameters (initial dose and contact time) were reported. Kinetic and isotherm models were employed to evaluate the sorption mechanisms. The obtained results indicate that the prepared microspheres demonstrate great potential in the efficient removal of nickel ions with maximum removal efficiency reached 98%. Kinetic study indicates the conformity of the pseudo-first-order model to the adsorption reaction and an excellent validity of the Freundlich model to the sorption process. Furthermore, the prepared microspheres can be washed, activated, and reused 5 times with the same efficacy without any change in their morphological and chemical structure.

Practical application of microsphere samples for benchmarking a quantitative phase imaging system.

Quantitative phase imaging (QPI) provides an approach for monitoring the dry mass of individual cells by measuring the optical pathlength of visible light as it passes through cells. A distinct advantage of QPI is that the measurements result in optical path length quantities that are, in principle, instrument independent. Reference materials that induce a well‐defined optical pathlength shift and are compatible with QPI imaging systems will be valuable in assuring the accuracy of such measurements on different instruments. In this study, we evaluate seven combinations of microspheres embedded in index refraction matching media as candidate reference materials for benchmarking the performance of a QPI system and as calibration standards for the optical pathlength measurement. Poly(methyl metharylate) microspheres and mineral oil were used to evaluate the range of illumination apertures, signal‐to‐noise ratios, and focus positions that allow an accurate quantitative optical pathlength measurement. The microsphere‐based reference material can be used to verify settings on an instrument that are suitable for obtaining an accurate pathlength measurement from biological cells. The microsphere/media reference material is applied to QPI‐based dry mass measurements of a population of HEK293 cells to benchmark and provide evidence that the QPI image data are accurate.

Characterization of Controlled Release Microspheres Using FIB-SEM and Image-Based Release Prediction

For polymer-based controlled release drug products (e.g. microspheres and implants), active pharmaceutical ingredient distribution and microporosity inside the polymer matrix are critical for product performance, particularly drug release kinetics. Due to the decreasing domain size and increasing complexity of such products, conventional characterization and release test techniques are limited by their resolution and speed. In this study, samples of controlled release poly(lactic-co-glycolic acid) microspheres in the diameter range of 30-80μm are investigated with focused ion beam scanning electron microscope imaging at 20nm or higher resolution. Image data is quantified with artificial intelligence-based image analytics to provide size distributions of drug particles and pores within the microsphere sample. With an innovative image-based numerical simulation method, release profiles are predicted in a matter of days regardless of the designed release time. A mechanistic understanding on the impact of porosity to the interplays of drug, formulation, process, and dissolution was gained.

Thin film Gallium nitride (GaN) based acoustofluidic Tweezer: Modelling and microparticle manipulation

Gallium nitride (GaN) is a compound semiconductor which shows advantages in new functionalities and applications due to its piezoelectric, optoelectronic, and piezo-resistive properties. This study develops a thin film GaN-based acoustic tweezer (GaNAT) using surface acoustic waves (SAWs) and demonstrates its acoustofluidic ability to pattern and manipulate microparticles. Although the piezoelectric performance of the GaNAT is compromised compared with conventional lithium niobate-based SAW devices, the inherited properties of GaN allow higher input powers and superior thermal stability. This study shows for the first time that thin film GaN is suitable for the fabrication of the acoustofluidic devices to manipulate microparticles with excellent performance. Numerical modelling of the acoustic pressure fields and the trajectories of mixtures of microparticles driven by the GaNAT was performed and the results were verified from the experimental studies using samples of polystyrene microspheres. The work has proved the robustness of thin film GaN as a candidate material to develop high-power acoustic tweezers, with the potential of monolithical integration with electronics to offer diverse microsystem applications.

Polymeric microsphere injection in large pore-size porous media

High water-cut has become a worldwide challenge for oil production. It requires extensive efforts to process and dispose. This entails expanding water handling facilities and incurring high power consumption costs. Polymeric microsphere injection is a cost-effective way to deal with excessive water production from subterranean formations. This study reports a laboratory investigation on polymeric microsphere injection in a large volume to identify its in-depth fluid diversion capacity in a porous media with large pore/particle size ratio. The performance of polymeric microsphere injection was evaluated using etched glass micromodels based on the pore network of a natural carbonate rock, which were treated as water-wet or oil-wet micromodels. Waterflooding was conducted to displace oil at reservoir temperature of 95 °C, followed by one pore volume of polymeric microsphere injection. Three polymeric microsphere samples with median particle size of 0.05, 0.3, and 20 μm were used to investigate the impact of particle size of the polymeric microspheres on incremental oil production capacity. Although the polymeric microspheres were much smaller than the pores, additional oil production was observed. The incremental oil production increased with increasing polymeric microsphere concentration and particle size. As a comparison, polymeric microsphere solutions were injected into oil-wet and water-wet micromodels after waterflooding. It was observed that the oil production in oil-wet micromodel was much higher than that in water-wet micromodel. The wettability of micromodels affected the distribution patterns of the remaining oil after waterflooding and further dominated the performance of the microsphere injection. The study supports the applicability of microsphere injection in oil-wet heterogeneous carbonates.

СУХИЕ СТРОИТЕЛЬНЫЕ СМЕСИ ДЛЯ ОТДЕЛОЧНЫХ ИЗДЕЛИЙ И ПРОИЗВОДСТВА ВНУТРЕННИХ РАБОТ

The aim of the study was to determine the relationship between the structure and properties of a gypsum composite based on semi-aquatic gypsum with a filler in the form of hollow glass microspheres with characteristics of water demand and the degree of filling of the mixture with microspheres. We used a glass filler with the sizes of hollow microspheres of 0.1 - 50 microns with a vacuum inside. To solve this problem, a two-factor planned experiment was chosen, where the ultimate compressive strength and the average density of the gypsum composite were selected as the output factors. The data obtained confirm the effectiveness of using hollow microspheres for producing light materials based on calcium sulfate hemihydrate. Domestic samples of glass microspheres were used. It is shown that they have a plasticizing effect in the composition of raw mixtures based on gypsum binder and contribute to a decrease in their average density.