Salt Preference Research Articles

소금 섭취 행태와 혈압: 맛에 대한 민감도와 선호도의 영향

The literature suggested that a small reduction in overall blood pressure can have a large effect on overall prevalence of hypertension, and therefore, the affect of taste preferences of the population on salt intake should be considered for long-term blood pressure intervention programs. The purpose of this study is to investigate the influence of salt taste preference and salt taste sensitivity on salt intake behavior as risk factors for high blood pressure. We collected information on blood pressure, diet and lifestyle behaviors, salt taste preference and salt taste sensitivity from 540 respondents from Suseo-dong, Seoul. Salt taste sensitivity was assessed by administering a 1% NaCl solution to the subject's tongue and measuring the perceived intensity on 10 level scale. Salt intake behavior was classified into 3 categories: frequency of high-sodium foods, practice of salt-reducing behavior and frequency of vegetable and fruit intake. Salt taste preference showed a significant relation to the subjects' blood pressure, i.e. subjects with a higher salt preference had higher blood pressure. Salt taste sensitivity did not show a significant relation to blood pressure. However, there was a positive correlation between salt taste preference and salt taste sensitivity. Among the 3 indicators used to measure salt intake behavior, the practice of salt-reducing behavior remained significantly correlated to blood pressure. Moreover, salt-reducing behavior and salt taste preference showed a significant correlation, i.e. people who do not like salty foods tend to practice more salt-reducing behavior, leading to reduced levels in blood pressure. In a population, a small reduction in overall blood pressure can have large effects in overall prevalence of hypertension, in contrast to clinical studies where achievement of an individual's normal blood pressure is emphasized. Therefore, taste preference of the population should be considered for long-term blood pressure intervention programs.

Salt intake and preference in different groups of Spanish children and adolescents.

The object of this study was to investigate the salt perception and preference, and its relationship with blood pressure (BP). Control families along with families with at least one of the parents with essential hypertension (EHT) and families which have been presented maternal vomitting during pregnancies were incorporated in the studies. Anthropometric values, and BP measurements were recorded and blood and urine samples were collected. Sodium fractional excretion (NaFE) was determined and salt gustatory performance was assessed by means of behavioural sensitivity and discrimination test. Approx. 80% of the mothers declared to cook with “little salt” (84% vs. 74% EHT, NS). No significant correlations were found between systolic nor diastolic blood pressure with NaFE, neither globally, nor in the study groups. NaFE and systolic BP in EHT presented correlation values close to the statistical signification (p=0.06). Taste appreciation for seven “salty” products (chip potatoes, etc…) was 5.59±0.16, with no significant correlation against NaFE, systolic and diastolic BP. The influence of declared salt addition while cooking (little, normal or much salt), on NaFE was not significant. Salt taste sensitivity showed a significant correlation with systolic BP (SBP) in “vomiter descendents” (r=−0.66; p=0.003), but not in “non-vomiter descendents”. Adjusted by gender, and actual height and weight, salt-sensitivity performance remained significantly related to SBP. Published and assumed recommendations followed by the general public about deleterious effect of salt, seem to slant the opinion about intake. A bias towards the declaration of little intakes was detected.

A field survey of iodine supplementation of primary school children and their parents in a rural village in the endemic area of iodine deficiency disorder, northeastern Thailand

Iodine deficiency disorder (IDD) is an important health problem in Thailand. Due to the geographical limitation of marine salt distribution, the Northern and Northeastern regions of Thailand are endemic areas of this disorder. In this study, a cross-sectional survey on the domestic use of iodine-enriched salt by the people in a rural village, Non Sam Ran, Borabue district, Mahasarakarm province in the northeastern region of Thailand was conducted. A salt survey was undertaken in the village, involving the specific health knowledge of both primary school students and their parents, and including a home visit with kitchen salt sampling. As a result of this survey, despite the smallness of the sample, concern is raised regarding the application of public health information about IDD due to a taste preference for non-iodised salt, and the quality control of the manufacture of iodine-fortified salt.

Preference for salts in cooking as perceived by sensory panelists

AbstractThis study was conducted to determine if consumers have a preference for sea, table or kosher salt. Mashed potatoes were tested and accepted as an adequate carrier. Preliminary sensory research was conducted over two trial days in the Food Science and Human Nutrition Department. The panelists (n = 100) conducted evaluations on three samples of mashed potatoes seasoned with three types of salt (sea, kosher and noniodized table) using preference testing. A control sample, unsalted mashed potatoes, was presented with each set. The objective of this study was to determine the ‘best overall salt flavor’. Consumers preferred the table and sea salt samples more than the kosher salt, but there was not a distinguishable difference between the table and the sea salts. However, there was no statistical preference by the participant for either of the salts.

ARTERIAL BAROREFLEX IS NOT INVOLVED IN SALT PREFERENCE IN RATS

1. One unusual and interesting feature of spontaneously hypertensive rats (SHR) is their salt preference. This behaviour is known to be independent of blood pressure. 2. Arterial baroreflex (ABR) function is impaired in SHR. Therefore, the present study was designed to explore the relationship between ABR function and salt preference in rats. 3. Twenty-seven SHR, aged 11 months, were used. Blood pressure and baroreflex sensitivity (BRS) were determined in conscious, freely moving SHR after the measurement of salt preference. It was found that BRS did not relate to the salt preference in these rats. 4. Another group of normotensive Sprague-Dawley rats, aged 10 weeks, underwent either sinoaortic denervation (SAD) or sham operation. Salt preference was determined before and 4 weeks after SAD. Sinoaortic denervation did not alter salt preference in normotensive rats. 5. It is concluded that ABR function does not influence the salt preference in rats.

Prenatal and early postnatal dietary sodium restriction sensitizes the adult rat to amphetamines

Acute sodium deficiency sensitizes adult rats to psychomotor effects of amphetamine. This study determined whether prenatal and early life manipulation of dietary sodium sensitized adult offspring to psychomotor effects of amphetamine (1 or 3 mg/kg ip) in two strains of rats. Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) dams were fed chow containing low NaCl (0.12%; LN), normal NaCl (1%; NN), or high NaCl (4%; HN) throughout breeding, gestation, and lactation. Male offspring were maintained on the test diet for an additional 3 wk postweaning and then fed standard chow thereafter until testing began. Overall, blood pressure (BP), total fluid intake, salt preference, and adrenal gland weight were greater in SHR than in WKY. WKY LN offspring had greater water intake and adrenal gland weight than did WKY NN and HN offspring, whereas WKY HN offspring had increased BP, salt intake, and salt preference compared with other WKY offspring. SHR HN offspring also had increased BP compared with other SHR offspring; all other measures were similar for SHR offspring. The low-dose amphetamine increased locomotor and stereotypical behavior compared with baseline and saline injection in both WKY and SHR offspring. Dietary sodium history affected the rats' psychomotor response to the higher dose of amphetamine. Injections of 3 mg/kg amphetamine in both strains produced significantly more behavioral activity in the LN offspring than in NN and HN offspring. These results show that early life experience with low-sodium diets produce long-term changes in adult rats' behavioral responses to amphetamine.

Angiotensin Type 1A Receptors on Glial Cells in Rostral Ventrolateral Medulla and Hypertension

During the 1970s and early 1980s, all the components of the renin–angiotensin system (RAS) were identified within the brain.1 Subsequent physiological studies have shown that angiotensin II (Ang II) can act at various sites within the brain stem and hypothalamus to regulate cardiovascular function and fluid and electrolyte balance. Further, there is increasing evidence that brain Ang II can contribute to increased sympathetic activity in hypertension and heart failure.2 In recent years, a number of investigators have studied the physiological effects of alteration of the expression of genes encoding various components of the RAS. As reviewed recently by Davisson,2 early studies by Ganten and colleagues showed that transgenic rats containing the mouse renin ( Ren -2) gene were hypertensive. Although there is an increased expression of Ang II in the hypothalamus and medulla oblongata of such animals, the extent to which the hypertension was caused by increased levels of central or peripheral Ang II was not clear. Later, with the development of new methods that enabled brain-selective expression of particular genes, transgenic mice in which the angiotensin type 1A (AT1A) receptors were overexpressed in the brain but not in peripheral tissues were produced.3 These animals exhibit exaggerated pressor responses to intracerebroventricular administration of Ang II, but have a normal resting arterial blood pressure.3 Thus, this indicates that an increased density of AT1A receptors alone is not sufficient to produce hypertension. Other genetic models, however, have demonstrated that overactivity of the brain RAS can produce hypertension. In transgenic mice containing both the human angiotensinogen …

Salt addiction: A different kind of drug addiction

Under the headline "drug addiction" the medical world has exclusively been interested in psychoactive drugs. For diagnosis of substance dependence (addiction), DSM-IV-TR has determined seven criteria, and fulfilling at least three of them signifies addiction. When studied salt intake according to these criteria it is seen that most of them are fulfilled, showing that sodium chloride, which is not classified under the psychoactive drugs, is capable of producing addiction. Namely: at the beginning of salt abstinence, anorexia and slight nausea during meal time (withdrawal symptoms); about 1000-fold difference of per capita salt consumption between several human societies, and life-long continuation of discretional salt intake behaviour (high dose and very long duration of use); difficulty of restriction of salt intake (unsuccessful efforts to cut down or control); lack of success of salt restriction campaigns in hypertensive patients (substance use despite health problem). Additionally, the decrease of salt preferences of individuals whose salt intake are restricted for some time, and vice versa, signifies tolerance. On the other hand, it is evident that as the main culprit of developing systemic hypertension and as producing or promoting some other important health problems, salt intake causes millions of deaths in the world yearly. The recognition of addicting property of salt will facilitate combating these health problems.

Lack of evidence for a role for either the in utero or suckling periods in the exaggerated salt preference of the spontaneously hypertensive rat

When offered as a choice with drinking water in two-bottle preference tests, the spontaneously hypertensive rats (SHR) of the Okamoto strain exhibit a marked preference for saline solutions. While this behaviour is thought to be in part genetically determined, the role of environmental influences–in particular, perinatal ones–are poorly understood. In this study, we have used combined embryo transfer and cross-fostering techniques between SHR and normotensive Wistar Kyoto (WKY) rats to delineate the relative roles of the prenatal and postnatal, suckling environment on the exaggerated saline preference of male SHR and WKY offspring at 20 weeks of age. We found, using two-bottle preference tests using water and 140 mmol/l sodium chloride solution, that neither the in utero period nor the postnatal, suckling period played a role in the development of the much larger total fluid intake (water plus saline) or saline preference (proportion of the total fluid intake taken as saline) of the SHR. We thus conclude that maternal and perinatal environmental factors do not play a major role in this behaviour and that the exaggerated saline preference of the SHR is probably largely genetically determined.

Increased salt appetite in patients with congenital adrenal hyperplasia 21-hydroxylase deficiency

Salt appetite was investigated in 14 patients with congenital adrenal hyperplasia of the salt-wasting form (SW group), 12 patients with the simple virilized form who are not salt losing, and 18 healthy siblings. Salt appetite was evaluated by questionnaire, preference tests, and dietary analyses. The findings showed that SW who were not therapeutically normalized showed increased salt appetite but no change in sweet preference. Their salt appetite correlated with symptoms of salt wasting, namely, plasma renin activity, plasma K(+), and urine Na(+) and (inversely) with blood pressure. Sensitivity to the taste of NaCl was not altered. Factor analyses of a larger group confirmed the distinction between salt appetite and sweet preference, but intake of dietary Na(+) and sweet carbohydrates and intake of salty and sweet snacks did not reflect distinct salt or sweet preferences. We confirm that putative perinatal dehydration, due to maternal nausea and vomiting during pregnancy, childhood vomiting, and diarrhea with occasional saline infusion, was related to increased salt appetite in adolescence. The findings suggest that salt appetite in humans is determined by interdependent, innate, physiological, and acquired attributes. Salt appetite in SW patients is an adaptive response mediated by the renin-angiotensin system, an innate predisposition to acquire salt preference (in anticipation of both sodium loss and its consequence), and imprinting by perinatal hyponatremic occurrences. Our findings contribute to understanding human salt intake, provide insight into the motivation for salt in patients with congenital adrenal hyperplasia 21-OH deficiency, and may point the way to improvements in therapeutic compliance in these patients.

Effect of Gamma Irradiation on the Preference Behavior and Lipid Metabolism in Grey Garden Slug Deroceras reticulatum Mull.

We studied the preference behavior of slugs Deroceras reticulatum in experimental light, thermal, and salt gradients. The zone of each gradients preferred by the majority of individuals had the lowest contents of total lipids and total fatty acids in the tissues as compared to animals in any other zones. Hard gamma irradiation of slugs D. reticulatum proved to induce qualitative changes in salt preference, to decrease photoresponse in light gradients, and to increase lipid content in tissues.

Salt preference of congenic strains derived from the spontaneously hypertensive rat

Previous studies using reciprocal crosses between the spontaneously hypertensive rat (SHR) and the normotensive Wistar–Kyoto (WKY) strain suggested a role for the Y chromosome in the SHR's exaggerated preference for saline solutions. We have reexamined the role of the Y chromosome in the salt preference of the SHR using a consomic strain derived from SHR and Brown Norway (BN-Lx) progenitors. We also studied congenic lines in which regions of BN-Lx chromosomes 8 and 20 had been introgressed into the SHR genome. Animals were given a choice of water and 0.9% saline to drink over a period of 7 days and their total fluid intake (TFI; water plus saline) and saline preference (proportion of the TFI taken as saline) calculated. SHR bearing the BN-Lx Y chromosome had a significantly reduced saline preference when compared to progenitor SHR. Evidence was also found for the existence of a region on chromosome 8, which influences fluid intake in the SHR. The causative genes involved in these effects however remain to be determined.

Intuitive evolutionary perspectives in marketing practices1

AbstractFirms spend considerable sums of money on marketing, and they continue to do so because marketing works. However, marketing can only work if marketers have a reasonably accurate view of human nature. It is argued that many consumer products and advertisements reflect an accurate view of human nature, a view that is compatible with the tenets of evolutionary psychology. Implicit theories of human nature that are out of synch with reality sell few products. An overview of an evolutionary perspective on marketing is provided here, and connections between marketing practices and evolved adaptations, including kin selection, prestige seeking, preferences for salt, sweets, and fat, and savanna‐like landscapes are examined. Adaptations that differ by sex and how they are mirrored in marketing are also examined. Finally, some marketing practices that reflect evolutionary principles of variation are discussed. © 2003 Wiley Periodicals, Inc.

An evolutionary explanation of the plasticity of salt preferences: Prophylaxis against sudden dehydration

Salt preferences, which vary widely across individuals, are a function of past exposure to both levels of dietary salt and dehydration. From an evolutionary perspective, such plasticity is puzzling, as the health costs of high salt intake, combined with the increased time and energy needed to obtain large quantities of salt under ancestral conditions, suggest that natural selection should have eliminated the plasticity in preferences that can produce such behavior. This puzzle is resolved once it is recognized that high salt intake may provide protection against sudden dehydration, a benefit that outweighs the costs associated with this pattern. It is proposed that an adaptive mechanism calibrates salt preferences as a function of the risk of dehydration as indexed by past dehydration events and maternal salt intake.

Salt intake, cured meat consumption, refrigerator use and stomach cancer incidence: a prospective cohort study (Netherlands).

Many case-control studies have reported that salt and cured meat intake are positively, and refrigerator use is inversely, associated with stomach cancer risk. In the current prospective study these associations were evaluated. The Netherlands Cohort Study consisted of 120,852 men and women ages 55-69 years at baseline in 1986. Salt exposure was measured by calculating mean daily sodium intake (dietary salt) from 150 food items and by specific salt questions. After 6.3 years of follow-up, 282 incident stomach cancer cases were available for analyses. Case-cohort analyses were based on the 282 cases and 3123 subcohort members. In multivariate analyses adjusted for age, sex, smoking, education, stomach disorders, history of stomach cancer in the family, rate ratios (RR) for increasing quintiles of energy-adjusted intake of dietary salt were 1.00, 1.49, 1.03, 1.54 and 1.18, respectively (p trend = 0.43). An inverse association was found between stomach cancer and salt added at the hot meal (p trend = 0.04). For salt added to home-made soup, use of salt at the table, salt preference and duration of refrigerator use, no associations were observed. Positive associations were found for bacon (RR highest/lowest intake = 1.33; 95% CI = 1.03-1.71) and other sliced cold meat (RR highest/lowest intake = 1.29; 95% CI = 0.96-1.72), but not for smoked sausage, total cold meats, rashers/bacon, boiled ham and smoked beef/pork loin roll. Separate analyses among subjects with self-reported stomach disorders revealed higher RR of stomach cancer for dietary salt and several types of cured meat. The present findings suggest that intake of dietary salt and several types of cured meat were weakly positively associated with stomach cancer risk.

Self-administered food frequency questionnaire used in the 5-year follow-up survey of the JPHC Study: questionnaire structure, computation algorithms, and area-based mean intake.

In this section we described the structure of the self-administered semiquantitative food frequency questionnaire used in the 5-year follow-up survey of the JPHC study, the computation algorithms, and the area-based mean intakes of nutrients and food groups in the subjects of the validation study. The FFQ consists of five sections: 1) semiquantitative frequency questions for rice and miso (fermented soybean paste)-soup, 2) those for alcoholic beverages, 3) those for vitamin supplements, 4) those for foods and beverages, and 5) questions on dietary and cooking behaviors. From the questions, intakes of nutrients and foods by food groups were computed. Although most of them were computed from the frequency and relative portion size indicated in the replies, together with the fixed portion size, a seasonal coefficient was added in the computation of vegetables and fruits. Only frequency of intake and fixed portion size were used for computation of beverages. Sugar and cream added in coffee and tea were computed from the frequency of coffee and tea intake. The intakes of cooking oil, cooking salt (sodium), and salt in noodle-soup were estimated from the questions of relative preference of oil, salt, and noodle-soup.

Glia- and Neuron-specific Expression of the Renin-Angiotensin System in Brain Alters Blood Pressure, Water Intake, and Salt Preference

The purpose of this study is to examine the regulation of blood pressure and fluid and electrolyte homeostasis in mice overexpressing angiotensin II (Ang-II) in the brain and to determine whether there are significant physiologic differences in Ang-II production in neurons or glia. Therefore, we generated and characterized transgenic mice overexpressing human renin (hREN) under the control of the glial fibrillary acidic protein (GFAP) promoter (GFAP-hREN) and synapsin-I promoter (SYN-hREN) and bred them with mice expressing human angiotensinogen (hAGT) under the control of the same promoters (GFAP-hAGT and SYN-hAGT). Both GFAP-hREN and SYN-hREN mice exhibited the highest hREN mRNA expression in the brain and had undetectable levels of hREN protein in the systemic circulation. In the brain of GFAP-hREN and SYN-hREN mice, hREN protein was observed almost exclusively in astrocytes and neurons, respectively. Transgenic mice overexpressing both hREN and hAGT transgenes in either glia or neurons were moderately hypertensive. In the glia-targeted mice, blood pressure could be corrected by intracerebroventricular injection of the Ang-II type 1 receptor antagonist losartan, and intravenous injection of a ganglion blocking agent, but not an arginine vasopressin V1 receptor antagonist, lowered blood pressure. These data suggest that stimulation of Ang-II type 1 receptors in the brain by Ang-II derived from local synthesis of renin and angiotensinogen can cause an elevation in blood pressure via a mechanism involving enhanced sympathetic outflow. Glia- and neuron-targeted mice also exhibited an increase in drinking volume and salt preference, suggesting that chronic overexpression of renin and angiotensinogen locally in the brain can result in hypertension and alterations in fluid homeostasis.

Budding tastes: Higher blood pressure in newborns links to salt preference

Science NewsVolume 162, Issue 7 p. 101-102 This Week Budding tastes: Higher blood pressure in newborns links to salt preference Nathan Seppa, Nathan SeppaSearch for more papers by this author Nathan Seppa, Nathan SeppaSearch for more papers by this author First published: 02 July 2009 https://doi.org/10.2307/4013789AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume162, Issue717 August 2002Pages 101-102 RelatedInformation

Neuron-specific expression of human angiotensinogen in brain causes increased salt appetite.

The brain renin-angiotensin system (RAS) has an important role in the regulation of cardiovascular function. In the brain, angiotensinogen (AGT) is expressed mainly in astrocytes (glia) and in some neurons in regions controlling cardiovascular activities. Because of the inability to dissect the functional role of astrocyte- vs. neuron-derived AGT in vivo by pharmacological approaches, the exact role of neuron-derived AGT in the regulation of blood pressure (BP) and fluid and electrolyte balance remains unclear. Therefore, we generated a transgenic mouse model overexpressing human AGT under the control of a neuron-specific (synapsin I) promoter (SYN-hAGT). These mice exhibited high-level expression of human AGT mRNA in the brain, with lower expression in the kidney and heart. Human AGT was not detected in plasma, but in the brain it was expressed exclusively in neurons. Intracerebroventricular (30 ng) but not intravenous (500 ng) injection of purified human renin (hREN) caused a pressor response, which was prevented by intracerebroventricular preinjection of the angiotensin II type 1 receptor antagonist losartan, indicating an AT(1) receptor-dependent functional role of neuron-derived AGT in the regulation of BP in response to exogenous REN. Double transgenic mice expressing both the hREN gene and SYN-hAGT transgene exhibited normal BP and water intake but had an increased preference for salt. These data suggest that neuronal AGT may play an important role in regulating salt intake and salt appetite.

Effect of sodium deprivation on morphine-and lithium-induced conditioned salt avoidance and taste reactivity.

When paired with morphine, rats suppress their intake of saccharin solution, but not a less palatable salt solution. The reward comparison hypothesis argues that when a taste is paired with morphine, intake of the solution is expected to decrease as the palatability of the taste increases. Therefore, morphine should more effectively suppress intake of salt solution in rats that are conditioned in a sodium-deprived state than in rats that are conditioned in a sodium-replete state. The present experiments evaluated the effect of furosemide-induced sodium deprivation on morphine and lithium-induced salt (experiment 1) and saccharin (experiment 2) avoidance and salt taste reactivity (experiment 4). Rats were injected with furosemide or saline 21 h prior to access to salt solution (experiments 1 and 3) or saccharin solution (experiment 2). Immediately following access to the solution, the rats were injected with saline, morphine or lithium chloride solution. In experiments 1 and 2, a two-bottle test measured the strength of the taste preference/avoidance. In experiments 3 and 4, the taste reactivity test evaluated the furosemide-induced unconditional palatability changes for salt solution (experiment 3) and the conditional palatability changes for salt previously paired with morphine or lithium (experiment 4). Sodium depletion induced by furosemide pretreatment conditionally enhanced subsequent preference for salt solution using both the taste avoidance test (experiment 1) and the taste reactivity test (experiment 4). Salt-lithium associations, but not salt-morphine associations, suppressed salt preference. However, the salt-morphine (40 mg/kg) association enhanced salt preference (in both experiments 1 and 4) when rats were conditioned in a sodium-deprived state. In experiment 2, morphine-saccharin associations resulted in conditioned saccharin avoidance regardless of pretreatment condition. When the palatability of salt was enhanced by sodium depletion, morphine produced a mild conditioned salt preference in both a two-bottle preference test and enhanced ingestion reactions in the taste reactivity test, but morphine produced conditioned saccharin avoidance.