Salivary Gland Cysts Research Articles

CLINICOMORPHOLOGICAL FEATURES, DIAGNOSTIC AND TREATMENT OF CYSTS OF THE MINOR SALIVARY GLANDS

Small salivary gland cysts occupy a large percentage in the structure of oral cavity diseases in children and adults.
 The aim of the study is to determine the main diagnostic criteria and treatment tactics for patients with small salivary gland cysts.
 Materials and methods. 5 adult patients aged from 21 to 50 years and 2 children aged from 3 and 16 years were examined and surgical removal of small salivary gland cysts was performed. Pathohistologic studies of biopsy material were performed.
 Results obtained. Women (85.7%) prevail among the patients with cysts of the minor salivary gland. The average age of the patients was 27,0±6,1 years. The most frequent localization of small salivary gland cysts was the mucous membrane of the lower lip (85,7%). In 5 patients it was confirmed that the cause of cyst formation was mechanical trauma, namely biting or bruising of the lower lip. Clinically, a cyst of the minor salivary gland was a single oval or rounded mass with a size ranging from 0.4 to 1.1 cm. The average size of the cyst was 0.69±0.08 cm in diameter.
 According to the results of the pathohistological examination, the extravasation type of cyst of the minor salivary gland was determined in 3 patients, the retention cyst was also determined in 3 patients on the lower lip. A superficial extravasation cyst has been diagnosed on a soft palate in a woman aged 50 years old.
 In 3 patients, cystectomy was carried out in a traditional surgical method, in 4 patients with the use of a high-intensity diode laser. Hyaluronic acid gel hyaDENT BG was used to accelerate wound healing after laser ablation.
 Conclusion. Based on literature analysis and own clinical observations, the main etiological factors and clinical-morphological signs of various clinical variants of cysts of the minor salivary glands were determined. It is shown that only the mucous retention cyst is a true cyst, because it histologically has an internal epithelial lining.

Triamcinolone Acetonide Injection and Topical as an Alternative Method for Mucocel Therapy

Introduction: Mucocele is a swelling caused by the collection of saliva from the ducts of minor salivary glands that are cut off or blocked. This is a salivary gland cyst that contains mucus and generally founded in the oral cavity. Surgery is the most popular therapy in the treatment of mucocele. There are various alternative therapeutic modalities that can be used including laser ablation, cryosurgery, sclerotherapy, micromarsupialization, laser surgery, injection of sclerosis agents, and corticosteroid injection. Case and management: This paper describes the treatment of mucoceles using triamcinolone acetonide that is quite often used in the oral cavity. The therapy carried out is intradermal injection of 0.2 ml of triamcinolone acetonide IA/ID (10 mg/ml) and topical application of triamcinolone acetonide ointment in orabase 0.1% 6x/day. One week later it was seen that the mucocele lesion had almost disappeared. Discussion: Corticosteroids act as potent anti-inflammatory agents and also act like sclerosing agents causing shrinkage of the dilated salivary ducts. Conclusion: Triamcinolone acetonide can be an alternative therapy besides surgery in the management of mucocele cases. The application can be done by intradermal injection and topical ointment. No side effects were found at the end of treatment.

MANAGEMENT OF BILATERAL RANULA: A CASE REPORT

Ranula is a retention pseudocyst caused by an obstruction or trauma in the duct of the sublingual salivary gland which causes mucus extravasation. The ranula that extends through the mylohyoid muscle into the submandibular space is called plunging ranula. The prevalence of ranula is approximately 0.2 cases per 1000 individuals, accounting for 6% of intraoral salivary gland cyst, meanwhile plunging ranulas are still unknown. Simple ranulas generally occurs in children and young adults, meanwhile plunging ranulas occurs in patients aged 20-29. Ranula conditions are generally unilateral, meanwhile bilateral ranula is a rare case. In this case, we presented a plunging ranula case with bilateral condition in a patient aged 10 years old. This paper aimed at presenting a rare case to highlight the etiology, diagnosis, treatment, and prognosis of this condition.

Uncommon Histopathological Variants of a Common Lesion: Mucocele

A mucocele is a salivary gland cyst, which contains mucous material. It usually arises from the minor salivary glands and is broadly of two types: mucus retention cysts and mucus extravasation phenomenon. A wide variety of histological features have been documented in the literature such as myxoglobulosis, mucoceles presenting papillary synovial metaplasia-like changes, superficial mucoceles, and clear cell changes. The present case shows histological features of myxoglobulosis and papillary synovial metaplasia like changes (PSM like changes). This paper reports a case of a 17 years old male patient with a chief complaint of a painless swelling on the lower lip since one and half year. Upon a provisional diagnosis of mucocele, surgical excision was carried out. Histopathological examination revealed a mucus extravasation cyst having lumen filled with unique mucinous globular structures, myxoglobulosis and papillary synovial metaplasia like changes.

Mucocele of the lower lip: A case report of a benign salivary gland cyst

We report a case of Mucocele in a 35-year-old male patient. Mucoceles are one of the most frequent lesion of the oral mucosa. The most common affected site is the lower lip. The most common treatment for mucocele is excision, however recurrence is common. Other treatment modalities available are Cryosurgery, CO 2 laser ablation, Intralesional steroid injection, and Diode lasers.

Myoepithelial Carcinoma Arising in a Salivary Duct Cyst of the Parotid Gland: Case Presentation

Cystic lesions observed in parotid glands are relatively rare and comprise 2-5% of all parotid primaries. A salivary duct cyst (SDC) is a true cyst representing 10% of all salivary gland cysts. The risk of malignant transformation of SDC's epithelium is extremely rare. In the literature, only three cases of carcinoma ex SDC of the parotid gland are described. This report presents the first in the literature case of myoepithelial carcinoma (MECA) arising from a parotid SDC. A 75-year-old male patient was referred to the Department of Cranio-Maxillofacial Surgery of the Jagiellonian University in Cracow, Poland due to a cystic tumor arising from the right parotid gland. Superficial parotidectomy with facial nerve preservation was performed. Histological examination confirmed a rare case of MECA emerging from the SDC. The immunohistochemical profile of MECA ex SDC was presented. During 6 months of the follow-up, local recurrence or distant metastasis was not observed.

Modified micromarsupialization technique as an alternative primary treatment for ranulas: A case series in a resource-challenged economy.

Ranula is one of the commonest salivary gland cysts that mostly occur due to mucus extravasation from the sublingual salivary gland. Treatment of this lesion is still somewhat shrouded in controversy and varies from conservative treatment to surgical excision of the causative gland. This was a case series in quasi-experimental design that evaluated the outcome and complications of the modified micromarsupialization technique as a newly introduced treatment at our center for simple sublingual ranula over a 2-year period. Twenty patients were treated by the modified micromarsupialization technique and followed up for 1 year. There was complete resolution following this technique in 17 patients (85%) with no evidence of recurrence or complications, whereas 2 patients (10%) showed partial resolution and the remaining 1 patient (5%) showed a failure and recurrence. The age of the patient, the size of the ranula, and the retention of sutures throughout the study period did not significantly affect the treatment outcome. The modified micromarsupialization technique was a simple and effective treatment that should be used as a primary treatment option for simple ranulas and we recommend it to be the first-choice treatment before surgical excision of the sublingual gland, especially in a resource-challenged economy like ours.

668P Comprehensive analysis of the tumor immune microenvironment (TIM) in advanced adenoid cystic (ACC) and non-adenoid cystic salivary gland cancers (SGC)

668P Comprehensive analysis of the tumor immune microenvironment (TIM) in advanced adenoid cystic (ACC) and non-adenoid cystic salivary gland cancers (SGC)

Cystic Salivary Gland Neoplasms: Diagnostic Approach With a Focus on Ancillary Studies.

Cystic salivary gland cytology can be challenging due to the fact that a cystic mass can be the clinical presentation of both non-neoplastic and neoplastic conditions. Neoplastic lesions consist of both benign and malignant neoplasms. The cytomorphologic features of these entities can overlap and the cystic background may additionally contribute to the complexity of these lesions and their interpretation. Ancillary studies have been reported in several studies to be beneficial in further characterization of the cellular components and subsequent diagnosis of the cystic lesions of the salivary gland. Fluorescence in situ hybridization, real-time polymerase chain reaction, and next-generation sequencing are now being utilized to detect molecular alterations in salivary gland neoplasms. MALM2 rearrangement is the most common gene fusion in mucoepidermoid carcinoma. PLAG1 rearrangement is present in more than half of pleomorphic adenomas. AKT1:E17K mutation is the key diagnostic feature of the mucinous adenocarcinoma. NR4A3 overexpression is highly sensitive and specific for the diagnosis of acinic cell carcinoma. MYB fusion is noted in adenoid cystic carcinoma. ETV6:NTRK3 fusion is helpful in diagnosis of secretory carcinoma. p16 and human papillomavirus (HPV) studies differentiate HPV-related squamous cell carcinoma from non-HPV-related neoplasms with overlapping features. NCOA4:RET fusion protein is the main fusion in intraductal carcinoma.

The involvement of chronic persistent viral infection to various diseases of the oral cavity

Relevance. According to the literature all over the world, there is a tendency to reduce immunological reactivity in humans, this is facilitated by the presence of chronic persistent herpes viral infection. Herpes infection has systemic immunosuppressive effects of the infection on the human body, and also highlighted the role of the virus in a slow occurrence of combined pathology of internal organs and infectious and inflammatory diseases of the oral tissues and periodontium. High interest of specialists to this problem сaused by the necessity of new methods of complex treatment polymorbidity human pathology. Purpose – to assess the degree of involvement of chronic cytomegalovirus persistence in a number of dental diseases.Materials and methods. In 67 patients dental surgery underwent surgery removal of benign tumors of the soft tissues of the oral cavity, periodontium and jaws, had a clinical blood analysis, blood testing for serological signs of chronic persistence of cytomegalovirus infection (antibodies to CMV Ig G (anti CMV IgG), PCR for CMV in blood and saliva, and also studied the cellular composition of blood immunogram. The age of patients averaged 46 years. Рatients were divided according to the nosological principle into 4 groups. The first group consisted of patients with periapical foci of chronic odontogenic inflammation and radicular cysts of the jaws. The second group consisted of persons with oral fibroids of different localization. The third group is patients with retention cysts of small salivary glands of the oral mucosa. The fourth group – patients with poligamy various locations. All operations are performed outside the phase of acute inflammation. The material obtained after the operation underwent histological examination.Results. Serological signs of chronic persistence of cytomegalovirus infection were revealed in all examined patients, the level of anti CMV Ig was 225 ± 25 U / ml (at the rate of 0.00-0.50 U / ml) (p 0.01). Also, all patients showed lymphocytosis of blood and this corresponded to the same type of changes in the cellular composition of the immunogram with a decrease in the quantitative parameters of B-lymphocytes (CD19+ CD3- ), true natural "killers" (NK-cells) (CD3- CD56+ CD45+ ), NK-cells cytokine-producing (CD3- CD16+ Cd56brightcd45+ ), NK-cells cytolytic (CD3- CD16+ (orhigh) sd56dimcd45+ ). The results of the histological study showed that focal mononuclear and lymphohistiocytic cell infiltration with giant cells with large nuclei are more often detected in areas of the oral mucosa in all patients with radical and retention cysts.Conclusion. The Obtained results demonstrate that in patients regardless of surgical dental diagnosis, chronic persistence of cytomegalovirus with the same type of hematological, immunological abnormalities was revealed. In areas of the oral mucosa with retention cysts of small salivary glands and with radicular cysts, focal lymphohistiocytic and mononuclear cell infiltration with giant cells with large nuclei was revealed.

Częstość występowania i różnorodność patologicznych zmian w jamie ustnej u pacjentów leczonych w Zakładzie Chirurgii Stomatologicznej WUM w latach 2012–2017. Badanie retrospektywne

Introduction A large number of lesions of various etiopathogenesis may be found in the oral cavity. They range from benign inflammatory-hyperplastic changes to malignant tumors. The following study aims to statistically show the frequency and type of changes depending on the age and sex of patients treated in the Department of Dental Surgery of the Medical University of Warsaw. Material and methods 612 results of histopathological examinations of sections or entire lesions of the oral cavity collected from patients in the years 2012–2017 were analyzed. The results were analyzed in terms of gender, age and the site of tissue collection. Neoplasms and 8 other groups of lesions of the mucosa were distinguished. Results The most common lesion was fibroma (35%), followed by a chronic inflammatory process (15.4%), and salivary gland cysts (11.9%). Papillomas (HPV) accounted for 10.5%, epilemomas 9.64%, tumors 6.54%, cysts and ulcers 4.74% and 4.25%, respectively. Pre-neoplastic lesions were found in 70 cases. These included ulcerations, leukoplakia, changes with metaplasia, dysplasia and pseudo-neoplastic hyperplasia. The most common localization of pathological changes in the oral cavity was related to the gums. Conclusions Many lesions of various etiology may present with a similar clinical manifestation. Therefore, in order to correctly diagnose pathological changes in the oral cavity, it is necessary to conduct a thorough medical history and physical examination, and identify the factors that may have caused the lesion. A particular group of pathological changes of the oral mucosa are ulcers which, despite a conservative approach, do not respond to treatment. In such cases a neoplasm should be suspected and a section of the lesion be obtained for histopathological evaluation which is the only reliable method that allows a final diagnosis.

Application of the Milan System for Reporting Salivary Gland Cytopathology to cystic salivary gland lesions.

Cystic salivary gland lesions present diagnostic challenges on fine-needle aspiration (FNA) specimens that are related to sampling limitations and a broad differential diagnosis. This study evaluated the benefit of applying the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) to a series of cystic salivary gland lesions. The pathology archives at the Johns Hopkins Hospital were searched to identify cystic salivary gland FNA specimens over a 19-year period (2000-2018). Patient demographics, cytomorphologic features, and clinical and surgical follow-up were recorded. The MSRSGC was applied to the cases. The risk of malignancy (ROM) and the risk of neoplasia (RON) were calculated for each category. One hundred seventy-eight cases were identified (96 males and 82 females) with a mean age of 53 years (range, 4-90 years). After the MSRSGC was applied, there were 52 nondiagnostic cases (29.2%), 80 nonneoplastic cases (44.9%), 35 cases of atypia of undetermined significance (AUS; 19.7%), 3 benign neoplasms (1.7%), 3 salivary gland neoplasms of uncertain malignant potential (SUMP; 1.7%), 4 cases suspicious for malignancy (SFM; 2.2%), and 1 malignant case (0.6%). One hundred fifty-six of the 178 patients (87.6%) had follow-up data available. The RON and ROM values for cases with surgical follow-up were 33.3% (3 of 9) and 22.2% (2 of 9) for the nondiagnostic category, 42.9% (9 of 21) and 19% (4 of 21) for the nonneoplastic category, 76.5% (13 of 17) and 29.4% (5 of 17) for the AUS category, 100.0% (2 of 2) and 50.0% (1 of 2) for the SUMP category, and 100% (2 of 2) and 100% (2 of 2) for the SFM category, respectively. Applying the MSRSGC to cystic salivary gland lesions improves patient management by preventing unnecessary surgery for nonneoplastic conditions. The ROM was highest in the SFM category (100%), which was followed by the SUMP, AUS, nondiagnostic, and nonneoplastic categories. Less than adequate specimens may increase the diagnosis of AUS.

Abstract 3418: A phase II basket trial of dual anti-CTLA-4 and anti-PD-1 blockade in rare tumors (DART) SWOG S1609: The salivary gland tumor cohort

Abstract Background: Since their first approval in 2011 for metastatic melanoma, checkpoint inhibitors have been successfully applied to multiple tumor types. To date, the potential role for these treatments in rare solid tumors has not been well studied. We report the results of three salivary gland neoplasm cohorts of SWOG S1609 Dual Anti-CTLA-4 & Anti-PD-1 blockade in Rare Tumors (DART) trial. Methods: We performed a prospective, open-label, multicenter phase 2 clinical trial of ipilimumab (1mg/kg intravenously every 6 weeks) plus nivolumab (240mg intravenously every 2 weeks) in multiple tumor types. Here, we report the results found in three salivary gland neoplasm cohorts that include patients with salivary gland tumor types arising in major salivary glands (cohort 2), other sites of origin (cohort 3) and adenoid cystic carcinomas of any site (cohort 34). Primary endpoints included overall response rate (ORR) (RECIST v1.1) (complete response (CR) and partial responses (PR)); secondary endpoints included progression-free survival (PFS) and overall survival (OS), stable disease >6 months, and toxicity. Results: Twenty six patients with adenoid cystic salivary gland tumors and thirty five patients with other histologic subtypes of salivary gland neoplasm received therapy. The most common site of origin was the parotid (35%; N=9 in the adenoid cystic group and 54%; N=19 in the remaining histologies). The overall ORR in the adenoid cystic group was 4% (CR, 0%; PR, 4%, N= 1) and the median PFS was 4.4 months. 6 month OS was 84% and median OS was 12 months. In the remaining histologic subtypes the ORR was 9% (CR, 0%; PR, 9%, N=3) and the median PFS was 4.6 months. 6-month OS was 89%, median OS was not reached. The most common toxicities were fatigue (39%) and diarrhea (26%), with diarrhea (8%) as the most common grade 3-5 immune-related adverse event. Conclusions: In salivary gland tumors, combination therapy with ipilimumab plus nivolumab resulted in a 4% ORR in adenoid cystic carcinoma and 9% in other histologies combined. Citation Format: Young Kwang Chae, Megan Othus, Sandip Pravin Patel, James P. Ohr, Francis P. Worden, Jennifer M. Suga, Aung Naing, Sarah E. Fenton, Hyunseok Kang, Sewan Gurung, Christine M. McLeod, Francis J. Giles, Helen X. Chen, Elad Sharon, Edward Mayerson, Melissa Plets, Christopher Ryan, Charles D. Blanke, Razelle Kurzrock. A phase II basket trial of dual anti-CTLA-4 and anti-PD-1 blockade in rare tumors (DART) SWOG S1609: The salivary gland tumor cohort [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 3418.

Lenvatinib and Pembrolizumab in People With Advanced Adenoid Cystic Carcinoma and Other Salivary Gland Cancers

Lenvatinib and Pembrolizumab in People With Advanced Adenoid Cystic Carcinoma and Other Salivary Gland Cancers

Beauty is only mucosa deep: a retrospective analysis of oral lumps and bumps caused by cosmetic fillers.

Introduction The injection of dermal fillers into orofacial tissues is becoming increasingly popular for cosmetic purposes, in particular for lip augmentation. Both natural and synthetic filler materials are available, producing a spectrum of clinical and histological appearances.Aims The aim of this study was to review the clinicopathological characteristics of dermal filler cases from 2006 to 2016, reported at a specialist oral pathology unit.Methods An archival search of the pathology database was performed to retrieve cases reported as being consistent with cosmetic fillers.Results Ten cases of orofacial cosmetic fillers were retrieved. Of these cases, 100% were from female patients and the mean age of presentation was 47.6 years (range 24-68 years). The lips were the most frequently involved site (80%, n = 8). The majority of provisional diagnoses were related to salivary gland disease, including neoplasms (30%, n = 3), cysts (20%, n = 2) or inflammatory disease (10%, n = 1). Only two cases (20%) were clinically thought to be related to previous cosmetic injections. A variety of filler materials were seen, including collagen, hydroxyapatite and silicone. However, hyaluronic acid-based materials were the most common (50%, n = 5).Conclusions Complications of cosmetic dermal fillers are becoming more common and should be considered within a differential diagnosis for unusual orofacial swellings.

Ectopic Thyroid Tissue in Submandibular Region

Ectopic thyroid is the presence of gland at any location except for its normal position in the anterior neck in front of the trachea. It may result from an early arrest of migration or migration along an abnormal path. Ectopic thyroid in the submandibular region is relatively unusual and may or may not be accompanied with the orthotopically located thyroid gland. Pathological changes reported in the literature in the ectopic gland include goitrous change, hyperplasia, malignancy, and, rarely, inflammation. Patients usually present as a palpable, mobile, and painless mass below the lateral jaw. The important differentials include salivary gland tumor, lymphoma, inflammatory lymphadenopathy, lipoma, and cysts. Ultrasonography, radionuclide scan, computed tomography, and magnetic resonance imaging are the diagnostic modalities for documenting the presence of ectopia. Evaluation of functional status with thyroid profile and histopathological examination after fine-needle aspiration cytology directs further management. Surgical removal is the preferred treatment for ectopic thyroid. Thyroidectomy predisposes the patient to iatrogenic hypothyroidism if eutopic thyroid is absent or hypofunctioning. Such patients require lifelong thyroid replacement. However, asymptomatic cases may be managed conservatively. Ectopic thyroid in the submandibular region has important clinical implications and hence, even though rare, should be considered as one of the differentials in the patient presenting with swelling below the lateral jaw.

Diagnostic Approach to Fine Needle Aspirations of Cystic Lesions of the Salivary Gland.

Fine needle aspiration (FNA) has diagnostic and therapeutic value in the management of salivary gland cysts. Rendering an accurate diagnosis from an aspirated salivary gland cyst is challenging because of the broad differential diagnosis, possibility of sampling error, frequent hypocellularity of specimens, morphologic heterogeneity, and overlapping cytomorphology of many cystic entities. To date, there have been no comprehensive review articles providing a practical diagnostic approach to FNA of cystic lesions of salivary glands. This article reviews the cytopathology of salivary gland cysts employing 2017 World Health Organization terminology, addresses the accuracy of FNA, and presents The Milan System approach for reporting in cystic salivary gland cases. The utility of separating FNA specimens from salivary gland cysts, based upon the presence of mucin and admixed lymphocytes in cyst fluid is demonstrated. A reliable approach to interpreting FNA specimens from patients with cystic salivary gland lesions is essential to accurately determine which of these patients may require subsequent surgery.

Salivary gland mucoceles: A clinical study of 103 cases

Mucocele is a tissue swelling composed of pooled mucus that escaped into the connective tissue from a severed salivary excretory duct (extravasated).In the present study 103 cases of mucoceles reviewed from the records of patients at the Department of the Oral Pathology, faculty of Dentistry , Baghdad University over 11 years period ( 1982-1992). Mucoceles were statically analyzed according to age, gender , site of occurrence and type.It was found that a greater number of mucoceles cases 37(36%) occur in patients at 2nd decade of age followed by 29(28.2) of cases occurred in 3rd decade of age. Mucoceles were occurred more in males than females 57(55.2%) ,46 (44.8%),respectively.Lower lip was the predominant site for occurrence of mucocele 84(81.6%) followed by the floor of the mouth 12(11.7%).The most frequent type of mucocele was of extravasated type100(97.1%) whereas it was only 3(2.9%)for mucous retention type.Key words: Mucocele, Salivary gland cyst.

Alternative Approach to Traumatic Stensen’s Duct Injuries Accompanied by Glandular Involvement: Botulinum Toxin Injection to the Gland in Conjunction with Microsurgical Repair of the Duct in an Acute Setting

There is high tendency to ignore the diagnosis as the incidence of the injury of parotid gland and its duct is relatively rare. In order to prevent the long-term complications such as facial deformities, sialoceles, cutaneous fistulae, salivary gland cysts and gustatory sweating (Frey’s syndrome) and to restore the parotid gland functions, it is important for the duct injuries to be diagnosed and treated immediately. 3 patients consulted to Plastic Surgery Clinic from the Emergency Room of Hacettepe University following maxillofacial trauma was reviewed in this study. Exploration of the facial nerve and Stenon duct was planned for all patients within the first 72 hours following the injury. Following intraoral catheterization of the Stenon duct through the papilla with an epidural catheter, microsurgical end-to-end anastomosis was performed. Concurrently, 100 Units of botulinum toxin A was injected at standardized 8 points on the parotid gland. Postoperative MR sialography revealed patency in all patients at the end of postoperative first year. The mean postoperative parotid volume of the injured and non-injured sides were 19,82±10,55 and 17,79±10,98 respectively and the results were found to be comparable. Fibrillation potentials in the postoperative electromyography recordings and clinical examination demonstrated the nerve regeneration. In conclusion, botulinum toxin A is appears to be effective in both treatment of the injuries of the duct accompanied by glandular involvement in the acute setting, as well as prevention of the long term complications.

Lymphoepithelial Sialadenitis Involving HIV-Infected and Sjogren Syndrome Patients: A Cytologic Study.

Lymphoepithelial salivary gland cysts are rarely seen in autoimmune diseases particularly Sjogren syndrome as well as in HIV for which medical management is advocated. To study the morphology of these cysts, correlate with the disease process and assess the final outcome. Case series. Fine needle aspiration clinic. HIV-infected and autoimmune disease patients with lymphoepithelial cysts. Antiretroviral therapy for HIV-patients and anti-inflammatory drugs for Sjogren syndrome. Three HIV-infected patients (two children and one adult) and three middle aged female patients presented with parotid and submandibular cysts, two of which were bilateral along with submandibular (one each in the HIV and the autoimmune group). In the adult HIV-patient, the cyst was found at the inception of the disease while the other pediatric HIV-patients just crossed a decade. Of the other three cases of Sjogren syndrome, two were primary and one, secondary to rheumatoid arthritis. All the cysts regressed completely with treatment of the respective diseases which was confirmed by ultrasonograms. Lymphoepithelial cysts are produced by release of serous secretion by the acinar and ductal cells within the epithelial islands in the process of their destruction. Possibly, antibody mediated increased secretion in the initial stages also plays a role. Lymphoepithelial cysts of HIV patients may occur in the course of treatment, not necessarily in the beginning, though it resolves spontaneously. Lymphoepithelial cysts of primary or secondary Sjogren syndrome may be repressed sufficiently by anti-inflammatory/immunosuppressant treatment.