Sample Of Adult Population Research Articles

Prevalence and associated factors of physical inactivity among middle-aged and older adults in India: results of a national cross-sectional community survey

ObjectiveThis study aimed to determine the prevalence and associated factors of physical inactivity in middle-aged and older adults in India.DesignPopulation-based cross-sectional study.SettingNationally representative sample of general community-dwelling middle-aged and older...

Post-traumatic stress disorder in the Canadian Longitudinal Study on Aging: A genome-wide association study

ObjectiveCanada exhibits one of highest lifetime prevalence for post-traumatic stress disorder (PTSD), but the etiology of this debilitating mental health condition still remains largely unknown. This study aims to examine the genetics of PTSD in the Canadian Longitudinal Study on Aging (CLSA) to identify potential genetic factors involved in the development of PTSD. MethodThe CLSA sample was screened for primary (PTSD status) and secondary outcomes (avoidance, detachment, guardedness, and nightmares) based on the Primary Care PTSD Screen Scale (PC-PTSD). After GWAS quality control and whole-genome imputation, single-marker, gene-based, and polygenic risk score (PRS) analyses were performed. ResultsBased on available genotype and phenotype data, N = 16,535 individuals were selected for the analyses. While genome-wide analyses did not show significant findings for our primary and secondary outcomes, PRS analyses showed variable levels of association between PC-PTSD items with trauma, major depressive disorder, schizophrenia, bipolar disorder, educational attainment, and insomnia (p < 5e-4). ConclusionThis is the first GWAS of PTSD status and individual PC-PTSD items in a population sample of older adults from Canada. This study was also able to replicate findings from previous studies. Genetic investigations into individual symptom components of PTSD may help untangle the complex genetic architecture of PTSD.

Estimating loss in capability wellbeing in the first year of the COVID-19 pandemic: a cross-sectional study of the general adult population in the UK, Australia and the Netherlands

ObjectivesTo estimate capability wellbeing lost from the general adult populations in the UK, Australia and the Netherlands in the first year of the COVID-19 pandemic and the associated social restrictions, including lockdowns.DesignCross-sectional with recalled timepoints.SettingOnline panels in the UK, Australia and the Netherlands conducted in February 2021 (data collected 26 January–2 March 2021).ParticipantsRepresentative general adult (≥ 18 years old) population samples in the UK (n = 1,017), Australia (n = 1,011) and the Netherlands (n = 1,017)Main outcome measureParticipants completed the ICECAP-A capability wellbeing measure in February 2021, and for two recalled timepoints during the initial lockdowns in April 2020 and in February 2020 (prior to COVID-19 restrictions in all three countries). ICECAP-A scores on a 0–1 no capability–full capability scale were calculated for each timepoint. Societal willingness to pay estimates for a year of full capability (YFC) was used to place a monetary value associated with change in capability per person and per country. Paired t tests were used to compare changes in ICECAP-A and YFC from pre- to post-COVID-19-related restrictions in each country.ResultsMean (standard deviation) loss of capability wellbeing during the initial lockdown was 0.100 (0.17) in the UK, 0.074 (0.17) in Australia and 0.049 (0.12) in the Netherlands. In February 2021, losses compared to pre-lockdown were 0.043 (0.14) in the UK, 0.022 (0.13) in Australia and 0.006 (0.11) in the Netherlands. In monetary terms, these losses were equivalent to £14.8 billion, AUD$8.6 billion and €2.1 billion lost per month in April 2020 and £6.4 billion, A$2.6 billion and €260 million per month in February 2021 for the UK, Australia and the Netherlands, respectively.ConclusionsThere were substantial losses in capability wellbeing in the first year of the COVID-19 pandemic. Future research is required to understand the specific impact of particular COVID-19 restrictions on people’s capabilities.

Disentangling the impact of childhood abuse and neglect on depressive affect in adulthood: A machine learning approach in a general population sample

BackgroundDifferent types of childhood maltreatment (CM) are key risk factors for psychopathology. Specifically, there is evidence for a unique role of emotional abuse in affective psychopathology in children and youth; however, its predictive power for depressive symptomatology in adulthood is still unknown. Additionally, emotional abuse encompasses several facets, but the strength of their individual contribution to depressive affect has not been examined. MethodHere, we used a machine learning (ML) approach based on Random Forests to assess the performance of domain scores and individual items from the Childhood Trauma Questionnaire (CTQ) in predicting self-reported levels of depressive affect in an adult general population sample. Models were generated in a training sample (N = 769) and validated in an independent test sample (N = 466). Using state-of-the-art methods from interpretable ML, we identified the most predictive domains and facets of CM for adult depressive affect. ResultsModels based on individual CM items explained more variance in the independent test sample than models based on CM domain scores (R2 = 7.6 % vs. 6.4 %). Emotional abuse, particularly its more subjective components such as reactions to and appraisal of the abuse, emerged as the strongest predictors of adult depressive affect. LimitationsAssessment of CM was retrospective and lacked information on timing and duration. Moreover, reported rates of CM and depressive affect were comparatively low. ConclusionsOur findings corroborate the strong role of subjective experience in CM-related psychopathology across the lifespan that necessitates greater attention in research, policy, and clinical practice.

Multidisciplinary approach to functional somatic syndromes: study protocol for a population-based prospective cohort study

IntroductionIsfahan functional disorders (ISFUN) cohort study aims to describe the interplay of genetic and environmental factors in shaping the characteristics of functional somatic syndromes (FSS). This study is primarily intended...

Proportion of ALGBT adult Brazilians, sociodemographic characteristics, and self-reported violence

Asexual, lesbian, gay, bisexual, and trans (ALGBT) individuals face worse life conditions and violence rates than their heterosexual cisgender counterparts. Brazil is often highlighted for having one of the highest rates of hate-related homicides against ALGBTs in the world. However, to date, Brazil’s ALGBT population has not been investigated with a representative sample, and basic information such as population size or sociodemographic characteristics are mostly based in non-systematic data. We aimed to assess the proportion of asexual, lesbian, gay, bisexual, trans and non-binary adults in Brazil, their sociodemographic characteristics, and self-reported violence rates. In 2018, a sample (n = 6000) of the Brazilian adult population answered a face-to-face survey assessing sociodemographic characteristics, gender identity, sexual orientation, and self-reported psychological, physical, verbal, and sexual violence. Among Brazilian adults, 12.04% are ALGBT: 5.76% asexual, 0.93% lesbian, 1.37% gay, 2.12% bisexual, 0.68 trans, and 1.18% non-binary. Compared to heterosexual cisgender men, most ALGBT individuals have worse socioeconomic indicators and higher rates of self-reported psychological and verbal violence. All ALGBT groups and heterosexual cisgender women reported sexual violence more often than heterosexual cisgender men. It was reported between 4 up to 25 times more often by heterosexual cisgender women and trans individuals, respectively. The rates of the other ALGBT groups sit among the two. Our findings provide evidence of the important size of the ALGBT Brazilian population, as well as their socioeconomic vulnerability, and concerning violence levels experienced by the group. Policy makers may refer to the present article in order to mitigate this population’s vulnerability and to better understand its sociodemographic characteristics.

Trends in prevalence and patterns of use of a heated tobacco product (IQOSTM) in Japan: A three-year repeated cross-sectional study

Background: Numerous smoke-free tobacco or nicotine-containing product (TNP) alternatives have been introduced to support individual- and population-level harm reduction relative to continued cigarette smoking. This article details the nationwide prevalence and patterns of TNP use between 2016 and 2019 in Japan following the commercialization of IQOSTM, a smoke-free heated tobacco product (HTP). Methods: Cross-sectional surveys were conducted over a period of three study years (2016/2017, 2017/2018, and 2018/2019) in representative samples of the Japanese general adult population and samples of Japanese adult IQOS users registered in the IQOS owner database of Philip Morris International’s affiliate in Japan. Results: Across the three study years (Y1-Y3), the prevalence of overall current TNP use (Y1-Y3: 18.5%, 18.9%, and 18.2%) and overall TNP use by age and sex remained similar. However, there was a growing shift from cigarette smoking to smoke-free TNP use across the three study years. While the cigarette smoking prevalence (Y1-Y3: 17.6%, 17.3%, and 16.0%) decreased, the use prevalence of smoke-free TNPs, including the HTP IQOS (Y1-Y3: 1.8%, 3.2%, and 3.3%) and e-cigarettes (Y1-Y3, 0.7%, 1.6%, and 2.0%) increased. At the same time, TNP initiation, TNP relapse, and TNP reinitiation with IQOS were all very low across the three study years. Across Y1-Y3, exclusive use of only one type of TNP (Y1-Y3: 82.3%, 75.0%, and 70.4%) decreased, while dual use of two types of TNPs (Y1-Y3: 14.3%, 17.2%, and 16.7%) increased, and poly-TNP use (Y1-Y3: 2.1%, 6.1%, and 10.0%) increased markedly. Moreover, the majority of adult IQOS users were exclusive IQOS users. Conclusions: These findings suggest that current IQOS use behavior trends are in line with the principles of tobacco harm reduction and that HTPs are effective tools for complementing current tobacco control measures.

Poor Response Inhibition and Symptoms of Inattentiveness Are Core Characteristics of Lifetime Illicit Substance Use among Young Adults in the General Norwegian Population: The HUNT Study

Background Impairments in neurocognitive functioning are associated with substance use behavior. Previous studies in neurocognitive predictors of substance use typically use self-report measures rather than neuropsychological performance measures and suffer from low sample sizes and use of clinical diagnostic cut offs. Methods Crossectional data from the HUNT4 Study (Helseundersøkelsen i Trøndelag) was used to study executive neuropsychological performance and self-reported measures of neurocognitive function associated with a history of illicit substance use in a general population sample of young adults in Norway. We performed both between group comparisons and logistic regression modeling and controlled for mental health symptomatology. Results Subjects in our cohort with a self-reported use of illicit substances had significantly higher self-reported mental health and neurocognitive symptom load. A logistic regression model with substance use as response included sex, commission errors and self-reported inattentiveness and anxiety as significant predictors. After 10-fold cross-validation this model achieved a moderate area under the receiver-operator curve of 0.64. To handle the class imbalance typically found in such population data, we also calculated balanced accuracy with a optimal model cut off of 0.234 with a sensitivity of 0.50 and specificity of 0.76 as well as precision recall—area under the curve of 0.28. Conclusions Subtle cognitive dysfunction differentiates subjects with and without a history of illicit substance use. Neurocognitive factors outperformed the effects of depressive symptoms on substance use behavior in this cohort. We highlight the need for using adequate statistical tools for evaluating the performance of models in unbalanced datasets.

Prevalence of drug allergy in South Australia.

Drug allergy is commonly reported in patient notes and electronic health records. The prevalence of self-reported drug allergy in the general Australian population has not previously been studied. To investigate the prevalence of self-reported drug allergy in the general adult population in South Australia. We surveyed a representative sample of the South Australian adult population regarding their own perception of drug allergy, including drug type and severity, as well as the use of medical alert devices. Data were weighted to correspond to age and sex of the South Australian population. Twenty-two percent of adults in South Australia consider themselves allergic to one or more drugs: 9.3% declared themselves to be allergic to penicillin, 5% to an antibiotic other than penicillin and 13% to one or more antibiotics. Drug allergy and penicillin allergy was significantly more prevalent in females and increased with age. Thirteen percent of those with an antibiotic allergy reported a severe reaction, of whom 27% wore a medical notification device. Of those allergic to penicillin, 75% had their index reaction more than 10 years ago and did not report severe features. Self-reported drug allergy is common in the general population, as it is in medical clinic and hospital populations. The majority of those reporting penicillin allergy would be considered low-risk and suitable for de-labelling procedures.

Determinants of Anxiety in the General Latvian Population During the COVID-19 State of Emergency.

BackgroundThe COVID-19 pandemic and its restrictive public health measures have seriously affected mental health of society. Social, psychological, and health-related factors have been linked to anxiety in the general population.AimWe investigate the association of various sociopsychological and health-related determinants of anxiety and identify the predicting factors for anxiety in the general population during the COVID-19 state of emergency from in Latvia.MethodsWe conducted an online survey using a randomized stratified sample of the general adult population in July 2020 for 3 weeks. Anxiety symptoms were measured using the State-Trait Anxiety Inventory (STAI-S). Sociodemographic, health-related, sociopsychological characteristics and suicidality were identified using the structured questionnaire. The statistical analysis included Pearson's chi-square test, post hoc analysis, and binomial logistic regression.ResultsThe weighted study sample included 2,608 participants. The mean STAY-S score of the total sample was 22.88 ± 12.25. In the total sample, 15.2% (n = 398) of participants were classified as having anxiety. The odds ratio (OR) of having anxiety was higher in females (OR = 2.44; 95% CI 1.75–3.33) and people who had experienced mental health problems in the past (OR = 1.45; 95% CI 1.03–2.04), had suicide attempt in the past (OR = 1.68; 95% CI 1.08–2.59), were worried about their health status due to COVID-19 (OR = 1.64; 95% CI 1.36–1.16), were worried about stigmatization from others if infected with COVID-19 (OR = 1.18; 95% CI 1.03–1.35), were worried about information regarding COVID-19 from the Internet (OR = 1.24; 95% CI 1.08–1.43), persons who were lonely (OR = 1.90; 95% CI 1.54–2.34), and persons with negative problem orientation (OR = 1.26; 95% CI 1.06–1.51). Protective factors were identified as having good self-rated general health (OR = 0.68, 95 % CI 0.58–0.81), maintaining a daily routine (OR = 0.74, 95 % CI 0.61–0.90), having financial stability (OR = 0.66, 95 % CI 0.55–0.79), and having good psychological resilience (OR = 0.90, 95 % CI 0.87–0.94).ConclusionsThis is the first study to report a prevalence of anxiety in the general population of Latvia. Certain factors that predict anxiety, as well as protective factors were identified.

The prevalence of diabetes and associated risk factors among adult population in a Turkish population (Trabzon city)

ObjectiveThe objectives of this study were to determine the prevalence of diagnosed and undiagnosed diabetes mellitus (DM) and prediabetes, and to evaluate the associated risk factors in a sample of adult Turkish population. MethodsA total of 4000 eligible study subjects, aged 20 years or older, chosen by multistage sampling on a field were considered. Of those 3721 subjects (2139 women and 1582 men) participated in the study. ResultsThe prevalence of prediabetes and DM were found to be as 6.4% and 10.4% (3.6% being newly diagnosed by this study), respectively. In multivariate logistic regression analysis, advanced age (OR:26.7, p < 0.0005 in the group 70 years and over), marriage (OR:2.05, p = 0.047), housewives (OR:1.34, p = 0.003), family history of diabetes (OR:2.84, p < 0.0005), overweight (OR:1.61, p = 0.026), obesity (OR:2.25, p < 0.0005), hypertension (OR:1.42, p = 0.007) and dyslipidemia (OR:1.38, p = 0.028) were independent risk factors for being diabetic. ConclusionsDM is an important health problem in the adult population of Trabzon city. Newly diagnosed diabetic patients who were unaware of their status are at high risk. To control DM and associated risk factors, effective public health education and taking urgent steps are needed.

Prevalence of alcohol use disorder among the Latvian general population and associations with the PHQ-9 screening results and sociodemographic factors

IntroductionBoth alcohol use disorder (AUD) and depression are potentially disabling and economically burdensome disorders. There is no available information about the prevalence of alcohol use disorder in the general population of Latvia.ObjectivesTo determine the 12-month prevalence of AUD and the association with depressive symptoms and socio-demographic factors among the Latvian general population.MethodsComputer assisted face-to-face interviews were carried out in 2019-2020 among a representative sample of the Latvian adult population (n=2687). The study sample was selected using a stratifyed random sampling method. The respondents were interviewed using the Patient Health Questionnaire-9 (a score of ≥10 was defined as indicating the presence of a clinically relevant depressive symptoms) and the Mini-International Neuropsychiatric Interview. Descriptive statistics and Chi-square test was applied.ResultsThere were 1238 males (46.1%) and 1449 females (53.9%) recruited. Mean age of respondents was 49.9 (SD 18.2). The 12-month prevalence of AUD according to the M.I.N.I was 13.1% with a statistically significant difference between the genders: 23.6% in men and 4.1% in women (p&lt;0.001). AUD was significantly more prevalent among the respondents younger than 40 years: 18.0% (p&lt;0.001), especially among young (18-44 y.o.) men – 28.1% of all diagnosed cases (p&lt;0.001); There was found an association between the severity stage of AUD and PHQ-9 screening results: 18.8% of those diagnosed with severe AUD had a score greater than 10 points in the PHQ-9 (p&lt;0.001).ConclusionsYoung men are at particularly high risk of alcohol use disorder. Those with diagnosed alcohol use disorder should be also screened for the depressive symptoms.DisclosureNo significant relationships.

Independent association of FTO rs9939609 polymorphism with overweight and obesity in Polish adults. Results from the representative population-based WOBASZ study.

Genetic factors play an important role in the origin of obesity. We investigated the association between the FTO rs9939609 genotype and overweight and obesity, along with additional anthropometric variables in the representative sample of adult Polish population. We genotyped a random sample of 3369 adult individuals examined in a cross-sectional population survey (WOBASZ 2003-2005). More than 40% of men and women had at least one A allele. The AA genotype was found in approximately one fifth of both men and women. The frequency of the AA genotype increased with higher BMI in both sexes and was associated with higher anthropometric obesity indicators in both men and women. The FTO rs9939609 AA genotype was significantly related to abnormal BMI [OR=1.55 (1.14-2.11)] and overweight [OR=1.55 (1.11-2.16)] or obesity [OR=1.56 (1.04-235)] in men regardless of age, tobacco smoking, physical activity, diet and diabetes, while in women it was related to abnormal BMI [OR=1.45 (1.05-2.01)] and overweight [OR=1.59 (1.11-2.29)] after adjustment in addition for menopause. The frequency of the A allele in the Polish population was the same as in other European countries. About one fifth of both men and women have the FTO rs9939609 AA variant. A significant relationship was found between the FTO genotype and anthropometric obesity indicators. The AA genotype was significantly associated with abnormal BMI and overweight in both sexes, but the relation to the obesity phenotype was observed only in men.

Association between purpose in life and healthcare use among women and men in Germany: cross-sectional analysis of the nationally representative German Socio-Economic Panel (GSOEP) study

ObjectivesIt remains almost unknown whether purpose in life is associated with healthcare use (HCU) in general. Therefore, the goal of this study was to examine the association between purpose in...

SCREENING FOR ATRIAL FIBRILLATION WITH ROUTINE AUTOMATED BLOOD PRESSURE MEASUREMENT IN THE ELDERLY: THE NATIONAL HEALTH SURVEY EMENO IN GREECE

Objective: Atrial fibrillation (AF) is the most common sustained arrhythmia which often is asymptomatic and undiagnosed. An automated blood pressure (BP) monitor with an algorithm which detects atrial fibrillation with high diagnostic accuracy during routine measurement was used for AF screening in the elderly general population Greece. Design and method: EMENO health survey (2013 to 2016) applied a multi-stage stratified random sampling method to select a random sample of the general adult (&gt; = 18 years) population of Greece. For participants aged &gt; = 65 years screening for AF was performed with triplicate automated BP measurements using a validated automated upper-arm cuff oscillometric device with embedded algorithm for detecting AF (Microlife BPA100 Plus AFIB). Results: A total of 1,838 individuals aged &gt; = 65 years were recruited and 975 with AF data on at least 1 BP measurement were analysed (mean [SD] age 75.3 (6.6)) years, men 45.1%, BMI 30.3 (5.2) kg/m2, hypertensives 80.7%). Of them, 65 (7.1%) had AF detected in all their 3 BP readings (AF group), 661 (69.5%) have no AF in all 3 readings (no AF group), and 249 (23.4%) had AF in 1 or 2 readings (uncertain AF group). Participants with AF were older than non-AF (by 3.4 years on average, p &lt; 0.001), had lower systolic BP (by 4.6 mmHg, p &lt; 0.05), and more frequent cardiovascular disease (29% vs 14%, p &lt; 0.01). Among AF patients, 43% reported a previous AF diagnosis compared to 8.8% and 11.9% in no AF and uncertain AF group respectively (p &lt; 0.001). Hypertension tended to be more common in the AF than the non-AF group (88% vs. 80%, p = NS). Of the 65 AF group, 57% were undiagnosed and all required anticoagulant therapy (men with CHA2DS2-VASc &gt; = 1 or women &gt; = 2). Conclusions: Almost 7% of people aged &gt; = 65 years in Greece had AF detected during routine automated BP measurement. 57% of them were undiagnosed and all required anticoagulant treatment for stroke prevention. Screening for AF using routing automated BP measurement in the elderly appears to be a useful method for early detection and management of asymptomatic AF.

Who you know: The classed structure of social capital.

This article focuses on the social structuring of social capital, understood as resources embedded in social networks. The analysis integrates key theoretical–methodological insights from two distinct approaches concerned with social capital and inequality: the position‐generator approach associated with Nan Lin and the spatial approach associated with Pierre Bourdieu. Empirically, we exploit the possibilities of survey data containing detailed information about the social ties of a representative sample of the Norwegian adult population (N = 4007). By means of Multiple Correspondence Analysis (MCA), we construct a space of social ties, a spatial representation of systematic similarities and differences between individuals' social ties to a set of 33 occupational positions. In this space, social capital is structured according to two primary dimensions: (i) the level of social ties, in terms of individuals' number of contacts; and (ii), the quality of social ties, in terms of a division between being connected to others in high‐status positions and others in low‐status positions. By means of Ascending Hierarchical Cluster analysis, five clusters are identified within the space of social ties: a homogenous working‐class cluster, a well‐connected working‐class cluster, a cluster of high‐status ties, a homogenous high‐status cluster and a low‐volume cluster. Moreover, the analysis clearly indicates that the structure of social capital is connected to respondents' class positions, their volumes of cultural and economic capital and their class origin. The analysis thus draws attention to the role of social capital in processes of social closure, regarding both resource monopolization and class formation.

SEASONAL VARIATION IN METEOROLOGICAL PARAMETERS AND BLOOD PRESSURE IN CROATIAN ADULT POPULATION

Objective: There are many reports on the seasonality of cardiovascular risk factors particularly of blood pressure (BP). Our aim was to analyze association of BP with various meteorological parameters in random sample of general Croatian adult population. Design and method: EHUH -2 study is nation-wide survey (Croatian Science Foundation) on prevalence, treatment and control of hypertension in Croatia. In 2018–2021 a random sample of 1321 subjects were enrolled. Office blood pressure (BP) and heart rate were measured in sitting position using Omron 3 device three times and average BP values were calculated. Estimated pulse wave velocity (ePWV) was calculated using validated equation. Meteorological data (mean daily 2 m air temperature – T2m, atmosphere pressure, air humidity measured at meteorological stations according to WMO standards) were collected in Croatian Meteorological and Hydrological Service. Results: We found significant difference in systolic and diastolic BP, heart rate and ePWV accorss nalys (Figure 1a and Figure 2), as well significant correlation between all parameters and T2m. (Figure 3 for systolic BP). There is nonsignificant trend in association between systolic BP and air humidity. We failed to find association of diastolic BP, heart rate and ePWV with any of nalysed meteorological parameters. Furthermore, we found inverse association between systolic BP, diastolic BP and heart rate with T2m i.e. we confirmed seasonal fluctuations (Figure 1b). Conclusions: Our data confirmed findings of seasonal (inverse) variation between BP and T2m. Interestingly, we found association of seasonal variation and ePWV. T2m has impact on long-term BP variability but also on ePWV and should be taken into account in clinical research as well as in regular clinical work.

Severity of alcohol dependence and mortality after 20years in an adult general population sample.

ObjectivesTo estimate mortality on grounds of the severity of alcohol dependence which has been assessed by two approaches: the frequency of alcohol dependence symptoms (FADS) and the number of alcohol dependence criteria (NADC).MethodsA random sample of adult community residents in northern Germany at age 18 to 64 had been interviewed in 1996. Among 4075 study participants at baseline, for 4028 vital status was ascertained 20 years later. The FADS was assessed by the Severity of Alcohol Dependence Scale among the 780 study participants who had one or more symptoms of alcohol dependence or abuse and vital status information. The NADC was estimated by the Munich Composite International Diagnostic Interview among 4028 study participants with vital status information. Cox proportional hazard models were used.ResultsThe age‐adjusted hazard ratio for the FADS (value range: 0–79) was 1.02 (95% confidence interval, CI: 1.016–1.028), for the NADC (value range: 0–7) it was 1.25 (CI: 1.19–1.32).ConclusionsThe FADS and NADC predicted time to death in a dose‐dependent manner in this adult general population sample.

The physical activity health paradox and risk factors for cardiovascular disease: A cross-sectional compositional data analysis in the Copenhagen City Heart Study.

Studies indicate that physical activity during leisure and work have opposite associations with cardiovascular disease (CVD) risk factors, referred to as the physical activity health paradox. We investigated how sedentary behaviour and physical activity types during leisure and work are associated with systolic blood pressure (SBP), waist circumference (WC), and low-density lipoprotein cholesterol (LDL-C) in an adult general population sample using compositional data analysis. Participants wore accelerometers for 7 days (right thigh and iliac crest; 24 h/day) and had their SBP, WC, and LDL-C measured. Accelerometer data was analysed using the software Acti4 to derive daily time spent in sedentary behaviour and physical activity types. The measure of association was quantified by reallocating time between sedentary behaviour and 1) walking, and 2) high-intensity physical activity (HIPA; sum of climbing stairs, running, cycling, and rowing), during both domains. In total, 652 participants were included in the analyses (median wear time: 6 days, 23.8 h/day). During leisure, the results indicated that less sedentary behaviour and more walking or more HIPA was associated with lower SBP, while during work, the findings indicated an association with higher SBP. During both domains, the findings indicated that less sedentary behaviour and more HIPA was associated with a smaller WC and lower LDL-C. However, the findings indicated less sedentary behaviour and more walking to be associated with a larger WC and higher LDL-C, regardless of domain. During leisure, less sedentary behaviour and more walking or HIPA seems to be associated with a lower SBP, but, during work, it seems to be associated with a higher SBP. No consistent differences between domains were observed for WC and LDL-C. These findings highlight the importance of considering the physical activity health paradox, at least for some risk factors for CVD.

Investigating emotion regulation and social information processing as mechanisms linking adverse childhood experiences with psychosocial functioning in young swiss adults: the FACE epidemiological accelerated cohort study

BackgroundAdverse childhood experiences increase the risk for psychological disorders and lower psychosocial functioning across the lifespan. However, less is known about the processes through which ACE are linked to multiple negative outcomes. The aim of the FACE epidemiological study is to investigate emotion regulation (emotional reactivity, perseverative thinking and self-efficacy for managing emotions) and social information processing (rejection sensitivity, interpretation biases and social understanding) as potential mechanisms linking adverse childhood experiences and psychosocial functioning in a large population sample of young adults. It is embedded in a larger project that also includes an ecological momentary assessment of emotion regulation and social information processing and informs the development and evaluation of an online self-help intervention for young adults with a history of ACE.MethodsThe study plans to recruit 5000 young adults aged 18 to 21 from the German-speaking Swiss population. Addresses are provided by Swiss Federal Statistical Office and participants are invited by mail to complete a self-report online survey. If the targeted sample size will not be reached, a second additional sample will be recruited via educational facilities such as universities or teacher training colleges or military training schools. Three follow-ups are planned after 1 year, 2 years and 3 years, resulting in ages 18–24 being covered. The main exposure variable is self-reported adverse childhood experiences before the age of 18, measured at the baseline. Primary outcomes are psychosocial functioning across the study period. Secondary outcomes are social information processing, emotion regulation and health care service use. Statistical analyses include a range of latent variable models to identify patterns of adverse childhood experiences and patterns and trajectories of psychosocial adaptation.DiscussionThe results will contribute to the understanding of the underlying mechanisms that link ACE with psychosocial functioning which is crucial for an improved insight into risk and resilience processes and for tailoring interventions. Furthermore, the identification of factors that facilitate or hinder service use among young adults with ACE informs healthcare policies and the provision of appropriate healthcare services.Trial registration number: NCT05122988. The study was reviewed and authorized by the ethical committee of Northwestern and Central Switzerland (BASEC number 2021-01204).