A novel noise-cancelling readout circuit (NCRC) is proposed to improve the linearity and sensitivity of traditional voltage–time (V–T) measurement system for ruthenium dioxide (RuO2) urea biosensor. To reduce the non-ideal effect related to traditional V–T measurement system that negatively threatened by the impact of power line noise, this NCRC adopts a new power line noise elimination scheme. Moreover, by employing the Twin-T notch filter and the Sallen–Key low-pass filter, the proposed NCRC can increase the linearity by 161% while retaining the sensitivity at an average level than V–T measurement system. A new NCRC for measuring the linearity and sensitivity of RuO2 urea biosensor is implemented by a real circuit board. The experimental results show that the proposed NCRC can achieve 0.956 linearity and 1.22 mV/(mg/dl) average sensitivity.
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