You have accessJournal of UrologyUrothelial Cancer: Medical & Surgical Therapy1 Apr 2011488 COULD A SALVAGE SURGERY AFTER CHEMOTHERAPY HAVE CLINICAL IMPACT ON CANCER SURVIVAL IN PATIENTS WITH METASTATIC UROTHELIAL CARCINOMA? Takashi Saika, Kensuke Bekku, Yasuyuki Kobayashi, Taiki Kanbara, Ryo Kishimoto, Shin Ebara, Yasutomo Nasu, and Hiromi Kumon Takashi SaikaTakashi Saika Okayama, Japan More articles by this author , Kensuke BekkuKensuke Bekku Okayama, Japan More articles by this author , Yasuyuki KobayashiYasuyuki Kobayashi Okayama, Japan More articles by this author , Taiki KanbaraTaiki Kanbara Okayama, Japan More articles by this author , Ryo KishimotoRyo Kishimoto Okayama, Japan More articles by this author , Shin EbaraShin Ebara Okayama, Japan More articles by this author , Yasutomo NasuYasutomo Nasu Okayama, Japan More articles by this author , and Hiromi KumonHiromi Kumon Okayama, Japan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.583AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES A clinical impact of salvage surgery after chemotherapy in patients with metastatic urothelial carcinoma on cancer survival is controversial. We verified a clinical role of salvage surgery with analyzing long-term outcome after salvage surgery in patients with metastatic urothelial carcinoma treated with Cisplatin/Gemcitabine/Paclitaxel -based chemotherapy at a single institution. METHODS From 2003 to 2010, 31 of 47patients (66%) with metastatic urothelial carcinoma showed objective responses (CR in 4, PR in 27) after multiple courses of the chemotherapy. Twelve of 27 patients with PR underwent salvage surgeries after the chemotherapy (10 male and 2 female, median 61.0 years old). All of the patients underwent metastatectomy of residual lesions (10 of retroperitoneal lymphnodes, 2 of lung). Seven of the patients underwent radical surgeries for primary lesions as well. Progression free survival and overall survival of the patients were analyzed retrospectively in comparison with those of patients without salvage surgery. RESULTS All 12 patients could achieve surgical CR. Pathological findings showed pathological CR in 2 patients. In median follow-up 32.5 months (range: 4.5–65.4), progression free survival (Figure 1) and over all survival (Figure 2) in patients with salvage surgery were better than those in 16 PR patients without the surgery (72.9% vs 0%, and 91.7% vs 10.6% at 2 years, p=0.0005 and 0.0003; Logrank test). CONCLUSIONS Although there were several biases in patients backgrounds (e.g. metastatic lesion, number, age), salvage surgery in patients with residual tumor after GCP chemotherapy could have strong impact on cancer survival. Surgical CR should be achieved in an affordable patient who is responder of GCP therapy. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e199 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Takashi Saika Okayama, Japan More articles by this author Kensuke Bekku Okayama, Japan More articles by this author Yasuyuki Kobayashi Okayama, Japan More articles by this author Taiki Kanbara Okayama, Japan More articles by this author Ryo Kishimoto Okayama, Japan More articles by this author Shin Ebara Okayama, Japan More articles by this author Yasutomo Nasu Okayama, Japan More articles by this author Hiromi Kumon Okayama, Japan More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...