Sub- Sahara Africa (SSA) has the lowest access to energy globally which is partly responsible for its dismal socio-economic indices. The continent, however, has the unique opportunity to fuel its sustainable development using clean and sustainable energy. Given the continent’s aspirations, as well as its position and peculiarities within the context of the Sustainable Development Goals (SDGs) such as its hosting up to 90% of the world’s poorest countries, and generally lagging behind in development as most countries in Africa are not on track to meet the SDGs with the exception of the SDG on climate action, an assessment of the interactions and implications between the goal to provide access to clean, reliable, affordable, sustainable, and modern energy (SDG 7) and the other non-energy related SDGs is important for coherent cross-sectoral sustainable development planning and decision-making. This paper analyzes the interactions between SDG 7 and selected non-energy SDGs for three energy-mix scenarios—the current (2018), 2040 energy mix scenario proposed by International Energy Agency (IEA), and 2065 energy mix scenario proposed by Joint Research Centre (JRC) of the European Commission. The analyses are done for two countries - Nigeria and Ethiopia—that capture the wide variation in economic growth and energy sources across SSA. The analyses were carried out by adapting a seven-point scoring typology proposed by Nilsson et al (2016). The results indicate that in the case of Nigeria, the interactions between SDG 7 and many non-energy SDGs, such as SDGs 2, 6, and 13, become negative for the IEA 2040 scenario while they were positive for 2018 scenario. For the same two scenarios (IEA 2040 and the current), for Ethiopia, there are some negative influences on selected non-energy SDGs, but the direction of overall interactions does not change from positive to negative. In the case of JRC 2065 scenario, there are marginal negative influences on some non-energy SDGs, but neither in Nigeria nor in Ethiopia, there is no complete reverse change from positive to negative for any non-energy SDGs. Hence, JRC 2065 scenario is preferred. The study concludes with recommendations for policy interventions that would prevent the change of the interactions that move from positive in the 2018 scenario towards negative in the 2065 scenario (such as those that protect the rights of local communities to natural resources), as well as policies that may reduce the influence of negative interactions seen in both scenarios (such as reduction of air pollution).