Iva xanthiifolia, an invasive annual weed species native to North American prairies, is an agricultural problem in different parts of the world and represents a health hazard as an allergen to humans. This study addresses the limited literature on its germination requirements, focusing on base temperature, base water potential, and salinity tolerance. Seeds from a Serbian population near Belgrade were tested to various conditions. The experiments were conducted using temperatures ranging from 1 °C to 30 °C and water potentials ranging from 0 to –2 MPa, while salinity tolerance was tested at three temperatures (1, 3, and 6 °C) and five salinity levels (0 to 16 dS/m). Results indicate higher germination rates at lower temperatures (1 °C) compared to higher temperatures (30 °C), with a base temperature of 0.7 ± 0.37 °C. Germination decreased with increased water potential, showing a base water potential of -1.58 ± 0.07 MPa. Salinity tolerance was observed, with germination even at 16 dS/m (the final germination rate was 54.5 % ±2.88). Additionally, germination was observed declining with increasing temperature in a saline environment. As germination is one of the major determinants of a species’ success, the possible spreading of this species under different climate change scenarios was simulated. Results of future distribution modelling suggested sensitivity to precipitation changes and potential northward expansion of this species. This research enhances our understanding of Iva xanthiifolia traits, useful for supporting management strategies for its control and mitigation of its impact, even under future climate change and land-use scenarios.